SI3423440T1 - 5-metil-6-fenil-4,5-dihidro-2H-piridazin-3-ON derivat za zdravljenje možganskih tumorjev - Google Patents
5-metil-6-fenil-4,5-dihidro-2H-piridazin-3-ON derivat za zdravljenje možganskih tumorjevInfo
- Publication number
- SI3423440T1 SI3423440T1 SI201730668T SI201730668T SI3423440T1 SI 3423440 T1 SI3423440 T1 SI 3423440T1 SI 201730668 T SI201730668 T SI 201730668T SI 201730668 T SI201730668 T SI 201730668T SI 3423440 T1 SI3423440 T1 SI 3423440T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pyridazin
- dihydro
- phenyl
- derivative
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2016042535 | 2016-03-04 | ||
PCT/JP2017/008246 WO2017150654A1 (en) | 2016-03-04 | 2017-03-02 | 5-methyl-6-phenyl-4,5-dihydro-2h-pyridazin-3-one derivative |
EP17711366.9A EP3423440B9 (en) | 2016-03-04 | 2017-03-02 | 5-methyl-6-phenyl-4,5-dihydro-2h-pyridazin-3-one derivative for the treatment of brain tumors |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3423440T1 true SI3423440T1 (sl) | 2021-07-30 |
Family
ID=58347859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201730668T SI3423440T1 (sl) | 2016-03-04 | 2017-03-02 | 5-metil-6-fenil-4,5-dihidro-2H-piridazin-3-ON derivat za zdravljenje možganskih tumorjev |
Country Status (28)
Country | Link |
---|---|
US (3) | US10611731B2 (sl) |
EP (1) | EP3423440B9 (sl) |
JP (1) | JP6596595B2 (sl) |
KR (1) | KR102350772B1 (sl) |
CN (1) | CN108779076B (sl) |
AU (2) | AU2017226674B2 (sl) |
CA (1) | CA3015331A1 (sl) |
CY (1) | CY1123927T1 (sl) |
DK (1) | DK3423440T3 (sl) |
EA (1) | EA036423B1 (sl) |
ES (1) | ES2862177T3 (sl) |
HR (1) | HRP20210395T1 (sl) |
HU (1) | HUE053358T2 (sl) |
IL (1) | IL261225B (sl) |
LT (1) | LT3423440T (sl) |
MX (1) | MX2018010535A (sl) |
MY (1) | MY196801A (sl) |
NZ (1) | NZ745688A (sl) |
PH (1) | PH12018501873A1 (sl) |
PL (1) | PL3423440T3 (sl) |
PT (1) | PT3423440T (sl) |
RS (1) | RS61593B1 (sl) |
SA (1) | SA518392275B1 (sl) |
SG (1) | SG11201807146SA (sl) |
SI (1) | SI3423440T1 (sl) |
TW (1) | TWI731041B (sl) |
WO (1) | WO2017150654A1 (sl) |
ZA (1) | ZA201805791B (sl) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7104588B2 (ja) * | 2017-09-01 | 2022-07-21 | 大塚製薬株式会社 | 5-メチル-6-フェニル-4,5-ジヒドロ-2h-ピリダジン-3-オン誘導体を含有する悪性腫瘍治療剤 |
AU2020215088A1 (en) * | 2019-02-01 | 2021-07-22 | Bayer Aktiengesellschaft | 1,2,4-triazin-3(2H)-one compounds for the treatment of hyperproliferative diseases |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63145272A (ja) | 1986-12-09 | 1988-06-17 | Morishita Seiyaku Kk | 4,5−ジヒドロ−6−(4−置換フエニル)−3(2h)−ピリダジノン誘導体 |
US5100892A (en) * | 1990-11-13 | 1992-03-31 | Glaxo Inc. | Dihydropyridine vasodilator agents |
US5563143A (en) * | 1994-09-21 | 1996-10-08 | Pfizer Inc. | Catechol diether compounds as inhibitors of TNF release |
CA2205757C (en) * | 1996-05-30 | 2006-01-24 | F. Hoffmann-La Roche Ag | Pyridazinone derivatives and their use as inhibitors of prostaglandin g/h synthase i and ii(cox i and ii) |
US20080090827A1 (en) * | 2004-11-30 | 2008-04-17 | Artesian Therapeutics, Inc. | Compounds With Mixed Pde-Inhibitory and Beta-Adrenergic Antagonist or Partial Agonist Activity For Treatment of Heart Failure |
EP2168959A1 (en) | 2007-06-19 | 2010-03-31 | Kyorin Pharmaceutical Co., Ltd. | Pyridazinone derivative and pde inhibitor containing the same as active ingredient |
CN101538245B (zh) * | 2008-03-18 | 2011-02-16 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物及其制备方法和制备药物的用途 |
US9890127B2 (en) * | 2013-03-11 | 2018-02-13 | The Broad Institute, Inc. | Compounds and compositions for the treatment of cancer |
-
2017
- 2017-03-02 US US16/081,260 patent/US10611731B2/en active Active
- 2017-03-02 MX MX2018010535A patent/MX2018010535A/es unknown
- 2017-03-02 HU HUE17711366A patent/HUE053358T2/hu unknown
- 2017-03-02 LT LTEP17711366.9T patent/LT3423440T/lt unknown
- 2017-03-02 AU AU2017226674A patent/AU2017226674B2/en active Active
- 2017-03-02 RS RS20210193A patent/RS61593B1/sr unknown
- 2017-03-02 JP JP2018544577A patent/JP6596595B2/ja active Active
- 2017-03-02 EA EA201891987A patent/EA036423B1/ru not_active IP Right Cessation
- 2017-03-02 ES ES17711366T patent/ES2862177T3/es active Active
- 2017-03-02 SG SG11201807146SA patent/SG11201807146SA/en unknown
- 2017-03-02 PT PT177113669T patent/PT3423440T/pt unknown
- 2017-03-02 CN CN201780013870.4A patent/CN108779076B/zh active Active
- 2017-03-02 CA CA3015331A patent/CA3015331A1/en active Pending
- 2017-03-02 EP EP17711366.9A patent/EP3423440B9/en active Active
- 2017-03-02 KR KR1020187028010A patent/KR102350772B1/ko active IP Right Grant
- 2017-03-02 TW TW106106813A patent/TWI731041B/zh active
- 2017-03-02 PL PL17711366T patent/PL3423440T3/pl unknown
- 2017-03-02 SI SI201730668T patent/SI3423440T1/sl unknown
- 2017-03-02 DK DK17711366.9T patent/DK3423440T3/da active
- 2017-03-02 NZ NZ745688A patent/NZ745688A/en unknown
- 2017-03-02 MY MYPI2018703021A patent/MY196801A/en unknown
- 2017-03-02 WO PCT/JP2017/008246 patent/WO2017150654A1/en active Application Filing
-
2018
- 2018-08-19 IL IL261225A patent/IL261225B/en unknown
- 2018-08-26 SA SA518392275A patent/SA518392275B1/ar unknown
- 2018-08-29 ZA ZA2018/05791A patent/ZA201805791B/en unknown
- 2018-09-03 PH PH12018501873A patent/PH12018501873A1/en unknown
-
2020
- 2020-02-12 US US16/788,894 patent/US20200181092A1/en not_active Abandoned
-
2021
- 2021-02-22 AU AU2021201135A patent/AU2021201135B2/en active Active
- 2021-02-23 US US17/182,549 patent/US20210171472A1/en active Pending
- 2021-02-24 CY CY20211100155T patent/CY1123927T1/el unknown
- 2021-03-08 HR HRP20210395TT patent/HRP20210395T1/hr unknown
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