|
US5300645A
(en)
|
1993-04-14 |
1994-04-05 |
Eli Lilly And Company |
Tetrahydro-pyrido-indole
|
|
US5858753A
(en)
|
1996-11-25 |
1999-01-12 |
Icos Corporation |
Lipid kinase
|
|
US5939421A
(en)
|
1997-07-01 |
1999-08-17 |
Signal Pharmaceuticals, Inc. |
Quinazoline analogs and related compounds and methods for treating inflammatory conditions
|
|
US6667300B2
(en)
|
2000-04-25 |
2003-12-23 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
|
WO2001085986A2
(en)
|
2000-05-10 |
2001-11-15 |
Icos Corporation |
Phosphatidyl inositol 3-kinase delta binding partner
|
|
DE10043667A1
(de)
|
2000-09-05 |
2002-03-14 |
Merck Patent Gmbh |
2-Guanidino-4-aryl-chinazoline
|
|
RU2329263C2
(ru)
|
2000-11-07 |
2008-07-20 |
Новартис Аг |
Производные имида индолилмалеиновой кислоты как ингибиторы протеинкиназы с
|
|
KR100833371B1
(ko)
|
2001-04-27 |
2008-05-28 |
젠야쿠코교가부시키가이샤 |
헤테로시클릭 화합물 및 이를 유효 성분으로 하는 항종양제
|
|
AR039209A1
(es)
|
2002-04-03 |
2005-02-09 |
Novartis Ag |
Derivados de indolilmaleimida
|
|
AU2003297740B2
(en)
|
2002-12-09 |
2008-09-11 |
The Board Of Regents Of The University Of Texas System |
Methods for selectively inhibiting Janus tyrosine kinase 3 (Jak3)
|
|
AU2003292437A1
(en)
|
2002-12-27 |
2004-07-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa |
Tetrahydro-4h-pyrido(1,2-a)pyrimidines and related compounds useful as hiv integrase inhibitors
|
|
US20050054614A1
(en)
|
2003-08-14 |
2005-03-10 |
Diacovo Thomas G. |
Methods of inhibiting leukocyte accumulation
|
|
US20050043239A1
(en)
|
2003-08-14 |
2005-02-24 |
Jason Douangpanya |
Methods of inhibiting immune responses stimulated by an endogenous factor
|
|
ES2389203T3
(es)
|
2004-01-12 |
2012-10-24 |
Ym Biosciences Australia Pty Ltd |
Inhibidores de quinasa selectivos
|
|
MXPA06008257A
(es)
|
2004-01-23 |
2006-08-31 |
Amgen Inc |
Ligandos del receptor vanilloide y su uso en tratamientos.
|
|
US8048454B2
(en)
*
|
2004-03-09 |
2011-11-01 |
Michael Martin |
Methods and compositions related to regulation of cytokine production by glycogen synthase kinase 3 (GSK-3)
|
|
CA2566436C
(en)
|
2004-05-13 |
2011-05-10 |
Vanderbilt University |
Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis
|
|
HRP20161751T1
(hr)
|
2004-05-13 |
2017-04-07 |
Icos Corporation |
Kinazolinoni kao inhibitori humane fosfatidilinozitol 3-kinaze delta
|
|
PL1761528T3
(pl)
|
2004-06-11 |
2008-05-30 |
Japan Tobacco Inc |
Pochodne 5-amino-2,4,7-triokso-3,4,7,8-tetrahydro-2H-pirydo[2,3-D]pirymidyny i związki pokrewne do leczenia raka
|
|
GB0423653D0
(en)
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
US20060128710A1
(en)
|
2004-12-09 |
2006-06-15 |
Chih-Hung Lee |
Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof
|
|
WO2006071095A1
(en)
|
2004-12-31 |
2006-07-06 |
Sk Chemicals Co., Ltd. |
Quinazoline derivatives for the treatment and prevention of diabetes and obesity
|
|
MX2007013595A
(es)
|
2005-05-04 |
2008-01-24 |
Renovis Inc |
Compuestos heterociclicos fusionados y composiciones y usos de estos.
