SK286080B6 - Heterocyklické aromatické zlúčeniny obsahujúce fosfonátovú skupinu, ich použitie a farmaceutická kompozícia obsahujúca uvedené zlúčeniny - Google Patents

Heterocyklické aromatické zlúčeniny obsahujúce fosfonátovú skupinu, ich použitie a farmaceutická kompozícia obsahujúca uvedené zlúčeniny Download PDF

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Publication number
SK286080B6
SK286080B6 SK316-2001A SK3162001A SK286080B6 SK 286080 B6 SK286080 B6 SK 286080B6 SK 3162001 A SK3162001 A SK 3162001A SK 286080 B6 SK286080 B6 SK 286080B6
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Slovakia
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group
alkyl
hydrogen
aryl
carbon atoms
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SK316-2001A
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English (en)
Slovak (sk)
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SK3162001A3 (en
Inventor
Qun Dang
Srinivas Rao Kasibhatla
K. Raja Reddy
Mark D. Erion
M. Rami Reddy
Atul Agarwal
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Metabasis Therapeutics, Inc.
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Publication of SK3162001A3 publication Critical patent/SK3162001A3/sk
Publication of SK286080B6 publication Critical patent/SK286080B6/sk

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
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    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
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    • C07F9/6578—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and sulfur atoms with or without oxygen atoms, as ring hetero atoms
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    • C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
    • C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system

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SK316-2001A 1998-09-09 1999-09-03 Heterocyklické aromatické zlúčeniny obsahujúce fosfonátovú skupinu, ich použitie a farmaceutická kompozícia obsahujúca uvedené zlúčeniny SK286080B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13550498P 1998-09-09 1998-09-09
US11107798P 1998-12-07 1998-12-07
PCT/US1999/020346 WO2000014095A1 (en) 1998-09-09 1999-09-03 Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase

Publications (2)

Publication Number Publication Date
SK3162001A3 SK3162001A3 (en) 2002-02-05
SK286080B6 true SK286080B6 (sk) 2008-03-05

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US (4) US6489476B1 (hu)
EP (1) EP1112275B9 (hu)
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Publication number Priority date Publication date Assignee Title
US6284748B1 (en) 1997-03-07 2001-09-04 Metabasis Therapeutics, Inc. Purine inhibitors of fructose 1,6-bisphosphatase
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US7312219B2 (en) 2007-12-25
US20070232571A1 (en) 2007-10-04
DE69910045T2 (de) 2004-04-22
NO20011174D0 (no) 2001-03-07
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PT1112275E (pt) 2003-12-31
CN1215076C (zh) 2005-08-17
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ATE246197T1 (de) 2003-08-15
AU761267B2 (en) 2003-05-29
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HUP0103143A2 (hu) 2002-04-29
EP1112275A1 (en) 2001-07-04
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WO2000014095A1 (en) 2000-03-16
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US20040058892A1 (en) 2004-03-25
AU761267C (en) 2007-08-09
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