SK413591A3 - Substituted androsta-1,4-diene 3,17-diones,method of their production and use and pharmaceutical agent - Google Patents

Substituted androsta-1,4-diene 3,17-diones,method of their production and use and pharmaceutical agent Download PDF

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Publication number
SK413591A3
SK413591A3 SK4135-91A SK413591A SK413591A3 SK 413591 A3 SK413591 A3 SK 413591A3 SK 413591 A SK413591 A SK 413591A SK 413591 A3 SK413591 A3 SK 413591A3
Authority
SK
Slovakia
Prior art keywords
compound
formula
diene
dione
hydrogen
Prior art date
Application number
SK4135-91A
Other languages
English (en)
Slovak (sk)
Inventor
Franco Buzzetti
Natale Barbugian
Paolo Lombardi
Salle Enrico Di
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK413591(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of SK413591A3 publication Critical patent/SK413591A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK4135-91A 1985-07-09 1991-12-30 Substituted androsta-1,4-diene 3,17-diones,method of their production and use and pharmaceutical agent SK413591A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (1)

Publication Number Publication Date
SK413591A3 true SK413591A3 (en) 1995-07-11

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
SK4135-91A SK413591A3 (en) 1985-07-09 1991-12-30 Substituted androsta-1,4-diene 3,17-diones,method of their production and use and pharmaceutical agent

Country Status (38)

Country Link
US (2) US4808616A (enExample)
JP (1) JPS6212797A (enExample)
KR (1) KR950003614B1 (enExample)
CN (1) CN86104664B (enExample)
AT (1) AT395157B (enExample)
AU (1) AU578840B2 (enExample)
BE (1) BE905067A (enExample)
BG (1) BG61370B2 (enExample)
BR (1) BR1100240A (enExample)
CA (1) CA1277656C (enExample)
CH (1) CH668599A5 (enExample)
CS (2) CS257794B2 (enExample)
CZ (1) CZ413591A3 (enExample)
DE (1) DE10199030I1 (enExample)
DK (1) DK163520C (enExample)
ES (2) ES8801304A1 (enExample)
FI (1) FI83424C (enExample)
FR (1) FR2584725B1 (enExample)
GB (2) GB8517360D0 (enExample)
GR (1) GR861780B (enExample)
HK (1) HK94190A (enExample)
HU (1) HU194274B (enExample)
IE (1) IE58949B1 (enExample)
IL (1) IL79336A (enExample)
IT (1) IT1196436B (enExample)
MY (1) MY102294A (enExample)
NL (2) NL193616C (enExample)
NO (2) NO165547C (enExample)
NZ (1) NZ216763A (enExample)
PH (1) PH21785A (enExample)
PT (1) PT82944B (enExample)
SE (1) SE468988B (enExample)
SG (1) SG80490G (enExample)
SK (1) SK413591A3 (enExample)
SU (2) SU1442077A3 (enExample)
UA (1) UA6046A1 (enExample)
YU (2) YU44585B (enExample)
ZA (1) ZA865079B (enExample)

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GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
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GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
DE69324595T2 (de) * 1992-09-30 1999-08-19 Teikoku Hormone Mfg. Co. 7-substituierte oxa-steroid verbindung
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
WO2002011705A2 (en) * 2000-08-09 2002-02-14 Pharmacia Italia Spa Composition for combined use of aromatase inhibitors
CA2419590A1 (en) * 2000-09-08 2002-03-14 Pharmacia Italia S.P.A. Exemestane as chemopreventing agent
WO2002072106A2 (en) * 2001-01-26 2002-09-19 Pharmacia Italia Spa Combined method for treating hormono-dependent disorders with exemestane
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
AU2002250968C1 (en) 2001-02-19 2018-01-04 Novartis Ag Cancer treatment
CZ299756B6 (cs) 2001-05-16 2008-11-12 Novartis Ag Kombinace s obsahem N-{5-[4-(4-methyl-piperazino-methyl)benzoylamido]-2-methylfenyl}-4-(3-pyridyl)-2-pyrimidin-aminu k lécení proliferativních onemocnení
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
PT1505959E (pt) 2002-05-16 2009-02-05 Novartis Ag Utilização de agentes de ligação do receptor edg em cancro
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
ES2382609T3 (es) * 2004-01-16 2012-06-11 Cedarburg Pharmaceuticals, Inc. Exemestano y sus productos intermedios y métodos de preparación de los mismos
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
BRPI0616639A2 (pt) 2005-09-30 2011-06-28 Endece Llc compostos de exemestano de (s)-6-metiloxaalquila e métodos de uso relacionados
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
KR20090007635A (ko) 2006-05-09 2009-01-19 노파르티스 아게 철 킬레이터 및 항-신생물 약제를 포함하는 조합물 및 그의용도
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
JP5558358B2 (ja) 2007-10-16 2014-07-23 レプロス セラピューティクス インコーポレイティド メタボリック症候群用のｔｒａｎｓ−クロミフェン
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
US8288571B2 (en) * 2008-01-21 2012-10-16 Cadila Healthcare Limited Process for preparing aromatiase inhibitor exemestane
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
WO2010127297A1 (en) 2009-05-01 2010-11-04 Parviz Gharagozloo Treating male infertility secondary to sperm oxidative stress
RU2425052C1 (ru) * 2010-03-04 2011-07-27 Татьяна Степановна Савинова Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
CA2794565C (en) 2010-04-08 2018-08-21 Emory University Substituted androst-4-ene diones
EP2558098A2 (en) 2010-04-16 2013-02-20 Novartis AG Treatment of endocrine resistant breast cancer
JP5981434B2 (ja) 2010-09-14 2016-08-31 エンディース エルエルシーＥｎｄｅｃｅ，Ｌｌｃ 選択的ＥＲ−βアゴニストとしての６−置換デメチル−エストラジオール誘導体
CA2865234A1 (en) 2012-02-29 2013-09-06 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
US20170165246A1 (en) * 2014-02-11 2017-06-15 Novartis Ag Pharmaceutical combinations comprising a pi3k inhibitor for the treatment of cancer
EP3373967B9 (en) 2015-11-10 2023-10-04 Paracrine Therapeutics AB Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

