SK287696B6 - Spôsob prípravy voľnej bázy racemického citalopramu a voľnej bázy S- alebo R-citalopramu - Google Patents
Spôsob prípravy voľnej bázy racemického citalopramu a voľnej bázy S- alebo R-citalopramu Download PDFInfo
- Publication number
- SK287696B6 SK287696B6 SK51-2004A SK512004A SK287696B6 SK 287696 B6 SK287696 B6 SK 287696B6 SK 512004 A SK512004 A SK 512004A SK 287696 B6 SK287696 B6 SK 287696B6
- Authority
- SK
- Slovakia
- Prior art keywords
- citalopram
- mixture
- mother liquor
- enantiomer
- addition salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100991 | 2001-06-25 | ||
| PCT/DK2002/000426 WO2003000672A1 (en) | 2001-06-25 | 2002-06-25 | Process for the preparation of racemic citalopram and/or s- or r-citalopram by separation of a mixture of r- and s-citalopram |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK512004A3 SK512004A3 (en) | 2004-05-04 |
| SK287696B6 true SK287696B6 (sk) | 2011-06-06 |
Family
ID=8160584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK51-2004A SK287696B6 (sk) | 2001-06-25 | 2002-06-25 | Spôsob prípravy voľnej bázy racemického citalopramu a voľnej bázy S- alebo R-citalopramu |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US7112686B2 (zh) |
| EP (1) | EP1412341B1 (zh) |
| JP (2) | JP4377219B2 (zh) |
| KR (4) | KR20100052550A (zh) |
| CN (2) | CN100429208C (zh) |
| AR (2) | AR034612A1 (zh) |
| AT (1) | ATE284395T1 (zh) |
| BG (1) | BG66372B1 (zh) |
| BR (1) | BRPI0210574B8 (zh) |
| CA (2) | CA2450890C (zh) |
| CO (1) | CO5550420A2 (zh) |
| CZ (1) | CZ305034B6 (zh) |
| DE (1) | DE60202216T2 (zh) |
| DK (1) | DK1412341T3 (zh) |
| EA (1) | EA006446B1 (zh) |
| ES (1) | ES2233834T3 (zh) |
| HK (2) | HK1068627A1 (zh) |
| HR (1) | HRP20031075B1 (zh) |
| HU (1) | HU228476B1 (zh) |
| IL (1) | IL159229A0 (zh) |
| IS (1) | IS2426B (zh) |
| JO (1) | JO2389B1 (zh) |
| MA (1) | MA26260A1 (zh) |
| ME (2) | MEP1508A (zh) |
| MX (1) | MXPA03011770A (zh) |
| MY (1) | MY133471A (zh) |
| NO (2) | NO329873B1 (zh) |
| NZ (1) | NZ530104A (zh) |
| PE (1) | PE20030122A1 (zh) |
| PL (1) | PL366560A1 (zh) |
| PT (1) | PT1412341E (zh) |
| RS (1) | RS50673B (zh) |
| SI (1) | SI1412341T1 (zh) |
| SK (1) | SK287696B6 (zh) |
| TN (1) | TNSN02062A1 (zh) |
| TW (1) | TWI236473B (zh) |
| UA (1) | UA75147C2 (zh) |
| UY (2) | UY27356A1 (zh) |
| WO (1) | WO2003000672A1 (zh) |
| ZA (1) | ZA200309633B (zh) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI306846B (en) | 2002-08-12 | 2009-03-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| EP2363389A1 (en) | 2002-12-23 | 2011-09-07 | H. Lundbeck A/S | A process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram |
| ES2385975T3 (es) * | 2002-12-23 | 2012-08-06 | H. Lundbeck A/S | Procedimiento para la preparación de citalopram diol racémico y/o S- O R-citalopram dioles y el uso de tales dioles para la preparación de citalopram racémico, R-citalopram y/o S-citalopram |
| PT1578738E (pt) | 2002-12-23 | 2008-04-11 | Lundbeck & Co As H | Bromidrato de escitalopram e um método para a sua preparação |
| US20050154052A1 (en) * | 2003-03-24 | 2005-07-14 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| CN100569765C (zh) | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
| TWI339651B (en) * | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| US20050196453A1 (en) | 2004-03-05 | 2005-09-08 | H. Lundbeck A/S | Crystalline composition containing escitalopram |
