SK11082003A3 - Kombinácia analógov epotilónu a chemoterapeutických činidiel na liečenie proliferatívnych ochorení - Google Patents
Kombinácia analógov epotilónu a chemoterapeutických činidiel na liečenie proliferatívnych ochorení Download PDFInfo
- Publication number
- SK11082003A3 SK11082003A3 SK1108-2003A SK11082003A SK11082003A3 SK 11082003 A3 SK11082003 A3 SK 11082003A3 SK 11082003 A SK11082003 A SK 11082003A SK 11082003 A3 SK11082003 A3 SK 11082003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- dihydroxy
- thiazolyl
- dione
- ethenyl
- Prior art date
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 18
- 201000010099 disease Diseases 0.000 title claims description 16
- 230000002062 proliferating effect Effects 0.000 title claims description 8
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 96
- 125000000217 alkyl group Chemical group 0.000 claims description 94
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 48
- 125000003118 aryl group Chemical group 0.000 claims description 45
- 239000011885 synergistic combination Substances 0.000 claims description 45
- LZWPOLSJFGLQCE-UHFFFAOYSA-N heptadecane-5,9-dione Chemical compound CCCCCCCCC(=O)CCCC(=O)CCCC LZWPOLSJFGLQCE-UHFFFAOYSA-N 0.000 claims description 43
- 125000003107 substituted aryl group Chemical group 0.000 claims description 35
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- 229910052736 halogen Inorganic materials 0.000 claims description 18
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Landscapes
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- Oncology (AREA)
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- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27580101P | 2001-03-14 | 2001-03-14 | |
| US31639501P | 2001-08-31 | 2001-08-31 | |
| PCT/US2002/006746 WO2002072085A1 (en) | 2001-03-14 | 2002-03-05 | Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK11082003A3 true SK11082003A3 (sk) | 2004-08-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1108-2003A SK11082003A3 (sk) | 2001-03-14 | 2002-03-05 | Kombinácia analógov epotilónu a chemoterapeutických činidiel na liečenie proliferatívnych ochorení |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US7312237B2 (cs) |
| EP (1) | EP1383490B1 (cs) |
| JP (1) | JP2004529904A (cs) |
| KR (1) | KR20040025904A (cs) |
| CN (1) | CN1496256A (cs) |
| AT (1) | ATE554756T1 (cs) |
| AU (1) | AU2002248542B9 (cs) |
| BG (1) | BG66289B1 (cs) |
| BR (1) | BRPI0207961B8 (cs) |
| CA (1) | CA2440555A1 (cs) |
| CZ (1) | CZ305799B6 (cs) |
| EE (1) | EE05417B1 (cs) |
| ES (1) | ES2384789T3 (cs) |
| HR (1) | HRP20030831B1 (cs) |
| HU (1) | HU230273B1 (cs) |
| IL (2) | IL157443A0 (cs) |
| IS (1) | IS2882B (cs) |
| MX (1) | MXPA03008135A (cs) |
| NO (1) | NO333972B1 (cs) |
| PL (1) | PL368973A1 (cs) |
| RU (1) | RU2321400C2 (cs) |
| SK (1) | SK11082003A3 (cs) |
| TW (1) | TWI330530B (cs) |
| WO (1) | WO2002072085A1 (cs) |
| ZA (1) | ZA200307123B (cs) |
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| US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO1999001124A1 (en) | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| NZ526871A (en) | 2001-01-25 | 2006-01-27 | Bristol Myers Squibb Co | Pharmaceutical dosage forms of epothilones for oral administration |
| IL156988A0 (en) | 2001-02-20 | 2004-02-08 | Bristol Myers Squibb Co | Pharmaceutical compositions containing epothilone derivatives |
| TWI315982B (en) | 2001-07-19 | 2009-10-21 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
| CZ2004287A3 (cs) * | 2001-08-31 | 2004-10-13 | Bristol@Myersásquibbácompany | Prostředky a způsoby pro léčení rakoviny |
| US20060089327A1 (en) * | 2002-01-14 | 2006-04-27 | Hohneker John A | Combinations comprising epothilones and anti-metabolites |
| TW200403994A (en) * | 2002-04-04 | 2004-03-16 | Bristol Myers Squibb Co | Oral administration of EPOTHILONES |
| TW200400191A (en) * | 2002-05-15 | 2004-01-01 | Bristol Myers Squibb Co | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives |
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