NO147950C - Analogifremgangsmaate for fremstilling av terapeutisk aktive aminoalkyl-heterocykliske forbindelser - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive aminoalkyl-heterocykliske forbindelser

Info

Publication number
NO147950C
NO147950C NO770804A NO770804A NO147950C NO 147950 C NO147950 C NO 147950C NO 770804 A NO770804 A NO 770804A NO 770804 A NO770804 A NO 770804A NO 147950 C NO147950 C NO 147950C
Authority
NO
Norway
Prior art keywords
aminoal
cool
preparation
therapeutically active
heterocyclic compounds
Prior art date
Application number
NO770804A
Other languages
English (en)
Other versions
NO147950B (no
NO770804L (no
Inventor
Anton Mentrup
Kurt Schromm
Ernst-Otto Renth
Richard Reichl
Werner Traunecker
Wolfgang Hoefke
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of NO770804L publication Critical patent/NO770804L/no
Publication of NO147950B publication Critical patent/NO147950B/no
Publication of NO147950C publication Critical patent/NO147950C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30Oxygen or sulfur atoms
    • C07D233/32One oxygen atom
    • C07D233/36One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nonwoven Fabrics (AREA)
  • Laminated Bodies (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
NO770804A 1976-03-09 1977-03-08 Analogifremgangsmaate for fremstilling av terapeutisk aktive aminoalkyl-heterocykliske forbindelser NO147950C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762609645 DE2609645A1 (de) 1976-03-09 1976-03-09 Aminoalkylheterocyclen

Publications (3)

Publication Number Publication Date
NO770804L NO770804L (no) 1977-09-12
NO147950B NO147950B (no) 1983-04-05
NO147950C true NO147950C (no) 1983-07-13

Family

ID=5971857

Family Applications (1)

Application Number Title Priority Date Filing Date
NO770804A NO147950C (no) 1976-03-09 1977-03-08 Analogifremgangsmaate for fremstilling av terapeutisk aktive aminoalkyl-heterocykliske forbindelser

Country Status (36)

Country Link
US (4) US4154829A (no)
JP (2) JPS52108970A (no)
AT (1) AT360542B (no)
AU (1) AU515953B2 (no)
BE (1) BE852223A (no)
BG (4) BG27743A3 (no)
CA (1) CA1086317A (no)
CH (8) CH630358A5 (no)
CS (2) CS220320B2 (no)
DD (1) DD130037A5 (no)
DE (1) DE2609645A1 (no)
DK (1) DK102177A (no)
ES (10) ES456622A1 (no)
FI (1) FI69070C (no)
FR (2) FR2343731A1 (no)
GB (1) GB1571231A (no)
GR (1) GR64553B (no)
HK (1) HK12884A (no)
HU (1) HU177953B (no)
IE (1) IE45300B1 (no)
IL (1) IL51627A (no)
LU (1) LU76898A1 (no)
MX (1) MX4878E (no)
MY (1) MY8500079A (no)
NL (1) NL7702403A (no)
NO (1) NO147950C (no)
NZ (1) NZ183536A (no)
PH (3) PH16110A (no)
PL (2) PL112937B1 (no)
PT (1) PT66282B (no)
RO (3) RO76589A (no)
SE (1) SE435059B (no)
SG (1) SG55583G (no)
SU (4) SU698530A3 (no)
YU (1) YU62377A (no)
ZA (1) ZA771412B (no)

