JP2015526452A5 - - Google Patents

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Publication number

JP2015526452A5

JP2015526452A5 JP2015527878A JP2015527878A JP2015526452A5 JP 2015526452 A5 JP2015526452 A5 JP 2015526452A5 JP 2015527878 A JP2015527878 A JP 2015527878A JP 2015527878 A JP2015527878 A JP 2015527878A JP 2015526452 A5 JP2015526452 A5 JP 2015526452A5

Authority

JP

Japan

Prior art keywords

tetrazol

tetrahydro

cyclohepta

pyridine

phenyl

Prior art date

2013-08-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• -1 amino, substituted amino, aminocarbonyl Chemical group 0.000 claims 72
• 150000001875 compounds Chemical class 0.000 claims 36
• 125000000217 alkyl group Chemical group 0.000 claims 26
• 125000001188 haloalkyl group Chemical group 0.000 claims 14
• 125000001072 heteroaryl group Chemical group 0.000 claims 14
• 125000000753 cycloalkyl group Chemical group 0.000 claims 13
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
• 229910052757 nitrogen Inorganic materials 0.000 claims 11
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims 10
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
• 229910052736 halogen Inorganic materials 0.000 claims 9
• 150000002367 halogens Chemical class 0.000 claims 9
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 9
• 125000001424 substituent group Chemical group 0.000 claims 9
• 125000003545 alkoxy group Chemical group 0.000 claims 7
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 7
• WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 claims 6
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 6
• 125000005120 alkyl cycloalkyl alkyl group Chemical group 0.000 claims 5
• 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 5
• 150000001412 amines Chemical class 0.000 claims 5
• 125000004438 haloalkoxy group Chemical group 0.000 claims 5
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 5
• 125000004076 pyridyl group Chemical group 0.000 claims 5
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims 4
• 201000001320 Atherosclerosis Diseases 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• 208000020832 chronic kidney disease Diseases 0.000 claims 4
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 4
• 125000004655 dihydropyridinyl group Chemical group N1(CC=CC=C1)* 0.000 claims 4
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 4
• 230000002265 prevention Effects 0.000 claims 4
• 125000003226 pyrazolyl group Chemical group 0.000 claims 4
• 125000003107 substituted aryl group Chemical group 0.000 claims 4
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
• 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
• 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• 125000004043 oxo group Chemical group O=* 0.000 claims 3
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
• 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 claims 3
• UZOPDZXSVSMIDY-UHFFFAOYSA-N 2-(1-methylcyclohexyl)-4-(2-methylpyridin-4-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound C1=NC(C)=CC(C=2C(=C(N=C3CCCCCC3=2)C2(C)CCCCC2)C(O)=O)=C1 UZOPDZXSVSMIDY-UHFFFAOYSA-N 0.000 claims 2
• UBYPSJXNOOGWGK-UHFFFAOYSA-N 2-(1-methylcyclopentyl)-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(N=C3CCCCCC3=2)C2(C)CCCC2)C2=NNN=N2)=C1 UBYPSJXNOOGWGK-UHFFFAOYSA-N 0.000 claims 2
• QXXOMPYKMBYIMD-UHFFFAOYSA-N 2-(2-methyloxolan-2-yl)-4-(2-methylpyrazol-3-yl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound CN1N=CC=C1C1=C(C(=NC=2CCCCC1=2)C1(OCCC1)C)C=1N=NNN=1 QXXOMPYKMBYIMD-UHFFFAOYSA-N 0.000 claims 2
• SKRDIGRVKJJTFE-UHFFFAOYSA-N 2-(oxolan-2-yl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCOC1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 SKRDIGRVKJJTFE-UHFFFAOYSA-N 0.000 claims 2
• QCYGXUDIJYZLOA-QFIPXVFZSA-N 2-[(2R)-2-(methoxymethyl)oxolan-2-yl]-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COC[C@@]1(CCCO1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 QCYGXUDIJYZLOA-QFIPXVFZSA-N 0.000 claims 2
• PCGSOKQXXMJPRX-JOCHJYFZSA-N 2-[(2r)-2-methyloxolan-2-yl]-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1[C@@]1(C)CCCO1 PCGSOKQXXMJPRX-JOCHJYFZSA-N 0.000 claims 2
• YEYKNGNEEYTUMK-INIZCTEOSA-N 2-[(3s)-oxolan-3-yl]oxy-4-phenyl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carbonitrile Chemical compound N1=C2CCCCCC2=C(C=2C=CC=CC=2)C(C#N)=C1O[C@H]1CCOC1 YEYKNGNEEYTUMK-INIZCTEOSA-N 0.000 claims 2
• XPKKXYOCPPMETJ-UHFFFAOYSA-N 2-cyclopentyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 XPKKXYOCPPMETJ-UHFFFAOYSA-N 0.000 claims 2
• WRAVCGCYMLNIJN-UHFFFAOYSA-N 2-cyclopentyl-6,6-difluoro-4-phenyl-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-quinoline Chemical compound N1=NNN=C1C=1C(C=2C=CC=CC=2)=C2CC(F)(F)CCC2=NC=1C1CCCC1 WRAVCGCYMLNIJN-UHFFFAOYSA-N 0.000 claims 2
• QGAOERSUSYBBDD-UHFFFAOYSA-N 2-cyclopentyl-6,6-dimethyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-quinoline Chemical compound C1=NC(C)=CC(C=2C(=C(C3CCCC3)N=C3CCC(C)(C)CC3=2)C2=NNN=N2)=C1 QGAOERSUSYBBDD-UHFFFAOYSA-N 0.000 claims 2
• LSPFDXQDUWKIKF-UHFFFAOYSA-N 2-cyclopentyl-6-methyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound N1=NNN=C1C=1C(C=2C=C(C)N=CC=2)=C2CC(C)CCC2=NC=1C1CCCC1 LSPFDXQDUWKIKF-UHFFFAOYSA-N 0.000 claims 2
• LUKNZXORBKOSFW-UHFFFAOYSA-N 4-(2-chloropyridin-4-yl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(Cl)N=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 LUKNZXORBKOSFW-UHFFFAOYSA-N 0.000 claims 2
• QGWYTYOYVYHBGE-UHFFFAOYSA-N 4-(2-fluoro-5-methoxyphenyl)-2-[2-(methoxymethyl)oxolan-2-yl]-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound FC1=C(C=C(C=C1)OC)C1=C(C(=NC=2CCCCC12)C1(OCCC1)COC)C=1N=NNN1 QGWYTYOYVYHBGE-UHFFFAOYSA-N 0.000 claims 2
• XDYCASUSHQEWAQ-UHFFFAOYSA-N 4-(2-methylpyrazol-3-yl)-2-(2-methylpyrrolidin-1-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CC1CCCN1C(C(=C1C=2N(N=CC=2)C)C2=NNN=N2)=NC2=C1CCCCC2 XDYCASUSHQEWAQ-UHFFFAOYSA-N 0.000 claims 2
• AKOMYFQLXHBFBI-UHFFFAOYSA-N 4-(3-chlorophenyl)-n,n-diethyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-2-amine Chemical compound N1=NNN=C1C=1C(N(CC)CC)=NC=2CCCCCC=2C=1C1=CC=CC(Cl)=C1 AKOMYFQLXHBFBI-UHFFFAOYSA-N 0.000 claims 2
• WAXFOMQRFSPVOG-HSZRJFAPSA-N 6,6-dimethyl-2-[(2R)-2-methyloxolan-2-yl]-4-phenyl-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound C[C@@]1(CCCO1)c1nc2CCC(C)(C)Cc2c(-c2ccccc2)c1-c1nn[nH]n1 WAXFOMQRFSPVOG-HSZRJFAPSA-N 0.000 claims 2
• LXMFGUVLRCVTBO-UHFFFAOYSA-N 6-methyl-4-(2-methylpyrazol-3-yl)-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound N1=NNN=C1C=1C(C=2N(N=CC=2)C)=C2CC(C)CCC2=NC=1N1CCCCC1 LXMFGUVLRCVTBO-UHFFFAOYSA-N 0.000 claims 2
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