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
UA100358C2
(xx)
|
2005-08-26 |
2012-12-25 |
Мерк Сероно Са |
Похідні піразину та їх застосування
|
|
GB0520657D0
(en)
|
2005-10-11 |
2005-11-16 |
Ludwig Inst Cancer Res |
Pharmaceutical compounds
|
|
CN101360738A
(zh)
|
2005-12-21 |
2009-02-04 |
佩因赛普托药物公司 |
调节门控离子通道的组合物和方法
|
|
GB0612630D0
(en)
|
2006-06-26 |
2006-08-02 |
Novartis Ag |
Organic compounds
|
|
US8673929B2
(en)
|
2006-07-20 |
2014-03-18 |
Gilead Sciences, Inc. |
4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
|
|
RU2009106722A
(ru)
*
|
2006-07-28 |
2010-09-10 |
Новартис АГ (CH) |
2,4-замещенные хиназолины в качестве ингибиторов липидной киназы
|
|
EP1891958A1
(en)
*
|
2006-08-03 |
2008-02-27 |
Universite Pierre Et Marie Curie (Paris Vi) |
Rho/Rock/PI3/Akt kinase inhibitors for the treatment of diseases associated with protozoan parasites.
|
|
AU2007323836B2
(en)
|
2006-11-13 |
2013-04-18 |
Icos Corporation |
Thienopyrimidinones for treatment of inflammatory disorders and cancers
|
|
US7919498B2
(en)
|
2007-03-23 |
2011-04-05 |
Amgen Inc. |
Substituted pyrazolo[3,4-d]pyrimidines as PI3K inhibitors
|
|
CN101715453B
(zh)
|
2007-03-23 |
2012-06-27 |
安姆根有限公司 |
杂环化合物及其应用
|
|
MX2009010050A
(es)
|
2007-03-23 |
2009-10-12 |
Amgen Inc |
Derivados de quinolina o quinoxalina 3-sustituidos y su uso como inhibidores de fosfotidilinositol 3-cinasa (p13k).
|
|
CA2682162C
(en)
|
2007-04-02 |
2016-05-10 |
Renovis, Inc. |
Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof
|
|
DE602008004650D1
(de)
|
2007-04-12 |
2011-03-03 |
Hoffmann La Roche |
Pyrimidinderivate als inhibitoren von phosphatidylinositol-3-kinase
|
|
GB0707087D0
(en)
|
2007-04-12 |
2007-05-23 |
Piramed Ltd |
Pharmaceutical compounds
|
|
KR20100016431A
(ko)
|
2007-04-12 |
2010-02-12 |
에프. 호프만-라 로슈 아게 |
약학적 화합물
|
|
HRP20130867T1
(hr)
|
2007-04-17 |
2013-10-25 |
Evotec Ag |
Kondenzirani heterocikliäśki spojevi 2-cijanofenila, te njihovi pripravci i uporaba
|
|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
WO2008150827A1
(en)
|
2007-05-29 |
2008-12-11 |
Smithkline Beecham Corporation |
Naphthyridine, derivatives as p13 kinase inhibitors
|
|
WO2008152394A1
(en)
|
2007-06-12 |
2008-12-18 |
F.Hoffmann-La Roche Ag |
Pharmaceutical compounds
|
|
WO2008152387A1
(en)
|
2007-06-12 |
2008-12-18 |
F.Hoffmann-La Roche Ag |
Quinazoline derivatives as pi3 kinase inhibitors
|
|
US7893060B2
(en)
|
2007-06-12 |
2011-02-22 |
F. Hoffmann-La Roche Ag |
Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase
|
|
UY31137A1
(es)
*
|
2007-06-14 |
2009-01-05 |
Smithkline Beecham Corp |
Derivados de quinazolina como inhibidores de la pi3 quinasa
|
|
RU2341527C1
(ru)
|
2007-07-17 |
2008-12-20 |
Общество С Ограниченной Ответственностью "Исследовательский Институт Химического Разнообразия" |
