ME00157B - Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena - Google Patents

Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena

Info

Publication number
ME00157B
ME00157B MEP-2008-157A MEP15708A ME00157B ME 00157 B ME00157 B ME 00157B ME P15708 A MEP15708 A ME P15708A ME 00157 B ME00157 B ME 00157B
Authority
ME
Montenegro
Prior art keywords
triscarboxymethyl
tetraazacyclododecane
dihydroxypropyl
hydroxymethyl
production
Prior art date
Application number
MEP-2008-157A
Other languages
German (de)
English (en)
French (fr)
Inventor
Johannes Platzek
Peter Blaszkiewicz
Orlin Petrov
Holger Hoffmann
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of MEP15708A publication Critical patent/MEP15708A/xx
Publication of ME00157B publication Critical patent/ME00157B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pronalazak se odnosi na kristalne litijumove komplekse N-(l-Hidroksimetil-2,3-dihidroksipropil)-l,4,7-triskarboksimetil-l,4,7,10-tet-raazaciklododekana, njihovo dobijanje i dobijanje od soli oslobođenog gadolinijum kompleksa N-( 1 -Hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tet- raazaciklododekana iz ovoga, bez primene jonskih izmenjivača.
MEP-2008-157A 2000-12-15 2001-12-05 Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena ME00157B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064467A DE10064467C2 (de) 2000-12-15 2000-12-15 Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
PCT/EP2001/014283 WO2002048119A2 (de) 2000-12-15 2001-12-05 Lithium-komplexe von n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren herstellung und verwendung

Publications (2)

Publication Number Publication Date
MEP15708A MEP15708A (en) 2010-06-10
ME00157B true ME00157B (me) 2010-10-10

Family

ID=7668584

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-157A ME00157B (me) 2000-12-15 2001-12-05 Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena

Country Status (35)

Country Link
US (1) US6894151B2 (me)
EP (1) EP1343770B1 (me)
JP (1) JP4399163B2 (me)
KR (1) KR100869627B1 (me)
CN (1) CN1229357C (me)
AR (1) AR035609A1 (me)
AT (1) ATE430737T1 (me)
AU (2) AU3165902A (me)
BG (1) BG66117B1 (me)
BR (1) BR0116219A (me)
CA (1) CA2431976C (me)
CY (1) CY1109280T1 (me)
CZ (1) CZ304573B6 (me)
DE (2) DE10064467C2 (me)
DK (1) DK1343770T3 (me)
EC (1) ECSP034676A (me)
EE (1) EE05245B1 (me)
ES (1) ES2325982T3 (me)
HK (1) HK1064098A1 (me)
HR (1) HRP20030576B1 (me)
HU (1) HU229657B1 (me)
IL (1) IL156432A0 (me)
ME (1) ME00157B (me)
MX (1) MXPA03005240A (me)
NO (1) NO324864B1 (me)
NZ (1) NZ526478A (me)
PL (1) PL204181B1 (me)
PT (1) PT1343770E (me)
RS (1) RS51862B (me)
RU (1) RU2003120513A (me)
SK (1) SK287424B6 (me)
TW (1) TWI302531B (me)
UY (1) UY27056A1 (me)
WO (1) WO2002048119A2 (me)
ZA (1) ZA200305421B (me)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007521254A (ja) * 2003-06-25 2007-08-02 ゲルベ 診断画像用化合物
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
WO2006002875A1 (en) * 2004-07-02 2006-01-12 Bracco Imaging Spa Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents
JP5518465B2 (ja) 2006-03-14 2014-06-11 マリンクロッド エルエルシー テトラアザ大員環誘導体の金属錯体
US7777029B2 (en) * 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
KR102003570B1 (ko) * 2011-04-21 2019-07-24 바이엘 인텔렉쳐 프로퍼티 게엠베하 고순도 가도부트롤의 제조
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210112910A (ko) * 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

Also Published As

Publication number Publication date
TWI302531B (en) 2008-11-01
BG66117B1 (bg) 2011-05-31
IL156432A0 (en) 2004-01-04
ZA200305421B (en) 2004-08-27
ATE430737T1 (de) 2009-05-15
BG107901A (bg) 2004-06-30
KR20030077555A (ko) 2003-10-01
MEP15708A (en) 2010-06-10
NO20032523L (no) 2003-06-04
WO2002048119A2 (de) 2002-06-20
NO324864B1 (no) 2007-12-17
PL366141A1 (en) 2005-01-24
RS51862B (sr) 2012-02-29
NO20032523D0 (no) 2003-06-04
US20020128472A1 (en) 2002-09-12
US6894151B2 (en) 2005-05-17
HUP0302563A3 (en) 2011-04-28
RU2003120513A (ru) 2004-12-27
CA2431976C (en) 2010-04-13
CZ304573B6 (cs) 2014-07-16
HU229657B1 (en) 2014-03-28
HRP20030576A2 (en) 2005-06-30
DE10064467A1 (de) 2002-07-11
MXPA03005240A (es) 2003-09-25
PT1343770E (pt) 2009-07-20
EE05245B1 (et) 2009-12-15
JP2004515545A (ja) 2004-05-27
EP1343770A2 (de) 2003-09-17
AU2002231659B2 (en) 2007-07-05
DK1343770T3 (da) 2009-08-10
KR100869627B1 (ko) 2008-11-21
BR0116219A (pt) 2006-02-21
JP4399163B2 (ja) 2010-01-13
EP1343770B1 (de) 2009-05-06
UY27056A1 (es) 2002-07-31
AU3165902A (en) 2002-06-24
NZ526478A (en) 2006-04-28
ECSP034676A (es) 2003-08-29
HK1064098A1 (en) 2005-01-21
CN1229357C (zh) 2005-11-30
WO2002048119A3 (de) 2002-11-07
CZ20031641A3 (cs) 2003-09-17
HUP0302563A2 (hu) 2003-12-29
DE50114889D1 (de) 2009-06-18
DE10064467C2 (de) 2002-10-31
CY1109280T1 (el) 2014-07-02
AR035609A1 (es) 2004-06-16
PL204181B1 (pl) 2009-12-31
SK287424B6 (sk) 2010-09-07
YU48103A (sh) 2006-05-25
CN1481371A (zh) 2004-03-10
CA2431976A1 (en) 2002-06-20
EE200300282A (et) 2003-10-15
HRP20030576B1 (en) 2011-09-30
ES2325982T3 (es) 2009-09-28
SK7292003A3 (en) 2003-11-04

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