• 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 2
• 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 2
• 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 claims 2
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
• 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
• 125000004858 cycloalkoxyalkyl group Chemical group 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• 125000005113 hydroxyalkoxy group Chemical group 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000005338 substituted cycloalkoxy group Chemical group 0.000 claims 2
• WRJVMTROTAWXEK-UHFFFAOYSA-N 1-[4-(3-chlorophenyl)-2-cyclobutyl-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-1,6-naphthyridin-6-yl]ethanone Chemical compound N1=NNN=C1C=1C(C=2C=C(Cl)C=CC=2)=C2CN(C(=O)C)CCC2=NC=1C1CCC1 WRJVMTROTAWXEK-UHFFFAOYSA-N 0.000 claims 1
• KUZMPIGGAAPGKE-UHFFFAOYSA-N 2,4-bis(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(C=3C=C(C)N=CC=3)C=3CCCCCC=3N=2)C2=NNN=N2)=C1 KUZMPIGGAAPGKE-UHFFFAOYSA-N 0.000 claims 1
• LHEBWXNIALOMGK-UHFFFAOYSA-N 2-(1,1,2,2,2-pentafluoroethyl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(F)(F)C(F)(F)F)=NC=2CCCCCC=2C=1C1=CC=CC=C1 LHEBWXNIALOMGK-UHFFFAOYSA-N 0.000 claims 1
• SFDYUGRERHXTPT-UHFFFAOYSA-N 2-(1,5-dimethylpyrazol-4-yl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NN(C)C(C)=C1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 SFDYUGRERHXTPT-UHFFFAOYSA-N 0.000 claims 1
• DZYVIQIAYAWSFE-UHFFFAOYSA-N 2-(1-methoxy-2-methylpropan-2-yl)-6,6-dimethyl-4-(2-methylpyrazol-3-yl)-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound COCC(C)(C)C1=NC=2CCC(CC2C(=C1C=1N=NNN1)C1=CC=NN1C)(C)C DZYVIQIAYAWSFE-UHFFFAOYSA-N 0.000 claims 1
• FHOHVTNOKNNKKS-UHFFFAOYSA-N 2-(1-methoxycyclopentyl)-4-(2-methoxypyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(OC)=CC(C=2C(=C(N=C3CCCCCC3=2)C2(CCCC2)OC)C2=NNN=N2)=C1 FHOHVTNOKNNKKS-UHFFFAOYSA-N 0.000 claims 1
• ZJTOKRIDFRKBER-UHFFFAOYSA-N 2-(1-methoxycyclopentyl)-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(C)N=CC=2)=C(C2=NNN=N2)C=1C1(OC)CCCC1 ZJTOKRIDFRKBER-UHFFFAOYSA-N 0.000 claims 1
• DGLHGKWDDLIGIW-UHFFFAOYSA-N 2-(1-methoxycyclopentyl)-4-phenyl-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound N=1C=2CCCCC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1C1(OC)CCCC1 DGLHGKWDDLIGIW-UHFFFAOYSA-N 0.000 claims 1
• YQFOMQPJWGMKML-UHFFFAOYSA-N 2-(1-methylcyclohexyl)-4-(2-methylpyrazol-3-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CN1N=CC=C1C1=C(CCCCC2)C2=NC(C2(C)CCCCC2)=C1C1=NNN=N1 YQFOMQPJWGMKML-UHFFFAOYSA-N 0.000 claims 1
• WSQOBWYUFXVLFW-UHFFFAOYSA-N 2-(1-methylcyclohexyl)-4-(2-methylpyrazol-3-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound CN1N=CC=C1C1=C(CCCCC2)C2=NC(C2(C)CCCCC2)=C1C(O)=O WSQOBWYUFXVLFW-UHFFFAOYSA-N 0.000 claims 1
• POKIRRVIYNZKMI-UHFFFAOYSA-N 2-(1-methylcyclohexyl)-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(N=C3CCCCCC3=2)C2(C)CCCCC2)C2=NNN=N2)=C1 POKIRRVIYNZKMI-UHFFFAOYSA-N 0.000 claims 1
• WHRQBVAXBHYTNG-UHFFFAOYSA-N 2-(1-methylcyclohexyl)-4-phenyl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound N=1C=2CCCCCC=2C(C=2C=CC=CC=2)=C(C(O)=O)C=1C1(C)CCCCC1 WHRQBVAXBHYTNG-UHFFFAOYSA-N 0.000 claims 1
• UPBVTFUTUSVGFX-UHFFFAOYSA-N 2-(1-methylcyclopentyl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1C1(C)CCCC1 UPBVTFUTUSVGFX-UHFFFAOYSA-N 0.000 claims 1
• JDSCRGACTSMWRB-UHFFFAOYSA-N 2-(1-methylcyclopentyl)-4-phenyl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound N=1C=2CCCCCC=2C(C=2C=CC=CC=2)=C(C(O)=O)C=1C1(C)CCCC1 JDSCRGACTSMWRB-UHFFFAOYSA-N 0.000 claims 1
• BXVMJUAFMOTUJE-UHFFFAOYSA-N 2-(2,2-difluoroethoxy)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCC(F)F)=NC=2CCCCCC=2C=1C1=CC=CC=C1 BXVMJUAFMOTUJE-UHFFFAOYSA-N 0.000 claims 1
• XAWXLXJEMWFUFJ-UHFFFAOYSA-N 2-(2-ethyloxolan-2-yl)-4-(2-methylpyrazol-3-yl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound CCC1(CCCO1)c1nc2CCCCc2c(-c2ccnn2C)c1-c1nn[nH]n1 XAWXLXJEMWFUFJ-UHFFFAOYSA-N 0.000 claims 1
• UISSMZGZADZUDI-UHFFFAOYSA-N 2-(2-ethyloxolan-2-yl)-4-phenyl-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound N=1C=2CCCCC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1C1(CC)CCCO1 UISSMZGZADZUDI-UHFFFAOYSA-N 0.000 claims 1
• JXMYWTAXJYSZPI-UHFFFAOYSA-N 2-(2-ethyloxolan-2-yl)-6,6-difluoro-4-phenyl-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound CCC1(CCCO1)c1nc2CCC(F)(F)Cc2c(-c2ccccc2)c1-c1nn[nH]n1 JXMYWTAXJYSZPI-UHFFFAOYSA-N 0.000 claims 1
• BWWYSWLENAFGTH-UHFFFAOYSA-N 2-(2-ethyloxolan-2-yl)-6,6-dimethyl-4-phenyl-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound CCC1(CCCO1)c1nc2CCC(C)(C)Cc2c(-c2ccccc2)c1-c1nn[nH]n1 BWWYSWLENAFGTH-UHFFFAOYSA-N 0.000 claims 1
• KOBUJRMTRCGYRL-UHFFFAOYSA-N 2-(2-methoxyethoxy)-3-(2h-tetrazol-5-yl)-4-[4-(trifluoromethyl)phenyl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCCOC)=NC=2CCCCCC=2C=1C1=CC=C(C(F)(F)F)C=C1 KOBUJRMTRCGYRL-UHFFFAOYSA-N 0.000 claims 1
• HEEQSEWUSHULSX-UHFFFAOYSA-N 2-(2-methoxyethoxy)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCCOC)=NC=2CCCCCC=2C=1C1=CC=CC=C1 HEEQSEWUSHULSX-UHFFFAOYSA-N 0.000 claims 1
• HWUMFMACFADNET-UHFFFAOYSA-N 2-(2-methyloxolan-2-yl)-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(N=C3CCCCCC3=2)C2(C)OCCC2)C2=NNN=N2)=C1 HWUMFMACFADNET-UHFFFAOYSA-N 0.000 claims 1
• VHFYVRCYNIURMD-UHFFFAOYSA-N 2-(2-methyloxolan-2-yl)-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound CC1(CCCO1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 VHFYVRCYNIURMD-UHFFFAOYSA-N 0.000 claims 1
• PCGSOKQXXMJPRX-UHFFFAOYSA-N 2-(2-methyloxolan-2-yl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1C1(C)CCCO1 PCGSOKQXXMJPRX-UHFFFAOYSA-N 0.000 claims 1
• QFTGLPPXAFIEKS-UHFFFAOYSA-N 2-(2-methylpyrrolidin-1-yl)-4-phenyl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound CC1CCCN1C(C(=C1C=2C=CC=CC=2)C(O)=O)=NC2=C1CCCCC2 QFTGLPPXAFIEKS-UHFFFAOYSA-N 0.000 claims 1
• YHOXTHMZOWDVJE-UHFFFAOYSA-N 2-(3,3-difluorocyclobutyl)-4-(1-methylpyrazol-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NN(C)C=C1C1=C(CCCCC2)C2=NC(C2CC(F)(F)C2)=C1C1=NNN=N1 YHOXTHMZOWDVJE-UHFFFAOYSA-N 0.000 claims 1
• VSIDAPKOENRMLU-UHFFFAOYSA-N 2-(3,3-difluorocyclobutyl)-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(C3CC(F)(F)C3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 VSIDAPKOENRMLU-UHFFFAOYSA-N 0.000 claims 1
• BLVBKOSWHIDFMA-UHFFFAOYSA-N 2-(3,3-difluorocyclobutyl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1C(F)(F)CC1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 BLVBKOSWHIDFMA-UHFFFAOYSA-N 0.000 claims 1
