ECSP034676A - Complejos de litio de n-(hidroximetil-2,3-dihidroxipropil)-1,4,7-triscarboximetil-1,4,7,10-tetraazaciclododecano, su preparacion y uso - Google Patents

Complejos de litio de n-(hidroximetil-2,3-dihidroxipropil)-1,4,7-triscarboximetil-1,4,7,10-tetraazaciclododecano, su preparacion y uso

Info

Publication number
ECSP034676A
ECSP034676A EC2003004676A ECSP034676A ECSP034676A EC SP034676 A ECSP034676 A EC SP034676A EC 2003004676 A EC2003004676 A EC 2003004676A EC SP034676 A ECSP034676 A EC SP034676A EC SP034676 A ECSP034676 A EC SP034676A
Authority
EC
Ecuador
Prior art keywords
preparation
triscarboximethyl
tetraazaciclododecano
dihydroxipropil
hydroximethyl
Prior art date
Application number
EC2003004676A
Other languages
English (en)
Inventor
Johannes Platzek
Orlin Petrov
Peter Blaszkiewicz
Holger Hoffmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of ECSP034676A publication Critical patent/ECSP034676A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La invención se refiere a complejos de litio cristalinos de N-(1-hidroximetil-2,3-dihidroxipropil)-1, 4, 7- tri-scarboximetil-1, 4, 7, 10-tetraazaciclododecano, a su preparación y a la obtención del complejo de gadolinio de N-(I-hidroximetil-2, 3-diidroxipropil)-1, 4, 7-triscarboximetil-1, 4, 7, 10-tetraazaciclo dodecano libre de sales a partir de los mismos, sin utilizar intercambiadores de iones.
EC2003004676A 2000-12-15 2003-06-26 Complejos de litio de n-(hidroximetil-2,3-dihidroxipropil)-1,4,7-triscarboximetil-1,4,7,10-tetraazaciclododecano, su preparacion y uso ECSP034676A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10064467A DE10064467C2 (de) 2000-12-15 2000-12-15 Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung

Publications (1)

Publication Number Publication Date
ECSP034676A true ECSP034676A (es) 2003-08-29

Family

ID=7668584

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004676A ECSP034676A (es) 2000-12-15 2003-06-26 Complejos de litio de n-(hidroximetil-2,3-dihidroxipropil)-1,4,7-triscarboximetil-1,4,7,10-tetraazaciclododecano, su preparacion y uso

Country Status (35)

Country Link
US (1) US6894151B2 (es)
EP (1) EP1343770B1 (es)
JP (1) JP4399163B2 (es)
KR (1) KR100869627B1 (es)
CN (1) CN1229357C (es)
AR (1) AR035609A1 (es)
AT (1) ATE430737T1 (es)
AU (2) AU3165902A (es)
BG (1) BG66117B1 (es)
BR (1) BR0116219A (es)
CA (1) CA2431976C (es)
CY (1) CY1109280T1 (es)
CZ (1) CZ304573B6 (es)
DE (2) DE10064467C2 (es)
DK (1) DK1343770T3 (es)
EC (1) ECSP034676A (es)
EE (1) EE05245B1 (es)
ES (1) ES2325982T3 (es)
HK (1) HK1064098A1 (es)
HR (1) HRP20030576B1 (es)
HU (1) HU229657B1 (es)
IL (1) IL156432A0 (es)
ME (1) ME00157B (es)
MX (1) MXPA03005240A (es)
NO (1) NO324864B1 (es)
NZ (1) NZ526478A (es)
PL (1) PL204181B1 (es)
PT (1) PT1343770E (es)
RS (1) RS51862B (es)
RU (1) RU2003120513A (es)
SK (1) SK287424B6 (es)
TW (1) TWI302531B (es)
UY (1) UY27056A1 (es)
WO (1) WO2002048119A2 (es)
ZA (1) ZA200305421B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060239913A1 (en) * 2003-06-25 2006-10-26 Marc Port Peptide conjugate for magnetic resonance imaging
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
CN1993357B (zh) * 2004-07-02 2011-10-19 伯拉考成像股份公司 用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂
JP5518465B2 (ja) * 2006-03-14 2014-06-11 マリンクロッド エルエルシー テトラアザ大員環誘導体の金属錯体
US7777029B2 (en) * 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
WO2011054480A1 (de) * 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) * 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
RS60001B1 (sr) 2011-04-21 2020-04-30 Bayer Ip Gmbh Pripremanje gadobutrola visoke čistoće
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210112910A (ko) * 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

Also Published As

Publication number Publication date
CA2431976C (en) 2010-04-13
HK1064098A1 (en) 2005-01-21
HUP0302563A3 (en) 2011-04-28
CN1481371A (zh) 2004-03-10
CZ304573B6 (cs) 2014-07-16
PT1343770E (pt) 2009-07-20
CA2431976A1 (en) 2002-06-20
HU229657B1 (en) 2014-03-28
WO2002048119A3 (de) 2002-11-07
US20020128472A1 (en) 2002-09-12
DE10064467A1 (de) 2002-07-11
JP4399163B2 (ja) 2010-01-13
SK287424B6 (sk) 2010-09-07
DE10064467C2 (de) 2002-10-31
DK1343770T3 (da) 2009-08-10
EP1343770A2 (de) 2003-09-17
PL366141A1 (en) 2005-01-24
BG66117B1 (bg) 2011-05-31
HUP0302563A2 (hu) 2003-12-29
AR035609A1 (es) 2004-06-16
NZ526478A (en) 2006-04-28
EE05245B1 (et) 2009-12-15
MEP15708A (en) 2010-06-10
CZ20031641A3 (cs) 2003-09-17
IL156432A0 (en) 2004-01-04
JP2004515545A (ja) 2004-05-27
CY1109280T1 (el) 2014-07-02
ATE430737T1 (de) 2009-05-15
AU2002231659B2 (en) 2007-07-05
EE200300282A (et) 2003-10-15
EP1343770B1 (de) 2009-05-06
YU48103A (sh) 2006-05-25
TWI302531B (en) 2008-11-01
ES2325982T3 (es) 2009-09-28
ZA200305421B (en) 2004-08-27
DE50114889D1 (de) 2009-06-18
RS51862B (sr) 2012-02-29
PL204181B1 (pl) 2009-12-31
NO324864B1 (no) 2007-12-17
ME00157B (me) 2010-10-10
BG107901A (bg) 2004-06-30
HRP20030576B1 (en) 2011-09-30
WO2002048119A2 (de) 2002-06-20
KR20030077555A (ko) 2003-10-01
UY27056A1 (es) 2002-07-31
CN1229357C (zh) 2005-11-30
RU2003120513A (ru) 2004-12-27
BR0116219A (pt) 2006-02-21
HRP20030576A2 (en) 2005-06-30
KR100869627B1 (ko) 2008-11-21
NO20032523L (no) 2003-06-04
US6894151B2 (en) 2005-05-17
NO20032523D0 (no) 2003-06-04
MXPA03005240A (es) 2003-09-25
SK7292003A3 (en) 2003-11-04
AU3165902A (en) 2002-06-24

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