SU683616A3 - Способ получени аминоалкилгетероциклических соединений или их солей - Google Patents

Способ получени аминоалкилгетероциклических соединений или их солей

Info

Publication number
SU683616A3
SU683616A3 SU772543651A SU2543651A SU683616A3 SU 683616 A3 SU683616 A3 SU 683616A3 SU 772543651 A SU772543651 A SU 772543651A SU 2543651 A SU2543651 A SU 2543651A SU 683616 A3 SU683616 A3 SU 683616A3
Authority
SU
USSR - Soviet Union
Prior art keywords
salts
preparation
heterocyclic compounds
aminoalkyl
aminoalkyl heterocyclic
Prior art date
Application number
SU772543651A
Other languages
English (en)
Inventor
Ментруп Антон
Шромм Курт
Рент Эрнст-Отто
Рейхл Рихард
Траунэккер Вернер
Хефке Вольфганг
Original Assignee
К.Х.Берингер Зон (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by К.Х.Берингер Зон (Фирма) filed Critical К.Х.Берингер Зон (Фирма)
Application granted granted Critical
Publication of SU683616A3 publication Critical patent/SU683616A3/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Description

(54) СПОСОБ ПОЛУЧЕНИЯ
АМИНОАЛКИЛГЕТЕРОЦИКЛИЧЕСКИХ СОЕДИНЕНИЙ ИЛИ ИХ СОЛЕЙ
о или
10
(R - алкил или замещенный алкил) с соединением формулы IV
IV
NH-Z,
с последующим выделением целевого продукта в свободном виде или в виде соли.
Исходные эфиры формулы III получают известными способами.
Пример 1.
CONHj
v
сн,
(O)) о
НО
Смесь из 5 г сложного эфира
COOOijо
лтг
но ) р- снг-та - с - )г-Х
сн.
он
100 мл метанола и 100 мл конц. раствора аммиака слегка нагревают до растворени  реакционной массы, выдерживают при комнатной температуре 12 ч и отдел ют 4,3 г вышеприведенного основани ; т. пл. 198°С. Гидрохлорид т. пл. 235°С.
Аналогично получают соединени , приведенные в таблице.
Таблица
П р одолжение

Claims (1)

1. К. Бюлер, Д. Пирсон. Органические синтезы, М., 1973, ч. 2, с. 390.
SU772543651A 1976-03-09 1977-11-16 Способ получени аминоалкилгетероциклических соединений или их солей SU683616A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762609645 DE2609645A1 (de) 1976-03-09 1976-03-09 Aminoalkylheterocyclen

Publications (1)

Publication Number Publication Date
SU683616A3 true SU683616A3 (ru) 1979-08-30

Family

ID=5971857

Family Applications (4)

Application Number Title Priority Date Filing Date
SU772453505A SU698530A3 (ru) 1976-03-09 1977-02-22 Способ получени аминоалкилгетероциклических соединений или их солей
SU772542149A SU685149A3 (ru) 1976-03-09 1977-11-16 Способ получени аминоалкилгетероциклических соединений или их солей
SU772543651A SU683616A3 (ru) 1976-03-09 1977-11-16 Способ получени аминоалкилгетероциклических соединений или их солей
SU772541704A SU676163A3 (ru) 1976-03-09 1977-11-16 Способ получени аминоалкилгетероциклических соединений или их солей

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SU772453505A SU698530A3 (ru) 1976-03-09 1977-02-22 Способ получени аминоалкилгетероциклических соединений или их солей
SU772542149A SU685149A3 (ru) 1976-03-09 1977-11-16 Способ получени аминоалкилгетероциклических соединений или их солей

Family Applications After (1)

Application Number Title Priority Date Filing Date
SU772541704A SU676163A3 (ru) 1976-03-09 1977-11-16 Способ получени аминоалкилгетероциклических соединений или их солей

Country Status (36)

Country Link
US (4) US4154829A (ru)
JP (2) JPS52108970A (ru)
AT (1) AT360542B (ru)
AU (1) AU515953B2 (ru)
BE (1) BE852223A (ru)
BG (4) BG28051A4 (ru)
CA (1) CA1086317A (ru)
CH (8) CH630358A5 (ru)
CS (2) CS220320B2 (ru)
DD (1) DD130037A5 (ru)
DE (1) DE2609645A1 (ru)
DK (1) DK102177A (ru)
ES (10) ES456622A1 (ru)
FI (1) FI69070C (ru)
FR (2) FR2343731A1 (ru)
GB (1) GB1571231A (ru)
GR (1) GR64553B (ru)
HK (1) HK12884A (ru)
HU (1) HU177953B (ru)
IE (1) IE45300B1 (ru)
IL (1) IL51627A (ru)
LU (1) LU76898A1 (ru)
MX (1) MX4878E (ru)
MY (1) MY8500079A (ru)
NL (1) NL7702403A (ru)
NO (1) NO147950C (ru)
NZ (1) NZ183536A (ru)
PH (3) PH16110A (ru)
PL (2) PL112937B1 (ru)
PT (1) PT66282B (ru)
RO (3) RO70569A (ru)
SE (1) SE435059B (ru)
SG (1) SG55583G (ru)
SU (4) SU698530A3 (ru)
YU (1) YU62377A (ru)
ZA (1) ZA771412B (ru)