• FLIULSGWTQMSHJ-UHFFFAOYSA-N 2-(3-fluorophenyl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound FC1=CC=CC(C=2C(=C(C=3C=CC=CC=3)C=3CCCCCC=3N=2)C2=NNN=N2)=C1 FLIULSGWTQMSHJ-UHFFFAOYSA-N 0.000 claims 1
• VYRYHQHVRYPVMX-UHFFFAOYSA-N 2-(3-fluoropropoxy)-3-(2h-tetrazol-5-yl)-4-thiophen-2-yl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCCCF)=NC=2CCCCCC=2C=1C1=CC=CS1 VYRYHQHVRYPVMX-UHFFFAOYSA-N 0.000 claims 1
• RZSYDTIZEPZPOM-UHFFFAOYSA-N 2-(3-fluoropropoxy)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCCCF)=NC=2CCCCCC=2C=1C1=CC=CC=C1 RZSYDTIZEPZPOM-UHFFFAOYSA-N 0.000 claims 1
• SIYZSVFBXMUCQE-UHFFFAOYSA-N 2-(3-methylpentan-3-yl)-4-(2-methylpyrazol-3-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(CC)CC)=NC=2CCCCCC=2C=1C1=CC=NN1C SIYZSVFBXMUCQE-UHFFFAOYSA-N 0.000 claims 1
• XKAODCUFDQKAKV-UHFFFAOYSA-N 2-(4-methyloxan-4-yl)-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound CC1(CCOCC1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 XKAODCUFDQKAKV-UHFFFAOYSA-N 0.000 claims 1
• KROJPMCRDBDPIB-UHFFFAOYSA-N 2-(diethylamino)-4-phenyl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound OC(=O)C=1C(N(CC)CC)=NC=2CCCCCC=2C=1C1=CC=CC=C1 KROJPMCRDBDPIB-UHFFFAOYSA-N 0.000 claims 1
• KMKPBIQWFFDNRW-UHFFFAOYSA-N 2-(diethylamino)-4-phenyl-6,7-dihydro-5h-cyclopenta[b]pyridine-3-carboxylic acid Chemical compound OC(=O)C=1C(N(CC)CC)=NC=2CCCC=2C=1C1=CC=CC=C1 KMKPBIQWFFDNRW-UHFFFAOYSA-N 0.000 claims 1
• NYIMABBQTUCDGQ-UHFFFAOYSA-N 2-(diethylamino)-6-methyl-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carboxylic acid Chemical compound OC(=O)C=1C(N(CC)CC)=NC=2CCC(C)CC=2C=1C1=CC=CC=C1 NYIMABBQTUCDGQ-UHFFFAOYSA-N 0.000 claims 1
• JDMNKYYXVUPKRA-UHFFFAOYSA-N 2-(furan-2-yl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C=2C=CC=CC=2)=C2CCCCCC2=NC=1C1=CC=CO1 JDMNKYYXVUPKRA-UHFFFAOYSA-N 0.000 claims 1
• XIQPKUQIMSFHAN-UHFFFAOYSA-N 2-(oxan-2-yl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound O1CCCCC1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 XIQPKUQIMSFHAN-UHFFFAOYSA-N 0.000 claims 1
• OMKSTBWEUWLZBV-UHFFFAOYSA-N 2-(oxan-4-yl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1COCCC1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 OMKSTBWEUWLZBV-UHFFFAOYSA-N 0.000 claims 1
• GMIIGYXIPLTNLT-UHFFFAOYSA-N 2-(oxan-4-yloxy)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1COCCC1OC(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 GMIIGYXIPLTNLT-UHFFFAOYSA-N 0.000 claims 1
• LKTDYTMMMWRGSM-UHFFFAOYSA-N 2-(oxolan-2-yl)-4-phenyl-3-(2h-tetrazol-5-yl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine Chemical compound C1CCOC1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCCC2 LKTDYTMMMWRGSM-UHFFFAOYSA-N 0.000 claims 1
• GHEHLUHXAGTOMD-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCOC1COC(C=1C2=NNN=N2)=NC=2CCCCCC=2C=1C1=CC=CC=C1 GHEHLUHXAGTOMD-UHFFFAOYSA-N 0.000 claims 1
• OBALAUSMBMPMPM-UHFFFAOYSA-N 2-(oxolan-3-yl)-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1OCCC1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 OBALAUSMBMPMPM-UHFFFAOYSA-N 0.000 claims 1
• VHFYVRCYNIURMD-OAQYLSRUSA-N 2-[(2R)-2-methyloxolan-2-yl]-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound C[C@@]1(CCCO1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 VHFYVRCYNIURMD-OAQYLSRUSA-N 0.000 claims 1
• QCYGXUDIJYZLOA-JOCHJYFZSA-N 2-[(2S)-2-(methoxymethyl)oxolan-2-yl]-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COC[C@]1(CCCO1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 QCYGXUDIJYZLOA-JOCHJYFZSA-N 0.000 claims 1
• VHFYVRCYNIURMD-NRFANRHFSA-N 2-[(2S)-2-methyloxolan-2-yl]-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound C[C@]1(CCCO1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 VHFYVRCYNIURMD-NRFANRHFSA-N 0.000 claims 1
• AGWJOSPDGVWHQQ-DEOSSOPVSA-N 2-[(2r)-2-(methoxymethyl)oxolan-2-yl]-6,6-dimethyl-4-phenyl-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-quinoline Chemical compound N=1C=2CCC(C)(C)CC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1[C@@]1(COC)CCCO1 AGWJOSPDGVWHQQ-DEOSSOPVSA-N 0.000 claims 1
• HWUMFMACFADNET-JOCHJYFZSA-N 2-[(2r)-2-methyloxolan-2-yl]-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(N=C3CCCCCC3=2)[C@]2(C)OCCC2)C2=NNN=N2)=C1 HWUMFMACFADNET-JOCHJYFZSA-N 0.000 claims 1
• LKTDYTMMMWRGSM-GOSISDBHSA-N 2-[(2r)-oxolan-2-yl]-4-phenyl-3-(2h-tetrazol-5-yl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine Chemical compound C1CCO[C@H]1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCCC2 LKTDYTMMMWRGSM-GOSISDBHSA-N 0.000 claims 1
• SKRDIGRVKJJTFE-QGZVFWFLSA-N 2-[(2r)-oxolan-2-yl]-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCO[C@H]1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 SKRDIGRVKJJTFE-QGZVFWFLSA-N 0.000 claims 1
• AGWJOSPDGVWHQQ-XMMPIXPASA-N 2-[(2s)-2-(methoxymethyl)oxolan-2-yl]-6,6-dimethyl-4-phenyl-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-quinoline Chemical compound N=1C=2CCC(C)(C)CC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1[C@]1(COC)CCCO1 AGWJOSPDGVWHQQ-XMMPIXPASA-N 0.000 claims 1
• HWUMFMACFADNET-QFIPXVFZSA-N 2-[(2s)-2-methyloxolan-2-yl]-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(N=C3CCCCCC3=2)[C@@]2(C)OCCC2)C2=NNN=N2)=C1 HWUMFMACFADNET-QFIPXVFZSA-N 0.000 claims 1
• PCGSOKQXXMJPRX-QFIPXVFZSA-N 2-[(2s)-2-methyloxolan-2-yl]-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1[C@]1(C)CCCO1 PCGSOKQXXMJPRX-QFIPXVFZSA-N 0.000 claims 1
• LKTDYTMMMWRGSM-SFHVURJKSA-N 2-[(2s)-oxolan-2-yl]-4-phenyl-3-(2h-tetrazol-5-yl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine Chemical compound C1CCO[C@@H]1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCCC2 LKTDYTMMMWRGSM-SFHVURJKSA-N 0.000 claims 1
• SKRDIGRVKJJTFE-KRWDZBQOSA-N 2-[(2s)-oxolan-2-yl]-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCO[C@@H]1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 SKRDIGRVKJJTFE-KRWDZBQOSA-N 0.000 claims 1
• YEYKNGNEEYTUMK-MRXNPFEDSA-N 2-[(3R)-oxolan-3-yl]oxy-4-phenyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile Chemical compound N#Cc1c(O[C@@H]2CCOC2)nc2CCCCCc2c1-c1ccccc1 YEYKNGNEEYTUMK-MRXNPFEDSA-N 0.000 claims 1
• MJPZSISLPXGDAR-LBPRGKRZSA-N 2-[(3s)-oxolan-3-yl]oxy-3-(2h-tetrazol-5-yl)-4-thiophen-2-yl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1OCC[C@@H]1OC(C(=C1C=2SC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 MJPZSISLPXGDAR-LBPRGKRZSA-N 0.000 claims 1
• IHTXQPMLPOJRMD-ZDUSSCGKSA-N 2-[(3s)-oxolan-3-yl]oxy-3-(2h-tetrazol-5-yl)-4-thiophen-3-yl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1OCC[C@@H]1OC(C(=C1C2=CSC=C2)C2=NNN=N2)=NC2=C1CCCCC2 IHTXQPMLPOJRMD-ZDUSSCGKSA-N 0.000 claims 1