| WO2005084643A1 (en) * | 2004-03-05 | 2005-09-15 | H. Lundbeck A/S | Crystalline composition containing escitalopram oxalate |
| ITMI20040717A1 (it) | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
| JP2006008603A (ja) * | 2004-06-25 | 2006-01-12 | Sumitomo Chemical Co Ltd | 光学活性シタロプラムの製造方法、その中間体およびその製造方法 |
| US7989645B2 (en) * | 2004-08-23 | 2011-08-02 | Sun Pharma Global Fze | Process for preparation of citalopram and enantiomers |
| WO2006021971A2 (en) * | 2004-08-23 | 2006-03-02 | Sun Pharmaceutical Industries Limited | 'process for preparation of citalopram and enantiomers' |
| WO2006123243A2 (en) * | 2005-05-20 | 2006-11-23 | Aurobindo Pharma Limited | Pharmaceutical dosage forms comprising escitalopram in form of granules |
| TWI358407B (en) * | 2005-06-22 | 2012-02-21 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersibl |
| US7834201B2 (en) | 2005-06-22 | 2010-11-16 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| BRPI0617382A2 (pt) | 2005-10-14 | 2017-07-11 | H Lundbeck As | Métodos para tratar um distúrbio do sistema nervoso central em um paciente, para tratar um paciente sofrendo de condições e uma disfunção sexual, e para reduzir um retardo na eficácia terapêutica em seguida ao início do tratamento |
| WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
| NZ570884A (en) | 2007-09-11 | 2010-03-26 | Lundbeck & Co As H | Fractionally crystallising 4-[4-(dimethyl amino)-1-(4'-fluorophenyl)-1-hydroxybutyI]-3-(hydroxymethyl)-benzonitrile and manufacturing escitalopram therefrom |
| US8022232B2 (en) * | 2007-09-11 | 2011-09-20 | H. Lundbeck A/S | Method for manufacture of escitalopram |
| CN100548974C (zh) * | 2007-10-11 | 2009-10-14 | 浙江大学 | 西酞普兰中间体的萃取分离方法 |
| CN101560199B (zh) * | 2008-04-16 | 2013-09-18 | 北京德众万全药物技术开发有限公司 | 一种依地普仑的制备方法 |
| TWI381813B (zh) | 2010-01-12 | 2013-01-11 | Taiwan Paiho Ltd | A Velcro assembly for a foamed article and a foamed article comprising the adhesive tape assembly |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| DE69920526T2 (de) * | 1999-10-25 | 2006-02-23 | H. Lundbeck A/S | Verfahren zur herstellung von citalopram |
-
2002
- 2002-06-21 AR ARP020102350A patent/AR034612A1/es active IP Right Grant
- 2002-06-23 JO JO200265A patent/JO2389B1/en active
- 2002-06-24 TN TNTNSN02062A patent/TNSN02062A1/en unknown
- 2002-06-24 PE PE2002000551A patent/PE20030122A1/es active IP Right Grant
- 2002-06-25 PT PT02742848T patent/PT1412341E/pt unknown
- 2002-06-25 BR BRPI0210574A patent/BRPI0210574B8/pt not_active IP Right Cessation
- 2002-06-25 CA CA2450890A patent/CA2450890C/en not_active Expired - Fee Related
- 2002-06-25 MA MA26713A patent/MA26260A1/fr unknown
- 2002-06-25 HU HU0400293A patent/HU228476B1/hu unknown
- 2002-06-25 UY UY27356A patent/UY27356A1/es not_active IP Right Cessation
- 2002-06-25 TW TW091113845A patent/TWI236473B/zh not_active IP Right Cessation
- 2002-06-25 ME MEP-15/08A patent/MEP1508A/xx unknown
- 2002-06-25 EA EA200400082A patent/EA006446B1/ru not_active IP Right Cessation
- 2002-06-25 CZ CZ2004-131A patent/CZ305034B6/cs not_active IP Right Cessation
- 2002-06-25 MX MXPA03011770A patent/MXPA03011770A/es active IP Right Grant
- 2002-06-25 DK DK02742848T patent/DK1412341T3/da active
