TR200302297T4 - (SS, RS)-S-adenozil-L-metiyoninin farmasötik olarak kabul edilebilir tuzlarının hazırlanması için bir işlem - Google Patents

(SS, RS)-S-adenozil-L-metiyoninin farmasötik olarak kabul edilebilir tuzlarının hazırlanması için bir işlem

Info

Publication number
TR200302297T4
TR200302297T4 TR2003/02297T TR200302297T TR200302297T4 TR 200302297 T4 TR200302297 T4 TR 200302297T4 TR 2003/02297 T TR2003/02297 T TR 2003/02297T TR 200302297 T TR200302297 T TR 200302297T TR 200302297 T4 TR200302297 T4 TR 200302297T4
Authority
TR
Turkey
Prior art keywords
adenosyl
methionine
preparation
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
TR2003/02297T
Other languages
English (en)
Inventor
Berna Marco
Sivieri Lino
Santambrogio Gianni
Valoti Ermanno
Original Assignee
Chementecno S. R. L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chementecno S. R. L filed Critical Chementecno S. R. L
Publication of TR200302297T4 publication Critical patent/TR200302297T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Bu bulus, (SS, RS)-S-adenozil-L-metiyoninin farmasötik olarak kabul edilebilir tuzlarinin hazirlanmasi için bir isleme iliskindir ve tuz haline çevrilmis (RS)-(+)-S-adenozil-L-metiyonin diyastereoizomerinin, tuz haline çevrilmis (SS)-(+)-S-adenozil-L- metiyonin diyastereoizomerine göre %3' ten düsük veya buna esit miktarlarda elde edilmesine imkan verir; bulusun islemiyle elde edilebilen tuzlar, zaman içerisinde sekillerini dengeli olarak muhafaza ederler.
TR2003/02297T 2000-05-25 2001-03-30 (SS, RS)-S-adenozil-L-metiyoninin farmasötik olarak kabul edilebilir tuzlarının hazırlanması için bir işlem TR200302297T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI001158A IT1318535B1 (it) 2000-05-25 2000-05-25 Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.

Publications (1)

Publication Number Publication Date
TR200302297T4 true TR200302297T4 (tr) 2004-02-23

Family

ID=11445118

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2003/02297T TR200302297T4 (tr) 2000-05-25 2001-03-30 (SS, RS)-S-adenozil-L-metiyoninin farmasötik olarak kabul edilebilir tuzlarının hazırlanması için bir işlem

Country Status (14)

Country Link
US (2) US20020010147A1 (tr)
EP (1) EP1283845B1 (tr)
JP (1) JP4777588B2 (tr)
KR (1) KR100737193B1 (tr)
AT (1) ATE256695T1 (tr)
AU (2) AU6584801A (tr)
CA (1) CA2407559C (tr)
DE (1) DE60101575T2 (tr)
DK (1) DK1283845T3 (tr)
ES (1) ES2208610T3 (tr)
IT (1) IT1318535B1 (tr)
PT (1) PT1283845E (tr)
TR (1) TR200302297T4 (tr)
WO (1) WO2001090130A1 (tr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033815B2 (en) 2001-03-30 2006-04-25 Board Of Regents, The University Of Texas System Biosynthesis of S-adenosylmethionine in a recombinant yeast strain
CN100398659C (zh) * 2002-09-16 2008-07-02 上海青瑞生物医药技术有限公司 旋光纯(s,s)-腺甘甲硫氨酸制备的方法
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ES2406412T3 (es) * 2005-06-09 2013-06-06 Gnosis S.P.A. Células de Saccharomyces cerevisiae secas, liofilizadas y/o microencapsuladas con un alto contenido de (S)-(+)-S-adenosil-metionina
ITRM20050344A1 (it) * 2005-06-30 2007-01-01 Luca Maria De Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi.
CN1955306B (zh) * 2005-10-28 2011-03-16 上海医药工业研究院 酵母菌生物合成、生产旋光纯腺苷甲硫氨酸的方法及其培养液
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
ES2371781T3 (es) * 2006-05-10 2012-01-10 Mitsubishi Gas Chemical Company, Inc. Método para producir una levadura seca que contiene s-adenosil-l-metionina y composición para ingestión oral.
US20070265211A1 (en) * 2006-05-12 2007-11-15 Matthias Rath Novel composition and method effective in inhibiting the atherogenic process
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
ES2824807T3 (es) 2013-01-16 2021-05-13 Hebert Sam E Llc Sales de indol-3-propionato estables de S-adenosil-L-metionina
ITMI20130426A1 (it) * 2013-03-20 2014-09-21 Gnosis Spa S-adenosilmetionina sterile ad alto contenuto di isomero attivo per soluzioni iniettabili e procedimento per ottenerla
CN106349311B (zh) * 2016-08-23 2018-04-13 北京金阳利康医药有限公司 从酵母发酵液中提取s‑腺苷蛋氨酸的方法
IT201700074957A1 (it) * 2017-07-04 2019-01-04 Gnosis Spa Sale di (ss)-adenosil metionina con inositolo esafosfato e procedimento per ottenerlo
CN110396120B (zh) * 2019-02-13 2020-05-12 山东惠仕莱生物科技有限公司 一种从s-腺苷蛋氨酸发酵液中提取分离s-腺苷蛋氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
JPS56145299A (en) * 1980-04-11 1981-11-11 Kanegafuchi Chem Ind Co Ltd Purification of s-adenosyl-l-methionine
JPS5929700A (ja) * 1982-08-13 1984-02-16 Nippon Zeon Co Ltd Ｓ−アデノシル−ｌ−メチオニンの精製法
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale

Also Published As

Publication number Publication date
DE60101575D1 (de) 2004-01-29
ES2208610T3 (es) 2004-06-16
ITMI20001158A1 (it) 2001-11-25
US20020010147A1 (en) 2002-01-24
CA2407559C (en) 2009-12-22
US6958233B2 (en) 2005-10-25
CA2407559A1 (en) 2001-11-29
EP1283845A1 (en) 2003-02-19
DK1283845T3 (da) 2004-04-13
ATE256695T1 (de) 2004-01-15
EP1283845B1 (en) 2003-12-17
IT1318535B1 (it) 2003-08-27
DE60101575T2 (de) 2004-06-03
WO2001090130A1 (en) 2001-11-29
KR100737193B1 (ko) 2007-07-10
JP4777588B2 (ja) 2011-09-21
ITMI20001158A0 (it) 2000-05-25
US20020173012A1 (en) 2002-11-21
KR20030036183A (ko) 2003-05-09
AU2001265848B8 (en) 2006-05-04
AU2001265848B2 (en) 2006-03-23
JP2003534349A (ja) 2003-11-18
PT1283845E (pt) 2004-04-30
AU6584801A (en) 2001-12-03

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