• POQDPVFCSIPJHR-AWEZNQCLSA-N 2-[(3s)-oxolan-3-yl]oxy-4-phenyl-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound C1OCC[C@@H]1OC(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCC2 POQDPVFCSIPJHR-AWEZNQCLSA-N 0.000 claims 1
• WIXOCDOUGJMLLX-UHFFFAOYSA-N 2-[1-(ethoxymethyl)cyclopentyl]-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound CCOCC1(CCCC1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 WIXOCDOUGJMLLX-UHFFFAOYSA-N 0.000 claims 1
• OZUHHMSUPKSPNJ-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclobutyl]-4-(1-methylpyrazol-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C2=CN(C)N=C2)=C(C2=NNN=N2)C=1C1(COC)CCC1 OZUHHMSUPKSPNJ-UHFFFAOYSA-N 0.000 claims 1
• ZTSMAUXALPPHBC-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclobutyl]-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(C)N=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCC1 ZTSMAUXALPPHBC-UHFFFAOYSA-N 0.000 claims 1
• INPUUAZJEFVBGR-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclobutyl]-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCC1 INPUUAZJEFVBGR-UHFFFAOYSA-N 0.000 claims 1
• RXUPNWFKHLHWHZ-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclohexyl]-4-(1-methylpyrazol-4-yl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COCC1(CCCCC1)C1=NC=2CCCCC=2C(=C1C=1N=NNN=1)C=1C=NN(C=1)C RXUPNWFKHLHWHZ-UHFFFAOYSA-N 0.000 claims 1
• UREKKNCYRWGBIN-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclohexyl]-4-(2-methylpyrazol-3-yl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COCC1(CCCCC1)C1=NC=2CCCCC2C(=C1C=1N=NNN1)C1=CC=NN1C UREKKNCYRWGBIN-UHFFFAOYSA-N 0.000 claims 1
• UECBPSMNNYZGAW-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclohexyl]-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COCC1(CCCCC1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 UECBPSMNNYZGAW-UHFFFAOYSA-N 0.000 claims 1
• LXYKXGQWDLNPKP-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-4-[2-(2,2,2-trifluoroethoxy)pyridin-4-yl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(OCC(F)(F)F)N=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 LXYKXGQWDLNPKP-UHFFFAOYSA-N 0.000 claims 1
• SLCOQROHHGQUTO-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-4-[2-(trifluoromethyl)pyridin-4-yl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(N=CC=2)C(F)(F)F)=C(C2=NNN=N2)C=1C1(COC)CCCC1 SLCOQROHHGQUTO-UHFFFAOYSA-N 0.000 claims 1
• SGLBWANAKYZRHX-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-(1-methylpyrazol-4-yl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COCC1(CCCC1)C1=NC=2CCCCC=2C(=C1C=1N=NNN=1)C=1C=NN(C=1)C SGLBWANAKYZRHX-UHFFFAOYSA-N 0.000 claims 1
• RURURPPJCWEHEK-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-(2-methoxypyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(OC)N=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 RURURPPJCWEHEK-UHFFFAOYSA-N 0.000 claims 1
• ZEPHMANGQUQROP-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-(2-methylpyrazol-3-yl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COCC1(CCCC1)C1=NC=2CCCCC2C(=C1C=1N=NNN1)C1=CC=NN1C ZEPHMANGQUQROP-UHFFFAOYSA-N 0.000 claims 1
• CJYGPIDDMZZSED-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-(2-methylpyrazol-3-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2N(N=CC=2)C)=C(C2=NNN=N2)C=1C1(COC)CCCC1 CJYGPIDDMZZSED-UHFFFAOYSA-N 0.000 claims 1
• HGUQNVMYBMQDSR-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(C)N=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 HGUQNVMYBMQDSR-UHFFFAOYSA-N 0.000 claims 1
• VAFOBLDDPPTUHU-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-(3-methoxyphenyl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COCC1(CCCC1)c1nc2CCCCc2c(-c2cccc(OC)c2)c1-c1nn[nH]n1 VAFOBLDDPPTUHU-UHFFFAOYSA-N 0.000 claims 1
• YOHDBLHUZBKLPH-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-(3-methoxyphenyl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(OC)C=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 YOHDBLHUZBKLPH-UHFFFAOYSA-N 0.000 claims 1
• ORJUFFAEEIZWHH-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-(3-methylsulfonylphenyl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COCC1(CCCC1)C1=NC=2CCCCC2C(=C1C=1N=NNN1)C1=CC(=CC=C1)S(=O)(=O)C ORJUFFAEEIZWHH-UHFFFAOYSA-N 0.000 claims 1
• VWHKBMQDGSONFE-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-(4-methyl-1h-pyrazol-5-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C2=C(C=NN2)C)=C(C2=NNN=N2)C=1C1(COC)CCCC1 VWHKBMQDGSONFE-UHFFFAOYSA-N 0.000 claims 1
• BLGJKHAMKUPWPZ-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COCC1(CCCC1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 BLGJKHAMKUPWPZ-UHFFFAOYSA-N 0.000 claims 1
• RJWOISQJBVAUKN-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-4-phenyl-3-(2H-tetrazol-5-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine Chemical compound COCC1(CCCC1)C1=C(C(=C2C(=N1)CCCCC2)C2=CC=CC=C2)C2=NN=NN2 RJWOISQJBVAUKN-UHFFFAOYSA-N 0.000 claims 1
• INSCOMCXXWKUPZ-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-6-methyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound N=1C=2CCC(C)CC=2C(C=2C=C(C)N=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 INSCOMCXXWKUPZ-UHFFFAOYSA-N 0.000 claims 1
• OGYHUAQNUJEKHA-UHFFFAOYSA-N 2-[1-(methoxymethyl)cyclopentyl]-6-pentyl-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound CCCCCC1CCc2nc(c(-c3nnn[nH]3)c(-c3ccccc3)c2C1)C1(COC)CCCC1 OGYHUAQNUJEKHA-UHFFFAOYSA-N 0.000 claims 1
• RLYXZTMFTVVNEI-UHFFFAOYSA-N 2-[1-(methylsulfonylmethyl)cyclopentyl]-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound CS(=O)(=O)CC1(CCCC1)C1=NC=2CCCCC2C(=C1C=1N=NNN1)C1=CC=CC=C1 RLYXZTMFTVVNEI-UHFFFAOYSA-N 0.000 claims 1
• QCYGXUDIJYZLOA-UHFFFAOYSA-N 2-[2-(methoxymethyl)oxolan-2-yl]-4-phenyl-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound COCC1(CCCO1)c1nc2CCCCc2c(-c2ccccc2)c1-c1nn[nH]n1 QCYGXUDIJYZLOA-UHFFFAOYSA-N 0.000 claims 1
• AGWJOSPDGVWHQQ-UHFFFAOYSA-N 2-[2-(methoxymethyl)oxolan-2-yl]-6,6-dimethyl-4-phenyl-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-quinoline Chemical compound N=1C=2CCC(C)(C)CC=2C(C=2C=CC=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCO1 AGWJOSPDGVWHQQ-UHFFFAOYSA-N 0.000 claims 1
• OQUKULOAUJELFK-UHFFFAOYSA-N 2-[2-[2-cyclopentyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]phenoxy]ethanol Chemical compound OCCOC1=CC=CC=C1C1=C(CCCCC2)C2=NC(C2CCCC2)=C1C1=NNN=N1 OQUKULOAUJELFK-UHFFFAOYSA-N 0.000 claims 1
• YFHQAUDGGDDARN-UHFFFAOYSA-N 2-[3-(methoxymethyl)pentan-3-yl]-4-(2-methylpyrazol-3-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(CC)(COC)CC)=NC=2CCCCCC=2C=1C1=CC=NN1C YFHQAUDGGDDARN-UHFFFAOYSA-N 0.000 claims 1
• OMVOHOYQRYYKKZ-UHFFFAOYSA-N 2-[3-(methoxymethyl)pentan-3-yl]-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(CC)(COC)CC)=NC=2CCCCCC=2C=1C1=CC=CC=C1 OMVOHOYQRYYKKZ-UHFFFAOYSA-N 0.000 claims 1