Аннелированные азагетероциклы, включающие пиримидиновый фрагмент, способ их получения и ингибиторы pi3k киназ
|
|
TW200908984A
(en)
|
2007-08-07 |
2009-03-01 |
Piramal Life Sciences Ltd |
Pyridyl derivatives, their preparation and use
|
|
WO2009036768A2
(en)
|
2007-09-19 |
2009-03-26 |
H. Lundbeck A/S |
Diagnosing potential weight gain in a subject
|
|
WO2009046448A1
(en)
|
2007-10-04 |
2009-04-09 |
Intellikine, Inc. |
Chemical entities and therapeutic uses thereof
|
|
WO2009047255A1
(en)
|
2007-10-09 |
2009-04-16 |
Ucb Pharma, S.A. |
Heterobicyclic compounds as histamine h4-receptor antagonists
|
|
WO2009058361A1
(en)
*
|
2007-10-31 |
2009-05-07 |
Dynavax Technologies Corp. |
Inhibition of type i ifn production
|
|
AU2008321099A1
(en)
|
2007-11-13 |
2009-05-22 |
Icos Corporation |
Inhibitors of human phosphatidyl-inositol 3-kinase delta
|
|
DK2240451T3
(da)
|
2008-01-04 |
2017-11-20 |
Intellikine Llc |
Isoquinolinonderivater substitueret med en purin, der er anvendelig som pi3k-inhibitorer
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
JP2011515462A
(ja)
|
2008-03-27 |
2011-05-19 |
アウククランド ウニセルビセス リミテッド |
置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用
|
|
US8436005B2
(en)
|
2008-04-03 |
2013-05-07 |
Abbott Laboratories |
Macrocyclic pyrimidine derivatives
|
|
JP5508400B2
(ja)
|
2008-06-05 |
2014-05-28 |
グラクソ グループ リミテッド |
Ｐｉ３キナーゼの阻害剤としてのベンズピラゾール誘導体
|
|
ATE552255T1
(de)
|
2008-06-05 |
2012-04-15 |
Glaxo Group Ltd |
4-aminoindazole
|
|
JP5502076B2
(ja)
|
2008-06-05 |
2014-05-28 |
グラクソ グループ リミテッド |
新規化合物
|
|
EA201170052A1
(ru)
|
2008-06-19 |
2011-06-30 |
Милленниум Фармасьютикалз, Инк. |
Производные тиофена или тиазола и их применение как ингибиторов pi3k
|
|
WO2010005558A2
(en)
|
2008-07-07 |
2010-01-14 |
Xcovery, Inc. |
Pi3k isoform selective inhibitors
|
|
US9096611B2
(en)
|
2008-07-08 |
2015-08-04 |
Intellikine Llc |
Kinase inhibitors and methods of use
|
|
WO2010036380A1
(en)
|
2008-09-26 |
2010-04-01 |
Intellikine, Inc. |
Heterocyclic kinase inhibitors
|
|
WO2010036908A1
(en)
*
|
2008-09-26 |
2010-04-01 |
Eisai R & D Management Co., Ltd. |
Use of benzoxazole compounds in the treatment of malaria
|
|
PT2355828T
(pt)
|
2008-11-13 |
2018-07-02 |
Gilead Calistoga Llc |
Terapias para malignidades hematológicas
|
|
WO2010059593A1
(en)
|
2008-11-18 |
2010-05-27 |
Intellikine, Inc. |
Methods and compositions for treatment of ophthalmic conditions
|
|
EP2365810A2
(en)
|
2008-12-04 |
2011-09-21 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Phosphatidylinositol-3-kinase p110 delta-targeted drugs in the treatment of cns disorders
|
|
ES2542551T3
(es)
|
2009-03-09 |
2015-08-06 |
Glaxo Group Limited |
4-Oxadiazol-2-il-indazoles como inhibidores de PI3 cinasas
|
|
EP2411003A4
(en)
|
2009-03-24 |
2012-10-17 |
Univ Singapore |
