SI3144318T1 - Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo - Google Patents

Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo

Info

Publication number
SI3144318T1
SI3144318T1 SI200932094T SI200932094T SI3144318T1 SI 3144318 T1 SI3144318 T1 SI 3144318T1 SI 200932094 T SI200932094 T SI 200932094T SI 200932094 T SI200932094 T SI 200932094T SI 3144318 T1 SI3144318 T1 SI 3144318T1
Authority
SI
Slovenia
Prior art keywords
alpha
sialylation
recombinant fsh
fsh including
including alpha
Prior art date
Application number
SI200932094T
Other languages
English (en)
Slovenian (sl)
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39717519&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3144318(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferring B.V. filed Critical Ferring B.V.
Publication of SI3144318T1 publication Critical patent/SI3144318T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI200932094T 2008-04-16 2009-04-16 Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo SI3144318T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
EP08251528 2008-04-25
EP16194925.0A EP3144318B1 (en) 2008-04-16 2009-04-16 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation

Publications (1)

Publication Number Publication Date
SI3144318T1 true SI3144318T1 (sl) 2020-12-31

Family

ID=39717519

Family Applications (6)

Application Number Title Priority Date Filing Date
SI200932094T SI3144318T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo
SI200931547A SI2808340T1 (sl) 2008-04-16 2009-04-16 Rekombinirani FSH, ki vključuje alfa 2,3- in alfa 2,6-sialilacijo
SI200932209T SI4015527T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vključuje alfa 2,3- in alfa 2,6-sialilacijo
SI200931670A SI3045471T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vključuje alfa 2,3 in alfa 2,6-sialilacijo
SI200930931T SI2268666T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo
SI200932205T SI3098234T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH,ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo

Family Applications After (5)

Application Number Title Priority Date Filing Date
SI200931547A SI2808340T1 (sl) 2008-04-16 2009-04-16 Rekombinirani FSH, ki vključuje alfa 2,3- in alfa 2,6-sialilacijo
SI200932209T SI4015527T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vključuje alfa 2,3- in alfa 2,6-sialilacijo
SI200931670A SI3045471T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vključuje alfa 2,3 in alfa 2,6-sialilacijo
SI200930931T SI2268666T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH, ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo
SI200932205T SI3098234T1 (sl) 2008-04-16 2009-04-16 Rekombinantni FSH,ki vsebuje alfa 2,3- in alfa 2,6-sialilacijo

Country Status (29)

Country Link
US (6) US8951967B2 (enExample)
EP (7) EP3098234B1 (enExample)
JP (7) JP2011519359A (enExample)
KR (5) KR101622944B1 (enExample)
CN (3) CN105906702A (enExample)
AR (1) AR071479A1 (enExample)
AU (5) AU2009237479B2 (enExample)
BR (1) BRPI0910461B8 (enExample)
CA (1) CA2725257A1 (enExample)
CY (1) CY1115413T1 (enExample)
DK (6) DK4015527T3 (enExample)
ES (5) ES2629392T3 (enExample)
FI (4) FI4015527T3 (enExample)
FR (3) FR17C1020I2 (enExample)
HR (5) HRP20140535T1 (enExample)
HU (9) HUE071059T2 (enExample)
IL (2) IL208538A (enExample)
LT (8) LT3098234T (enExample)
MX (3) MX348622B (enExample)
NO (4) NO2017025I1 (enExample)
NZ (1) NZ588381A (enExample)
PL (6) PL3045471T3 (enExample)
PT (6) PT2808340T (enExample)
RU (3) RU2537268C2 (enExample)
SA (1) SA109300228B1 (enExample)
SI (6) SI3144318T1 (enExample)
TW (1) TWI488640B (enExample)
WO (1) WO2009127826A1 (enExample)
ZA (1) ZA201007373B (enExample)

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TWI532495B (zh) 2009-10-05 2016-05-11 菲瑞茵國際中心股份有限公司 藥學製劑
EP2417982A1 (en) 2010-07-30 2012-02-15 Ferring B.V. Stabilization of gonadotropins
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RS54214B2 (sr) 2010-09-29 2024-02-29 Ferring Bv Smeša za upotrebu u lečenju infertiliteta
CN103154243A (zh) 2010-10-15 2013-06-12 日本化学研究株式会社 糖链的非还原末端为甘露糖残基的糖蛋白的制造方法
ES2693273T3 (es) * 2011-03-31 2018-12-10 Ferring B.V. Preparación farmacéutica
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) * 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
AU2012340501A1 (en) * 2011-12-19 2013-07-11 Grifols, S.A. Compositions, methods, and kits for preparing sialylated recombinant proteins
JP6279466B2 (ja) * 2012-04-27 2018-02-14 Ｊｃｒファーマ株式会社 新規な発現ベクター
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JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
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HUE048757T2 (hu) 2015-04-17 2020-08-28 Ferring Bv FSH meddõség kezelésére
AU2016282916B2 (en) 2015-06-26 2022-01-20 Ferring B.V. Methods of purification and/or viral inactivation
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GB201603280D0 (en) 2016-02-24 2016-04-13 Ferring Bv Stable liquid gonadotropin formulation
EP3382014A1 (en) * 2017-03-29 2018-10-03 CEVEC Pharmaceuticals GmbH Recombinant glycoproteins with reduced antennary fucosylation
EP3441471A1 (en) 2017-08-08 2019-02-13 CEVEC Pharmaceuticals GmbH Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines
MA50034B1 (fr) 2017-09-01 2022-02-28 Ferring Bv Composition de stimulation ovarienne contrôlée
PL3787667T3 (pl) 2018-04-30 2025-07-28 Ferring B.V. Kompozycja do kontrolowanej stymulacji jajników
TWI846743B (zh) 2018-10-17 2024-07-01 荷蘭商菲林公司 用於控制性卵巢刺激之組成物及方法
WO2021081670A1 (en) * 2019-11-01 2021-05-06 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
TW202237173A (zh) 2020-12-09 2022-10-01 荷蘭商菲林公司 用於受控的卵巢刺激之組成物及方法
AU2022451605A1 (en) 2022-04-01 2024-09-26 Ferring B.V. Mixed protocol for treatment of infertility
KR20250016113A (ko) 2022-05-26 2025-02-03 훼링 비.브이. 남성 불임 치료를 위한 조성물 및 방법
MA71382A (fr) 2022-07-08 2025-04-30 Ferring B.V. Compositions et procédés d'insémination intra-utérine (iiu)
TW202504578A (zh) 2023-07-20 2025-02-01 荷蘭商輝凌責任有限公司 緩釋載藥微粒