• VPJWQINFBMRXNE-UHFFFAOYSA-N 2-butan-2-yl-4-(1-methylpyrazol-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)CC)=NC=2CCCCCC=2C=1C=1C=NN(C)C=1 VPJWQINFBMRXNE-UHFFFAOYSA-N 0.000 claims 1
• AOKRNHAOMAMZKH-UHFFFAOYSA-N 2-butan-2-yl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)CC)=NC=2CCCCCC=2C=1C1=CC=NC(C)=C1 AOKRNHAOMAMZKH-UHFFFAOYSA-N 0.000 claims 1
• XBKNWEKAZJTOHN-UHFFFAOYSA-N 2-butan-2-yl-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)CC)=NC=2CCCCCC=2C=1C1=CC=CC=C1 XBKNWEKAZJTOHN-UHFFFAOYSA-N 0.000 claims 1
• LRPBZWZQMWCGGJ-UHFFFAOYSA-N 2-cyclohexyl-4-(2-methylpyrazol-3-yl)-3-(2H-tetrazol-5-yl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinoline Chemical compound C1(CCCCC1)C1=NC=2CCC(CC2C(=C1C=1N=NNN1)C1=CC=NN1C)C(F)(F)F LRPBZWZQMWCGGJ-UHFFFAOYSA-N 0.000 claims 1
• QSTUCEXTEVPQRS-UHFFFAOYSA-N 2-cyclohexyl-4-(2-methylpyrazol-3-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CN1N=CC=C1C1=C(CCCCC2)C2=NC(C2CCCCC2)=C1C1=NNN=N1 QSTUCEXTEVPQRS-UHFFFAOYSA-N 0.000 claims 1
• ALFQKPZYXQRVDU-UHFFFAOYSA-N 2-cyclohexyl-4-(2-methylpyridin-4-yl)-3-(2H-tetrazol-5-yl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinoline Chemical compound Cc1cc(ccn1)-c1c2CC(CCc2nc(C2CCCCC2)c1-c1nn[nH]n1)C(F)(F)F ALFQKPZYXQRVDU-UHFFFAOYSA-N 0.000 claims 1
• AUYLDYJAESOSKN-UHFFFAOYSA-N 2-cyclohexyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound C1=NC(C)=CC(C=2C(=C(C3CCCCC3)N=C3CCCCC3=2)C2=NNN=N2)=C1 AUYLDYJAESOSKN-UHFFFAOYSA-N 0.000 claims 1
• APIAOXWDYDNHGL-UHFFFAOYSA-N 2-cyclohexyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(C3CCCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 APIAOXWDYDNHGL-UHFFFAOYSA-N 0.000 claims 1
• NTWYRWIJHXRLFA-UHFFFAOYSA-N 2-cyclohexyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7-dihydro-5h-cyclopenta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(C3CCCCC3)N=C3CCCC3=2)C2=NNN=N2)=C1 NTWYRWIJHXRLFA-UHFFFAOYSA-N 0.000 claims 1
• OKTFIFZNVGOBEB-UHFFFAOYSA-N 2-cyclohexyl-4-(2-methylpyridin-4-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound C1=NC(C)=CC(C=2C(=C(C3CCCCC3)N=C3CCCCCC3=2)C(O)=O)=C1 OKTFIFZNVGOBEB-UHFFFAOYSA-N 0.000 claims 1
• ZORIWUTWPKHZBS-UHFFFAOYSA-N 2-cyclohexyl-4-(2-methylpyrimidin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CC1=NC=CC(C=2C(=C(C3CCCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=N1 ZORIWUTWPKHZBS-UHFFFAOYSA-N 0.000 claims 1
• QCTMKOKULABDOB-UHFFFAOYSA-N 2-cyclohexyl-4-(3-fluoropyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound FC1=CN=CC=C1C1=C(CCCCC2)C2=NC(C2CCCCC2)=C1C1=NNN=N1 QCTMKOKULABDOB-UHFFFAOYSA-N 0.000 claims 1
• VCQPXLUELLFJHC-UHFFFAOYSA-N 2-cyclohexyl-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCCC1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 VCQPXLUELLFJHC-UHFFFAOYSA-N 0.000 claims 1
• IIISEJQJOJMTSP-UHFFFAOYSA-N 2-cyclohexyl-4-phenyl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=C(C2CCCCC2)N=C2CCCCCC2=C1C1=CC=CC=C1 IIISEJQJOJMTSP-UHFFFAOYSA-N 0.000 claims 1
• BKKVLZZSVLXQAO-UHFFFAOYSA-N 2-cyclohexyl-4-pyrimidin-4-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCCC1C(C(=C1C=2N=CN=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 BKKVLZZSVLXQAO-UHFFFAOYSA-N 0.000 claims 1
• FCSRHKWNBLNTEU-UHFFFAOYSA-N 2-cyclohexyl-6-methyl-4-(2-methylpyrazol-3-yl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound CC1CCc2nc(C3CCCCC3)c(-c3nn[nH]n3)c(-c3ccnn3C)c2C1 FCSRHKWNBLNTEU-UHFFFAOYSA-N 0.000 claims 1
• MQBNWOAKGOMFJO-UHFFFAOYSA-N 2-cyclohexyl-6-methyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound N1=NNN=C1C=1C(C=2C=C(C)N=CC=2)=C2CC(C)CCC2=NC=1C1CCCCC1 MQBNWOAKGOMFJO-UHFFFAOYSA-N 0.000 claims 1
• GJXFAEWMNKWJMO-UHFFFAOYSA-N 2-cyclohexyl-8-ethyl-4-phenyl-6,7-dihydro-5h-1,8-naphthyridine-3-carboxylic acid Chemical compound CCN1CCCC(C(=C2C(O)=O)C=3C=CC=CC=3)=C1N=C2C1CCCCC1 GJXFAEWMNKWJMO-UHFFFAOYSA-N 0.000 claims 1
• IAQOFJXPRWPXAO-UHFFFAOYSA-N 2-cyclopentyl-3-(2h-tetrazol-5-yl)-4-[2-(trifluoromethyl)pyridin-4-yl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C(F)(F)F)=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 IAQOFJXPRWPXAO-UHFFFAOYSA-N 0.000 claims 1
• SFYWKXCUYCQHIQ-UHFFFAOYSA-N 2-cyclopentyl-4-(2-ethylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(CC)=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 SFYWKXCUYCQHIQ-UHFFFAOYSA-N 0.000 claims 1
• AMKPFJLLZLDEDO-UHFFFAOYSA-N 2-cyclopentyl-4-(2-methoxypyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(OC)=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 AMKPFJLLZLDEDO-UHFFFAOYSA-N 0.000 claims 1
• GWNPEPCQBRTAGY-UHFFFAOYSA-N 2-cyclopentyl-4-(2-methylpyrazol-3-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CN1N=CC=C1C1=C(CCCCC2)C2=NC(C2CCCC2)=C1C1=NNN=N1 GWNPEPCQBRTAGY-UHFFFAOYSA-N 0.000 claims 1
• ODPMPFINFBCDSO-UHFFFAOYSA-N 2-cyclopentyl-4-(2-methylpyrazol-3-yl)-3-(2h-tetrazol-5-yl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinoline Chemical compound CN1N=CC=C1C1=C(CC(CC2)C(F)(F)F)C2=NC(C2CCCC2)=C1C1=NNN=N1 ODPMPFINFBCDSO-UHFFFAOYSA-N 0.000 claims 1
• PSPZDBBBDBGJEK-UHFFFAOYSA-N 2-cyclopentyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound C1=NC(C)=CC(C=2C(=C(C3CCCC3)N=C3CCCCC3=2)C2=NNN=N2)=C1 PSPZDBBBDBGJEK-UHFFFAOYSA-N 0.000 claims 1
• OQLIJDYKDUUAOF-UHFFFAOYSA-N 2-cyclopentyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7-dihydro-5h-cyclopenta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(C3CCCC3)N=C3CCCC3=2)C2=NNN=N2)=C1 OQLIJDYKDUUAOF-UHFFFAOYSA-N 0.000 claims 1
• KDJDBKMUYQROIB-UHFFFAOYSA-N 2-cyclopentyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinoline Chemical compound C1=NC(C)=CC(C=2C(=C(C3CCCC3)N=C3CCC(CC3=2)C(F)(F)F)C2=NNN=N2)=C1 KDJDBKMUYQROIB-UHFFFAOYSA-N 0.000 claims 1
• OKDDOXPTKZIUDV-UHFFFAOYSA-N 2-cyclopentyl-4-(2-methylpyrimidin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CC1=NC=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=N1 OKDDOXPTKZIUDV-UHFFFAOYSA-N 0.000 claims 1
• RHIQYYLTNMOHPZ-UHFFFAOYSA-N 2-cyclopentyl-4-(2-propan-2-ylpyrimidin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CC(C)C1=NC=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=N1 RHIQYYLTNMOHPZ-UHFFFAOYSA-N 0.000 claims 1
• SUJJASTXEQXPEQ-UHFFFAOYSA-N 2-cyclopentyl-4-(3-fluoropyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound FC1=CN=CC=C1C1=C(CCCCC2)C2=NC(C2CCCC2)=C1C1=NNN=N1 SUJJASTXEQXPEQ-UHFFFAOYSA-N 0.000 claims 1
• JOMPCSMCZGWBQU-UHFFFAOYSA-N 2-cyclopentyl-4-(6-methoxypyridin-2-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound COC1=CC=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=N1 JOMPCSMCZGWBQU-UHFFFAOYSA-N 0.000 claims 1
