JPS56145299A - Purification of s-adenosyl-l-methionine - Google Patents
Purification of s-adenosyl-l-methionineInfo
- Publication number
- JPS56145299A JPS56145299A JP4895880A JP4895880A JPS56145299A JP S56145299 A JPS56145299 A JP S56145299A JP 4895880 A JP4895880 A JP 4895880A JP 4895880 A JP4895880 A JP 4895880A JP S56145299 A JPS56145299 A JP S56145299A
- Authority
- JP
- Japan
- Prior art keywords
- sam
- adenosyl
- methionine
- adsorb
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE: A solution containing S-adenosyl-L-methionine is treated with an H+ type weak acid cationic exchange resin, then with active carbon, to produce the titled compound of high purity used as a chemotherapeutic preparation for diseases caused by metabolism disorder with industrial advantage.
CONSTITUTION: A bread yeast is cultured in a medium to accumulate S-adenosyl-L- methionine (SAM) in the cell bodies and subjected to shaking extraction, then centrifuged to give a solution containing SAM. The solution is passed through a column filled with an H+ type weak acid cationic exchange resin to make SAM adsorb on it. The SAM is eluted with an acidic aqueous solution and the elute is passed through a column filled with active carbon for chromatography to make the SAM adsorb on it. The SAM is fractionated by eluting with a mixture of an acidic aqueous medium and an organic solvent to give the objective purified SAM.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4895880A JPS56145299A (en) | 1980-04-11 | 1980-04-11 | Purification of s-adenosyl-l-methionine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4895880A JPS56145299A (en) | 1980-04-11 | 1980-04-11 | Purification of s-adenosyl-l-methionine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56145299A true JPS56145299A (en) | 1981-11-11 |
Family
ID=12817779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4895880A Pending JPS56145299A (en) | 1980-04-11 | 1980-04-11 | Purification of s-adenosyl-l-methionine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56145299A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5929700A (en) * | 1982-08-13 | 1984-02-16 | Nippon Zeon Co Ltd | Purification of s-adenosyl-l-methionine |
| US4558122A (en) * | 1981-09-11 | 1985-12-10 | Bioresearch S.P.A. | Stable s-adenosylmethionine derivatives, the process for their preparation, and therapeutic compositions which contain them as active principle |
| JP4777588B2 (en) * | 2000-05-25 | 2011-09-21 | ケメンテクノ・エツセ・エルレ・エルレ | Method for preparing a pharmaceutically acceptable salt of (SS, RS) -S-adenosyl-L-methionine |
-
1980
- 1980-04-11 JP JP4895880A patent/JPS56145299A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4558122A (en) * | 1981-09-11 | 1985-12-10 | Bioresearch S.P.A. | Stable s-adenosylmethionine derivatives, the process for their preparation, and therapeutic compositions which contain them as active principle |
| JPS5929700A (en) * | 1982-08-13 | 1984-02-16 | Nippon Zeon Co Ltd | Purification of s-adenosyl-l-methionine |
| JPS635039B2 (en) * | 1982-08-13 | 1988-02-01 | Nippon Zeon Co | |
| JP4777588B2 (en) * | 2000-05-25 | 2011-09-21 | ケメンテクノ・エツセ・エルレ・エルレ | Method for preparing a pharmaceutically acceptable salt of (SS, RS) -S-adenosyl-L-methionine |
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