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GB929985A (enExample) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
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Also Published As

Publication number Publication date
NL193616C (nl) 2000-04-04
ATA181986A (de) 1992-02-15
JPS6212797A (ja) 1987-01-21
ES8802429A1 (es) 1988-06-01
US4808616A (en) 1989-02-28
YU103687A (en) 1988-08-31
NL193616B (nl) 1999-12-01
CH668599A5 (de) 1989-01-13
PT82944B (pt) 1989-01-30
CS258498B2 (en) 1988-08-16
FI83424B (fi) 1991-03-28
CA1277656C (en) 1990-12-11
GB2177700B (en) 1988-12-07
ES556550A0 (es) 1987-12-16
PH21785A (en) 1988-02-24
SE468988B (sv) 1993-04-26
IE58949B1 (en) 1993-12-01
NL300017I2 (nl) 2001-01-02
NO165547B (no) 1990-11-19
GB8616585D0 (en) 1986-08-13
GR861780B (en) 1986-11-11
GB8517360D0 (en) 1985-08-14
HU194274B (en) 1988-01-28
NZ216763A (en) 1988-05-30
SU1501923A3 (ru) 1989-08-15
PT82944A (en) 1986-08-01
FI83424C (fi) 1991-07-10
IL79336A (en) 1991-06-10
AU5979986A (en) 1987-01-15
BR1100240A (pt) 1999-12-28
AU578840B2 (en) 1988-11-03
CN86104664B (zh) 1988-06-29
US4904650A (en) 1990-02-27
YU44628B (en) 1990-10-31
NO165547C (no) 1991-02-27
BG61370B2 (bg) 1997-06-30
CN86104664A (zh) 1987-02-18
ES8801304A1 (es) 1987-12-16
IT8621004A0 (it) 1986-07-02
GB2177700A (en) 1987-01-28
YU120186A (en) 1988-02-29
BE905067A (fr) 1987-01-08
YU44585B (en) 1990-10-31
MY102294A (en) 1992-05-15
FR2584725B1 (fr) 1988-05-13
ES557466A0 (es) 1988-06-01
KR950003614B1 (ko) 1995-04-17
NO862753L (no) 1987-01-12
NL8601785A (nl) 1987-02-02
JPH0443919B2 (enExample) 1992-07-20
UA6046A1 (uk) 1994-12-29
HUT42780A (en) 1987-08-28
SE8603046L (sv) 1987-01-10
SG80490G (en) 1990-11-23
CS521486A2 (en) 1987-09-17
SU1442077A3 (ru) 1988-11-30
DK163520B (da) 1992-03-09
NL300017I1 (nl) 2000-11-01
FR2584725A1 (fr) 1987-01-16
NO862753D0 (no) 1986-07-08
IE861821L (en) 1987-01-09
FI862871A7 (fi) 1987-01-10
DK324386D0 (da) 1986-07-08
HK94190A (en) 1990-11-23
AT395157B (de) 1992-10-12
FI862871A0 (fi) 1986-07-07
KR870001140A (ko) 1987-03-11
DK324386A (da) 1987-01-10
IT1196436B (it) 1988-11-16
DK163520C (da) 1992-07-27
ZA865079B (en) 1987-03-25
SE8603046D0 (sv) 1986-07-08
CS257794B2 (en) 1988-06-15
IL79336A0 (en) 1986-10-31
NO2000009I1 (no) 2000-10-05
DE10199030I1 (de) 2001-10-04
CZ413591A3 (en) 1994-03-16

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