SI2794600T1 - 2,3-Dihydro-benzo (1,4) oxazine derivatives and related compounds as phosphoinositide-3 kinase inhibitors (PI3K) for the treatment, e.g. rheumatoid arthritis - Google Patents

2,3-Dihydro-benzo (1,4) oxazine derivatives and related compounds as phosphoinositide-3 kinase inhibitors (PI3K) for the treatment, e.g. rheumatoid arthritis Download PDF

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Publication number
SI2794600T1
SI2794600T1 SI201231221T SI201231221T SI2794600T1 SI 2794600 T1 SI2794600 T1 SI 2794600T1 SI 201231221 T SI201231221 T SI 201231221T SI 201231221 T SI201231221 T SI 201231221T SI 2794600 T1 SI2794600 T1 SI 2794600T1
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SI
Slovenia
Prior art keywords
dihydro
yloxy
oxazin
benzo
pyrrolidin
Prior art date
Application number
SI201231221T
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English (en)
Slovenian (sl)
Inventor
Giorgio Caravatti
Sylvie Chamoin
Pascal Furet
Klemens Hogenauer
Konstanze Hurth
Christoph Kalis
Karen Kammertoens
Ian Lewis
Henrik Moebitz
Alexander Baxter Smith
Nicolas Soldermann
Romain Wolf
Frederic Zecri
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Novartis Ag
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Publication of SI2794600T1 publication Critical patent/SI2794600T1/en

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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SI201231221T 2011-12-22 2012-12-20 2,3-Dihydro-benzo (1,4) oxazine derivatives and related compounds as phosphoinositide-3 kinase inhibitors (PI3K) for the treatment, e.g. rheumatoid arthritis SI2794600T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579231P 2011-12-22 2011-12-22
PCT/IB2012/057554 WO2013093849A1 (en) 2011-12-22 2012-12-20 Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives
EP12823036.4A EP2794600B1 (en) 2011-12-22 2012-12-20 2,3-Dihydro-benzo[1,4]oxazine derivatives and related compounds as phosphoinositide-3 kinase (PI3K) inhibitors for the treatment of e.g. rheumatoid arthritis

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Publication Number Publication Date
SI2794600T1 true SI2794600T1 (en) 2018-03-30

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SI201231221T SI2794600T1 (en) 2011-12-22 2012-12-20 2,3-Dihydro-benzo (1,4) oxazine derivatives and related compounds as phosphoinositide-3 kinase inhibitors (PI3K) for the treatment, e.g. rheumatoid arthritis

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US (2) US9539260B2 (enExample)
EP (1) EP2794600B1 (enExample)
JP (1) JP5903499B2 (enExample)
KR (1) KR101656592B1 (enExample)
CN (1) CN104011045B (enExample)
AP (1) AP4055A (enExample)
AR (1) AR089424A1 (enExample)
AU (1) AU2012356083B2 (enExample)
BR (1) BR112014015103B1 (enExample)
CA (1) CA2859764C (enExample)
CL (1) CL2014001452A1 (enExample)
CO (1) CO6990717A2 (enExample)
CR (2) CR20200286A (enExample)
CU (1) CU20140072A7 (enExample)
CY (1) CY1119939T1 (enExample)
DK (1) DK2794600T3 (enExample)
EA (1) EA025322B1 (enExample)
EC (1) ECSP14009999A (enExample)
ES (1) ES2661864T3 (enExample)
GT (1) GT201400131A (enExample)
HR (1) HRP20180384T1 (enExample)
HU (1) HUE036953T2 (enExample)
IL (1) IL233117A (enExample)
IN (1) IN2014CN04174A (enExample)
JO (1) JO3398B1 (enExample)
LT (1) LT2794600T (enExample)
MA (1) MA37142B1 (enExample)
MX (1) MX353342B (enExample)
MY (1) MY170922A (enExample)
NO (1) NO2809782T3 (enExample)
PE (1) PE20141598A1 (enExample)
PH (1) PH12014501417A1 (enExample)
PL (1) PL2794600T3 (enExample)
PT (1) PT2794600T (enExample)
RS (1) RS56891B1 (enExample)
SG (1) SG11201402237WA (enExample)
SI (1) SI2794600T1 (enExample)
TN (1) TN2014000210A1 (enExample)
TW (1) TWI577674B (enExample)
UA (1) UA112558C2 (enExample)
UY (1) UY34541A (enExample)
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EA025322B1 (ru) 2011-12-22 2016-12-30 Новартис Аг Производные дигидробензооксазина и дигидропиридооксазина
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TW201422625A (zh) * 2012-11-26 2014-06-16 Novartis Ag 二氫－吡啶并－□衍生物之固體形式
CN105541698B (zh) * 2015-12-23 2018-07-10 滨海康杰化学有限公司 一种5-溴-2-三氟甲基吡啶的制备方法
GB2550437B (en) * 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
CN111936484A (zh) 2017-12-22 2020-11-13 拉文纳制药公司 作为磷脂酰肌醇磷酸激酶抑制剂的色烯并吡啶衍生物
BR112021002298A2 (pt) 2018-08-13 2021-05-04 F. Hoffmann-La Roche Ag compostos heterocíclicos como inibidores da monoacilglicerol lipase
CA3116141C (en) 2018-12-06 2023-09-05 Daiichi Sankyo Company, Limited Cycloalkane-1,3-diamine derivative
TW202112784A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物
PH12022550339A1 (en) 2019-09-12 2023-03-13 Hoffmann La Roche 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors
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KR20220155593A (ko) * 2020-03-19 2022-11-23 아르커스 바이오사이언시즈 인코포레이티드 Hif-2알파의 억제제로서의 테트랄린 및 테트라히드로퀴놀린 화합물
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AU2023232562A1 (en) 2022-03-08 2024-09-05 Equashield Medical Ltd Fluid transfer station in a robotic pharmaceutical preparation system
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