DE10199030I1 - Substituierte Androsta-1, 4-dien-3, 17-dione und Verfahren zu deren Herstellung - Google Patents

Substituierte Androsta-1, 4-dien-3, 17-dione und Verfahren zu deren Herstellung

Info

Publication number
DE10199030I1
DE10199030I1 DE2001199030 DE10199030C DE10199030I1 DE 10199030 I1 DE10199030 I1 DE 10199030I1 DE 2001199030 DE2001199030 DE 2001199030 DE 10199030 C DE10199030 C DE 10199030C DE 10199030 I1 DE10199030 I1 DE 10199030I1
Authority
DE
Germany
Prior art keywords
diones
diene
preparation
substituted androsta
androsta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2001199030
Other languages
English (en)
Inventor
Franco Buzzetti
Natale Barbugian
Paolo Lombardi
Enrico Di Salle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10199030(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of DE10199030I1 publication Critical patent/DE10199030I1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2001199030 1985-07-09 1986-07-08 Substituierte Androsta-1, 4-dien-3, 17-dione und Verfahren zu deren Herstellung Pending DE10199030I1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (1)

Publication Number Publication Date
DE10199030I1 true DE10199030I1 (de) 2001-10-04

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2001199030 Pending DE10199030I1 (de) 1985-07-09 1986-07-08 Substituierte Androsta-1, 4-dien-3, 17-dione und Verfahren zu deren Herstellung

Country Status (38)

