SK284046B6 - Deriváty 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazínu, spôsob ich prípravy, ich použitie a farmaceutické prostriedky s ich obsahom - Google Patents

Deriváty 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazínu, spôsob ich prípravy, ich použitie a farmaceutické prostriedky s ich obsahom Download PDF

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Publication number
SK284046B6
SK284046B6 SK86-2000A SK862000A SK284046B6 SK 284046 B6 SK284046 B6 SK 284046B6 SK 862000 A SK862000 A SK 862000A SK 284046 B6 SK284046 B6 SK 284046B6
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SK
Slovakia
Prior art keywords
triazolo
pyrido
pyridazine
formula
pharmaceutically acceptable
Prior art date
Application number
SK86-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK862000A3 (en
Inventor
Ferrer Jordi Gracia
Crespo Ma Isabel Crespo
Noverola Armando Vega
Garcia Andr�S Fernandez
Original Assignee
Almirall Prodesfarma, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma, S.A. filed Critical Almirall Prodesfarma, S.A.
Publication of SK862000A3 publication Critical patent/SK862000A3/sk
Publication of SK284046B6 publication Critical patent/SK284046B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK86-2000A 1997-07-29 1998-07-13 Deriváty 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazínu, spôsob ich prípravy, ich použitie a farmaceutické prostriedky s ich obsahom SK284046B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
PCT/EP1998/004340 WO1999006404A1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
SK862000A3 SK862000A3 (en) 2000-07-11
SK284046B6 true SK284046B6 (sk) 2004-08-03

Family

ID=8300216

Family Applications (1)

Application Number Title Priority Date Filing Date
SK86-2000A SK284046B6 (sk) 1997-07-29 1998-07-13 Deriváty 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazínu, spôsob ich prípravy, ich použitie a farmaceutické prostriedky s ich obsahom

Country Status (36)

Country Link
US (2) US6407108B1 (ru)
EP (1) EP1001955B1 (ru)
JP (1) JP4320118B2 (ru)
KR (1) KR20010022353A (ru)
CN (1) CN1135231C (ru)
AR (1) AR015927A1 (ru)
AT (1) ATE207069T1 (ru)
AU (1) AU737709B2 (ru)
BG (1) BG64448B1 (ru)
BR (1) BR9810829B1 (ru)
CA (1) CA2298935A1 (ru)
CO (1) CO4970780A1 (ru)
CZ (1) CZ290208B6 (ru)
DE (1) DE69802100T2 (ru)
DK (1) DK1001955T3 (ru)
EE (1) EE04313B1 (ru)
EG (1) EG24041A (ru)
ES (2) ES2137113B1 (ru)
HK (1) HK1024914A1 (ru)
HU (1) HUP0004708A3 (ru)
ID (1) ID24506A (ru)
IL (1) IL134081A (ru)
MY (1) MY118796A (ru)
NO (1) NO315118B1 (ru)
NZ (1) NZ502356A (ru)
PE (1) PE111099A1 (ru)
PL (1) PL191031B1 (ru)
PT (1) PT1001955E (ru)
RU (1) RU2202552C2 (ru)
SI (1) SI1001955T1 (ru)
SK (1) SK284046B6 (ru)
TR (1) TR200000243T2 (ru)
TW (1) TW542837B (ru)
UA (1) UA60339C2 (ru)
WO (1) WO1999006404A1 (ru)
ZA (1) ZA986248B (ru)

