SK287424B6 - Lítiové komplexy N-(1-hydroxymetyl-2,3-dihydroxypropyl)-1,4,7- triskarboxymetyl-1,4,7,10-tetraazacyklodekánu, ich výroba a použitie - Google Patents
Lítiové komplexy N-(1-hydroxymetyl-2,3-dihydroxypropyl)-1,4,7- triskarboxymetyl-1,4,7,10-tetraazacyklodekánu, ich výroba a použitie Download PDFInfo
- Publication number
- SK287424B6 SK287424B6 SK729-2003A SK7292003A SK287424B6 SK 287424 B6 SK287424 B6 SK 287424B6 SK 7292003 A SK7292003 A SK 7292003A SK 287424 B6 SK287424 B6 SK 287424B6
- Authority
- SK
- Slovakia
- Prior art keywords
- lithium
- tetraazacyclododecane
- hydroxymethyl
- water
- dihydroxypropyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 7
- JZNZSKXIEDHOBD-UHFFFAOYSA-N 2-[4,10-bis(carboxymethyl)-7-(1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OCC(O)C(CO)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 JZNZSKXIEDHOBD-UHFFFAOYSA-N 0.000 title abstract description 4
- 150000002641 lithium Chemical class 0.000 title abstract description 4
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 claims description 12
- ZPDFIIGFYAHNSK-CTHHTMFSSA-K 2-[4,10-bis(carboxylatomethyl)-7-[(2r,3s)-1,3,4-trihydroxybutan-2-yl]-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+) Chemical compound [Gd+3].OC[C@@H](O)[C@@H](CO)N1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 ZPDFIIGFYAHNSK-CTHHTMFSSA-K 0.000 claims description 8
- 229960003411 gadobutrol Drugs 0.000 claims description 8
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Chemical compound [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 claims description 5
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 229910001416 lithium ion Inorganic materials 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 claims description 3
- 229940106681 chloroacetic acid Drugs 0.000 claims description 3
- WBJINCZRORDGAQ-UHFFFAOYSA-N ethyl formate Chemical compound CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 claims description 3
- FRELRIWZBXADCT-UHFFFAOYSA-N 2,2-dimethyl-6-(1,4,7,10-tetrazacyclododec-1-yl)-1,3-dioxepan-5-ol Chemical compound C1OC(C)(C)OCC(O)C1N1CCNCCNCCNCC1 FRELRIWZBXADCT-UHFFFAOYSA-N 0.000 claims description 2
- 239000002798 polar solvent Substances 0.000 claims description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical group [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- 150000001805 chlorine compounds Chemical group 0.000 claims 1
- 229910052688 Gadolinium Inorganic materials 0.000 abstract description 10
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 10
- 239000000203 mixture Substances 0.000 description 8
- -1 1-hydroxymethyl-2,3-dihydroxypropyl Chemical group 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 239000008139 complexing agent Substances 0.000 description 6
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 229910052744 lithium Inorganic materials 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 3
- PQVSTLUFSYVLTO-UHFFFAOYSA-N ethyl n-ethoxycarbonylcarbamate Chemical compound CCOC(=O)NC(=O)OCC PQVSTLUFSYVLTO-UHFFFAOYSA-N 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- GLXDVVHUTZTUQK-UHFFFAOYSA-M lithium hydroxide monohydrate Substances [Li+].O.[OH-] GLXDVVHUTZTUQK-UHFFFAOYSA-M 0.000 description 3
- 229940040692 lithium hydroxide monohydrate Drugs 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000000921 elemental analysis Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- PHKYYUQQYARDIU-UHFFFAOYSA-N 3-methyl-9h-carbazole Chemical compound C1=CC=C2C3=CC(C)=CC=C3NC2=C1 PHKYYUQQYARDIU-UHFFFAOYSA-N 0.000 description 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N DMSO Substances CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010612 desalination reaction Methods 0.000 description 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229940075613 gadolinium oxide Drugs 0.000 description 1
