YU48103A - Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil) 1,4,7-triskarboksimetil 1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena - Google Patents

Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil) 1,4,7-triskarboksimetil 1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena

Info

Publication number
YU48103A
YU48103A YU48103A YUP48103A YU48103A YU 48103 A YU48103 A YU 48103A YU 48103 A YU48103 A YU 48103A YU P48103 A YUP48103 A YU P48103A YU 48103 A YU48103 A YU 48103A
Authority
YU
Yugoslavia
Prior art keywords
triscarboxymethyl
tetraazacyclododecane
hydroxymethyl
production
dihidroxypropyl
Prior art date
Application number
YU48103A
Other languages
English (en)
Inventor
Johannes Platzek
Peter Blaszkiewicz
Orlin Petrov
Holger Hoffmann
Original Assignee
Schering Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag. filed Critical Schering Ag.
Publication of YU48103A publication Critical patent/YU48103A/sh
Publication of RS51862B publication Critical patent/RS51862B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic System
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Pronalazak se odnosi na kristalne litijumove komplekse N-(1-Hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana, njihovo dobijanje i dobijanje od soli oslobodjenog gadolinijum kompleksa N-(1-Hidroksimetil-2,3-dihidroksipropil)-1,4,7-triskarboksimetil-1,4,7,10-tetraazaciklododekana iz ovoga, bez primene jonskih izmenjivača.[The invention relates to crystalline lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane of formula (I), wherein: all of the three X's represent n lithium ions and m hydrogen atoms, whereby n and m each represent numbers from 0 to 3, preferably from 0.8 to 2.2, and the sum of n and m equals 3, and; Y represents chloride and bromide. The invention relates to the preparation of the inventive complexes and to production of the salt-free gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane from the same without involving the use of ion exchangers.
YU48103A 2000-12-15 2001-12-05 Litijumovi kompleksi n-(1-hidroksimetil2,3-dihidroksipropil) -1,4,7-triskarboksimetil 1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena RS51862B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10064467A DE10064467C2 (de) 2000-12-15 2000-12-15 Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung

Publications (2)

Publication Number Publication Date
YU48103A true YU48103A (sh) 2006-05-25
RS51862B RS51862B (sr) 2012-02-29

Family

ID=7668584

Country Status (35)

Country Link
US (1) US6894151B2 (sh)
EP (1) EP1343770B1 (sh)
JP (1) JP4399163B2 (sh)
KR (1) KR100869627B1 (sh)
CN (1) CN1229357C (sh)
AR (1) AR035609A1 (sh)
AT (1) ATE430737T1 (sh)
AU (2) AU3165902A (sh)
BG (1) BG66117B1 (sh)
BR (1) BR0116219A (sh)
CA (1) CA2431976C (sh)
CY (1) CY1109280T1 (sh)
CZ (1) CZ304573B6 (sh)
DE (2) DE10064467C2 (sh)
DK (1) DK1343770T3 (sh)
EC (1) ECSP034676A (sh)
EE (1) EE05245B1 (sh)
ES (1) ES2325982T3 (sh)
HK (1) HK1064098A1 (sh)
HR (1) HRP20030576B1 (sh)
HU (1) HU229657B1 (sh)
IL (1) IL156432A0 (sh)
ME (1) ME00157B (sh)
MX (1) MXPA03005240A (sh)
NO (1) NO324864B1 (sh)
NZ (1) NZ526478A (sh)
PL (1) PL204181B1 (sh)
PT (1) PT1343770E (sh)
RS (1) RS51862B (sh)
RU (1) RU2003120513A (sh)
SK (1) SK287424B6 (sh)
TW (1) TWI302531B (sh)
UY (1) UY27056A1 (sh)
WO (1) WO2002048119A2 (sh)
ZA (1) ZA200305421B (sh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060239913A1 (en) * 2003-06-25 2006-10-26 Marc Port Peptide conjugate for magnetic resonance imaging
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
CN1993357B (zh) * 2004-07-02 2011-10-19 伯拉考成像股份公司 用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂
JP5518465B2 (ja) * 2006-03-14 2014-06-11 マリンクロッド エルエルシー テトラアザ大員環誘導体の金属錯体
US7777029B2 (en) * 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
WO2011054480A1 (de) * 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) * 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
RS60001B1 (sr) 2011-04-21 2020-04-30 Bayer Ip Gmbh Pripremanje gadobutrola visoke čistoće
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210112910A (ko) * 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