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FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
MXPA02001830A (es) 1999-08-21 2002-08-12 Byk Gulden Lomberg Chem Fab Combinacion sinergica de inhibidores de pde y agonista de beta 2 adrenoceptor.
WO2002080974A1 (fr) * 2001-04-04 2002-10-17 Sankyo Company, Limited Utilisation medicale d'inhibiteur de production de cytokine
ES2282469T3 (es) 2001-09-19 2007-10-16 Nycomed Gmbh Combinacion de un nsaid y un inhibidor de pde-4.
FR2832711B1 (fr) * 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
CN100572381C (zh) * 2002-11-06 2009-12-23 Aska制药株式会社 吡唑并二氮杂萘衍生物
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
RU2246496C1 (ru) * 2003-09-12 2005-02-20 Тец Виктор Вениаминович Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
KR100959771B1 (ko) * 2005-06-10 2010-05-28 머크 샤프 앤드 돔 코포레이션 Ａｋｔ 활성의 억제제
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP1925617B1 (en) * 2005-09-15 2012-11-14 ASKA Pharmaceutical Co., Ltd. Heterocyclic compound, and production process and use thereof
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2026813A2 (en) 2006-05-09 2009-02-25 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2057164A1 (en) 2006-08-07 2009-05-13 Incyte Corporation Triazolotriazines as kinase inhibitors
EP2068872A1 (en) 2006-09-08 2009-06-17 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
HUE026659T2 (en) 2006-11-22 2016-07-28 Incyte Holdings Corp Imidazotriazines and imidazopyrimidines as kinase inhibitors
WO2009089027A1 (en) * 2008-01-09 2009-07-16 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Service, National Institutes Of Health Phosphodiesterase inhibitors
EP2300455B1 (en) 2008-05-21 2017-07-19 Incyte Holdings Corporation Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
NZ601033A (en) 2009-12-31 2014-02-28 Ct Nac Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
CA2788398C (en) 2010-02-03 2018-02-27 Incyte Corporation Imidazo[1,2-b][1,2,4]triazines as c-met inhibitors
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
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Also Published As

Publication number Publication date
ID24506A (id) 2000-07-20
DE69802100D1 (de) 2001-11-22
RU2202552C2 (ru) 2003-04-20
TR200000243T2 (tr) 2000-07-21
PT1001955E (pt) 2002-02-28
MY118796A (en) 2005-01-31
PL191031B1 (pl) 2006-03-31
EE04313B1 (et) 2004-06-15
US6407108B1 (en) 2002-06-18
EP1001955B1 (en) 2001-10-17
ES2162466T3 (es) 2001-12-16
HK1024914A1 (en) 2000-10-27
NZ502356A (en) 2001-03-30
UA60339C2 (ru) 2003-10-15
ZA986248B (en) 1999-02-05
CA2298935A1 (en) 1999-02-11
JP2001512121A (ja) 2001-08-21
AU8861298A (en) 1999-02-22
SI1001955T1 (en) 2002-02-28
ES2137113B1 (es) 2000-09-16
EE200000052A (et) 2000-10-16
CZ2000333A3 (cs) 2000-05-17
PL338214A1 (en) 2000-10-09
ES2137113A1 (es) 1999-12-01
WO1999006404A1 (en) 1999-02-11
DE69802100T2 (de) 2002-03-14
NO315118B1 (no) 2003-07-14
BR9810829B1 (pt) 2009-08-11
BR9810829A (pt) 2000-07-25
DK1001955T3 (da) 2001-11-19
TW542837B (en) 2003-07-21
JP4320118B2 (ja) 2009-08-26
CN1266434A (zh) 2000-09-13
US20020183326A1 (en) 2002-12-05
CO4970780A1 (es) 2000-11-07
PE111099A1 (es) 1999-11-18
CZ290208B6 (cs) 2002-06-12
ATE207069T1 (de) 2001-11-15
HUP0004708A3 (en) 2002-11-28
KR20010022353A (ko) 2001-03-15
EP1001955A1 (en) 2000-05-24
NO20000394L (no) 2000-03-27
CN1135231C (zh) 2004-01-21
IL134081A0 (en) 2001-04-30
BG64448B1 (en) 2005-02-28
AR015927A1 (es) 2001-05-30
EG24041A (en) 2008-04-03
HUP0004708A2 (hu) 2001-07-30
NO20000394D0 (no) 2000-01-26
IL134081A (en) 2004-02-08
BG104112A (en) 2001-01-31
AU737709B2 (en) 2001-08-30
SK862000A3 (en) 2000-07-11

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Effective date: 20100713