ES452636A1 - Procedimiento para la preparacion de nuevos derivados de ce-falosporina. - Google Patents
Procedimiento para la preparacion de nuevos derivados de ce-falosporina.Info
- Publication number
- ES452636A1 ES452636A1 ES452636A ES452636A ES452636A1 ES 452636 A1 ES452636 A1 ES 452636A1 ES 452636 A ES452636 A ES 452636A ES 452636 A ES452636 A ES 452636A ES 452636 A1 ES452636 A1 ES 452636A1
- Authority
- ES
- Spain
- Prior art keywords
- cephalosporin antibiotics
- cephalosporin
- antibiotics
- cephalosporin antibiotic
- antibiotic derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/64—Acyl halides
- C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Procedimiento para la preparación de nuevos derivados de cefalosporina de la fórmula **(Fórmula)** En que arilo es fenilo o 2-tienilo; Y es hidrógeno, cloro, bromo un grupo alquilo inferior recto o ramificado de 1 a 4 átomos o un grupo de alcoxi inferior de 1 a 4 átomos de carbono con la condición de que, cuando arilo es 2-tienilo, Y es hidrógeno; Z es un enlace, oxigeno, azufre o imino, con la condición de que, cuando arilo es 2-tienilo, Z es un enlace; W es hidrógeno, metilo, amino, hidroxi, SO3H o COOR1, en que R1 es hidrógeno o 5-indanilo; n es cero, 1 o 2, con la condición de que, cuando W es otro hidrógeno o metilo y Z es otro que un enlace, n no es cero, R2 es hidrógeno o metoxi; M es un anión alcanoiloximetilo, en que la mitad de alcanoil contiene de 1 a 5 átomos de carbono y puede ser recto o ramificado; alcanoilaminometilo, en que la mitad de alcanoilo contiene de 1 a 5 átomos de carbono.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/625,570 US4026887A (en) | 1975-10-24 | 1975-10-24 | Cephalosporin antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES452636A1 true ES452636A1 (es) | 1978-01-01 |
Family
ID=24506691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES452636A Expired ES452636A1 (es) | 1975-10-24 | 1976-10-22 | Procedimiento para la preparacion de nuevos derivados de ce-falosporina. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US4026887A (es) |
| JP (1) | JPS5251391A (es) |
| AU (1) | AU508080B2 (es) |
| BE (1) | BE847549A (es) |
| CA (1) | CA1070671A (es) |
| DE (1) | DE2647571A1 (es) |
| DK (1) | DK479876A (es) |
| ES (1) | ES452636A1 (es) |
| FR (1) | FR2328474A1 (es) |
| GB (1) | GB1512130A (es) |
| IE (1) | IE44352B1 (es) |
| NL (1) | NL7611705A (es) |
| NO (1) | NO763602L (es) |
| NZ (1) | NZ182403A (es) |
| SE (1) | SE7611779L (es) |
| ZA (1) | ZA766307B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4031083A (en) * | 1975-10-24 | 1977-06-21 | Yeda Research And Development Co., Ltd. | Cephalosporin antibiotics |
| US4045438A (en) * | 1975-10-24 | 1977-08-30 | Yeda Research And Development Co. Ltd. | Cephalosporin antibiotics |
| US4026887A (en) * | 1975-10-24 | 1977-05-31 | Yeda Research & Development Co. Ltd. | Cephalosporin antibiotics |
| US4171434A (en) * | 1977-11-07 | 1979-10-16 | Yeda Research And Development Co. Ltd. | 7-[(Pyridylthiomethyl)phenyl]acetamidocephalosporin derivatives |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA892580A (en) | 1972-02-08 | Patchornik Avraham | Polymer acylation of penicillins | |
