ATA181986A - Verfahren zur herstellung von neuen substituierten androsta-1,4-dien-3,17-dionen - Google Patents

Verfahren zur herstellung von neuen substituierten androsta-1,4-dien-3,17-dionen

Info

Publication number
ATA181986A
ATA181986A AT0181986A AT181986A ATA181986A AT A181986 A ATA181986 A AT A181986A AT 0181986 A AT0181986 A AT 0181986A AT 181986 A AT181986 A AT 181986A AT A181986 A ATA181986 A AT A181986A
Authority
AT
Austria
Prior art keywords
diones
dien
producing new
new substituted
substituted androsta
Prior art date
Application number
AT0181986A
Other languages
English (en)
Other versions
AT395157B (de
Inventor
Franco Buzzetti
Natale Barbugian
Paolo Lombardi
Enrico Di Salle
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATA181986(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of ATA181986A publication Critical patent/ATA181986A/de
Application granted granted Critical
Publication of AT395157B publication Critical patent/AT395157B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0181986A 1985-07-09 1986-07-04 Verfahren zur herstellung von neuen substituierten androsta-1,4-dien-3,17-dionen AT395157B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (2)

Publication Number Publication Date
ATA181986A true ATA181986A (de) 1992-02-15
AT395157B AT395157B (de) 1992-10-12

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0181986A AT395157B (de) 1985-07-09 1986-07-04 Verfahren zur herstellung von neuen substituierten androsta-1,4-dien-3,17-dionen

Country Status (38)

Country Link
US (2) US4808616A (de)
JP (1) JPS6212797A (de)
KR (1) KR950003614B1 (de)
CN (1) CN86104664B (de)
AT (1) AT395157B (de)
AU (1) AU578840B2 (de)
BE (1) BE905067A (de)
BG (1) BG61370B2 (de)
BR (1) BR1100240A (de)
CA (1) CA1277656C (de)
CH (1) CH668599A5 (de)
CS (2) CS257794B2 (de)
CZ (1) CZ413591A3 (de)
DE (1) DE10199030I1 (de)
DK (1) DK163520C (de)
ES (2) ES8801304A1 (de)
FI (1) FI83424C (de)
FR (1) FR2584725B1 (de)
GB (2) GB8517360D0 (de)
GR (1) GR861780B (de)
HK (1) HK94190A (de)
HU (1) HU194274B (de)
IE (1) IE58949B1 (de)
IL (1) IL79336A (de)
IT (1) IT1196436B (de)
MY (1) MY102294A (de)
NL (2) NL193616C (de)
NO (2) NO165547C (de)
NZ (1) NZ216763A (de)
PH (1) PH21785A (de)
PT (1) PT82944B (de)
SE (1) SE468988B (de)
SG (1) SG80490G (de)
SK (1) SK413591A3 (de)
SU (2) SU1442077A3 (de)
UA (1) UA6046A1 (de)
YU (2) YU44585B (de)
ZA (1) ZA865079B (de)

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GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
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GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
CA2107102A1 (en) * 1991-03-28 1992-09-29 Naoyuki Koizumi Novel oxa- or azasteroid derivatives
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
HU221191B1 (en) * 1992-09-30 2002-08-28 Teikoku Hormone Mfg Co Ltd 7-substituted oxasteroid compounds, process for their preparation and pharmaceutical compositions containing the same
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
EP1322333A2 (de) * 2000-08-09 2003-07-02 Pharmacia Italia S.p.A. Zusammensetzung zur kombinierten verwendung von aromatase inhibitoren
JP2004508334A (ja) * 2000-09-08 2004-03-18 フアルマシア・イタリア・エツセ・ピー・アー 化学予防剤としてのエクセメスタン
EP1377298B1 (de) * 2001-01-26 2006-08-30 Pfizer Italia S.r.l. Exemestan zur behandlung von hormonabhängigen störungen
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
CN1551767A (zh) 2001-02-19 2004-12-01 ��˹��ŵ�� 癌症的治疗
AU2002342335B2 (en) 2001-05-16 2006-02-02 Novartis Ag Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
JP5227492B2 (ja) 2002-05-16 2013-07-03 ノバルティス アーゲー 癌におけるｅｄｇレセプター結合剤の使用
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
ATE548375T1 (de) * 2004-01-16 2012-03-15 Cedarburg Pharmaceuticals Inc Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
CN101312743A (zh) 2005-09-30 2008-11-26 安德西有限公司 (s)-6-甲基氧杂烷基依西美坦化合物及相关使用方法
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
JP2009536180A (ja) 2006-05-09 2009-10-08 ノバルティス アクチエンゲゼルシャフト 鉄キレート剤と抗新生物剤を含む組合せ剤およびそれらの使用
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
MX2010004195A (es) 2007-10-16 2010-06-02 Repros Therapeutics Inc Trans-clomifeno para el sindrome metabolico.
EP2070943A1 (de) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Verfahren zur Herstellung von 6-Alkylidenandrost-1,4-dien-3-onen
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
WO2009093262A2 (en) * 2008-01-21 2009-07-30 Cadila Healthcare Limited Process for preparing aromatase inhibitor exemestane
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
ES2587977T3 (es) 2009-05-01 2016-10-28 Celloxess Llc Tratamiento de la infertilidad masculina secundaria al estrés oxidativo de esperma
RU2425052C1 (ru) * 2010-03-04 2011-07-27 Татьяна Степановна Савинова Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
AU2011237592B2 (en) 2010-04-08 2016-10-27 Emory University Substituted androst-4-ene diones
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
MX343059B (es) 2010-09-14 2016-10-24 Endece Llc Derivados de desmetil-estradiol sustituido en 6 como agonistas de er-beta selectivos.
MX2014009322A (es) 2012-02-29 2014-11-10 Repros Therapeutics Inc Terapia de combinacion para el tratamiento de la deficiencia androgenica.
AU2015216590A1 (en) 2014-02-11 2016-06-30 Novartis Ag Pharmaceutical combinations comprising a PI3K inhibitor for the treatment of cancer
US11633382B2 (en) 2015-11-10 2023-04-25 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