• RTQNMAHZDXQVSL-UHFFFAOYSA-N 2-cyclopentyl-4-(6-methoxypyridin-2-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound COC1=CC=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C(O)=O)=N1 RTQNMAHZDXQVSL-UHFFFAOYSA-N 0.000 claims 1
• INLNVKHLOVKNEZ-UHFFFAOYSA-N 2-cyclopentyl-4-(6-methylpyridin-2-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CC1=CC=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=N1 INLNVKHLOVKNEZ-UHFFFAOYSA-N 0.000 claims 1
• LRLDHNJZQZSGJH-UHFFFAOYSA-N 2-cyclopentyl-4-(6-oxo-1h-pyridin-2-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=C(C2CCCC2)N=C2CCCCCC2=C1C1=CC=CC(=O)N1 LRLDHNJZQZSGJH-UHFFFAOYSA-N 0.000 claims 1
• LFMQKGIKEQVNQY-UHFFFAOYSA-N 2-cyclopentyl-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCC1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 LFMQKGIKEQVNQY-UHFFFAOYSA-N 0.000 claims 1
• DWAHKKLYXKZEGZ-UHFFFAOYSA-N 2-cyclopentyl-4-phenyl-3-(2h-tetrazol-5-yl)-6-(2,2,2-trifluoroethyl)-7,8-dihydro-5h-1,6-naphthyridine Chemical compound N1=NNN=C1C=1C(C=2C=CC=CC=2)=C2CN(CC(F)(F)F)CCC2=NC=1C1CCCC1 DWAHKKLYXKZEGZ-UHFFFAOYSA-N 0.000 claims 1
• ACVIIQBYZGWVGS-UHFFFAOYSA-N 2-cyclopentyl-4-phenyl-5,6,7,8-tetrahydroquinoline-3-carboxylic acid Chemical compound OC(=O)C1=C(C2CCCC2)N=C2CCCCC2=C1C1=CC=CC=C1 ACVIIQBYZGWVGS-UHFFFAOYSA-N 0.000 claims 1
• JEJPZWWZBOIXJL-UHFFFAOYSA-N 2-cyclopentyl-4-pyridazin-4-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCC1C(C(=C1C=2C=NN=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 JEJPZWWZBOIXJL-UHFFFAOYSA-N 0.000 claims 1
• SCDHGDXFTPQWLM-UHFFFAOYSA-N 2-cyclopentyl-4-pyridin-2-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCC1C(C(=C1C=2N=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 SCDHGDXFTPQWLM-UHFFFAOYSA-N 0.000 claims 1
• VVSJEHKDDUXEJQ-UHFFFAOYSA-N 2-cyclopentyl-4-pyridin-4-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCC1C(C(=C1C=2C=CN=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 VVSJEHKDDUXEJQ-UHFFFAOYSA-N 0.000 claims 1
• KIPCSTFHWCRJOO-UHFFFAOYSA-N 2-cyclopentyl-4-pyrimidin-2-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCC1C(C(=C1C=2N=CC=CN=2)C2=NNN=N2)=NC2=C1CCCCC2 KIPCSTFHWCRJOO-UHFFFAOYSA-N 0.000 claims 1
• VCFVVCYDXQNFBV-UHFFFAOYSA-N 2-cyclopentyl-4-pyrimidin-4-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCC1C(C(=C1C=2N=CN=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 VCFVVCYDXQNFBV-UHFFFAOYSA-N 0.000 claims 1
• SIFGZFFBXRXVCR-UHFFFAOYSA-N 2-cyclopentyl-6,8-dimethyl-4-phenyl-6,7-dihydro-5h-1,8-naphthyridine-3-carboxylic acid Chemical compound OC(=O)C=1C(C=2C=CC=CC=2)=C2CC(C)CN(C)C2=NC=1C1CCCC1 SIFGZFFBXRXVCR-UHFFFAOYSA-N 0.000 claims 1
• VZTHDEPHPGCZCU-UHFFFAOYSA-N 2-cyclopentyl-6-methoxy-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound N1=NNN=C1C=1C(C=2C=C(C)N=CC=2)=C2CC(OC)CCC2=NC=1C1CCCC1 VZTHDEPHPGCZCU-UHFFFAOYSA-N 0.000 claims 1
• ATSFVNIKDCVVKI-UHFFFAOYSA-N 2-cyclopentyl-8-ethyl-4-phenyl-6,7-dihydro-5h-1,8-naphthyridine-3-carboxylic acid Chemical compound CCN1CCCC(C(=C2C(O)=O)C=3C=CC=CC=3)=C1N=C2C1CCCC1 ATSFVNIKDCVVKI-UHFFFAOYSA-N 0.000 claims 1
• XWFWLDCGNRAQCQ-UHFFFAOYSA-N 2-cyclopentyl-8-ethyl-6-methyl-4-phenyl-6,7-dihydro-5h-1,8-naphthyridine-3-carboxylic acid Chemical compound CCN1CC(C)CC(C(=C2C(O)=O)C=3C=CC=CC=3)=C1N=C2C1CCCC1 XWFWLDCGNRAQCQ-UHFFFAOYSA-N 0.000 claims 1
• WHUCVSGYTZAVMJ-UHFFFAOYSA-N 2-ethoxy-4-(1-methylpyrazol-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCC)=NC=2CCCCCC=2C=1C=1C=NN(C)C=1 WHUCVSGYTZAVMJ-UHFFFAOYSA-N 0.000 claims 1
• NVZGVZGKGGMNLW-UHFFFAOYSA-N 2-ethoxy-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCC)=NC=2CCCCCC=2C=1C1=CC=NC(C)=C1 NVZGVZGKGGMNLW-UHFFFAOYSA-N 0.000 claims 1
• VBHSCPLWNHXRDI-UHFFFAOYSA-N 2-ethoxy-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCC)=NC=2CCCCCC=2C=1C1=CC=CC=C1 VBHSCPLWNHXRDI-UHFFFAOYSA-N 0.000 claims 1
• PHYAEOACIYIZFN-UHFFFAOYSA-N 2-methoxy-4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OC)=NC=2CCCCCC=2C=1C1=CC=CC=C1 PHYAEOACIYIZFN-UHFFFAOYSA-N 0.000 claims 1
• CKMYBOQKUFQYPI-UHFFFAOYSA-N 2-methyl-2-[4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-2-yl]propanoic acid Chemical compound C1=NC(C)=CC(C=2C(=C(N=C3CCCCCC3=2)C(C)(C)C(O)=O)C2=NNN=N2)=C1 CKMYBOQKUFQYPI-UHFFFAOYSA-N 0.000 claims 1
• HKJUOALJBDUXQT-UHFFFAOYSA-N 2-pentan-3-yl-4-(2-propan-2-ylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(CC)CC)=NC=2CCCCCC=2C=1C1=CC=NC(C(C)C)=C1 HKJUOALJBDUXQT-UHFFFAOYSA-N 0.000 claims 1
• CWMHWCOUBYXGCK-UHFFFAOYSA-N 2-piperidin-1-yl-4-pyridin-4-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCCN1C(C(=C1C=2C=CN=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 CWMHWCOUBYXGCK-UHFFFAOYSA-N 0.000 claims 1
• KQOXMLPAMPAGLD-UHFFFAOYSA-N 2-propan-2-yl-3-(2h-tetrazol-5-yl)-4-[2-(2,2,2-trifluoroethoxy)pyridin-4-yl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)C)=NC=2CCCCCC=2C=1C1=CC=NC(OCC(F)(F)F)=C1 KQOXMLPAMPAGLD-UHFFFAOYSA-N 0.000 claims 1
• JMKCACOMURZNMI-UHFFFAOYSA-N 2-propan-2-yl-4-(2-propan-2-ylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C(C)C)=CC(C=2C(=C(C(C)C)N=C3CCCCCC3=2)C2=NNN=N2)=C1 JMKCACOMURZNMI-UHFFFAOYSA-N 0.000 claims 1
• DKJDFLSIZWQBNF-UHFFFAOYSA-N 2-propan-2-yl-4-(2-propan-2-ylpyrimidin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CC(C)C1=NC=CC(C=2C(=C(C(C)C)N=C3CCCCCC3=2)C2=NNN=N2)=N1 DKJDFLSIZWQBNF-UHFFFAOYSA-N 0.000 claims 1
• QOKZHIHSVZPZPZ-UHFFFAOYSA-N 2-propyl-4-pyridin-4-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(CCC)=NC=2CCCCCC=2C=1C1=CC=NC=C1 QOKZHIHSVZPZPZ-UHFFFAOYSA-N 0.000 claims 1
• DTQWOXITSNCPEX-UHFFFAOYSA-N 2-tert-butyl-3-(2h-tetrazol-5-yl)-4-(2h-triazol-4-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCCCCC=2C=1C=1C=NNN=1 DTQWOXITSNCPEX-UHFFFAOYSA-N 0.000 claims 1
• DLAJMXPQEAMMGI-UHFFFAOYSA-N 2-tert-butyl-3-(2h-tetrazol-5-yl)-4-[3-(trifluoromethyl)phenyl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCCCCC=2C=1C1=CC=CC(C(F)(F)F)=C1 DLAJMXPQEAMMGI-UHFFFAOYSA-N 0.000 claims 1
• OYPZEJPTDCOLIH-UHFFFAOYSA-N 2-tert-butyl-3-(2h-tetrazol-5-yl)-4-[4-(trifluoromethyl)phenyl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCCCCC=2C=1C1=CC=C(C(F)(F)F)C=C1 OYPZEJPTDCOLIH-UHFFFAOYSA-N 0.000 claims 1
• UVLMRTNHHYYTHS-UHFFFAOYSA-N 2-tert-butyl-3-(2h-tetrazol-5-yl)-4-[5-(trifluoromethyl)-1h-imidazol-2-yl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCCCCC=2C=1C1=NC=C(C(F)(F)F)N1 UVLMRTNHHYYTHS-UHFFFAOYSA-N 0.000 claims 1
• JMRDCLUEOAGDDT-UHFFFAOYSA-N 2-tert-butyl-4-(1-methylpyrazol-3-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CN1C=CC(C=2C(=C(N=C3CCCCCC3=2)C(C)(C)C)C2=NNN=N2)=N1 JMRDCLUEOAGDDT-UHFFFAOYSA-N 0.000 claims 1
