SI9300169B - 3,4-disubstituirani fenilcikloheks-1-ilkarboksilati, uporabni za zdravljenje bolezni, ki so v zvezis PDE IV - Google Patents

3,4-disubstituirani fenilcikloheks-1-ilkarboksilati, uporabni za zdravljenje bolezni, ki so v zvezis PDE IV Download PDF

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Publication number
SI9300169B
SI9300169B SI9300169A SI9300169A SI9300169B SI 9300169 B SI9300169 B SI 9300169B SI 9300169 A SI9300169 A SI 9300169A SI 9300169 A SI9300169 A SI 9300169A SI 9300169 B SI9300169 B SI 9300169B
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treatingpde
phenylcyclohex
disubstituted
related diseases
carboxylates useful
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SI9300169A
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SI9300169A (en
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Siegfried Benjamin Christensen
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Smithkline Beecham Corp
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Priority claimed from SG1996007903A external-priority patent/SG47107A1/en
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Publication of SI9300169A publication Critical patent/SI9300169A/sl
Publication of SI9300169B publication Critical patent/SI9300169B/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Tu so opisane nove spojine s formulo (I) Te spojine inhibirajo nastajanje faktorja tumorske nekrozein so uporabne pri zdravljenju bolezenskih stanj,ki jih posreduje ali poslabsuje nastajanje TNF. Spojine v smislu izuma so tudi uporabne pri posredovanju ali inhibiciji encimske ali katalitske aktivnosti fosfodiesteraze IV in so zato uporabne pri zdravljenju bolezenskih stanj, pri katerih je potrebno njeno posredovanje ali inhibiranje.

Claims (4)

1 Patentni zahtevki 1. Spojina s formulo (IA)
kjer je Ri ciklopentil; X je YR2, kjer je Y O in je R2 CH3; Χ4 je Z R3 kjer je R3 CN; Z je C(0)0Rh, kjer je R)4 H; in je X5H.
2. Spojina po zahtevku 1, označena s tem, daje cis[4-ciano-4-(3-ciklopentiloksi-4-metoksifenil)cikloheksan-1 -karboksilna kislina; trans-[4-ciano-4-(3-ciklopentiloksi-4-metoksifenil)cikloheksan-1 -karboksilna kislina; ali njena farmacevtsko sprejemljiva sol.
3. Farmacevtski pripravek, označen s tem, da obsega spojino po zahtevku 1 ali zahtevku 2 ali njeno farmacevtsko sprejemljivo sol in farmacevtsko sprejemljiv nosilec zanjo.
4. Uporaba spojine po zahtevku 1 ali zahtevku 2 ali njene farmacevtsko sprejemljive soli za pripravo zdravila za zdravljenje astme.
SI9300169A 1992-04-02 1993-04-02 3,4-disubstituirani fenilcikloheks-1-ilkarboksilati, uporabni za zdravljenje bolezni, ki so v zvezis PDE IV SI9300169B (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86203092A 1992-04-02 1992-04-02
US96876292A 1992-10-30 1992-10-30
SG1996007903A SG47107A1 (en) 1992-04-02 1993-03-05 Compounds useful for treating allergic and inflammatory diseases
PCT/US1993/001991 WO1993019749A1 (en) 1992-04-02 1993-03-05 Compounds useful for treating allergic and inflammatory diseases

Publications (2)

Publication Number Publication Date
SI9300169A SI9300169A (en) 1993-12-31
SI9300169B true SI9300169B (sl) 2008-04-30

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SI9300169A SI9300169B (sl) 1992-04-02 1993-04-02 3,4-disubstituirani fenilcikloheks-1-ilkarboksilati, uporabni za zdravljenje bolezni, ki so v zvezis PDE IV

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US (4) US5552438A (sl)
EP (1) EP0633776B1 (sl)
CN (1) CN1066436C (sl)
AP (2) AP516A (sl)
AU (1) AU677776B2 (sl)
BG (1) BG62235B1 (sl)
CA (1) CA2133439C (sl)
CZ (1) CZ283425B6 (sl)
FI (1) FI944549A (sl)
GR (1) GR3036347T3 (sl)
HU (1) HU225869B1 (sl)
IL (1) IL105221A (sl)
MX (1) MX9301943A (sl)
NO (1) NO303116B1 (sl)
NZ (1) NZ251092A (sl)
SI (1) SI9300169B (sl)
SK (1) SK279958B6 (sl)
WO (1) WO1993019749A1 (sl)

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EP0633776B1 (en) 2001-05-09
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GR3036347T3 (en) 2001-11-30
NO943663L (no) 1994-11-15
AP9300508A0 (en) 1993-04-30
IL105221A (en) 2000-01-31
HU9402817D0 (en) 1995-01-30
NZ251092A (en) 1996-12-20
CZ239794A3 (en) 1995-05-17
EP0633776A4 (sl) 1995-01-25
CN1066436C (zh) 2001-05-30
AU677776B2 (en) 1997-05-08
HUT70523A (en) 1995-10-30
US5552438A (en) 1996-09-03
FI944549A (fi) 1994-11-30
NO303116B1 (no) 1998-06-02
CZ283425B6 (cs) 1998-04-15
US5614540A (en) 1997-03-25
MX9301943A (es) 1994-08-31
BG62235B1 (bg) 1999-06-30
EP0633776A1 (en) 1995-01-18
WO1993019749A1 (en) 1993-10-14
CA2133439A1 (en) 1993-10-14
CN1092406A (zh) 1994-09-21
FI944549A0 (fi) 1994-09-30
SK117194A3 (en) 1995-06-07
BG99080A (bg) 1995-08-28
AU3791093A (en) 1993-11-08
US5643946A (en) 1997-07-01
AP516A (en) 1996-08-23
SI9300169A (en) 1993-12-31
IL105221A0 (en) 1994-08-26
AP9600794A0 (en) 1996-04-30
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CA2133439C (en) 2005-07-26
HU225869B1 (en) 2007-11-28

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