Country Link
US (2) US4808616A (de)
JP (1) JPS6212797A (de)
KR (1) KR950003614B1 (de)
CN (1) CN86104664B (de)
AT (1) AT395157B (de)
AU (1) AU578840B2 (de)
BE (1) BE905067A (de)
BG (1) BG61370B2 (de)
BR (1) BR1100240A (de)
CA (1) CA1277656C (de)
CH (1) CH668599A5 (de)
CS (2) CS257794B2 (de)
CZ (1) CZ413591A3 (de)
DE (1) DE10199030I1 (de)
DK (1) DK163520C (de)
ES (2) ES8801304A1 (de)
FI (1) FI83424C (de)
FR (1) FR2584725B1 (de)
GB (2) GB8517360D0 (de)
GR (1) GR861780B (de)
HK (1) HK94190A (de)
HU (1) HU194274B (de)
IE (1) IE58949B1 (de)
IL (1) IL79336A (de)
IT (1) IT1196436B (de)
MY (1) MY102294A (de)
NL (2) NL193616C (de)
NO (2) NO165547C (de)
NZ (1) NZ216763A (de)
PH (1) PH21785A (de)
PT (1) PT82944B (de)
SE (1) SE468988B (de)
SG (1) SG80490G (de)
SK (1) SK413591A3 (de)
SU (2) SU1442077A3 (de)
UA (1) UA6046A1 (de)
YU (2) YU44585B (de)
ZA (1) ZA865079B (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
DE3715869A1 (de) * 1987-05-07 1988-11-17 Schering Ag Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren
GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
EP0582713B1 (de) * 1991-03-28 1997-06-04 Teikoku Hormone Mfg. Co., Ltd. Neue D-Homo-17-oxa und D-Homo-17-aza-androstanderivate
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
DE69324595T2 (de) * 1992-09-30 1999-08-19 Teikoku Hormone Mfg. Co. 7-substituierte oxa-steroid verbindung
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
EP1322333A2 (de) * 2000-08-09 2003-07-02 Pharmacia Italia S.p.A. Zusammensetzung zur kombinierten verwendung von aromatase inhibitoren
MXPA03001983A (es) * 2000-09-08 2003-06-24 Pharmacia Italia Spa Exemestano como agente quimiopreventivo.
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
ES2269682T3 (es) * 2001-01-26 2007-04-01 Pfizer Italia S.R.L. Exemestano para tratar transtornos que dependen de hormonas.
EP3406249A1 (de) 2001-02-19 2018-11-28 Novartis AG Behandlung von brusttumoren mit einem rapamycinderivat in kombination mit einem aromatasehemmer
HUP0400038A3 (en) 2001-05-16 2007-05-29 Novartis Ag Combination comprising n-{5-[4-{-methyl-piperazino-methyl)-benzoylamino]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
SI1505959T1 (sl) 2002-05-16 2009-04-30 Novartis Ag Uporaba vezavnih sredstev EDG receptorjev pri raku
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
US8183401B2 (en) * 2004-01-16 2012-05-22 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
BRPI0616639A2 (pt) 2005-09-30 2011-06-28 Endece Llc compostos de exemestano de (s)-6-metiloxaalquila e métodos de uso relacionados
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
JP2009536180A (ja) 2006-05-09 2009-10-08 ノバルティス アクチエンゲゼルシャフト 鉄キレート剤と抗新生物剤を含む組合せ剤およびそれらの使用
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
JP5558358B2 (ja) 2007-10-16 2014-07-23 レプロス セラピューティクス インコーポレイティド メタボリック症候群用のｔｒａｎｓ−クロミフェン
EP2070943A1 (de) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Verfahren zur Herstellung von 6-Alkylidenandrost-1,4-dien-3-onen
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
ES2461092T3 (es) * 2008-01-21 2014-05-16 Cadila Healthcare Limited Procedimiento para preparar el inhibidor de aromatasa Exemestano
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
EP2429299B1 (de) 2009-05-01 2016-06-01 Celloxess Llc Behandlung männlicher unfruchtbarkeit nach oxidativem stress der spermien
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
AU2011237592B2 (en) 2010-04-08 2016-10-27 Emory University Substituted androst-4-ene diones
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
ES2605960T3 (es) 2010-09-14 2017-03-17 Endece, Llc Derivados de desmetil-estradiol 6-sustituido como agonistas del RE-beta
AU2013225869B2 (en) 2012-02-29 2017-06-08 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
JP2017505345A (ja) 2014-02-11 2017-02-16 ノバルティス アーゲー がんの処置のためのｐｉ３ｋ阻害剤を含む組合せ医薬
EP3373967B9 (de) 2015-11-10 2023-10-04 Paracrine Therapeutics AB Behandlung von er-negativem brustkrebs mit einem pdgf-cc-inhibitor und einem antiöstrogen
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB929985A (de) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
BE759143A (fr) * 1969-11-19 1971-05-19 Upjohn Co Procede de preparation d'un nouveau compose steroide
US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
FR2584725B1 (fr) 1988-05-13
ES8802429A1 (es) 1988-06-01
FI862871A0 (fi) 1986-07-07
AT395157B (de) 1992-10-12
CS258498B2 (en) 1988-08-16
KR870001140A (ko) 1987-03-11
US4808616A (en) 1989-02-28
IL79336A0 (en) 1986-10-31
ATA181986A (de) 1992-02-15
NO862753D0 (no) 1986-07-08
SG80490G (en) 1990-11-23
NO165547C (no) 1991-02-27
GR861780B (en) 1986-11-11
IL79336A (en) 1991-06-10
YU44628B (en) 1990-10-31
MY102294A (en) 1992-05-15
FI862871A (fi) 1987-01-10
DK163520B (da) 1992-03-09
ES8801304A1 (es) 1987-12-16
IE58949B1 (en) 1993-12-01
NO2000009I1 (no) 2000-10-05
CA1277656C (en) 1990-12-11
JPH0443919B2 (de) 1992-07-20
GB2177700B (en) 1988-12-07
FI83424B (fi) 1991-03-28
NL193616C (nl) 2000-04-04
ES556550A0 (es) 1987-12-16
FI83424C (fi) 1991-07-10
NL193616B (nl) 1999-12-01
SE468988B (sv) 1993-04-26
US4904650A (en) 1990-02-27
NL300017I2 (nl) 2001-01-02
GB8616585D0 (en) 1986-08-13
NO862753L (no) 1987-01-12
SK413591A3 (en) 1995-07-11
YU120186A (en) 1988-02-29
CN86104664A (zh) 1987-02-18
CZ413591A3 (en) 1994-03-16
PH21785A (en) 1988-02-24
GB8517360D0 (en) 1985-08-14
CH668599A5 (de) 1989-01-13
JPS6212797A (ja) 1987-01-21
DK163520C (da) 1992-07-27
BE905067A (fr) 1987-01-08
DK324386A (da) 1987-01-10
BR1100240A (pt) 1999-12-28
PT82944A (en) 1986-08-01
IT1196436B (it) 1988-11-16
SE8603046D0 (sv) 1986-07-08
KR950003614B1 (ko) 1995-04-17
HU194274B (en) 1988-01-28
ZA865079B (en) 1987-03-25
CS257794B2 (en) 1988-06-15
CS521486A2 (en) 1987-09-17
SU1501923A3 (ru) 1989-08-15
ES557466A0 (es) 1988-06-01
FR2584725A1 (fr) 1987-01-16
AU5979986A (en) 1987-01-15
CN86104664B (zh) 1988-06-29
HK94190A (en) 1990-11-23
NO165547B (no) 1990-11-19
IT8621004A0 (it) 1986-07-02
PT82944B (pt) 1989-01-30
HUT42780A (en) 1987-08-28
YU44585B (en) 1990-10-31
YU103687A (en) 1988-08-31
IE861821L (en) 1987-01-09
SE8603046L (sv) 1987-01-10
NL300017I1 (nl) 2000-11-01
BG61370B2 (bg) 1997-06-30
SU1442077A3 (ru) 1988-11-30
GB2177700A (en) 1987-01-28
NZ216763A (en) 1988-05-30
DK324386D0 (da) 1986-07-08
UA6046A1 (uk) 1994-12-29
AU578840B2 (en) 1988-11-03
NL8601785A (nl) 1987-02-02

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