ZA977209B - Thrombin inhibitors. - Google Patents

Thrombin inhibitors.

Info

Publication number
ZA977209B
ZA977209B ZA9707209A ZA977209A ZA977209B ZA 977209 B ZA977209 B ZA 977209B ZA 9707209 A ZA9707209 A ZA 9707209A ZA 977209 A ZA977209 A ZA 977209A ZA 977209 B ZA977209 B ZA 977209B
Authority
ZA
South Africa
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
Prior art date
Application number
ZA9707209A
Other languages
English (en)
Inventor
Constant Adriaan Anton Boeckel
Anton Egbert Peter Adang
Jacobus Albertus Maria Peters
Johannes Bernardus Ma Rewinkel
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of ZA977209B publication Critical patent/ZA977209B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9707209A 1996-08-23 1997-08-12 Thrombin inhibitors. ZA977209B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96202336 1996-08-23

Publications (1)

Publication Number Publication Date
ZA977209B true ZA977209B (en) 1998-02-20

Family

ID=8224306

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9707209A ZA977209B (en) 1996-08-23 1997-08-12 Thrombin inhibitors.

Country Status (10)

Country Link
EP (1) EP0956293B1 (de)
AR (1) AR009302A1 (de)
AT (1) ATE282629T1 (de)
AU (1) AU4618197A (de)
DE (1) DE69731664D1 (de)
ID (1) ID18075A (de)
IL (1) IL121474A0 (de)
TW (1) TW515803B (de)
WO (1) WO1998007308A2 (de)
ZA (1) ZA977209B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877156A (en) * 1997-04-24 1999-03-02 Akzo Nobel, N.V. Thrombin inhibitors
EP0884325A1 (de) * 1997-04-24 1998-12-16 Akzo Nobel N.V. Inhibitoren des Thrombins, die einen peptid-Heterocyclus aufweisen
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
ATE502951T1 (de) 2006-05-23 2011-04-15 Irm Llc Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer
CA2651762A1 (en) 2006-05-23 2007-11-29 Irm Llc Compounds and compositions as channel activating protease inhibitors
KR20090108131A (ko) 2007-02-09 2009-10-14 아이알엠 엘엘씨 채널 활성화 프로테아제 억제제로서의 화합물 및 조성물
CN117143179B (zh) * 2023-09-18 2024-07-12 安徽峆一药业股份有限公司 一种凝血酶发色底物s-2238的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672582A (en) * 1993-04-30 1997-09-30 Merck & Co., Inc. Thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them
CA2208773A1 (en) * 1994-12-22 1996-06-27 John Dimaio Heterocyclic keto arginine peptides as thrombin inhibitors
US5827860A (en) * 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
IL119466A (en) * 1995-11-03 2001-08-26 Akzo Nobel Nv Thrombin inhibitors, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO1998007308A3 (en) 2000-08-24
TW515803B (en) 2003-01-01
WO1998007308A2 (en) 1998-02-26
IL121474A0 (en) 1998-02-08
AR009302A1 (es) 2000-04-12
AU4618197A (en) 1998-03-06
EP0956293B1 (de) 2004-11-17
EP0956293A1 (de) 1999-11-17
ATE282629T1 (de) 2004-12-15
DE69731664D1 (de) 2004-12-23
ID18075A (id) 1998-02-26

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