Also Published As

Publication number Publication date
CA2431976C (en) 2010-04-13
HK1064098A1 (en) 2005-01-21
HUP0302563A3 (en) 2011-04-28
CN1481371A (zh) 2004-03-10
CZ304573B6 (cs) 2014-07-16
PT1343770E (pt) 2009-07-20
CA2431976A1 (en) 2002-06-20
HU229657B1 (en) 2014-03-28
WO2002048119A3 (de) 2002-11-07
US20020128472A1 (en) 2002-09-12
DE10064467A1 (de) 2002-07-11
JP4399163B2 (ja) 2010-01-13
SK287424B6 (sk) 2010-09-07
DE10064467C2 (de) 2002-10-31
DK1343770T3 (da) 2009-08-10
EP1343770A2 (de) 2003-09-17
PL366141A1 (en) 2005-01-24
BG66117B1 (bg) 2011-05-31
HUP0302563A2 (hu) 2003-12-29
AR035609A1 (es) 2004-06-16
NZ526478A (en) 2006-04-28
EE05245B1 (et) 2009-12-15
MEP15708A (en) 2010-06-10
ECSP034676A (es) 2003-08-29
CZ20031641A3 (cs) 2003-09-17
IL156432A0 (en) 2004-01-04
JP2004515545A (ja) 2004-05-27
CY1109280T1 (el) 2014-07-02
ATE430737T1 (de) 2009-05-15
AU2002231659B2 (en) 2007-07-05
EE200300282A (et) 2003-10-15
EP1343770B1 (de) 2009-05-06
TWI302531B (en) 2008-11-01
ES2325982T3 (es) 2009-09-28
ZA200305421B (en) 2004-08-27
DE50114889D1 (de) 2009-06-18
RS51862B (sr) 2012-02-29
PL204181B1 (pl) 2009-12-31
NO324864B1 (no) 2007-12-17
ME00157B (me) 2010-10-10
BG107901A (bg) 2004-06-30
HRP20030576B1 (en) 2011-09-30
WO2002048119A2 (de) 2002-06-20
KR20030077555A (ko) 2003-10-01
UY27056A1 (es) 2002-07-31
CN1229357C (zh) 2005-11-30
RU2003120513A (ru) 2004-12-27
BR0116219A (pt) 2006-02-21
HRP20030576A2 (en) 2005-06-30
KR100869627B1 (ko) 2008-11-21
NO20032523L (no) 2003-06-04
US6894151B2 (en) 2005-05-17
NO20032523D0 (no) 2003-06-04
MXPA03005240A (es) 2003-09-25
SK7292003A3 (en) 2003-11-04
AU3165902A (en) 2002-06-24

Similar Documents

Publication Publication Date Title
YU48103A (sh) Litijumovi kompleksi n-(1-hidroksimetil-2,3-dihidroksipropil) 1,4,7-triskarboksimetil 1,4,7,10-tetraazaciklododekana, njihovo dobijanje i primena
AP1614A (en) New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-bacterial agents.
MY136446A (en) New salts of valsartan
JO2311B1 (en) Alkyl inhibitors Ariel phosphodiesterase-4
MXPA02011370A (es) Iminoazinas substituidas.
EP1719713A3 (en) Kit of water-soluble or water dispersible pouches
PL338339A1 (en) Novel derivatives of tetrazole
BG103947A (en) Derivatives of 9-oxymerythromycin
HUP0103896A2 (hu) Oxigéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
ATE303384T1 (de) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
DE60107272D1 (de) Eisenverbindungen
MXPA03010766A (es) Nuevos compuestos y composiciones como inhibicores de las catepsinas.
NZ515025A (en) Solvates of pymetrozine
MX9702203A (es) Derivados de pirazolil-pirazol substituidos, procedimientos para su preparacion y su uso como agentes con accion herbicida.
TR200402070T4 (tr) Siklobüten-dion türevleri ve bunların damar sertliği tedavisinde kullanımı
MXPA02004441A (es) Derivados de isoxazol como inhibidores de la fosfodiesterasa.
CA2124306A1 (en) Quinazolinone derivatives
HUP0303151A2 (hu) Biotin aminoszármazékai és ezek makrociklusos kelátképző szerekkel képzett konjugátumai
MXPA03010259A (es) Nuevos derivados de 5-tio-ss-d-xilopiranosida, procedimiento de preparacion, composiciones farmaceuticas que los contienen y el uso terapeutico de los mismos.
DE60227113D1 (de) Kondensierte camptothecine als antitumormittel
JO2187B1 (en) Production and use of complex lithium compounds for N- (1- hydroxy methyl -2-3-dihydroxypropyl) -1,4,7- tri-carboxy methyl -1,4,7,10- tetra-azaclododecane
CA2425164A1 (en) (4-acylaminopiperidin-1-yl)acetamides as neurokinin antagonists