SK285601B6 - Použitie jedného alebo viacerých dialkylfumarátovna výrobu farmaceutického prípravku a farmaceutický prípravok - Google Patents

Použitie jedného alebo viacerých dialkylfumarátovna výrobu farmaceutického prípravku a farmaceutický prípravok Download PDF

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Publication number
SK285601B6
SK285601B6 SK576-2001A SK5762001A SK285601B6 SK 285601 B6 SK285601 B6 SK 285601B6 SK 5762001 A SK5762001 A SK 5762001A SK 285601 B6 SK285601 B6 SK 285601B6
Authority
SK
Slovakia
Prior art keywords
use according
preparation
pellets
dialkyl fumarates
treatment
Prior art date
Application number
SK576-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK5762001A3 (en
Inventor
Rajendra K. Joshi
Hans-Peter Strebel
Original Assignee
Fumapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7888396&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK285601(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fumapharm Ag filed Critical Fumapharm Ag
Publication of SK5762001A3 publication Critical patent/SK5762001A3/sk
Publication of SK285601B6 publication Critical patent/SK285601B6/sk

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891Coated capsules; Multilayered drug free capsule shells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225Polycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
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    • A61K9/2846Poly(meth)acrylates
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    • A61K9/2833Organic macromolecular compounds
    • A61K9/2853Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
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    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
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    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
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    • A61P37/00Drugs for immunological or allergic disorders
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • AHUMAN NECESSITIES
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    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/2095Tabletting processes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
SK576-2001A 1998-11-19 1999-10-29 Použitie jedného alebo viacerých dialkylfumarátovna výrobu farmaceutického prípravku a farmaceutický prípravok SK285601B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853487A DE19853487A1 (de) 1998-11-19 1998-11-19 Verwendung von Dialkylfumaraten
PCT/EP1999/008215 WO2000030622A2 (de) 1998-11-19 1999-10-29 Verwendung von dialkylfumaraten zur behandlung von host-versus-graft reaktionen und von autoimmunerkrankungen

Publications (2)

Publication Number Publication Date
SK5762001A3 SK5762001A3 (en) 2002-03-05
SK285601B6 true SK285601B6 (sk) 2007-04-05

Family

ID=7888396

Family Applications (1)

Application Number Title Priority Date Filing Date
SK576-2001A SK285601B6 (sk) 1998-11-19 1999-10-29 Použitie jedného alebo viacerých dialkylfumarátovna výrobu farmaceutického prípravku a farmaceutický prípravok

Country Status (34)

Country Link
US (9) US6509376B1 (https=)
EP (1) EP1131065B1 (https=)
JP (7) JP2002530324A (https=)
CN (2) CN1182844C (https=)
AT (1) ATE242633T1 (https=)
BE (1) BE2014C040I2 (https=)
BG (1) BG64837B1 (https=)
BR (1) BR9914606A (https=)
CA (1) CA2346438C (https=)
CY (1) CY2014027I1 (https=)
CZ (1) CZ299409B6 (https=)
DE (2) DE19853487A1 (https=)
DK (1) DK1131065T3 (https=)
EE (1) EE04389B1 (https=)
ES (1) ES2195664T3 (https=)
FR (1) FR14C0051I2 (https=)
HK (1) HK1042242B (https=)
HU (2) HU226689B1 (https=)
IL (2) IL142728A0 (https=)
LT (1) LTC1131065I2 (https=)
LU (1) LU92488I2 (https=)
ME (1) ME00731B (https=)
MX (1) MXPA01005007A (https=)
NO (3) NO333257B1 (https=)
NZ (1) NZ510247A (https=)
PL (2) PL205948B1 (https=)
PT (1) PT1131065E (https=)
RS (1) RS49995B (https=)
RU (1) RU2215524C2 (https=)
SI (1) SI1131065T1 (https=)
SK (1) SK285601B6 (https=)
TR (1) TR200101204T2 (https=)
WO (1) WO2000030622A2 (https=)
ZA (1) ZA200202335B (https=)

Families Citing this family (115)