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DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
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ES2316559T3 (es) 2001-04-18 2009-04-16 Euro-Celtique S.A. Compuestos espiroindeno y espiroindano.
HUP0402510A3 (en) * 2001-04-18 2012-08-28 Euro Celtique Sa Nociceptin analogs and pharmaceutical compositions containing them
DE60228072D1 (de) 2001-04-18 2008-09-18 Euro Celtique Sa Benzimidazolon-verbindungen
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US20070060748A1 (en) * 2002-11-27 2007-03-15 Hamilton Gregory S Compounds with mixed pde-inhibitory and beta-adrenergic antagonist or partial agonist activity for treatment of heart failure
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Also Published As

Publication number Publication date
US4363814A (en) 1982-12-14
CH630358A5 (de) 1982-06-15
ES456622A1 (es) 1978-03-16
IL51627A0 (en) 1977-05-31
US4154829A (en) 1979-05-15
SU685149A3 (ru) 1979-09-05
PL112937B1 (en) 1980-11-29
DD130037A5 (de) 1978-03-01
FR2372810A1 (fr) 1978-06-30
GR64553B (en) 1980-04-14
CS220320B2 (en) 1983-03-25
FR2343731A1 (fr) 1977-10-07
CH630365A5 (de) 1982-06-15
JPS52108970A (en) 1977-09-12
NO147950C (no) 1983-07-13
FI69070B (fi) 1985-08-30
CH630360A5 (de) 1982-06-15
BG28052A4 (en) 1980-02-25
ATA122377A (de) 1980-06-15
HK12884A (en) 1984-02-24
BG28053A4 (en) 1980-02-25
NO147950B (no) 1983-04-05
PT66282A (pt) 1977-04-01
SG55583G (en) 1984-07-27
PL196505A1 (pl) 1979-06-18
CH630362A5 (de) 1982-06-15
US4215119A (en) 1980-07-29
PH17635A (en) 1984-10-18
ES466600A1 (es) 1978-10-01
ES466605A1 (es) 1978-10-01
ES466602A1 (es) 1978-10-01
BE852223A (fr) 1977-09-08
PL111240B1 (en) 1980-08-30
MX4878E (es) 1982-11-26
SU676163A3 (ru) 1979-07-25
DK102177A (da) 1977-09-10
AU2300977A (en) 1978-09-14
ES466599A1 (es) 1978-10-01
SE435059B (sv) 1984-09-03
CS209435B2 (en) 1981-12-31
PH16110A (en) 1983-06-30
IE45300B1 (en) 1982-07-28
JPS6172A (ja) 1986-01-06
AT360542B (de) 1981-01-12
SE7702609L (sv) 1977-10-11
FR2343731B1 (ru) 1982-02-26
ES466601A1 (es) 1978-10-01
RO76589A (ro) 1981-04-30
NO770804L (no) 1977-09-12
ZA771412B (en) 1978-11-29
US4271158A (en) 1981-06-02
CH630363A5 (de) 1982-06-15
HU177953B (en) 1982-02-28
IE45300L (en) 1977-09-09
ES466604A1 (es) 1978-10-01
CH630364A5 (de) 1982-06-15
NL7702403A (nl) 1977-09-13
IL51627A (en) 1980-10-26
DE2609645A1 (de) 1977-09-15
RO79706A (ro) 1982-08-17
LU76898A1 (ru) 1978-06-01
CH630359A5 (de) 1982-06-15
BG28051A4 (en) 1980-02-25
YU62377A (en) 1982-10-31
AU515953B2 (en) 1981-05-14
PT66282B (pt) 1979-01-17
CA1086317A (en) 1980-09-23
ES466598A1 (es) 1978-10-01
CH630361A5 (de) 1982-06-15
NZ183536A (en) 1981-11-19
ES466603A1 (es) 1978-10-01
ES466606A1 (es) 1978-10-01
FI770586A (ru) 1977-09-10
GB1571231A (en) 1980-07-09
BG27743A3 (en) 1979-12-12
FI69070C (fi) 1985-12-10
FR2372810B1 (ru) 1982-11-26
PH16149A (en) 1983-07-12
SU698530A3 (ru) 1979-11-15
MY8500079A (en) 1985-12-31
RO70569A (ro) 1981-11-24

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