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DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
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DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
DK187880A (da) 1979-05-04 1980-11-05 Continental Pharma Fremgangsmaade til fremstilling af fenyl tylaminderivater
DE3026534A1 (de) * 1980-07-12 1982-03-18 C.H. Boehringer Sohn, 6507 Ingelheim 3,1-benzoxazin-2-one, ihre herstellung und verwendung
US4460581A (en) * 1982-10-12 1984-07-17 Boehringer Ingelheim Kg (1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
DE3325875A1 (de) * 1983-07-18 1985-01-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue 1-phenylimidazolidin-2-on-derivate, ihre herstellung und verwendung
US4743613A (en) * 1986-04-08 1988-05-10 Smithkline Beckman Corporation Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity
GB8609331D0 (en) * 1986-04-16 1986-05-21 Pfizer Ltd Anti-arrythmia agents
TW203049B (no) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
DE69711519T2 (de) 1996-09-05 2002-10-31 Lilly Co Eli Carbazolanaloge als selektive beta3-adrenergische Agonisten
US5808080A (en) * 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
CA2444489C (en) 2001-04-18 2010-06-22 Euro-Celtique, S.A. Benzimidazolone compounds
YU82303A (sh) 2001-04-18 2006-03-03 Euro-Celtique S.A. Analozi nociceptina
US6828440B2 (en) 2001-04-18 2004-12-07 Euro-Celtique, S.A. Spiroindene and spiroindane compounds
IL158486A0 (en) * 2001-04-18 2004-05-12 Euro Celtique Sa Nociceptin analogs
KR100628292B1 (ko) 2001-04-18 2006-09-27 유로-셀티크 소시에떼 아노뉨 스파이로파이라졸 화합물
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US20070060748A1 (en) * 2002-11-27 2007-03-15 Hamilton Gregory S Compounds with mixed pde-inhibitory and beta-adrenergic antagonist or partial agonist activity for treatment of heart failure
US20070117978A1 (en) * 2002-12-23 2007-05-24 Artesian Therapecutics, Inc Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase
DE102004001413A1 (de) * 2004-01-09 2005-08-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Hydroxymethyl-4-Hydroxy-Phenyl-Derivate zur Behandlung von chronisch obstruktiver Lungenerkrankung
DE102004003428A1 (de) * 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel
US20050272726A1 (en) * 2004-04-22 2005-12-08 Boehringer Ingelheim International Gmbh Novel medicaments for the treatment of respiratory diseases
DE102004021779A1 (de) * 2004-04-30 2005-11-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US20050256115A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Aerosol formulation for the inhalation of beta-agonists
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
US7220742B2 (en) * 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004045648A1 (de) * 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika zur Behandlung von Atemwegserkrankungen
EP1833480A2 (en) * 2004-11-30 2007-09-19 Artesian Therapeutics, Inc. Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase
JP2008521806A (ja) * 2004-11-30 2008-06-26 アーテシアン セラピューティクス, インコーポレイテッド 心不全を治療するための混合型のPDE−阻害活性およびβ−アドレナリン作用性アンタゴニスト活性または部分アゴニスト活性を有する化合物
DE102005007654A1 (de) * 2005-02-19 2006-08-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Betamimetika zur Behandlung von Atemwegserkrankungen
DE102005030733A1 (de) * 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
MX2008001976A (es) * 2005-08-15 2008-03-25 Boehringer Ingelheim Int Procedimiento para la preparacion de betamimeticos.
DE102005052101A1 (de) * 2005-10-28 2007-05-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102005052102A1 (de) * 2005-10-28 2007-05-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102005052127A1 (de) * 2005-10-28 2007-05-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue indol-haltige Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
WO2007093608A1 (de) * 2006-02-16 2007-08-23 Boehringer Ingelheim International Gmbh Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
PE20080142A1 (es) * 2006-03-15 2008-04-14 Boehringer Ingelheim Int Beta-agonistas enantiomericamente puros y sus procedimientos de preparacion
US20090324510A1 (en) 2006-08-07 2009-12-31 Boehringer Ingelheim International Gmbh Drug combinations for the treatment of respiratory tract diseases
US9604926B2 (en) 2007-08-16 2017-03-28 The University Of Mississippi Highly selective sigma receptor radioligands
US8809381B2 (en) * 2007-08-16 2014-08-19 The University Of Mississippi Highly selective sigma receptor ligands
US8686008B2 (en) * 2007-08-16 2014-04-01 The University Of Mississippi Highly selective sigma receptor ligands

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CA631296A (en) * 1961-11-21 L. Clark Robert Substituted benzimidazolones
CH149009A (de) * 1929-08-10 1931-08-15 Chem Ind Basel Verfahren zur Darstellung einer N-substituierten Verbindung der Pyridonreihe.
US2857394A (en) * 1957-05-10 1958-10-21 Ciba Pharm Prod Inc Heterocyclic compounds
NL284529A (no) * 1961-10-24
FR1516714A (fr) * 1962-11-07 1968-02-05 Bayer Ag Procédé de préparation de dérivés de l'imidazolidine
FR1384708A (fr) * 1963-11-21 1965-01-08 Thomson Houston Comp Francaise Perfectionnements aux dispositifs de mise en place d'objets
BE659364A (no) * 1964-02-05
US3355457A (en) * 1965-05-21 1967-11-28 American Cyanamid Co Substituted 2-imidazolinones
FR1573739A (no) * 1968-07-26 1969-07-04
US3984405A (en) * 1971-06-28 1976-10-05 E. R. Squibb & Sons, Inc. Anti-inflammatory agents
BE787103A (fr) * 1971-08-04 1973-02-02 Pfizer Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant
FR2168140A1 (en) * 1972-01-17 1973-08-31 Bellon Labor Sa Roger Dihydro-benzoxazine derivs - antidepressants
US3925383A (en) * 1972-12-08 1975-12-09 Janssen Pharmaceutica Nv Bicyclic imidazoles and pyrimidines
US3994901A (en) * 1974-06-13 1976-11-30 Otsuka Pharmaceutical Company Limited 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen

