IE58949B1 - Subtituted androsta-1,4-diene-3,17-diones and process for their preparation - Google Patents

Subtituted androsta-1,4-diene-3,17-diones and process for their preparation

Info

Publication number
IE58949B1
IE58949B1 IE182186A IE182186A IE58949B1 IE 58949 B1 IE58949 B1 IE 58949B1 IE 182186 A IE182186 A IE 182186A IE 182186 A IE182186 A IE 182186A IE 58949 B1 IE58949 B1 IE 58949B1
Authority
IE
Ireland
Prior art keywords
dione
compound
diene
formula
hydrogen
Prior art date
Application number
IE182186A
Other languages
English (en)
Other versions
IE861821L (en
Inventor
Franco Buzzetti
Natale Barbugian
Paolo Lombardi
Enrico Di-Salle
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE58949(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of IE861821L publication Critical patent/IE861821L/en
Publication of IE58949B1 publication Critical patent/IE58949B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IE182186A 1985-07-09 1986-07-07 Subtituted androsta-1,4-diene-3,17-diones and process for their preparation IE58949B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (2)

Publication Number Publication Date
IE861821L IE861821L (en) 1987-01-09
IE58949B1 true IE58949B1 (en) 1993-12-01

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
IE182186A IE58949B1 (en) 1985-07-09 1986-07-07 Subtituted androsta-1,4-diene-3,17-diones and process for their preparation

Country Status (38)

Country Link
US (2) US4808616A (enExample)
JP (1) JPS6212797A (enExample)
KR (1) KR950003614B1 (enExample)
CN (1) CN86104664B (enExample)
AT (1) AT395157B (enExample)
AU (1) AU578840B2 (enExample)
BE (1) BE905067A (enExample)
BG (1) BG61370B2 (enExample)
BR (1) BR1100240A (enExample)
CA (1) CA1277656C (enExample)
CH (1) CH668599A5 (enExample)
CS (2) CS258498B2 (enExample)
CZ (1) CZ413591A3 (enExample)
DE (1) DE10199030I1 (enExample)
DK (1) DK163520C (enExample)
ES (2) ES8801304A1 (enExample)
FI (1) FI83424C (enExample)
FR (1) FR2584725B1 (enExample)
GB (2) GB8517360D0 (enExample)
GR (1) GR861780B (enExample)
HK (1) HK94190A (enExample)
HU (1) HU194274B (enExample)
IE (1) IE58949B1 (enExample)
IL (1) IL79336A (enExample)
IT (1) IT1196436B (enExample)
MY (1) MY102294A (enExample)
NL (2) NL193616C (enExample)
NO (2) NO165547C (enExample)
NZ (1) NZ216763A (enExample)
PH (1) PH21785A (enExample)
PT (1) PT82944B (enExample)
SE (1) SE468988B (enExample)
SG (1) SG80490G (enExample)
SK (1) SK413591A3 (enExample)
SU (2) SU1442077A3 (enExample)
UA (1) UA6046A1 (enExample)
YU (2) YU44585B (enExample)
ZA (1) ZA865079B (enExample)

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GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
DE3715869A1 (de) * 1987-05-07 1988-11-17 Schering Ag Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren
GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
JP3293623B2 (ja) * 1991-03-28 2002-06-17 帝国臓器製薬株式会社 新規なオキサ又はアザステロイド誘導体
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GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
ATE179179T1 (de) * 1992-09-30 1999-05-15 Teikoku Hormone Mfg Co Ltd 7-substituierte oxa-steroid verbindung
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en) * 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
JP2004505909A (ja) * 2000-08-09 2004-02-26 フアルマシア・イタリア・エツセ・ピー・アー アロマターゼ阻害薬の併用型組成物
AU2001289865B2 (en) * 2000-09-08 2007-03-01 Pharmacia Italia S.P.A. Exemestane as chemopreventing agent
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
ES2269682T3 (es) * 2001-01-26 2007-04-01 Pfizer Italia S.R.L. Exemestano para tratar transtornos que dependen de hormonas.
CZ303611B6 (cs) 2001-02-19 2013-01-09 Novartis Ag Farmaceutické prostredky s obsahem derivátu rapamycinu pro lécení solidních nádoru
RU2318517C2 (ru) 2001-05-16 2008-03-10 Новартис Аг Комбинация, включающая n-{5-[4-(4-метилпиперазинометил)бензоиламидо]-2-метилфенил}-4-(3-пиридил)-2-пиримидинамин и химиотерапевтический агент
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
NZ536513A (en) 2002-05-16 2007-10-26 Novartis Ag Use of EDG receptor binding agents in cancer
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
ES2382609T3 (es) * 2004-01-16 2012-06-11 Cedarburg Pharmaceuticals, Inc. Exemestano y sus productos intermedios y métodos de preparación de los mismos
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US7846918B2 (en) 2005-09-30 2010-12-07 Endece, Llc Exemestane compounds, compositions and related methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
EP2272511A1 (en) 2006-05-09 2011-01-12 Novartis AG Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
MX2010004195A (es) 2007-10-16 2010-06-02 Repros Therapeutics Inc Trans-clomifeno para el sindrome metabolico.
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
ES2461092T3 (es) * 2008-01-21 2014-05-16 Cadila Healthcare Limited Procedimiento para preparar el inhibidor de aromatasa Exemestano
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
US8377454B2 (en) 2009-05-01 2013-02-19 Parviz Gharagozloo Treating male infertility secondary to sperm oxidative stress
RU2425052C1 (ru) * 2010-03-04 2011-07-27 Татьяна Степановна Савинова Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
US8969327B2 (en) 2010-04-08 2015-03-03 Emory University Substituted androst-4-ene diones
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
MX343059B (es) 2010-09-14 2016-10-24 Endece Llc Derivados de desmetil-estradiol sustituido en 6 como agonistas de er-beta selectivos.
AU2013225869B2 (en) 2012-02-29 2017-06-08 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
RU2016135413A (ru) 2014-02-11 2018-03-14 Новартис Аг Фармацевтические комбинации, включающие ингибитор pi3k, для лечения рака
JP7048505B2 (ja) 2015-11-10 2022-04-05 パラクリン セラピューティクス エービー Ｐｄｇｆ－ｃｃ阻害剤および抗エストロゲン剤によるｅｒ陰性乳癌の処置
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

