SI2794600T1 - 2,3-Dihydro-benzo (1,4) oxazine derivatives and related compounds as phosphoinositide-3 kinase inhibitors (PI3K) for the treatment, e.g. rheumatoid arthritis - Google Patents

2,3-Dihydro-benzo (1,4) oxazine derivatives and related compounds as phosphoinositide-3 kinase inhibitors (PI3K) for the treatment, e.g. rheumatoid arthritis Download PDF

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Publication number
SI2794600T1
SI2794600T1 SI201231221T SI201231221T SI2794600T1 SI 2794600 T1 SI2794600 T1 SI 2794600T1 SI 201231221 T SI201231221 T SI 201231221T SI 201231221 T SI201231221 T SI 201231221T SI 2794600 T1 SI2794600 T1 SI 2794600T1
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Slovenia
Prior art keywords
dihydro
yloxy
oxazin
benzo
pyrrolidin
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Application number
SI201231221T
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English (en)
Slovenian (sl)
Inventor
Giorgio Caravatti
Sylvie Chamoin
Pascal Furet
Klemens Hogenauer
Konstanze Hurth
Christoph Kalis
Karen Kammertoens
Ian Lewis
Henrik Moebitz
Alexander Baxter Smith
Nicolas Soldermann
Romain Wolf
Frederic Zecri
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Novartis Ag
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Publication of SI2794600T1 publication Critical patent/SI2794600T1/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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SI201231221T 2011-12-22 2012-12-20 2,3-Dihydro-benzo (1,4) oxazine derivatives and related compounds as phosphoinositide-3 kinase inhibitors (PI3K) for the treatment, e.g. rheumatoid arthritis SI2794600T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579231P 2011-12-22 2011-12-22
PCT/IB2012/057554 WO2013093849A1 (en) 2011-12-22 2012-12-20 Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
EP12823036.4A EP2794600B1 (en) 2011-12-22 2012-12-20 2,3-Dihydro-benzo[1,4]oxazine derivatives and related compounds as phosphoinositide-3 kinase (PI3K) inhibitors for the treatment of e.g. rheumatoid arthritis

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SI2794600T1 true SI2794600T1 (en) 2018-03-30

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SI201231221T SI2794600T1 (en) 2011-12-22 2012-12-20 2,3-Dihydro-benzo (1,4) oxazine derivatives and related compounds as phosphoinositide-3 kinase inhibitors (PI3K) for the treatment, e.g. rheumatoid arthritis

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US (2) US9539260B2 (enExample)
EP (1) EP2794600B1 (enExample)
JP (1) JP5903499B2 (enExample)
KR (1) KR101656592B1 (enExample)
CN (1) CN104011045B (enExample)
AP (1) AP4055A (enExample)
AR (1) AR089424A1 (enExample)
AU (1) AU2012356083B2 (enExample)
BR (1) BR112014015103B1 (enExample)
CA (1) CA2859764C (enExample)
CL (1) CL2014001452A1 (enExample)
CO (1) CO6990717A2 (enExample)
CR (2) CR20200286A (enExample)
CU (1) CU20140072A7 (enExample)
CY (1) CY1119939T1 (enExample)
DK (1) DK2794600T3 (enExample)
EA (1) EA025322B1 (enExample)
EC (1) ECSP14009999A (enExample)
ES (1) ES2661864T3 (enExample)
GT (1) GT201400131A (enExample)
HR (1) HRP20180384T1 (enExample)
HU (1) HUE036953T2 (enExample)
IL (1) IL233117A (enExample)
IN (1) IN2014CN04174A (enExample)
JO (1) JO3398B1 (enExample)
LT (1) LT2794600T (enExample)
MA (1) MA37142B1 (enExample)
MX (1) MX353342B (enExample)
MY (1) MY170922A (enExample)
NO (1) NO2809782T3 (enExample)
PE (1) PE20141598A1 (enExample)
PH (1) PH12014501417A1 (enExample)
PL (1) PL2794600T3 (enExample)
PT (1) PT2794600T (enExample)
RS (1) RS56891B1 (enExample)
SG (1) SG11201402237WA (enExample)
SI (1) SI2794600T1 (enExample)
TN (1) TN2014000210A1 (enExample)
TW (1) TWI577674B (enExample)
UA (1) UA112558C2 (enExample)
UY (1) UY34541A (enExample)
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AR089284A1 (es) 2011-12-22 2014-08-13 Galapagos Nv Dihidropirimidinoisoquinolinonas y composiciones farmaceuticas de las mismas para el tratamiento de trastornos inflamatorios
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TW201422625A (zh) * 2012-11-26 2014-06-16 Novartis Ag 二氫－吡啶并－□衍生物之固體形式
CN105541698B (zh) * 2015-12-23 2018-07-10 滨海康杰化学有限公司 一种5-溴-2-三氟甲基吡啶的制备方法
GB2550437B (en) * 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
AU2018392816B2 (en) * 2017-12-22 2023-04-20 HiberCell Inc. Chromenopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
MA53219B1 (fr) 2018-08-13 2024-09-30 F. Hoffmann-La Roche Ag Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase
MX2021006696A (es) 2018-12-06 2021-07-07 Daiichi Sankyo Co Ltd Derivado de cicloalcano-1,3-diamina.
TW202112784A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物
BR112022002375A2 (pt) 2019-09-12 2022-07-19 Hoffmann La Roche Compostos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inibidores de magl
EP4061821B1 (en) * 2019-11-20 2025-08-06 F. Hoffmann-La Roche AG Spiro(isobenzofuranazetidine) compounds for the treatment of autoimmune disease
CN115298165B (zh) * 2020-03-19 2024-09-17 艾库斯生物科学有限公司 作为HIF-2α抑制剂的四氢化萘和四氢喹啉化合物
WO2022013311A1 (en) 2020-07-15 2022-01-20 Chiesi Farmaceutici S.P.A. Pyrido oxazine derivatives as alk5 inhibitors
JP2025509154A (ja) 2022-03-08 2025-04-11 エクアシールド メディカル リミテッド ロボット医薬品調製システムにおける流体移送ステーション
CN116535436B (zh) * 2023-05-06 2024-04-30 遵义医科大学 一种氟离子荧光探针及其合成方法和应用
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