Also Published As

Publication number Publication date
IE45300L (en) 1977-09-09
US4271158A (en) 1981-06-02
HU177953B (en) 1982-02-28
CS220320B2 (en) 1983-03-25
AU515953B2 (en) 1981-05-14
JPS6172A (ja) 1986-01-06
CH630359A5 (de) 1982-06-15
PL196505A1 (pl) 1979-06-18
FI770586A (no) 1977-09-10
SE7702609L (sv) 1977-10-11
PL112937B1 (en) 1980-11-29
ES466604A1 (es) 1978-10-01
FI69070B (fi) 1985-08-30
IE45300B1 (en) 1982-07-28
ES466602A1 (es) 1978-10-01
ES456622A1 (es) 1978-03-16
SU685149A3 (ru) 1979-09-05
US4363814A (en) 1982-12-14
HK12884A (en) 1984-02-24
DD130037A5 (de) 1978-03-01
US4154829A (en) 1979-05-15
PT66282B (pt) 1979-01-17
SG55583G (en) 1984-07-27
CH630363A5 (de) 1982-06-15
MX4878E (es) 1982-11-26
SU676163A3 (ru) 1979-07-25
CH630360A5 (de) 1982-06-15
BG28053A4 (en) 1980-02-25
DK102177A (da) 1977-09-10
FI69070C (fi) 1985-12-10
JPS52108970A (en) 1977-09-12
ES466599A1 (es) 1978-10-01
GR64553B (en) 1980-04-14
MY8500079A (en) 1985-12-31
PH17635A (en) 1984-10-18
BG28052A4 (en) 1980-02-25
NL7702403A (nl) 1977-09-13
PH16149A (en) 1983-07-12
FR2372810A1 (fr) 1978-06-30
NO147950B (no) 1983-04-05
CA1086317A (en) 1980-09-23
FR2343731A1 (fr) 1977-10-07
CH630364A5 (de) 1982-06-15
NO770804L (no) 1977-09-12
NZ183536A (en) 1981-11-19
FR2343731B1 (no) 1982-02-26
CS209435B2 (en) 1981-12-31
SE435059B (sv) 1984-09-03
SU683616A3 (ru) 1979-08-30
RO76589A (ro) 1981-04-30
AU2300977A (en) 1978-09-14
FR2372810B1 (no) 1982-11-26
ES466603A1 (es) 1978-10-01
CH630358A5 (de) 1982-06-15
ES466605A1 (es) 1978-10-01
PH16110A (en) 1983-06-30
AT360542B (de) 1981-01-12
CH630362A5 (de) 1982-06-15
PT66282A (pt) 1977-04-01
ES466598A1 (es) 1978-10-01
YU62377A (en) 1982-10-31
LU76898A1 (no) 1978-06-01
IL51627A0 (en) 1977-05-31
CH630361A5 (de) 1982-06-15
ZA771412B (en) 1978-11-29
BG27743A3 (en) 1979-12-12
ES466606A1 (es) 1978-10-01
RO79706A (ro) 1982-08-17
IL51627A (en) 1980-10-26
SU698530A3 (ru) 1979-11-15
DE2609645A1 (de) 1977-09-15
ATA122377A (de) 1980-06-15
CH630365A5 (de) 1982-06-15
GB1571231A (en) 1980-07-09
ES466601A1 (es) 1978-10-01
PL111240B1 (en) 1980-08-30
RO70569A (ro) 1981-11-24
BG28051A4 (en) 1980-02-25
ES466600A1 (es) 1978-10-01
BE852223A (fr) 1977-09-08
US4215119A (en) 1980-07-29

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