- 2002-06-25 CA CA2691149A patent/CA2691149C/en not_active Expired - Fee Related
- 2002-06-25 MY MYPI20022382A patent/MY133471A/en unknown
- 2002-06-25 SK SK51-2004A patent/SK287696B6/sk unknown
- 2002-06-25 NZ NZ530104A patent/NZ530104A/en not_active IP Right Cessation
- 2002-06-25 KR KR1020107006751A patent/KR20100052550A/ko not_active Application Discontinuation
- 2002-06-25 WO PCT/DK2002/000426 patent/WO2003000672A1/en active Application Filing
- 2002-06-25 PL PL02366560A patent/PL366560A1/xx not_active Application Discontinuation
- 2002-06-25 US US10/482,000 patent/US7112686B2/en not_active Expired - Lifetime
- 2002-06-25 IL IL15922902A patent/IL159229A0/xx active IP Right Grant
- 2002-06-25 UA UA20031211986A patent/UA75147C2/uk unknown
- 2002-06-25 RS YUP-1014/03A patent/RS50673B/sr unknown
- 2002-06-25 KR KR1020037016853A patent/KR100902530B1/ko active IP Right Grant
- 2002-06-25 CN CNB028126688A patent/CN100429208C/zh not_active Expired - Lifetime
- 2002-06-25 EP EP02742848A patent/EP1412341B1/en not_active Expired - Lifetime
- 2002-06-25 KR KR1020097004586A patent/KR100939945B1/ko active IP Right Grant
- 2002-06-25 ES ES02742848T patent/ES2233834T3/es not_active Expired - Lifetime
- 2002-06-25 ME MEP-2008-15A patent/ME00027B/me unknown
- 2002-06-25 AT AT02742848T patent/ATE284395T1/de active
- 2002-06-25 KR KR1020087026708A patent/KR20080100498A/ko active Application Filing
- 2002-06-25 SI SI200230078T patent/SI1412341T1/xx unknown
- 2002-06-25 CN CN2008102158851A patent/CN101440079B/zh not_active Expired - Lifetime
- 2002-06-25 DE DE60202216T patent/DE60202216T2/de not_active Expired - Lifetime
- 2002-06-25 JP JP2003507077A patent/JP4377219B2/ja not_active Expired - Lifetime
-
2003
- 2003-12-08 IS IS7068A patent/IS2426B/is unknown
- 2003-12-11 ZA ZA2003/09633A patent/ZA200309633B/en unknown
- 2003-12-18 NO NO20035671A patent/NO329873B1/no not_active IP Right Cessation
- 2003-12-23 HR HR20031075A patent/HRP20031075B1/xx not_active IP Right Cessation
-
2004
- 2004-01-14 BG BG108532A patent/BG66372B1/bg unknown
- 2004-01-22 CO CO04004620A patent/CO5550420A2/es not_active Application Discontinuation
-
2005
- 2005-02-07 HK HK05101034.1A patent/HK1068627A1/xx not_active IP Right Cessation
-
2009
- 2009-04-17 JP JP2009101188A patent/JP5064436B2/ja not_active Expired - Lifetime
- 2009-11-12 HK HK09110569.1A patent/HK1132729A1/xx not_active IP Right Cessation
-
2010
- 2010-10-13 NO NO20101420A patent/NO335106B1/no not_active IP Right Cessation
-
2011
- 2011-10-19 AR ARP110103869A patent/AR083483A2/es active IP Right Grant
-
2014
- 2014-11-21 UY UY0001035850A patent/UY35850A/es not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5064436B2 (ja) | Ｒ−及びｓ−シタロプラムの混合物を分離することによってラセミシタロプラム及びｓ−もしくはｒ−シタロプラムを製造する方法 | |
| JP4505335B2 (ja) | ラセミ体シタロプラムジオール（ｒａｃｅｍｉｃｃｉｔａｌｏｐｒａｍｄｉｏｌ）および／またはＳ−もしくはＲ−シタロプラムジオールの製造方法、およびラセミ体シタロプラム、Ｒ−シタロプラムおよび／またはＳ−シタロプラムを製造するために、上記ジオールを使用する方法。 | |
| AU2002344948B8 (en) | Process for the preparation of racemic citalopram and/or S- or R-citalopram by separation of a mixture of R- and S-citalopram | |
| KR101076640B1 (ko) | 라세미 시탈로프람 디올 및/또는 ｓ― 또는 ｒ―시탈로프람디올의 제조 방법 및 라세미 시탈로프람, ｒ―시탈로프람및/또는 ｓ―시탈로프람의 제조를 위한 상기 디올의 용도 | |
| AU2002344948A1 (en) | Process for the preparation of racemic citalopram and/or S- or R-citalopram by separation of a mixture of R- and S-citalopram |