SU538665A3 - Способ получени д-гомостероидов - Google Patents
Способ получени д-гомостероидовInfo
- Publication number
- SU538665A3 SU538665A3 SU2008473A SU2008473A SU538665A3 SU 538665 A3 SU538665 A3 SU 538665A3 SU 2008473 A SU2008473 A SU 2008473A SU 2008473 A SU2008473 A SU 2008473A SU 538665 A3 SU538665 A3 SU 538665A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- dioxane
- fluorine
- obtaining
- homo
- homosteroids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B19/00—Oxazine dyes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (1)
- (54) СПОСОБ ПОЛУЧЕНИЯ D - ГОМОСТЕРОИДОВ 3 + 105° Гс.-0.101,диоксан е i4i 14400. D - гомо - 9а - фторгидрокортизон, т.пл.239-241°С; aljj +- 131° (с - 0,102, диоксан); С гз 1682U, D - гомо - 9а - фторпреднизолон; т. пл 241-246 С (разд.); aJij-- - 10Г (с - 0,097, диоксан); 5 G 238 14540, 6а фтор - D - гомогидрокортизон, Т.ПЛ. 233-235С; с.р +110 (с - 0,103, диоксан); е 236 13400,-6а - фтор - D - гомопреднизолон, т.пл. 261-264°С; «, + 93° (с- о , 106 диоксан ); е J41 15200, и D - гомопреднизолон, 10 т;пл. 250°С (разл.), соответственно. Формула изобретени Способ получени D - гомостероидов общей формулы где R, - водород, фтор или метил; R, - водород, фтор; Вз и R, - окси- или адилоксигруппа, причем по меньшей мере один из R и R - оксигруппа, или их 1,2-дегидропроизводных, отличающийс тем, что ацилоксигруппу в О-гомостероиде формулы 1 или его 1,2 - дегидропроизв одном, содержащих по меньшей мере одну R, и R, - ацилоксигруппу , омьш ют Щелочной среде и выдел ют целевой продукт.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH466672A CH571018A5 (ru) | 1972-03-29 | 1972-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU538665A3 true SU538665A3 (ru) | 1976-12-05 |
Family
ID=4280344
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU2008893A SU492080A3 (ru) | 1972-03-29 | 1973-03-27 | Способ получени -гомостероидов |
| SU731901008A SU697054A3 (ru) | 1972-03-29 | 1973-03-27 | Способ получени -гомостероидов или их 1,2-дегидропроизводных |
| SU742008892A SU612636A3 (ru) | 1972-03-29 | 1974-03-27 | Способ получени -гомостероидов |
| SU2008896A SU506288A3 (ru) | 1972-03-29 | 1974-03-27 | Способ получени -гомостероидов |
| SU2008890A SU517263A3 (ru) | 1972-03-29 | 1974-03-27 | Способ получени д-гомостероидов |
| SU2008891A SU509211A3 (ru) | 1972-03-29 | 1974-03-27 | Способ получени д-гомостероидов |
| SU2008473A SU538665A3 (ru) | 1972-03-29 | 1974-03-27 | Способ получени д-гомостероидов |
Family Applications Before (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU2008893A SU492080A3 (ru) | 1972-03-29 | 1973-03-27 | Способ получени -гомостероидов |
| SU731901008A SU697054A3 (ru) | 1972-03-29 | 1973-03-27 | Способ получени -гомостероидов или их 1,2-дегидропроизводных |
| SU742008892A SU612636A3 (ru) | 1972-03-29 | 1974-03-27 | Способ получени -гомостероидов |
| SU2008896A SU506288A3 (ru) | 1972-03-29 | 1974-03-27 | Способ получени -гомостероидов |