• GQQKRBGJEPXQTG-UHFFFAOYSA-N 2-tert-butyl-4-(1-methylpyrazol-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NN(C)C=C1C1=C(CCCCC2)C2=NC(C(C)(C)C)=C1C1=NNN=N1 GQQKRBGJEPXQTG-UHFFFAOYSA-N 0.000 claims 1
• DHQXEXXDGVADOH-UHFFFAOYSA-N 2-tert-butyl-4-(2-butyl-1h-imidazol-5-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1C(CCCC)=NC=C1C1=C(CCCCC2)C2=NC(C(C)(C)C)=C1C1=NNN=N1 DHQXEXXDGVADOH-UHFFFAOYSA-N 0.000 claims 1
• BRGNTCLMIAAERJ-UHFFFAOYSA-N 2-tert-butyl-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(N=C3CCCCCC3=2)C(C)(C)C)C2=NNN=N2)=C1 BRGNTCLMIAAERJ-UHFFFAOYSA-N 0.000 claims 1
• JRBZTFPVRIITFG-UHFFFAOYSA-N 2-tert-butyl-4-(3-fluorophenyl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCCCCC=2C=1C1=CC=CC(F)=C1 JRBZTFPVRIITFG-UHFFFAOYSA-N 0.000 claims 1
• RJSFXJGEBPFAMM-UHFFFAOYSA-N 2-tert-butyl-4-(4-chloro-1h-pyrazol-5-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCCCCC=2C=1C=1NN=CC=1Cl RJSFXJGEBPFAMM-UHFFFAOYSA-N 0.000 claims 1
• RFEVJWFFJKXVRG-UHFFFAOYSA-N 2-tert-butyl-4-(4-fluorophenyl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCCCCC=2C=1C1=CC=C(F)C=C1 RFEVJWFFJKXVRG-UHFFFAOYSA-N 0.000 claims 1
• QZCCGYFTJUEGCX-UHFFFAOYSA-N 2-tert-butyl-4-(4-methyl-1h-pyrazol-5-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NNC(C=2C(=C(N=C3CCCCCC3=2)C(C)(C)C)C2=NNN=N2)=C1C QZCCGYFTJUEGCX-UHFFFAOYSA-N 0.000 claims 1
• XMMBSJNJJMPFSS-UHFFFAOYSA-N 2-tert-butyl-4-(5-cyclopropyl-1h-pyrazol-3-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCCCCC=2C=1C(=NN1)C=C1C1CC1 XMMBSJNJJMPFSS-UHFFFAOYSA-N 0.000 claims 1
• AKRFMHIOGBFVLJ-UHFFFAOYSA-N 2-tert-butyl-4-phenyl-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-thiopyrano[4,3-b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCSCC=2C=1C1=CC=CC=C1 AKRFMHIOGBFVLJ-UHFFFAOYSA-N 0.000 claims 1
• PLFARTPSBGQNAE-UHFFFAOYSA-N 2-tert-butyl-6,6-difluoro-4-(1-methylpyrazol-4-yl)-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound C(C)(C)(C)C1=NC=2CCC(CC2C(=C1C1=NN=NN1)C=1C=NN(C1)C)(F)F PLFARTPSBGQNAE-UHFFFAOYSA-N 0.000 claims 1
• BXKGMCVNVZSTTE-UHFFFAOYSA-N 2-tert-butyl-6,6-difluoro-4-(2-methylpyrazol-3-yl)-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-quinoline Chemical compound CN1N=CC=C1C1=C(CC(F)(F)CC2)C2=NC(C(C)(C)C)=C1C1=NNN=N1 BXKGMCVNVZSTTE-UHFFFAOYSA-N 0.000 claims 1
• VXBRAZDBRHOVEW-UHFFFAOYSA-N 2-tert-butyl-6,6-difluoro-4-(2-methylpyridin-4-yl)-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-quinoline Chemical compound C1=NC(C)=CC(C=2C(=C(N=C3CCC(F)(F)CC3=2)C(C)(C)C)C2=NNN=N2)=C1 VXBRAZDBRHOVEW-UHFFFAOYSA-N 0.000 claims 1
• XCHROEVYLYHEQX-UHFFFAOYSA-N 2-tert-butyl-7,7-dimethyl-4-phenyl-3-(2h-tetrazol-5-yl)-5,6-dihydrocyclopenta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC(C(CC2)(C)C)=C2C=1C1=CC=CC=C1 XCHROEVYLYHEQX-UHFFFAOYSA-N 0.000 claims 1
• LIIAPYNHOFIBPI-UHFFFAOYSA-N 2-tert-butyl-8,8-dimethyl-4-(1-methylpyrazol-4-yl)-3-(2H-tetrazol-5-yl)-6,7-dihydro-5H-quinoline Chemical compound Cn1cc(cn1)-c1c2CCCC(C)(C)c2nc(c1-c1nnn[nH]1)C(C)(C)C LIIAPYNHOFIBPI-UHFFFAOYSA-N 0.000 claims 1
• PXGNKCSKFYXMIQ-UHFFFAOYSA-N 2-tert-butyl-8,8-dimethyl-4-(2-methylpyridin-4-yl)-3-(2H-tetrazol-5-yl)-6,7-dihydro-5H-quinoline Chemical compound Cc1cc(ccn1)-c1c2CCCC(C)(C)c2nc(c1-c1nnn[nH]1)C(C)(C)C PXGNKCSKFYXMIQ-UHFFFAOYSA-N 0.000 claims 1
• RBTOEELWTAQUML-UHFFFAOYSA-N 2-tert-butyl-8,8-dimethyl-4-phenyl-3-(2h-tetrazol-5-yl)-6,7-dihydro-5h-quinoline Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC(C(CCC2)(C)C)=C2C=1C1=CC=CC=C1 RBTOEELWTAQUML-UHFFFAOYSA-N 0.000 claims 1
• JOWMPMUVXICZFS-UHFFFAOYSA-N 3-[2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-2-methylphenol Chemical compound N=1C=2CCCCCC=2C(C=2C(=C(O)C=CC=2)C)=C(C2=NNN=N2)C=1C1(COC)CCCC1 JOWMPMUVXICZFS-UHFFFAOYSA-N 0.000 claims 1
• ZAKUXPKAPWYKQK-UHFFFAOYSA-N 3h-oxathiadiazole Chemical compound N1SOC=N1 ZAKUXPKAPWYKQK-UHFFFAOYSA-N 0.000 claims 1
• JRBYDYSKISGXFK-UHFFFAOYSA-N 4-(1,5-dimethylpyrazol-4-yl)-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NN(C)C(C)=C1C1=C(CCCCC2)C2=NC(N2CCCCC2)=C1C1=NNN=N1 JRBYDYSKISGXFK-UHFFFAOYSA-N 0.000 claims 1
• YPMADWBWOKLRTD-UHFFFAOYSA-N 4-(1,5-dimethylpyrazol-4-yl)-n,n-diethyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-2-amine Chemical compound N1=NNN=C1C=1C(N(CC)CC)=NC=2CCCCCC=2C=1C=1C=NN(C)C=1C YPMADWBWOKLRTD-UHFFFAOYSA-N 0.000 claims 1
• KGEGRRWBIPKMPW-UHFFFAOYSA-N 4-(1-methylpyrazol-4-yl)-2-propan-2-yloxy-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OC(C)C)=NC=2CCCCCC=2C=1C=1C=NN(C)C=1 KGEGRRWBIPKMPW-UHFFFAOYSA-N 0.000 claims 1
• YFNFKIFIHBSWPG-UHFFFAOYSA-N 4-(1h-indazol-4-yl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=3C=NNC=3C=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 YFNFKIFIHBSWPG-UHFFFAOYSA-N 0.000 claims 1
• LXJYWJVGYLQGIZ-UHFFFAOYSA-N 4-(1h-indol-4-yl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=3C=CNC=3C=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 LXJYWJVGYLQGIZ-UHFFFAOYSA-N 0.000 claims 1
• HTWYPWBSBFFSLC-UHFFFAOYSA-N 4-(2-chloropyridin-4-yl)-2-(1-methoxycyclopentyl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(Cl)N=CC=2)=C(C2=NNN=N2)C=1C1(OC)CCCC1 HTWYPWBSBFFSLC-UHFFFAOYSA-N 0.000 claims 1
• RYDAPYSOTWCKCZ-OAHLLOKOSA-N 4-(2-chloropyridin-4-yl)-2-[(2r)-oxolan-2-yl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(Cl)=CC(C=2C(=C([C@@H]3OCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 RYDAPYSOTWCKCZ-OAHLLOKOSA-N 0.000 claims 1
• RYDAPYSOTWCKCZ-HNNXBMFYSA-N 4-(2-chloropyridin-4-yl)-2-[(2s)-oxolan-2-yl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(Cl)=CC(C=2C(=C([C@H]3OCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 RYDAPYSOTWCKCZ-HNNXBMFYSA-N 0.000 claims 1
• QWCITHMADIHGPM-UHFFFAOYSA-N 4-(2-chloropyridin-4-yl)-2-cyclopentyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(Cl)=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 QWCITHMADIHGPM-UHFFFAOYSA-N 0.000 claims 1
• FYSGNFHXVQCQLC-UHFFFAOYSA-N 4-(2-ethoxypyridin-4-yl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(OCC)=CC(C=2C(=C(N=C3CCCCCC3=2)C2(COC)CCCC2)C2=NNN=N2)=C1 FYSGNFHXVQCQLC-UHFFFAOYSA-N 0.000 claims 1
• CBEZILOOYNJUOT-UHFFFAOYSA-N 4-(2-ethoxypyridin-4-yl)-2-propan-2-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(OCC)=CC(C=2C(=C(C(C)C)N=C3CCCCCC3=2)C2=NNN=N2)=C1 CBEZILOOYNJUOT-UHFFFAOYSA-N 0.000 claims 1
• FKBUQDHUIVUPSG-UHFFFAOYSA-N 4-(2-ethylpyridin-4-yl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(CC)=CC(C=2C(=C(N=C3CCCCCC3=2)C2(COC)CCCC2)C2=NNN=N2)=C1 FKBUQDHUIVUPSG-UHFFFAOYSA-N 0.000 claims 1
• AIZWGGUDCKHBQJ-UHFFFAOYSA-N 4-(2-ethylpyridin-4-yl)-2-propan-2-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(CC)=CC(C=2C(=C(C(C)C)N=C3CCCCCC3=2)C2=NNN=N2)=C1 AIZWGGUDCKHBQJ-UHFFFAOYSA-N 0.000 claims 1