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DE19853487A1 (de) * 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
DE10000577A1 (de) 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
US6912052B2 (en) * 2000-11-17 2005-06-28 Cymer, Inc. Gas discharge MOPA laser spectral analysis module
US7157423B2 (en) * 2001-01-12 2007-01-02 Fumapharm Ag Fumaric acid amides
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
US20050259709A1 (en) * 2002-05-07 2005-11-24 Cymer, Inc. Systems and methods for implementing an interaction between a laser shaped as a line beam and a film deposited on a substrate
DE10217314A1 (de) 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
AU2003236156A1 (en) * 2003-04-24 2005-01-04 Shin-Jen Shiao Pharmaceutical compositions used for immune disease treatment and improvement
US7277188B2 (en) * 2003-04-29 2007-10-02 Cymer, Inc. Systems and methods for implementing an interaction between a laser shaped as a line beam and a film deposited on a substrate
DE10360869A1 (de) * 2003-09-09 2005-04-07 Fumapharm Ag Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma
CA2526586C (en) * 2003-09-09 2010-03-16 Biogen International Gmbh The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
DE10342423A1 (de) * 2003-09-13 2005-04-14 Heidland, August, Prof. Dr.med. Dr.h.c. Verwendung von Fumarsäurederivaten zur Prophylaxe und zur Behandlung von Genomschäden
US6894785B2 (en) * 2003-09-30 2005-05-17 Cymer, Inc. Gas discharge MOPA laser spectral analysis module
US6873418B1 (en) 2003-09-30 2005-03-29 Cymer, Inc. Optical mountings for gas discharge MOPA laser spectral analysis module
CA2478458A1 (en) * 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
PL2316430T3 (pl) * 2004-10-08 2012-11-30 Forward Pharma As Kompozycje farmaceutyczne o kontrolowanym uwalnianiu, zawierające ester kwasu fumarowego
US20080004344A1 (en) * 2004-11-10 2008-01-03 Aditech Pharma Ab Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use
US7653095B2 (en) * 2005-06-30 2010-01-26 Cymer, Inc. Active bandwidth control for a laser
EP1915334A2 (en) * 2005-07-07 2008-04-30 Aditech Pharma AB Novel salts of fumaric acid monoalkylesters and their pharmaceutical use
WO2007006308A1 (en) * 2005-07-07 2007-01-18 Aditech Pharma Ab Novel glucopyranose esters and glucofuranose esters of alkyl- fu marates and their pharmaceutical use
EP1940382A2 (en) * 2005-10-07 2008-07-09 Aditech Pharma AB Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
WO2007042034A1 (en) * 2005-10-07 2007-04-19 Aditech Pharma Ab Controlled release pharmaceutical compositions comprising a fumaric acid ester
US7317179B2 (en) * 2005-10-28 2008-01-08 Cymer, Inc. Systems and methods to shape laser light as a homogeneous line beam for interaction with a film deposited on a substrate
US7679029B2 (en) * 2005-10-28 2010-03-16 Cymer, Inc. Systems and methods to shape laser light as a line beam for interaction with a substrate having surface variations
ES2599227T3 (es) 2007-02-08 2017-01-31 Biogen Ma Inc. Neuroprotección en enfermedades desmielinizantes
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ZA200202335B (en) 2003-08-27
US20030018072A1 (en) 2003-01-23
MXPA01005007A (es) 2002-04-24
US6509376B1 (en) 2003-01-21
RS49995B (sr) 2008-09-29
PL205948B1 (pl) 2010-06-30
WO2000030622A3 (de) 2000-11-02
US20090181085A1 (en) 2009-07-16
NO2014016I2 (no) 2018-08-20
HUP0103182A3 (en) 2002-02-28
JP5828614B2 (ja) 2015-12-09
NZ510247A (en) 2003-10-31
EE04389B1 (et) 2004-12-15
NO333257B1 (no) 2013-04-22
AU752733B2 (en) 2002-09-26
BE2014C040I2 (https=) 2019-03-13
CY2014027I2 (el) 2015-12-09
CA2346438C (en) 2006-10-03
JP2019123738A (ja) 2019-07-25
JP2002530324A (ja) 2002-09-17
US7915310B2 (en) 2011-03-29
US7612110B2 (en) 2009-11-03
US7619001B2 (en) 2009-11-17
HK1042242A1 (en) 2002-08-09
JP2017226681A (ja) 2017-12-28
US20110293711A1 (en) 2011-12-01
TR200101204T2 (tr) 2001-09-21
CZ2001939A3 (cs) 2002-05-15
CN1325302A (zh) 2001-12-05
CA2346438A1 (en) 2000-06-02
JP2005097323A (ja) 2005-04-14
CZ299409B6 (cs) 2008-07-16
US8759393B2 (en) 2014-06-24
JP2009256384A (ja) 2009-11-05
NO2014016I1 (no) 2014-06-26
CN1615839A (zh) 2005-05-18
LU92488I2 (fr) 2015-11-02
HK1042242B (zh) 2005-08-19
US20140066505A1 (en) 2014-03-06
AU1157200A (en) 2000-06-13
US20090182047A1 (en) 2009-07-16
BR9914606A (pt) 2001-07-03
EE200100266A (et) 2002-12-16
DE19853487A1 (de) 2000-05-25
JP2016047830A (ja) 2016-04-07
US20130004526A1 (en) 2013-01-03
NO20011242D0 (no) 2001-03-12
HUP0103182A2 (hu) 2002-01-28
DE59905954D1 (de) 2003-07-17
PL226074B1 (pl) 2017-06-30
JP2012255020A (ja) 2012-12-27
IL142728A0 (en) 2002-03-10
EP1131065B1 (de) 2003-06-11
RU2215524C2 (ru) 2003-11-10
ATE242633T1 (de) 2003-06-15
US8524773B2 (en) 2013-09-03
US20070248663A1 (en) 2007-10-25
HU226689B1 (en) 2009-06-29
BG105396A (en) 2001-12-29
FR14C0051I2 (fr) 2019-01-18
BG64837B1 (bg) 2006-06-30
US20070248662A1 (en) 2007-10-25
ME00731B (me) 2008-09-29
CY2014027I1 (el) 2015-12-09
US7320999B2 (en) 2008-01-22
CN1182844C (zh) 2005-01-05
PL348147A1 (en) 2002-05-06
IL142728A (en) 2006-12-10
NO20011242L (no) 2001-05-18
NO20121479L (no) 2001-05-18
US7803840B2 (en) 2010-09-28
DK1131065T3 (da) 2003-08-25
PT1131065E (pt) 2003-10-31
EP1131065A2 (de) 2001-09-12
FR14C0051I1 (https=) 2014-08-08
ES2195664T3 (es) 2003-12-01
LTC1131065I2 (lt) 2019-05-27
SI1131065T1 (en) 2003-10-31
SK5762001A3 (en) 2002-03-05
WO2000030622A2 (de) 2000-06-02
HUS1400034I1 (hu) 2018-11-28

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