EE200300282A - N-(1-hüdroksümetüül-2,3-dihüdroksüpropüül)-1,4,7-triskarboksümetüül-1,4,7,10-tetra asatsüklododekaani liitiumikompleksid, nende valmistamine ja kasutamine - Google Patents

N-(1-hüdroksümetüül-2,3-dihüdroksüpropüül)-1,4,7-triskarboksümetüül-1,4,7,10-tetra asatsüklododekaani liitiumikompleksid, nende valmistamine ja kasutamine

Info

Publication number
EE200300282A
EE200300282A EEP200300282A EEP200300282A EE200300282A EE 200300282 A EE200300282 A EE 200300282A EE P200300282 A EEP200300282 A EE P200300282A EE P200300282 A EEP200300282 A EE P200300282A EE 200300282 A EE200300282 A EE 200300282A
Authority
EE
Estonia
Prior art keywords
tricarboxymethyl
tetraazacyclododecane
dihydroxypropyl
hydroxymethyl
preparation
Prior art date
Application number
EEP200300282A
Other languages
English (en)
Inventor
Platzek Johannes
Blaszkiewicz Peter
Petrov Orlin
Hoffmann Holger
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of EE200300282A publication Critical patent/EE200300282A/et
Publication of EE05245B1 publication Critical patent/EE05245B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EEP200300282A 2000-12-15 2001-12-05 N-(1-hdroksmetl-2,3-dihdrokspropl)-1,4,7-triskarboksmetl-1,4,7,10-tetraasatsklododekaani liitiumikompleksid, nende valmistamine ja kasutamine EE05245B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064467A DE10064467C2 (de) 2000-12-15 2000-12-15 Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
PCT/EP2001/014283 WO2002048119A2 (de) 2000-12-15 2001-12-05 Lithium-komplexe von n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren herstellung und verwendung

Publications (2)

Publication Number Publication Date
EE200300282A true EE200300282A (et) 2003-10-15
EE05245B1 EE05245B1 (et) 2009-12-15

Family

ID=7668584

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300282A EE05245B1 (et) 2000-12-15 2001-12-05 N-(1-hdroksmetl-2,3-dihdrokspropl)-1,4,7-triskarboksmetl-1,4,7,10-tetraasatsklododekaani liitiumikompleksid, nende valmistamine ja kasutamine

Country Status (35)

Country Link
US (1) US6894151B2 (et)
EP (1) EP1343770B1 (et)
JP (1) JP4399163B2 (et)
KR (1) KR100869627B1 (et)
CN (1) CN1229357C (et)
AR (1) AR035609A1 (et)
AT (1) ATE430737T1 (et)
AU (2) AU2002231659B2 (et)
BG (1) BG66117B1 (et)
BR (1) BR0116219A (et)
CA (1) CA2431976C (et)
CY (1) CY1109280T1 (et)
CZ (1) CZ304573B6 (et)
DE (2) DE10064467C2 (et)
DK (1) DK1343770T3 (et)
EC (1) ECSP034676A (et)
EE (1) EE05245B1 (et)
ES (1) ES2325982T3 (et)
HK (1) HK1064098A1 (et)
HR (1) HRP20030576B1 (et)
HU (1) HU229657B1 (et)
IL (1) IL156432A0 (et)
ME (1) ME00157B (et)
MX (1) MXPA03005240A (et)
NO (1) NO324864B1 (et)
NZ (1) NZ526478A (et)
PL (1) PL204181B1 (et)
PT (1) PT1343770E (et)
RS (1) RS51862B (et)
RU (1) RU2003120513A (et)
SK (1) SK287424B6 (et)
TW (1) TWI302531B (et)
UY (1) UY27056A1 (et)
WO (1) WO2002048119A2 (et)
ZA (1) ZA200305421B (et)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004112840A2 (en) * 2003-06-25 2004-12-29 Guerbet Peptide conjugate for magnetic resonance imaging
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
EP1765812B1 (en) * 2004-07-02 2009-04-29 Bracco Imaging S.p.A Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents
KR20080108989A (ko) * 2006-03-14 2008-12-16 말린크로트, 인코포레이티드 테트라아자거대고리 유도체의 금속 착체
US7777029B2 (en) * 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
RS60001B1 (sr) 2011-04-21 2020-04-30 Bayer Ip Gmbh Pripremanje gadobutrola visoke čistoće
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210112910A (ko) * 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de) 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

Also Published As

Publication number Publication date
RU2003120513A (ru) 2004-12-27
CZ304573B6 (cs) 2014-07-16
CA2431976A1 (en) 2002-06-20
HK1064098A1 (en) 2005-01-21
NZ526478A (en) 2006-04-28
ZA200305421B (en) 2004-08-27
BG66117B1 (bg) 2011-05-31
NO20032523L (no) 2003-06-04
EP1343770B1 (de) 2009-05-06
CZ20031641A3 (cs) 2003-09-17
HU229657B1 (en) 2014-03-28
AU3165902A (en) 2002-06-24
BG107901A (bg) 2004-06-30
NO20032523D0 (no) 2003-06-04
DE50114889D1 (de) 2009-06-18
YU48103A (sh) 2006-05-25
CA2431976C (en) 2010-04-13
CN1481371A (zh) 2004-03-10
TWI302531B (en) 2008-11-01
ECSP034676A (es) 2003-08-29
PL204181B1 (pl) 2009-12-31
KR100869627B1 (ko) 2008-11-21
WO2002048119A3 (de) 2002-11-07
DE10064467A1 (de) 2002-07-11
MXPA03005240A (es) 2003-09-25
JP4399163B2 (ja) 2010-01-13
KR20030077555A (ko) 2003-10-01
PL366141A1 (en) 2005-01-24
IL156432A0 (en) 2004-01-04
EE05245B1 (et) 2009-12-15
SK7292003A3 (en) 2003-11-04
DK1343770T3 (da) 2009-08-10
ES2325982T3 (es) 2009-09-28
UY27056A1 (es) 2002-07-31
US20020128472A1 (en) 2002-09-12
AU2002231659B2 (en) 2007-07-05
EP1343770A2 (de) 2003-09-17
WO2002048119A2 (de) 2002-06-20
MEP15708A (en) 2010-06-10
CN1229357C (zh) 2005-11-30
HRP20030576A2 (en) 2005-06-30
SK287424B6 (sk) 2010-09-07
HUP0302563A3 (en) 2011-04-28
RS51862B (sr) 2012-02-29
JP2004515545A (ja) 2004-05-27
US6894151B2 (en) 2005-05-17
ME00157B (me) 2010-10-10
NO324864B1 (no) 2007-12-17
PT1343770E (pt) 2009-07-20
CY1109280T1 (el) 2014-07-02
ATE430737T1 (de) 2009-05-15
AR035609A1 (es) 2004-06-16
HUP0302563A2 (hu) 2003-12-29
HRP20030576B1 (en) 2011-09-30
BR0116219A (pt) 2006-02-21
DE10064467C2 (de) 2002-10-31

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Effective date: 20101231

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