DK324386D0 - Substitueret androsta-1,4-dien-3,17-dion og fremgangsmaade til fremstilling deraf - Google Patents

Substitueret androsta-1,4-dien-3,17-dion og fremgangsmaade til fremstilling deraf

Info

Publication number
DK324386D0
DK324386D0 DK324386A DK324386A DK324386D0 DK 324386 D0 DK324386 D0 DK 324386D0 DK 324386 A DK324386 A DK 324386A DK 324386 A DK324386 A DK 324386A DK 324386 D0 DK324386 D0 DK 324386D0
Authority
DK
Denmark
Prior art keywords
dion
dien
preparing
procedure
substituted androsta
Prior art date
Application number
DK324386A
Other languages
English (en)
Other versions
DK163520B (da
DK163520C (da
DK324386A (da
Inventor
Franco Buzzetti
Natale Barbugian
Paolo Lombardi
Enrico Di Salle
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK324386(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of DK324386D0 publication Critical patent/DK324386D0/da
Publication of DK324386A publication Critical patent/DK324386A/da
Publication of DK163520B publication Critical patent/DK163520B/da
Application granted granted Critical
Publication of DK163520C publication Critical patent/DK163520C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK324386A 1985-07-09 1986-07-08 Substitueret androsta-1,4-dien-3,17-dioner, fremgangsmaade til fremstilling deraf, praeparater indeholdende saadanne forbindelser samt anvendelsen af disse til fremstilling af farmaceutiske praeparater DK163520C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones
GB8517360 1985-07-09

Publications (4)

Publication Number Publication Date
DK324386D0 true DK324386D0 (da) 1986-07-08
DK324386A DK324386A (da) 1987-01-10
DK163520B DK163520B (da) 1992-03-09
DK163520C DK163520C (da) 1992-07-27

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
DK324386A DK163520C (da) 1985-07-09 1986-07-08 Substitueret androsta-1,4-dien-3,17-dioner, fremgangsmaade til fremstilling deraf, praeparater indeholdende saadanne forbindelser samt anvendelsen af disse til fremstilling af farmaceutiske praeparater

Country Status (38)

Country Link
US (2) US4808616A (da)
JP (1) JPS6212797A (da)
KR (1) KR950003614B1 (da)
CN (1) CN86104664B (da)
AT (1) AT395157B (da)
AU (1) AU578840B2 (da)
BE (1) BE905067A (da)
BG (1) BG61370B2 (da)
BR (1) BR1100240A (da)
CA (1) CA1277656C (da)
CH (1) CH668599A5 (da)
CS (2) CS257794B2 (da)
CZ (1) CZ413591A3 (da)
DE (1) DE10199030I1 (da)
DK (1) DK163520C (da)
ES (2) ES8801304A1 (da)
FI (1) FI83424C (da)
FR (1) FR2584725B1 (da)
GB (2) GB8517360D0 (da)
GR (1) GR861780B (da)
HK (1) HK94190A (da)
HU (1) HU194274B (da)
IE (1) IE58949B1 (da)
IL (1) IL79336A (da)
IT (1) IT1196436B (da)
MY (1) MY102294A (da)
NL (2) NL193616C (da)
NO (2) NO165547C (da)
NZ (1) NZ216763A (da)
PH (1) PH21785A (da)
PT (1) PT82944B (da)
SE (1) SE468988B (da)
SG (1) SG80490G (da)
SK (1) SK413591A3 (da)
SU (2) SU1442077A3 (da)
UA (1) UA6046A1 (da)
YU (2) YU44585B (da)
ZA (1) ZA865079B (da)

