SK287696B6 - Spôsob prípravy voľnej bázy racemického citalopramu a voľnej bázy S- alebo R-citalopramu - Google Patents

Spôsob prípravy voľnej bázy racemického citalopramu a voľnej bázy S- alebo R-citalopramu Download PDF

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Publication number
SK287696B6
SK287696B6 SK51-2004A SK512004A SK287696B6 SK 287696 B6 SK287696 B6 SK 287696B6 SK 512004 A SK512004 A SK 512004A SK 287696 B6 SK287696 B6 SK 287696B6
Authority
SK
Slovakia
Prior art keywords
citalopram
mixture
mother liquor
enantiomer
addition salt
Prior art date
Application number
SK51-2004A
Other languages
English (en)
Slovak (sk)
Other versions
SK512004A3 (en
Inventor
Rikke Eva Humble
Troels Volsgaard Christensen
Michael Harold Rock
Ole Nielsen
Hans Petersen
Robert Dancer
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of SK512004A3 publication Critical patent/SK512004A3/sk
Publication of SK287696B6 publication Critical patent/SK287696B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SK51-2004A 2001-06-25 2002-06-25 Spôsob prípravy voľnej bázy racemického citalopramu a voľnej bázy S- alebo R-citalopramu SK287696B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200100991 2001-06-25
PCT/DK2002/000426 WO2003000672A1 (en) 2001-06-25 2002-06-25 Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram

Publications (2)

Publication Number Publication Date
SK512004A3 SK512004A3 (en) 2004-05-04
SK287696B6 true SK287696B6 (sk) 2011-06-06

Family

ID=8160584

Family Applications (1)

Application Number Title Priority Date Filing Date
SK51-2004A SK287696B6 (sk) 2001-06-25 2002-06-25 Spôsob prípravy voľnej bázy racemického citalopramu a voľnej bázy S- alebo R-citalopramu

Country Status (40)

Country Link
US (1) US7112686B2 (zh)
EP (1) EP1412341B1 (zh)
JP (2) JP4377219B2 (zh)
KR (4) KR100939945B1 (zh)
CN (2) CN101440079B (zh)
AR (2) AR034612A1 (zh)
AT (1) ATE284395T1 (zh)
BG (1) BG66372B1 (zh)
BR (1) BRPI0210574B8 (zh)
CA (2) CA2450890C (zh)
CO (1) CO5550420A2 (zh)
CZ (1) CZ305034B6 (zh)
DE (1) DE60202216T2 (zh)
DK (1) DK1412341T3 (zh)
EA (1) EA006446B1 (zh)
ES (1) ES2233834T3 (zh)
HK (2) HK1068627A1 (zh)
HR (1) HRP20031075B1 (zh)
HU (1) HU228476B1 (zh)
IL (1) IL159229A0 (zh)
IS (1) IS2426B (zh)
JO (1) JO2389B1 (zh)
MA (1) MA26260A1 (zh)
ME (2) ME00027B (zh)
MX (1) MXPA03011770A (zh)
MY (1) MY133471A (zh)
NO (2) NO329873B1 (zh)
NZ (1) NZ530104A (zh)
PE (1) PE20030122A1 (zh)
PL (1) PL366560A1 (zh)
PT (1) PT1412341E (zh)
RS (1) RS50673B (zh)
SI (1) SI1412341T1 (zh)
SK (1) SK287696B6 (zh)
TN (1) TNSN02062A1 (zh)
TW (1) TWI236473B (zh)
UA (1) UA75147C2 (zh)
UY (2) UY27356A1 (zh)
WO (1) WO2003000672A1 (zh)
ZA (1) ZA200309633B (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI306846B (en) 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
RS51092B (sr) 2002-12-23 2010-10-31 H. Lundbeck A/S. Escitalopram bromhidrat i postupak za njegovo pripremanje
RS52152B (sr) * 2002-12-23 2012-08-31 H. Lundbeck A/S Postupak pripremanja racemskog citalopram diola i/ili s- ili r-citalopram diola i upotreba takvih diola za pripremanje racemskog citaloprama, r-citaloprama i/ili s-citaloprama
AU2003291960B2 (en) 2002-12-23 2009-11-19 H. Lundbeck A/S A process for the preparation of racemic citalopram diol and/or S- or R- citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
BRPI0508266A (pt) * 2004-03-05 2007-07-31 Lundbeck & Co As H partìculas cristalinas de oxalato de escitalopram, forma de dosagem única sólida, e, métodos para a fabricação de partìculas cristalinas de oxalato de escitalopram e para reduzir a quantidade de hidroxila que contém impurezas no citalopram, escitalopram ou uma mistura não racêmica de r- e s-citalopram
US20050196453A1 (en) 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
JP2006008603A (ja) * 2004-06-25 2006-01-12 Sumitomo Chemical Co Ltd 光学活性シタロプラムの製造方法、その中間体およびその製造方法
EP1797060A2 (en) * 2004-08-23 2007-06-20 Sun Pharmaceutical Industries Limited "process for preparation of citalopram and enantiomers"
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
WO2006123243A2 (en) * 2005-05-20 2006-11-23 Aurobindo Pharma Limited Pharmaceutical dosage forms comprising escitalopram in form of granules
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EA200801081A1 (ru) 2005-10-14 2008-10-30 Х. Лундбекк А/С Способы лечения расстройств центральной нервной системы комбинацией малых доз эсциталопрама и бупропиона
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
FI121570B (fi) 2007-09-11 2011-01-14 Lundbeck & Co As H Menetelmä essitalopraamin valmistamiseksi
US8022232B2 (en) * 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN101560199B (zh) * 2008-04-16 2013-09-18 北京德众万全药物技术开发有限公司 一种依地普仑的制备方法
TWI381813B (zh) 2010-01-12 2013-01-11 Taiwan Paiho Ltd A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
ATE277032T1 (de) * 1999-10-25 2004-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram

Also Published As

Publication number Publication date
HRP20031075B1 (en) 2011-12-31
ES2233834T3 (es) 2005-06-16
JP2004536093A (ja) 2004-12-02
AR083483A2 (es) 2013-02-27
CN101440079A (zh) 2009-05-27
EA200400082A1 (ru) 2004-06-24
BR0210574B1 (pt) 2014-03-04
EA006446B1 (ru) 2005-12-29
BG108532A (bg) 2005-04-30
ME00027B (me) 2010-02-10
CN101440079B (zh) 2011-05-25
US20040259940A1 (en) 2004-12-23
PT1412341E (pt) 2005-04-29
BRPI0210574B8 (pt) 2021-05-25
NO20101420L (no) 2003-12-18
BG66372B1 (bg) 2013-10-31
IS2426B (is) 2008-10-15
CN1520405A (zh) 2004-08-11
NO329873B1 (no) 2011-01-17
NZ530104A (en) 2006-08-31
HUP0400293A2 (hu) 2004-09-28
SK512004A3 (en) 2004-05-04
ZA200309633B (en) 2005-02-23
MXPA03011770A (es) 2004-04-02
KR20080100498A (ko) 2008-11-18
JP2009203233A (ja) 2009-09-10
EP1412341B1 (en) 2004-12-08
JO2389B1 (en) 2007-06-17
UY35850A (es) 2016-06-30
BR0210574A (pt) 2004-08-03
KR20040030702A (ko) 2004-04-09
HK1068627A1 (en) 2005-04-29
AR034612A1 (es) 2004-03-03
IL159229A0 (en) 2004-06-01
PE20030122A1 (es) 2003-02-12
KR100902530B1 (ko) 2009-06-15
TWI236473B (en) 2005-07-21
JP4377219B2 (ja) 2009-12-02
UA75147C2 (en) 2006-03-15
HU228476B1 (en) 2013-03-28
CZ2004131A3 (cs) 2004-04-14
CA2450890A1 (en) 2003-01-03
MY133471A (en) 2007-11-30
NO20035671D0 (no) 2003-12-18
RS101403A (en) 2007-02-05
HUP0400293A3 (en) 2007-05-29
NO20035671L (no) 2003-12-18
RS50673B (sr) 2010-06-30
TNSN02062A1 (en) 2005-12-23
HRP20031075A2 (en) 2004-04-30
DE60202216D1 (de) 2005-01-13
IS7068A (is) 2003-12-08
CA2691149C (en) 2011-09-13
US7112686B2 (en) 2006-09-26
KR100939945B1 (ko) 2010-02-04
JP5064436B2 (ja) 2012-10-31
SI1412341T1 (en) 2005-04-30
CZ305034B6 (cs) 2015-04-08
PL366560A1 (en) 2005-02-07
DK1412341T3 (da) 2005-04-04
KR20090031958A (ko) 2009-03-30
WO2003000672A1 (en) 2003-01-03
CA2691149A1 (en) 2003-01-03
CN100429208C (zh) 2008-10-29
ATE284395T1 (de) 2004-12-15
EP1412341A1 (en) 2004-04-28
HK1132729A1 (en) 2010-03-05
MA26260A1 (fr) 2004-09-01
UY27356A1 (es) 2003-01-31
KR20100052550A (ko) 2010-05-19
CO5550420A2 (es) 2005-08-31
MEP1508A (xx) 2010-02-10
CA2450890C (en) 2011-02-15
AU2002344948B2 (en) 2007-08-16
NO335106B1 (no) 2014-09-15
DE60202216T2 (de) 2005-12-08

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