- 229910001938 gadolinium oxide Inorganic materials 0.000 description 1
- CMIHHWBVHJVIGI-UHFFFAOYSA-N gadolinium(iii) oxide Chemical compound [O-2].[O-2].[O-2].[Gd+3].[Gd+3] CMIHHWBVHJVIGI-UHFFFAOYSA-N 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/02—Lithium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10064467A DE10064467C2 (de) | 2000-12-15 | 2000-12-15 | Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung |
| PCT/EP2001/014283 WO2002048119A2 (de) | 2000-12-15 | 2001-12-05 | Lithium-komplexe von n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren herstellung und verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK7292003A3 SK7292003A3 (en) | 2003-11-04 |
| SK287424B6 true SK287424B6 (sk) | 2010-09-07 |
Family
ID=7668584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK729-2003A SK287424B6 (sk) | 2000-12-15 | 2001-12-05 | Lítiové komplexy N-(1-hydroxymetyl-2,3-dihydroxypropyl)-1,4,7- triskarboxymetyl-1,4,7,10-tetraazacyklodekánu, ich výroba a použitie |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6894151B2 (zh) |
| EP (1) | EP1343770B1 (zh) |
| JP (1) | JP4399163B2 (zh) |
| KR (1) | KR100869627B1 (zh) |
| CN (1) | CN1229357C (zh) |
| AR (1) | AR035609A1 (zh) |
| AT (1) | ATE430737T1 (zh) |
| AU (2) | AU3165902A (zh) |
| BG (1) | BG66117B1 (zh) |
| BR (1) | BR0116219A (zh) |
| CA (1) | CA2431976C (zh) |
| CY (1) | CY1109280T1 (zh) |
| CZ (1) | CZ304573B6 (zh) |
| DE (2) | DE10064467C2 (zh) |
| DK (1) | DK1343770T3 (zh) |
| EC (1) | ECSP034676A (zh) |
| EE (1) | EE05245B1 (zh) |
| ES (1) | ES2325982T3 (zh) |
| HK (1) | HK1064098A1 (zh) |
| HR (1) | HRP20030576B1 (zh) |
| HU (1) | HU229657B1 (zh) |
| IL (1) | IL156432A0 (zh) |
| ME (1) | ME00157B (zh) |
| MX (1) | MXPA03005240A (zh) |
| NO (1) | NO324864B1 (zh) |
| NZ (1) | NZ526478A (zh) |
| PL (1) | PL204181B1 (zh) |
| PT (1) | PT1343770E (zh) |
| RS (1) | RS51862B (zh) |
| RU (1) | RU2003120513A (zh) |
| SK (1) | SK287424B6 (zh) |
| TW (1) | TWI302531B (zh) |
| UY (1) | UY27056A1 (zh) |
| WO (1) | WO2002048119A2 (zh) |
| ZA (1) | ZA200305421B (zh) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007521254A (ja) * | 2003-06-25 | 2007-08-02 | ゲルベ | 診断画像用化合物 |
| FR2867473B1 (fr) | 2004-03-12 | 2006-06-23 | Guerbet Sa | Compose de porphyrines et utilisation a haut champ en irm |
| ATE430146T1 (de) * | 2004-07-02 | 2009-05-15 | Bracco Imaging Spa | Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten |
| EP1999118B1 (en) | 2006-03-14 | 2012-10-17 | Mallinckrodt LLC | Metal complexes of tetraazamacrocycle derivatives |
| US7777029B2 (en) * | 2006-05-02 | 2010-08-17 | San Diego State University (Sdsu) Foundation | Bifunctional chelators for sequestering lanthanides |
| DE102009053252B3 (de) * | 2009-11-09 | 2011-09-01 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels keramischer Membran |
| WO2011054480A1 (de) * | 2009-11-09 | 2011-05-12 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels keramischer membran |
| DE102009057274B4 (de) | 2009-12-02 | 2011-09-01 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels Trioxobicyclo-octan |
| DE102010013833A1 (de) | 2010-03-29 | 2011-09-29 | Bayer Schering Pharma Aktiengesellschaft | Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal |
| DE102010023105A1 (de) | 2010-06-04 | 2011-12-08 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol |
| KR20190079682A (ko) | 2011-04-21 | 2019-07-05 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 고순도 가도부트롤의 제조 |
| CN106543094A (zh) * | 2016-11-04 | 2017-03-29 | 嘉实（湖南）医药科技有限公司 | 高纯度钆布醇的制备方法 |