| US3341531A (en) * | 1967-02-15 | 1967-09-12 | American Cyanamid Co | Substituted 7-acetylamino cephalosporanic acids |
| GB1229453A (es) | 1968-01-30 | 1971-04-21 | ||
| US3657232A (en) | 1970-06-19 | 1972-04-18 | R & L Molecular Research Ltd | 7-((o-aminomethylphenylthio)-acetamido) cephalosporanic acid |
| DE2118635A1 (de) * | 1971-04-17 | 1972-11-02 | Farbwerke Hoechst AG, vormals Meister Lucius & Brüning, 6000 Frankfurt | Acylaminocephalosporansäuren und Verfahren zu ihrer Herstellung |
| US3778432A (en) | 1971-12-13 | 1973-12-11 | Merck & Co Inc | Isocyanates and carbamates of penicillins and 3-cephem-4-carboxylic acids |
| NL7305936A (es) * | 1972-05-05 | 1973-11-07 | ||
| DE2236620A1 (de) | 1972-07-26 | 1973-08-02 | Werner Selzer | Fussboden- bzw. sockelleiste |
| US4024249A (en) * | 1973-03-30 | 1977-05-17 | Ciba-Geigy Corporation | Heteroarylacetamido cephalosporin |
| US3919206A (en) * | 1973-09-25 | 1975-11-11 | Yeda Res & Dev | 7-(Halomethylaryl)acetamidocephalosporin derivatives |
| US4026887A (en) * | 1975-10-24 | 1977-05-31 | Yeda Research & Development Co. Ltd. | Cephalosporin antibiotics |
-
1975
- 1975-10-24 US US05/625,570 patent/US4026887A/en not_active Expired - Lifetime
-
1976
- 1976-10-12 CA CA263,197A patent/CA1070671A/en not_active Expired
- 1976-10-21 DE DE19762647571 patent/DE2647571A1/de not_active Withdrawn
- 1976-10-22 FR FR7631923A patent/FR2328474A1/fr active Granted
- 1976-10-22 ZA ZA766307A patent/ZA766307B/xx unknown
- 1976-10-22 AU AU18919/76A patent/AU508080B2/en not_active Expired
- 1976-10-22 BE BE171716A patent/BE847549A/xx unknown
- 1976-10-22 ES ES452636A patent/ES452636A1/es not_active Expired
- 1976-10-22 DK DK479876A patent/DK479876A/da not_active Application Discontinuation
- 1976-10-22 SE SE7611779A patent/SE7611779L/xx unknown
- 1976-10-22 IE IE2326/76A patent/IE44352B1/en unknown
- 1976-10-22 NZ NZ182403A patent/NZ182403A/xx unknown
- 1976-10-22 NL NL7611705A patent/NL7611705A/xx not_active Application Discontinuation
- 1976-10-22 NO NO763602A patent/NO763602L/no unknown
- 1976-10-23 JP JP51126823A patent/JPS5251391A/ja active Pending
- 1976-10-25 GB GB44186/76A patent/GB1512130A/en not_active Expired
-
1977
- 1977-01-14 US US05/759,466 patent/US4093804A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5251391A (en) | 1977-04-25 |
| US4026887A (en) | 1977-05-31 |
| FR2328474B1 (es) | 1980-04-18 |
| CA1070671A (en) | 1980-01-29 |
| FR2328474A1 (fr) | 1977-05-20 |
| NL7611705A (nl) | 1977-04-26 |
| SE7611779L (sv) | 1977-04-25 |
| DE2647571A1 (de) | 1977-05-05 |
| DK479876A (da) | 1977-04-25 |
| AU508080B2 (en) | 1980-03-06 |
| GB1512130A (en) | 1978-05-24 |
| NO763602L (es) | 1977-04-26 |
| ZA766307B (en) | 1977-09-28 |
| AU1891976A (en) | 1978-04-27 |
| NZ182403A (en) | 1979-03-16 |
| IE44352L (en) | 1977-04-24 |
| IE44352B1 (en) | 1981-11-04 |
| US4093804A (en) | 1978-06-06 |
| BE847549A (fr) | 1977-02-14 |
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