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GB929985A (de) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
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DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
PT82944A (en) 1986-08-01
SK413591A3 (en) 1995-07-11
AU5979986A (en) 1987-01-15
YU120186A (en) 1988-02-29
US4904650A (en) 1990-02-27
GR861780B (en) 1986-11-11
NO2000009I1 (no) 2000-10-05
FR2584725A1 (fr) 1987-01-16
HK94190A (en) 1990-11-23
US4808616A (en) 1989-02-28
CZ413591A3 (en) 1994-03-16
FI83424C (fi) 1991-07-10
DE10199030I1 (de) 2001-10-04
SG80490G (en) 1990-11-23
SU1501923A3 (ru) 1989-08-15
AT395157B (de) 1992-10-12
IT1196436B (it) 1988-11-16
PT82944B (pt) 1989-01-30
ES557466A0 (es) 1988-06-01
IL79336A0 (en) 1986-10-31
IT8621004A0 (it) 1986-07-02
AU578840B2 (en) 1988-11-03
NL300017I2 (nl) 2001-01-02
ZA865079B (en) 1987-03-25
KR950003614B1 (ko) 1995-04-17
DK163520B (da) 1992-03-09
IE861821L (en) 1987-01-09
IE58949B1 (en) 1993-12-01
CN86104664A (zh) 1987-02-18
GB2177700A (en) 1987-01-28
KR870001140A (ko) 1987-03-11
PH21785A (en) 1988-02-24
NO862753D0 (no) 1986-07-08
GB8616585D0 (en) 1986-08-13
FR2584725B1 (fr) 1988-05-13
YU44628B (en) 1990-10-31
CS521486A2 (en) 1987-09-17
MY102294A (en) 1992-05-15
GB2177700B (en) 1988-12-07
NL193616B (nl) 1999-12-01
FI862871A7 (fi) 1987-01-10
HU194274B (en) 1988-01-28
SE468988B (sv) 1993-04-26
CA1277656C (en) 1990-12-11
FI862871A0 (fi) 1986-07-07
CS258498B2 (en) 1988-08-16
SE8603046L (sv) 1987-01-10
CN86104664B (zh) 1988-06-29
ES556550A0 (es) 1987-12-16
BR1100240A (pt) 1999-12-28
NL193616C (nl) 2000-04-04
HUT42780A (en) 1987-08-28
DK163520C (da) 1992-07-27
UA6046A1 (uk) 1994-12-29
JPH0443919B2 (de) 1992-07-20
BG61370B2 (bg) 1997-06-30
IL79336A (en) 1991-06-10
BE905067A (fr) 1987-01-08
NO165547B (no) 1990-11-19
FI83424B (fi) 1991-03-28
GB8517360D0 (en) 1985-08-14
ES8801304A1 (es) 1987-12-16
SU1442077A3 (ru) 1988-11-30
CS257794B2 (en) 1988-06-15
JPS6212797A (ja) 1987-01-21
SE8603046D0 (sv) 1986-07-08
NZ216763A (en) 1988-05-30
NL8601785A (nl) 1987-02-02
NL300017I1 (nl) 2000-11-01
DK324386A (da) 1987-01-10
DK324386D0 (da) 1986-07-08
CH668599A5 (de) 1989-01-13
YU44585B (en) 1990-10-31
NO165547C (no) 1991-02-27
NO862753L (no) 1987-01-12
YU103687A (en) 1988-08-31
ES8802429A1 (es) 1988-06-01

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ELA Expired due to lapse of time