| SU2008890A SU517263A3 (ru) | 1972-03-29 | 1974-03-27 | Способ получени д-гомостероидов |
| SU2008891A SU509211A3 (ru) | 1972-03-29 | 1974-03-27 | Способ получени д-гомостероидов |
Country Status (27)
| Country | Link |
|---|---|
| JP (2) | JPS5844360B2 (ru) |
| KR (3) | KR780000672B1 (ru) |
| AR (1) | AR208389A1 (ru) |
| AT (1) | AT326282B (ru) |
| AU (1) | AU468918B2 (ru) |
| BE (1) | BE797412A (ru) |
| CA (1) | CA1006156A (ru) |
| CH (1) | CH571018A5 (ru) |
| DD (1) | DD105216A5 (ru) |
| DE (1) | DE2314592C2 (ru) |
| DK (1) | DK135722B (ru) |
| ES (13) | ES413083A1 (ru) |
| FI (1) | FI52099C (ru) |
| FR (1) | FR2182911B1 (ru) |
| GB (1) | GB1365469A (ru) |
| HU (2) | HU166580B (ru) |
| IE (1) | IE37444B1 (ru) |
| IL (1) | IL41752A (ru) |
| LU (1) | LU67304A1 (ru) |
| NL (1) | NL176945C (ru) |
| NO (1) | NO139524C (ru) |
| PH (1) | PH9660A (ru) |
| PL (7) | PL92130B1 (ru) |
| SE (2) | SE404530B (ru) |
| SU (7) | SU492080A3 (ru) |
| YU (4) | YU35775B (ru) |
| ZA (1) | ZA731563B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK142289B (da) * | 1973-03-28 | 1980-10-06 | Hoffmann La Roche | Analogifremgangsmåde til fremstilling af D-homopregn-4-en-3,20-dioner. |
| DE2442615A1 (de) * | 1974-09-04 | 1976-03-18 | Schering Ag | Neue d-homo-steroide |
| SE411351B (sv) * | 1974-10-07 | 1979-12-17 | Hoffmann La Roche | Forfarande for framstellning av d-homosteroider tillhorande pregnanserien |
| SE427276B (sv) * | 1975-04-03 | 1983-03-21 | Hoffmann La Roche | Forfarande for framstellning av d-homosteroider |
| AT356301B (de) * | 1976-09-03 | 1980-04-25 | Hoffmann La Roche | Verfahren zur herstellung von neuen d-homo- steroiden |
| US4202841A (en) * | 1977-08-25 | 1980-05-13 | Hoffmann-La Roche Inc. | D-Homopregnanes |
| DE3038855A1 (de) * | 1980-10-10 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue d-homo-kortikoide, ihre herstellung und verwendung |
| DE3409554A1 (de) * | 1984-03-13 | 1985-09-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 6(alpha)-methyl-d-homo-kortikoide |
| JPH0356125Y2 (ru) * | 1985-07-30 | 1991-12-16 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2860158A (en) * | 1954-10-18 | 1958-11-11 | Sterling Drug Inc | Compounds of the perhydrochrysene series and preparation thereof |
-
1972
- 1972-03-29 CH CH466672A patent/CH571018A5/xx not_active IP Right Cessation
-
1973
- 1973-01-01 AR AR247212A patent/AR208389A1/es active
- 1973-03-06 ZA ZA731563A patent/ZA731563B/xx unknown
- 1973-03-12 AU AU53207/73A patent/AU468918B2/en not_active Expired
- 1973-03-12 IL IL41752A patent/IL41752A/en unknown
- 1973-03-19 FI FI730839A patent/FI52099C/fi active
- 1973-03-23 DE DE2314592A patent/DE2314592C2/de not_active Expired
- 1973-03-23 IE IE470/73A patent/IE37444B1/xx unknown
- 1973-03-26 NL NLAANVRAGE7304193,A patent/NL176945C/xx not_active IP Right Cessation
- 1973-03-26 PH PH14464*UA patent/PH9660A/en unknown
- 1973-03-27 YU YU315/73A patent/YU35775B/xx unknown
- 1973-03-27 LU LU67304A patent/LU67304A1/xx unknown