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RS54214B2 (sr) 2010-09-29 2024-02-29 Ferring Bv Smeša za upotrebu u lečenju infertiliteta
ES2693273T3 (es) 2011-03-31 2018-12-10 Ferring B.V. Preparación farmacéutica
EP2717904A1 (en) 2011-06-06 2014-04-16 Ferring BV Pharmaceutical preparation comprising recombinant fsh
JO3092B1 (ar) 2011-08-08 2017-03-15 Ferring Bv مركب لتحفيز مسيطر عليه للمبيض
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Also Published As

Publication number Publication date
PT3098234T (pt) 2024-10-21
LT3098234T (lt) 2024-09-10
HUS2500008I1 (hu) 2025-02-28
MX2010011343A (es) 2011-01-20
PL4015527T3 (pl) 2025-05-26
DK2268666T3 (da) 2014-05-12
EP4015527A1 (en) 2022-06-22
ES2629392T3 (es) 2017-08-09
EP3144318A1 (en) 2017-03-22
ZA201007373B (en) 2011-06-29
EP2722339A1 (en) 2014-04-23
ES2610277T3 (es) 2017-04-26
HRP20140535T1 (hr) 2014-07-18
NO2025006I1 (no) 2025-01-16
KR20160056960A (ko) 2016-05-20
RU2682270C2 (ru) 2019-03-18
RU2010141908A (ru) 2012-05-27
AU2017225020A1 (en) 2017-09-28
HRP20250313T1 (hr) 2025-05-09
AU2017204259B2 (en) 2017-08-17
JP2020040956A (ja) 2020-03-19
NO2017025I1 (no) 2017-06-06
ES2989729T3 (es) 2024-11-27
PL3098234T3 (pl) 2025-01-07
LTPA2017029I1 (lt) 2017-10-10
NO2025032I1 (no) 2025-07-14
EP2808340A1 (en) 2014-12-03
KR20110005863A (ko) 2011-01-19
US20160347811A1 (en) 2016-12-01
HUS1700025I1 (hu) 2017-06-28
PT2268666E (pt) 2014-06-25
SI2268666T1 (sl) 2014-07-31
EP3144318B1 (en) 2020-09-23
IL230571A (en) 2015-11-30
US8951967B2 (en) 2015-02-10
WO2009127826A1 (en) 2009-10-22
DK3045471T3 (en) 2017-06-26
CN105906702A (zh) 2016-08-31
FR17C1020I2 (fr) 2020-04-10
PT3045471T (pt) 2017-06-14
US20210332099A1 (en) 2021-10-28
HK1199039A1 (en) 2015-06-19
DK3098234T3 (da) 2024-10-21
FR17C1020I1 (enExample) 2020-04-10
HUE033830T2 (en) 2018-01-29
CN102066414A (zh) 2011-05-18
PL2268666T3 (pl) 2014-08-29
SI2808340T1 (sl) 2016-12-30
LTPA2025505I1 (enExample) 2025-02-10
LTPA2017018I1 (lt) 2017-06-26
BRPI0910461A2 (pt) 2018-03-27
US9546204B2 (en) 2017-01-17
RU2014141994A3 (enExample) 2018-05-28
PT4015527T (pt) 2025-04-10
AR071479A1 (es) 2010-06-23
PT3144318T (pt) 2020-11-04
EP2268666B1 (en) 2014-03-12
JP2024038000A (ja) 2024-03-19
FI3098234T3 (fi) 2024-10-31
DK4015527T3 (da) 2025-04-14
AU2009237479A1 (en) 2009-10-22
HUS1700036I1 (hu) 2017-10-30
US20110105398A1 (en) 2011-05-05
KR20180095140A (ko) 2018-08-24
KR20190092608A (ko) 2019-08-07
TW200948378A (en) 2009-12-01
HUE071059T2 (hu) 2025-07-28
FI4015527T3 (fi) 2025-04-29
JP2018021037A (ja) 2018-02-08
JP7316905B2 (ja) 2023-07-28
RU2014141994A (ru) 2016-05-10
DK3144318T3 (da) 2020-12-07
SI3098234T1 (sl) 2024-10-30
PL3144318T3 (pl) 2021-02-08
NZ588381A (en) 2012-05-25
AU2014203277B2 (en) 2017-04-06
HUE068565T2 (hu) 2025-01-28
TWI488640B (zh) 2015-06-21
US20240327487A1 (en) 2024-10-03
JP2017060476A (ja) 2017-03-30
HRP20161520T1 (hr) 2016-12-30
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