USE OF ARTEMISININE DERIVATIVES IN THE TREATMENT OF ASTHMA AND CHRONIC OBSTRUCTIVE BRONCHO-PNEUMOPATHY (COPD)
|
|
CA2756347A1
(en)
|
2009-03-24 |
2010-09-30 |
Gilead Calistoga Llc |
Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
|
|
WO2010120991A1
(en)
|
2009-04-17 |
2010-10-21 |
Wyeth Llc |
5, 6, 7, 8-tetrahydropyrido[4,3-d]pyrimidine compounds, their use as mtor, pi3, and hsmg-1 kinase inhibitors, and their syntheses
|
|
US8546409B2
(en)
|
2009-04-20 |
2013-10-01 |
Gilead Calistoga Llc |
Methods of treatment for solid tumors
|
|
TWI516487B
(zh)
|
2009-04-30 |
2016-01-11 |
葛蘭素集團有限公司 |
新穎化合物、其醫藥組合物及作為激酶活性抑制劑之用途
|
|
EP2427195B1
(en)
*
|
2009-05-07 |
2019-05-01 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
AU2010254161A1
(en)
|
2009-05-27 |
2011-11-10 |
F. Hoffmann-La Roche Ag |
Bicyclic pyrimidine PI3K inhibitor compounds selective for p110 delta, and methods of use
|
|
EP2451811A1
(en)
|
2009-05-27 |
2012-05-16 |
F. Hoffmann-La Roche AG |
Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
|
|
WO2010151737A2
(en)
|
2009-06-25 |
2010-12-29 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
|
UY32742A
(es)
|
2009-06-25 |
2010-12-31 |
Amgen Inc |
Compuestos heterocíclicos y sus usos
|
|
CA2765817A1
(en)
|
2009-06-25 |
2010-12-29 |
Amgen Inc. |
4h-pyrido[1,2-a]pyrimidin-4-one derivatives as pi3k inhibitors
|
|
UY32743A
(es)
|
2009-06-25 |
2010-12-31 |
Amgen Inc |
Compuestos heterocíclicos y sus usos
|
|
CN102482278B
(zh)
|
2009-06-29 |
2015-04-22 |
因塞特公司 |
作为pi3k抑制剂的嘧啶酮类
|
|
US8846670B2
(en)
|
2009-07-02 |
2014-09-30 |
Sanofi |
1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
|
|
AU2010267814B2
(en)
|
2009-07-02 |
2015-07-16 |
Sanofi |
Novel 2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
|
|
BR112012001325A2
(pt)
|
2009-07-21 |
2017-05-02 |
Gilead Calistoga Llc |
tratamento de distúrbios do fígado com inibidaores de pi3k
|
|
ES2534326T3
(es)
|
2009-08-20 |
2015-04-21 |
Karus Therapeutics Limited |
Compuestos tricíclicos heterocíclicos como inhibidores de la fosfoinositida 3-cinasa
|
|
AU2010300719A1
(en)
|
2009-09-29 |
2012-05-03 |
Xcovery Holding Company Llc |
PI3K (delta) selective inhibitors
|
|
GB0918249D0
(en)
|
2009-10-19 |
2009-12-02 |
Respivert Ltd |
Compounds
|
|
EP3444242A3
(en)
|
2009-11-05 |
2019-03-20 |
Rhizen Pharmaceuticals S.A. |
Novel benzopyran kinase modulators
|
|
AU2010316700A1
(en)
|
2009-11-06 |
2012-05-31 |
Piramal Enterprises Limited |
Imidazopyridine derivatives
|
|
ES2607952T3
(es)
|
2009-11-13 |
2017-04-04 |
Merck Serono S.A. |
Derivados tricíclicos de Pirazol Amina
|
|
WO2011067366A1
(en)
|
2009-12-03 |
2011-06-09 |
Glaxo Group Limited |
Indazole derivatives as pi 3 - kinase inhibitors
|
|
EP2507226A1
(en)
|
2009-12-03 |
2012-10-10 |
Glaxo Group Limited |
Novel compounds
|
|
US20120245171A1