- 1973-03-27 SU SU2008893A patent/SU492080A3/ru active
- 1973-03-27 SU SU731901008A patent/SU697054A3/ru active
- 1973-03-27 DD DD169749A patent/DD105216A5/xx unknown
- 1973-03-27 YU YU00815/73A patent/YU81573A/xx unknown
- 1973-03-28 AT AT270973A patent/AT326282B/de not_active IP Right Cessation
- 1973-03-28 HU HUHO1558A patent/HU166580B/hu unknown
- 1973-03-28 BE BE129332A patent/BE797412A/xx not_active IP Right Cessation
- 1973-03-28 DK DK170673AA patent/DK135722B/da not_active IP Right Cessation
- 1973-03-28 NO NO1286/73A patent/NO139524C/no unknown
- 1973-03-28 JP JP48034733A patent/JPS5844360B2/ja not_active Expired
- 1973-03-28 ES ES413083A patent/ES413083A1/es not_active Expired
- 1973-03-28 HU HUHO1719A patent/HU170428B/hu unknown
- 1973-03-28 KR KR7300503A patent/KR780000672B1/ko active
- 1973-03-28 SE SE7304403A patent/SE404530B/xx unknown
- 1973-03-28 CA CA167,420A patent/CA1006156A/en not_active Expired
- 1973-03-29 FR FR7311339A patent/FR2182911B1/fr not_active Expired
- 1973-03-29 PL PL1973181066A patent/PL92130B1/pl unknown
- 1973-03-29 GB GB1511273A patent/GB1365469A/en not_active Expired
- 1973-03-29 PL PL1973161579A patent/PL86797B1/pl unknown
- 1973-03-29 PL PL1973181065A patent/PL92076B1/pl unknown
- 1973-03-29 PL PL1973181063A patent/PL98710B1/pl unknown
- 1973-03-29 PL PL1973181062A patent/PL92077B1/pl unknown
- 1973-03-29 PL PL1973181067A patent/PL98714B1/pl unknown
- 1973-03-29 PL PL1973181064A patent/PL98712B1/pl unknown
-
1974
- 1974-03-27 SU SU742008892A patent/SU612636A3/ru active
- 1974-03-27 SU SU2008896A patent/SU506288A3/ru active
- 1974-03-27 SU SU2008890A patent/SU517263A3/ru active
- 1974-03-27 SU SU2008891A patent/SU509211A3/ru active
- 1974-03-27 SU SU2008473A patent/SU538665A3/ru active
-
1975
- 1975-08-01 ES ES439948A patent/ES439948A1/es not_active Expired
- 1975-08-01 ES ES439959A patent/ES439959A1/es not_active Expired
- 1975-08-01 ES ES439953A patent/ES439953A1/es not_active Expired
- 1975-08-01 ES ES439950A patent/ES439950A1/es not_active Expired
- 1975-08-01 ES ES439952A patent/ES439952A1/es not_active Expired
- 1975-08-01 ES ES439958A patent/ES439958A1/es not_active Expired
- 1975-08-01 ES ES439955A patent/ES439955A1/es not_active Expired
- 1975-08-01 ES ES439954A patent/ES439954A1/es not_active Expired
- 1975-08-01 ES ES439951A patent/ES439951A1/es not_active Expired
- 1975-08-01 ES ES439949A patent/ES439949A1/es not_active Expired
- 1975-08-01 ES ES439956A patent/ES439956A1/es not_active Expired
- 1975-08-01 ES ES439957A patent/ES439957A1/es not_active Expired
-
1976
- 1976-02-27 SE SE7602850A patent/SE7602850L/xx unknown
-
1978
- 1978-04-29 KR KR7801294A patent/KR780000673B1/ko active
- 1978-04-29 KR KR7801305A patent/KR780000675B1/ko active
-
1979
- 1979-03-08 YU YU568/79A patent/YU35452B/xx unknown
- 1979-03-08 YU YU569/79A patent/YU35453B/xx unknown
-
1982
- 1982-10-01 JP JP57171109A patent/JPS6052160B2/ja not_active Expired
Also Published As
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