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US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
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DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
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US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
JPS6212797A (ja) 1987-01-21
FI83424C (fi) 1991-07-10
NO862753L (no) 1987-01-12
MY102294A (en) 1992-05-15
FR2584725B1 (fr) 1988-05-13
YU103687A (en) 1988-08-31
UA6046A1 (uk) 1994-12-29
DK163520B (da) 1992-03-09
PH21785A (en) 1988-02-24
DK324386A (da) 1987-01-10
AU578840B2 (en) 1988-11-03
GB8517360D0 (en) 1985-08-14
SU1442077A3 (ru) 1988-11-30
CN86104664B (zh) 1988-06-29
HUT42780A (en) 1987-08-28
HU194274B (en) 1988-01-28
NL300017I2 (nl) 2001-01-02
NO2000009I1 (no) 2000-10-05
NO862753D0 (no) 1986-07-08
NL8601785A (nl) 1987-02-02
NO165547C (no) 1991-02-27
CN86104664A (zh) 1987-02-18
IE861821L (en) 1987-01-09
PT82944A (en) 1986-08-01
CH668599A5 (de) 1989-01-13
CZ413591A3 (en) 1994-03-16
GB8616585D0 (en) 1986-08-13
AT395157B (de) 1992-10-12
GB2177700B (en) 1988-12-07
CA1277656C (en) 1990-12-11
DK324386D0 (da) 1986-07-08
DK163520C (da) 1992-07-27
NL193616B (nl) 1999-12-01
HK94190A (en) 1990-11-23
FI862871A7 (fi) 1987-01-10
YU44585B (en) 1990-10-31
YU120186A (en) 1988-02-29
SE8603046L (sv) 1987-01-10
IL79336A (en) 1991-06-10
YU44628B (en) 1990-10-31
JPH0443919B2 (enExample) 1992-07-20
IT1196436B (it) 1988-11-16
US4904650A (en) 1990-02-27
ES556550A0 (es) 1987-12-16
US4808616A (en) 1989-02-28
ZA865079B (en) 1987-03-25
GR861780B (en) 1986-11-11
BE905067A (fr) 1987-01-08
CS258498B2 (en) 1988-08-16
ES8801304A1 (es) 1987-12-16
ES8802429A1 (es) 1988-06-01
FI83424B (fi) 1991-03-28
SE8603046D0 (sv) 1986-07-08
KR950003614B1 (ko) 1995-04-17
GB2177700A (en) 1987-01-28
FR2584725A1 (fr) 1987-01-16
IL79336A0 (en) 1986-10-31
SU1501923A3 (ru) 1989-08-15
SE468988B (sv) 1993-04-26
DE10199030I1 (de) 2001-10-04
SK413591A3 (en) 1995-07-11
FI862871A0 (fi) 1986-07-07
BR1100240A (pt) 1999-12-28
ATA181986A (de) 1992-02-15
KR870001140A (ko) 1987-03-11
NL300017I1 (nl) 2000-11-01
NZ216763A (en) 1988-05-30
BG61370B2 (bg) 1997-06-30
ES557466A0 (es) 1988-06-01
PT82944B (pt) 1989-01-30
IT8621004A0 (it) 1986-07-02
AU5979986A (en) 1987-01-15
NL193616C (nl) 2000-04-04
CS521486A2 (en) 1987-09-17
NO165547B (no) 1990-11-19
SG80490G (en) 1990-11-23
CS257794B2 (en) 1988-06-15

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Free format text: SPC 003/2000, 22.02.2000

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