| KR101971435B1 (ko) * | 2017-08-29 | 2019-04-24 | 주식회사 엔지켐생명과학 | 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법 |
| KR102033964B1 (ko) * | 2018-01-19 | 2019-10-18 | 주식회사 엔지켐생명과학 | 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법 |
| CN111039885B (zh) * | 2019-12-06 | 2021-03-05 | 广州康瑞泰药业有限公司 | 一种制备高纯度考布曲钙的方法 |
| KR20210112910A (ko) * | 2020-03-06 | 2021-09-15 | 주식회사 엔지켐생명과학 | 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4009119A1 (de) * | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE19724186C2 (de) * | 1997-06-02 | 2002-07-18 | Schering Ag | Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe |
-
2000
- 2000-12-15 DE DE10064467A patent/DE10064467C2/de not_active Expired - Lifetime
-
2001
- 2001-11-07 TW TW090127671A patent/TWI302531B/zh not_active IP Right Cessation
- 2001-12-05 SK SK729-2003A patent/SK287424B6/sk not_active IP Right Cessation
- 2001-12-05 CZ CZ2003-1641A patent/CZ304573B6/cs not_active IP Right Cessation
- 2001-12-05 PL PL366141A patent/PL204181B1/pl unknown
- 2001-12-05 DK DK01991788T patent/DK1343770T3/da active
- 2001-12-05 ME MEP-2008-157A patent/ME00157B/me unknown
- 2001-12-05 IL IL15643201A patent/IL156432A0/xx active IP Right Grant
- 2001-12-05 MX MXPA03005240A patent/MXPA03005240A/es active IP Right Grant
- 2001-12-05 CA CA2431976A patent/CA2431976C/en not_active Expired - Lifetime
- 2001-12-05 JP JP2002549650A patent/JP4399163B2/ja not_active Expired - Lifetime
- 2001-12-05 EE EEP200300282A patent/EE05245B1/xx unknown
- 2001-12-05 AU AU3165902A patent/AU3165902A/xx active Pending
- 2001-12-05 PT PT01991788T patent/PT1343770E/pt unknown
- 2001-12-05 RS YU48103A patent/RS51862B/sr unknown
- 2001-12-05 AT AT01991788T patent/ATE430737T1/de active
- 2001-12-05 RU RU2003120513/04A patent/RU2003120513A/ru not_active Application Discontinuation
- 2001-12-05 AU AU2002231659A patent/AU2002231659B2/en not_active Expired
- 2001-12-05 EP EP01991788A patent/EP1343770B1/de not_active Expired - Lifetime
- 2001-12-05 WO PCT/EP2001/014283 patent/WO2002048119A2/de active IP Right Grant
- 2001-12-05 DE DE50114889T patent/DE50114889D1/de not_active Expired - Lifetime
- 2001-12-05 CN CNB018206808A patent/CN1229357C/zh not_active Expired - Lifetime
- 2001-12-05 BR BRPI0116219-5A patent/BR0116219A/pt not_active IP Right Cessation
- 2001-12-05 ES ES01991788T patent/ES2325982T3/es not_active Expired - Lifetime
- 2001-12-05 NZ NZ526478A patent/NZ526478A/en not_active IP Right Cessation
- 2001-12-05 KR KR1020037008035A patent/KR100869627B1/ko active IP Right Grant
- 2001-12-05 UY UY27056A patent/UY27056A1/es not_active Application Discontinuation
- 2001-12-05 HU HU0302563A patent/HU229657B1/hu unknown
- 2001-12-13 US US10/013,840 patent/US6894151B2/en not_active Expired - Lifetime
- 2001-12-14 AR ARP010105797A patent/AR035609A1/es unknown
-
2003
- 2003-06-04 NO NO20032523A patent/NO324864B1/no not_active IP Right Cessation
- 2003-06-12 BG BG107901A patent/BG66117B1/bg unknown
- 2003-06-26 EC EC2003004676A patent/ECSP034676A/es unknown
- 2003-07-14 ZA ZA200305421A patent/ZA200305421B/en unknown
- 2003-07-15 HR HR20030576A patent/HRP20030576B1/xx not_active IP Right Cessation
-
2004
- 2004-09-10 HK HK04106890A patent/HK1064098A1/xx not_active IP Right Cessation
-
2009
- 2009-08-06 CY CY20091100837T patent/CY1109280T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC4A | Assignment and transfer of rights |
Owner name: BAYER INTELLECTUAL PROPERTY GMBH, MONHEIM, DE Free format text: FORMER OWNER: BAYER PHARMA AKTIENGESELLSCHAFT, BERLIN, DE Effective date: 20121112 |
|
| TC4A | Change of owner's name |
Owner name: BAYER PHARMA AKTIENGESELLSCHAFT, BERLIN, DE Effective date: 20130123 |
|
| MK4A | Expiry of patent |
Expiry date: 20211205 |