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GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
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GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
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CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
ATE179179T1 (de) * 1992-09-30 1999-05-15 Teikoku Hormone Mfg Co Ltd 7-substituierte oxa-steroid verbindung
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
JP2004505909A (ja) * 2000-08-09 2004-02-26 フアルマシア・イタリア・エツセ・ピー・アー アロマターゼ阻害薬の併用型組成物
AU8986501A (en) * 2000-09-08 2002-03-22 Pharmacia & Upjohn Spa Exemestane as chemopreventing agent
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
DK1377298T3 (da) * 2001-01-26 2007-01-02 Pfizer Italia Srl Exemestan til behandling af hormon-afhængige lidelser
PT2269603E (pt) 2001-02-19 2015-09-09 Novartis Ag Tratamento de tumores da mama com um derivado de rapamicina em combinação com exemestano
JP4477303B2 (ja) 2001-05-16 2010-06-09 ノバルティス アーゲー Ｎ−｛５−［４−（４−メチル−ピペラジノ−メチル）−ベンゾイルアミド］−２−メチルフェニル｝−４−（３−ピリジル）−２−ピリミジン−アミンおよび化学療法剤を含んでなる併用剤
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
CN1652757B (zh) 2002-05-16 2012-02-08 诺瓦提斯公司 Edg受体结合剂在癌症中的应用
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
US8183401B2 (en) * 2004-01-16 2012-05-22 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
KR101484134B1 (ko) 2005-09-30 2015-01-21 엔디씨, 엘엘씨 (ｓ)-６-메틸옥사알킬 엑스메스탄 화합물 및 관련 사용방법
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
US20090317489A1 (en) 2006-05-09 2009-12-24 Hanspeter Nick Combination Comprising an Iron Chelator and an Anti-Neoplastic Agent and Use Thereof
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
NZ585389A (en) 2007-10-16 2011-10-28 Repros Therapeutics Inc Trans-clomiphene for metabolic syndrome
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
EP2231691B1 (en) * 2008-01-21 2014-04-09 Cadila Healthcare Limited Process for preparing aromatase inhibitor exemestane
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
EP2429299B1 (en) 2009-05-01 2016-06-01 Celloxess Llc Treating male infertility secondary to sperm oxidative stress
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
EP2556082B1 (en) 2010-04-08 2017-02-22 Emory University Substituted androst-4-ene diones
WO2011128434A2 (en) 2010-04-16 2011-10-20 Novartis Ag Treatment of endocrine resistant breast cancer
AU2011302065B2 (en) 2010-09-14 2016-12-01 Endece, Llc 6-substituted demethyl-estradiol derivatives as ER-beta agonists
CA2865234A1 (en) 2012-02-29 2013-09-06 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
MX2016010482A (es) 2014-02-11 2016-10-17 Novartis Ag Combinaciones farmaceuticas que comprenden un inhibidor de pi3k para el tratamiento de cancer.
CN108348605B (zh) 2015-11-10 2023-06-09 帕拉卡林治疗公司 用pdgf-cc抑制剂和抗雌激素治疗er阴性乳癌
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

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GB929985A (da) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
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US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
SE8603046D0 (sv) 1986-07-08
ES557466A0 (es) 1988-06-01
GB8616585D0 (en) 1986-08-13
YU103687A (en) 1988-08-31
NO862753D0 (no) 1986-07-08
JPH0443919B2 (da) 1992-07-20
SK413591A3 (en) 1995-07-11
UA6046A1 (uk) 1994-12-29
HK94190A (en) 1990-11-23
ATA181986A (de) 1992-02-15
NL193616C (nl) 2000-04-04
JPS6212797A (ja) 1987-01-21
BR1100240A (pt) 1999-12-28
FI862871A0 (fi) 1986-07-07
ZA865079B (en) 1987-03-25
NO165547B (no) 1990-11-19
CS257794B2 (en) 1988-06-15
SU1501923A3 (ru) 1989-08-15
CZ413591A3 (en) 1994-03-16
PT82944A (en) 1986-08-01
FI83424B (fi) 1991-03-28
US4904650A (en) 1990-02-27
CA1277656C (en) 1990-12-11
CN86104664A (zh) 1987-02-18
DK163520B (da) 1992-03-09
HU194274B (en) 1988-01-28
IE861821L (en) 1987-01-09
PT82944B (pt) 1989-01-30
MY102294A (en) 1992-05-15
NO862753L (no) 1987-01-12
DK163520C (da) 1992-07-27
NL300017I2 (nl) 2001-01-02
NL193616B (nl) 1999-12-01
ES8802429A1 (es) 1988-06-01
FI83424C (fi) 1991-07-10
DK324386A (da) 1987-01-10
ES8801304A1 (es) 1987-12-16
CS521486A2 (en) 1987-09-17
PH21785A (en) 1988-02-24
GB2177700B (en) 1988-12-07
IL79336A0 (en) 1986-10-31
FR2584725B1 (fr) 1988-05-13
AU5979986A (en) 1987-01-15
CH668599A5 (de) 1989-01-13
SE8603046L (sv) 1987-01-10
IT8621004A0 (it) 1986-07-02
NO165547C (no) 1991-02-27
AT395157B (de) 1992-10-12
SU1442077A3 (ru) 1988-11-30
CN86104664B (zh) 1988-06-29
FI862871A (fi) 1987-01-10
YU44628B (en) 1990-10-31
NL8601785A (nl) 1987-02-02
KR950003614B1 (ko) 1995-04-17
IT1196436B (it) 1988-11-16
US4808616A (en) 1989-02-28
KR870001140A (ko) 1987-03-11
SG80490G (en) 1990-11-23
ES556550A0 (es) 1987-12-16
DE10199030I1 (de) 2001-10-04
YU120186A (en) 1988-02-29
CS258498B2 (en) 1988-08-16
SE468988B (sv) 1993-04-26
GB8517360D0 (en) 1985-08-14
NZ216763A (en) 1988-05-30
AU578840B2 (en) 1988-11-03
HUT42780A (en) 1987-08-28
NO2000009I1 (no) 2000-10-05
IL79336A (en) 1991-06-10
BG61370B2 (bg) 1997-06-30
GR861780B (en) 1986-11-11
IE58949B1 (en) 1993-12-01
NL300017I1 (nl) 2000-11-01
FR2584725A1 (fr) 1987-01-16
YU44585B (en) 1990-10-31
BE905067A (fr) 1987-01-08
GB2177700A (en) 1987-01-28

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CTFF Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2000 00007

Filing date: 20000316

Extension date: 20110708

PUP Patent expired