(en)
|
2009-12-03 |
2012-09-27 |
Glaxo Group Limited |
Benzpyrazole derivatives as inhibitors of pi3 kinases
|
|
WO2011075643A1
(en)
|
2009-12-18 |
2011-06-23 |
Incyte Corporation |
Substituted heteroaryl fused derivatives as pi3k inhibitors
|
|
US8680108B2
(en)
|
2009-12-18 |
2014-03-25 |
Incyte Corporation |
Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
|
|
EP2513109A1
(en)
|
2009-12-18 |
2012-10-24 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
|
CN102762565A
(zh)
|
2010-02-22 |
2012-10-31 |
弗·哈夫曼-拉罗切有限公司 |
吡啶并[3,2-d]嘧啶PI3δ抑制剂化合物及使用方法
|
|
UY33304A
(es)
|
2010-04-02 |
2011-10-31 |
Amgen Inc |
Compuestos heterocíclicos y sus usos
|
|
EP2558463A1
(en)
|
2010-04-14 |
2013-02-20 |
Incyte Corporation |
Fused derivatives as i3 inhibitors
|
|
GB201007347D0
(en)
|
2010-04-30 |
2010-06-16 |
Karus Therapeutics Ltd |
Compounds
|
|
EP2571357B1
(en)
|
2010-05-21 |
2016-07-06 |
Infinity Pharmaceuticals, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
US9062055B2
(en)
|
2010-06-21 |
2015-06-23 |
Incyte Corporation |
Fused pyrrole derivatives as PI3K inhibitors
|
|
UA112517C2
(uk)
*
|
2010-07-06 |
2016-09-26 |
Новартіс Аг |
Тетрагідропіридопіримідинові похідні
|
|
WO2012007493A1
(en)
|
2010-07-14 |
2012-01-19 |
F. Hoffmann-La Roche Ag |
Purine compounds selective for ρi3κ p110 delta, and methods of use
|
|
WO2012037226A1
(en)
|
2010-09-14 |
2012-03-22 |
Exelixis, Inc. |
Inhibitors of pi3k-delta and methods of their use and manufacture
|
|
AR082985A1
(es)
|
2010-09-14 |
2013-01-23 |
Exelixis Inc |
INHIBIDORES DE PI3K-d Y METODOS DE SU USO Y PREPARACION
|
|
DK2663309T3
(en)
|
2011-01-10 |
2017-06-19 |
Infinity Pharmaceuticals Inc |
METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES
|
|
US9108984B2
(en)
|
2011-03-14 |
2015-08-18 |
Incyte Corporation |
Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
|
|
CA2825966A1
(en)
|
2011-03-21 |
2012-09-27 |
F. Hoffmann-La Roche Ag |
Benzoxazepin compounds selective for pi3k p110 delta and methods of use
|
|
US9126948B2
(en)
|
2011-03-25 |
2015-09-08 |
Incyte Holdings Corporation |
Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
|
|
AU2012236722A1
(en)
|
2011-03-28 |
2013-10-17 |
Mei Pharma, Inc. |
(alpha-substituted cycloalkylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
|
|
US8530470B2
(en)
|
2011-04-13 |
2013-09-10 |
Astrazeneca Ab |
Chromenone derivatives
|
|
EP2518071A1
(en)
|
2011-04-29 |
2012-10-31 |
Almirall, S.A. |
Imidazopyridine derivatives as PI3K inhibitors
|
|
EP2518070A1
(en)
|
2011-04-29 |
2012-10-31 |
Almirall, S.A. |
Pyrrolotriazinone derivatives as PI3K inhibitors
|
|
CN103987699A
(zh)
|
2011-10-21 |
2014-08-13 |
诺华股份有限公司 |
作为pi3k调节剂的喹唑啉衍生物
|
|
EP2790705B1
(en)
|
2011-12-15 |
2017-12-06 |
Novartis AG |
Use of inhibitors of the activity or function of pi3k
|