ES452769A1 - Un procedimiento para preparar un compuesto de cefalospori- na. - Google Patents
Un procedimiento para preparar un compuesto de cefalospori- na.Info
- Publication number
- ES452769A1 ES452769A1 ES452769A ES452769A ES452769A1 ES 452769 A1 ES452769 A1 ES 452769A1 ES 452769 A ES452769 A ES 452769A ES 452769 A ES452769 A ES 452769A ES 452769 A1 ES452769 A1 ES 452769A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- cephalosporins
- mercaptotetrazole
- antibiotics
- replacement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Esta invención se refiere a una nueva serie de compuestos de cefalosporina que tienen actividad antibacteriana cuando se administran por vía parenteral y a los compuestos intermedios para su preparación. En particular, las estructuras de los compuestos de cefalosporinas biológicamente activos de esta invención se caracterizan por tener un grupo de tetrazoliltiometilo sustituido por sulfaminoalcohilo en la posición 3- del núcleo de cefem. Esta invención se extiende también a métodos y composiciones para tratar ciertas infecciones bacterianas usando estos nuevos compuestos, así como a ciertos compuestos químicos intermedios y métodos para preparar los compuestos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62716475A | 1975-10-30 | 1975-10-30 | |
| US66583776A | 1976-03-11 | 1976-03-11 | |
| US05/704,142 US4118491A (en) | 1976-03-11 | 1976-07-12 | 7-Acyl-3-(sulfaminoalkyl substituted tetrazolylthiomethyl)cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES452769A1 true ES452769A1 (es) | 1978-01-16 |
Family
ID=27417417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES452769A Expired ES452769A1 (es) | 1975-10-30 | 1976-10-27 | Un procedimiento para preparar un compuesto de cefalospori- na. |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS6053026B2 (es) |
| AT (1) | AT353957B (es) |
| AU (1) | AU505141B2 (es) |
| CA (1) | CA1071188A (es) |
| CH (1) | CH627757A5 (es) |
| DE (1) | DE2649545A1 (es) |
| DK (1) | DK463176A (es) |
| ES (1) | ES452769A1 (es) |
| FI (1) | FI60868C (es) |
| FR (3) | FR2361896A1 (es) |
| GB (3) | GB1570093A (es) |
| GR (1) | GR61667B (es) |
| IE (1) | IE44393B1 (es) |
| IL (3) | IL50546A (es) |
| LU (1) | LU76092A1 (es) |
| NL (1) | NL7612010A (es) |
| SE (3) | SE435291B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117123A (en) * | 1977-06-09 | 1978-09-26 | Smithkline Corporation | 7-Acylamino-3-[1-(2-sulfamidoethyl)tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acids |
| AT383811B (de) * | 1983-09-22 | 1987-08-25 | Biochemie Gmbh | Verfahren zur herstellung von monoalkalisalzen von 7-amino-3-cephem-4-carbonsaeurederivaten |
| US4717531A (en) * | 1983-09-23 | 1988-01-05 | Westinghouse Electric Corp. | Fuel transfer system upender using translation drive |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR207752A1 (es) * | 1973-03-30 | 1976-10-29 | Fujisawa Pharmaceutical Co | Procedimiento para obtener acidos 7-amino-sustituido-3-tiometilsustituido-3-cefem-4-carboxilicos |
| NL7414119A (nl) * | 1973-10-31 | 1975-05-02 | Fujisawa Pharmaceutical Co | Werkwijze ter bereiding van 1h-tetrazool-5-thiol- derivaten en 1-gesubstitueerde 1h-tetrazool- -5-thiolen. |
| GB1449420A (en) * | 1973-11-26 | 1976-09-15 | Sankyo Co | 7alpha-methoxycephalosporing derivatives |
| NZ176206A (en) * | 1973-12-25 | 1978-03-06 | Takeda Chemical Industries Ltd | Cephalosporins |
| US4066762A (en) * | 1976-07-12 | 1978-01-03 | Smithkline Corporation | Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid |
-
1976
- 1976-09-23 IL IL50546A patent/IL50546A/xx unknown
- 1976-09-28 SE SE7610722A patent/SE435291B/xx not_active IP Right Cessation
- 1976-09-28 SE SE8006413A patent/SE452621B/sv not_active IP Right Cessation
- 1976-09-30 CA CA262,347A patent/CA1071188A/en not_active Expired
- 1976-10-14 AU AU18702/76A patent/AU505141B2/en not_active Ceased
- 1976-10-14 DK DK463176A patent/DK463176A/da not_active Application Discontinuation
- 1976-10-21 FR FR7631723A patent/FR2361896A1/fr active Granted
- 1976-10-26 GB GB44441/76A patent/GB1570093A/en not_active Expired
- 1976-10-26 GB GB19786/79A patent/GB1570094A/en not_active Expired
- 1976-10-26 GB GB19863/79A patent/GB1570095A/en not_active Expired
- 1976-10-26 FI FI763044A patent/FI60868C/fi not_active IP Right Cessation
- 1976-10-27 ES ES452769A patent/ES452769A1/es not_active Expired
- 1976-10-27 IE IE2377/76A patent/IE44393B1/en unknown
- 1976-10-28 LU LU76092A patent/LU76092A1/xx unknown
- 1976-10-29 DE DE19762649545 patent/DE2649545A1/de not_active Ceased
- 1976-10-29 GR GR52030A patent/GR61667B/el unknown
- 1976-10-29 AT AT807276A patent/AT353957B/de not_active IP Right Cessation
- 1976-10-29 NL NL7612010A patent/NL7612010A/xx not_active Application Discontinuation
- 1976-10-29 JP JP51131157A patent/JPS6053026B2/ja not_active Expired
- 1976-10-29 CH CH1369576A patent/CH627757A5/de not_active IP Right Cessation
-
1977
- 1977-03-22 FR FR7708504A patent/FR2351982A1/fr active Granted
- 1977-03-22 FR FR7708505A patent/FR2337720A1/fr active Granted
-
1979
- 1979-02-28 IL IL56758A patent/IL56758A0/xx unknown
- 1979-02-28 IL IL56757A patent/IL56757A0/xx unknown
-
1980
- 1980-09-12 SE SE8006414A patent/SE437025B/sv not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981103 |