• DRRUGEMEMSDNHA-UHFFFAOYSA-N 4-(2-fluoro-5-methoxyphenyl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C(=CC=C(OC)C=2)F)=C(C2=NNN=N2)C=1C1(COC)CCCC1 DRRUGEMEMSDNHA-UHFFFAOYSA-N 0.000 claims 1
• GBZKPCZFXWLMOU-UHFFFAOYSA-N 4-(2-fluorophenyl)-2-(2-methoxyethoxy)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCCOC)=NC=2CCCCCC=2C=1C1=CC=CC=C1F GBZKPCZFXWLMOU-UHFFFAOYSA-N 0.000 claims 1
• YDFOPOKSLGHOSQ-ZDUSSCGKSA-N 4-(2-fluorophenyl)-2-[(3s)-oxolan-3-yl]oxy-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound FC1=CC=CC=C1C1=C(CCCCC2)C2=NC(O[C@@H]2COCC2)=C1C1=NNN=N1 YDFOPOKSLGHOSQ-ZDUSSCGKSA-N 0.000 claims 1
• ONANKYNVCYXUOO-UHFFFAOYSA-N 4-(2-methoxypyridin-4-yl)-2-(1-methylcyclopentyl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(OC)=CC(C=2C(=C(N=C3CCCCCC3=2)C2(C)CCCC2)C2=NNN=N2)=C1 ONANKYNVCYXUOO-UHFFFAOYSA-N 0.000 claims 1
• FPXJTUIQMQLMJM-UHFFFAOYSA-N 4-(2-methylpyrazol-3-yl)-2-pentan-3-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(C(CC)CC)=NC=2CCCCCC=2C=1C1=CC=NN1C FPXJTUIQMQLMJM-UHFFFAOYSA-N 0.000 claims 1
• BMOIFGWCNJOFJR-UHFFFAOYSA-N 4-(2-methylpyrazol-3-yl)-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine Chemical compound CN1N=CC=C1C1=C(CCCCCC2)C2=NC(N2CCCCC2)=C1C1=NNN=N1 BMOIFGWCNJOFJR-UHFFFAOYSA-N 0.000 claims 1
• CNLUPGWMVQHHEN-UHFFFAOYSA-N 4-(2-methylpyrazol-3-yl)-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound CN1N=CC=C1C1=C(CCCCC2)C2=NC(N2CCCCC2)=C1C1=NNN=N1 CNLUPGWMVQHHEN-UHFFFAOYSA-N 0.000 claims 1
• AICJGIDXUUSAFL-UHFFFAOYSA-N 4-(2-methylpyridin-4-yl)-2-(oxan-4-yloxy)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(OC3CCOCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 AICJGIDXUUSAFL-UHFFFAOYSA-N 0.000 claims 1
• NIXLPJQLGRRRME-AWEZNQCLSA-N 4-(2-methylpyridin-4-yl)-2-[(3S)-oxolan-3-yl]oxy-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound Cc1cc(ccn1)-c1c2CCCCc2nc(O[C@H]2CCOC2)c1-c1nnn[nH]1 NIXLPJQLGRRRME-AWEZNQCLSA-N 0.000 claims 1
• NITSHOLVUJTFGA-HNNXBMFYSA-N 4-(2-methylpyridin-4-yl)-2-[(3s)-oxolan-3-yl]oxy-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1=NC(C)=CC(C=2C(=C(O[C@@H]3COCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 NITSHOLVUJTFGA-HNNXBMFYSA-N 0.000 claims 1
• QEYQTGGHGTWZGD-UHFFFAOYSA-N 4-(3,5-difluorophenyl)-2-(2-methoxyethoxy)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCCOC)=NC=2CCCCCC=2C=1C1=CC(F)=CC(F)=C1 QEYQTGGHGTWZGD-UHFFFAOYSA-N 0.000 claims 1
• DGTPISJBOUAIOU-HNNXBMFYSA-N 4-(3,5-difluorophenyl)-2-[(3s)-oxolan-3-yl]oxy-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound FC1=CC(F)=CC(C=2C(=C(O[C@@H]3COCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 DGTPISJBOUAIOU-HNNXBMFYSA-N 0.000 claims 1
• XADGHCPXCCWMPX-UHFFFAOYSA-N 4-(3-chlorophenyl)-2-(1-methylcyclopentyl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(Cl)C=CC=2)=C(C2=NNN=N2)C=1C1(C)CCCC1 XADGHCPXCCWMPX-UHFFFAOYSA-N 0.000 claims 1
• UNUUBVANNDDCET-UHFFFAOYSA-N 4-(3-chlorophenyl)-2-(2-methyloxolan-2-yl)-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound CC1(CCCO1)c1nc2CCCCc2c(-c2cccc(Cl)c2)c1-c1nn[nH]n1 UNUUBVANNDDCET-UHFFFAOYSA-N 0.000 claims 1
• HWCUGAZUHIXZAQ-UHFFFAOYSA-N 4-(3-chlorophenyl)-2-(2-methyloxolan-2-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(Cl)C=CC=2)=C(C2=NNN=N2)C=1C1(C)CCCO1 HWCUGAZUHIXZAQ-UHFFFAOYSA-N 0.000 claims 1
• HWCUGAZUHIXZAQ-JOCHJYFZSA-N 4-(3-chlorophenyl)-2-[(2r)-2-methyloxolan-2-yl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(Cl)C=CC=2)=C(C2=NNN=N2)C=1[C@@]1(C)CCCO1 HWCUGAZUHIXZAQ-JOCHJYFZSA-N 0.000 claims 1
• HWCUGAZUHIXZAQ-QFIPXVFZSA-N 4-(3-chlorophenyl)-2-[(2s)-2-methyloxolan-2-yl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(Cl)C=CC=2)=C(C2=NNN=N2)C=1[C@]1(C)CCCO1 HWCUGAZUHIXZAQ-QFIPXVFZSA-N 0.000 claims 1
• OZVJPHIWEUAMIC-UHFFFAOYSA-N 4-(3-chlorophenyl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(Cl)C=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 OZVJPHIWEUAMIC-UHFFFAOYSA-N 0.000 claims 1
• VGOPZSQPYBXWKT-UHFFFAOYSA-N 4-(3-chlorophenyl)-2-[2-(methoxymethyl)oxolan-2-yl]-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound ClC=1C=C(C=CC1)C1=C(C(=NC=2CCCCC12)C1(OCCC1)COC)C=1N=NNN1 VGOPZSQPYBXWKT-UHFFFAOYSA-N 0.000 claims 1
• MROZBRKRRBXONJ-UHFFFAOYSA-N 4-(3-chlorophenyl)-2-cyclobutyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound ClC1=CC=CC(C=2C(=C(C3CCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 MROZBRKRRBXONJ-UHFFFAOYSA-N 0.000 claims 1
• QMFGUFQMACWJPU-UHFFFAOYSA-N 4-(3-chlorophenyl)-2-cyclohexyl-8-ethyl-6,7-dihydro-5h-1,8-naphthyridine-3-carboxylic acid Chemical compound CCN1CCCC(C(=C2C(O)=O)C=3C=C(Cl)C=CC=3)=C1N=C2C1CCCCC1 QMFGUFQMACWJPU-UHFFFAOYSA-N 0.000 claims 1
• BVHQFMWLDSVERO-UHFFFAOYSA-N 4-(3-chlorophenyl)-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound ClC1=CC=CC(C=2C(=C(N3CCCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 BVHQFMWLDSVERO-UHFFFAOYSA-N 0.000 claims 1
• HTWUZADYUQQKCT-UHFFFAOYSA-N 4-(3-chlorophenyl)-6-methyl-2-piperidin-1-yl-5,6,7,8-tetrahydroquinoline-3-carboxylic acid Chemical compound OC(=O)C=1C(C=2C=C(Cl)C=CC=2)=C2CC(C)CCC2=NC=1N1CCCCC1 HTWUZADYUQQKCT-UHFFFAOYSA-N 0.000 claims 1
• ZIWCOTIWBPHJNA-UHFFFAOYSA-N 4-(3-chlorophenyl)-6-methyl-2-pyrrolidin-1-yl-5,6,7,8-tetrahydroquinoline-3-carboxylic acid Chemical compound OC(=O)C=1C(C=2C=C(Cl)C=CC=2)=C2CC(C)CCC2=NC=1N1CCCC1 ZIWCOTIWBPHJNA-UHFFFAOYSA-N 0.000 claims 1
• QAZAPXKVOMPSTG-UHFFFAOYSA-N 4-(3-fluorophenyl)-2-(2-methoxyethoxy)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OCCOC)=NC=2CCCCCC=2C=1C1=CC=CC(F)=C1 QAZAPXKVOMPSTG-UHFFFAOYSA-N 0.000 claims 1
• PXXYHTYXAMPVKE-AWEZNQCLSA-N 4-(3-fluorophenyl)-2-[(3S)-oxolan-3-yl]oxy-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound FC=1C=C(C=CC1)C1=C(C(=NC=2CCCCC12)O[C@@H]1COCC1)C1=NN=NN1 PXXYHTYXAMPVKE-AWEZNQCLSA-N 0.000 claims 1
• ZQDNHWXQDPSXDK-HNNXBMFYSA-N 4-(3-fluorophenyl)-2-[(3s)-oxolan-3-yl]oxy-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound FC1=CC=CC(C=2C(=C(O[C@@H]3COCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 ZQDNHWXQDPSXDK-HNNXBMFYSA-N 0.000 claims 1
• OZDMLDDGOLEVLM-UHFFFAOYSA-N 4-(3-fluoropyridin-4-yl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C(=CN=CC=2)F)=C(C2=NNN=N2)C=1C1(COC)CCCC1 OZDMLDDGOLEVLM-UHFFFAOYSA-N 0.000 claims 1
• QIPDFGZPWXTBJN-UHFFFAOYSA-N 4-(3-methoxyphenyl)-2-(2-methyloxolan-2-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound COC1=CC=CC(C=2C(=C(N=C3CCCCCC3=2)C2(C)OCCC2)C2=NNN=N2)=C1 QIPDFGZPWXTBJN-UHFFFAOYSA-N 0.000 claims 1
• QIPDFGZPWXTBJN-HSZRJFAPSA-N 4-(3-methoxyphenyl)-2-[(2r)-2-methyloxolan-2-yl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound COC1=CC=CC(C=2C(=C(N=C3CCCCCC3=2)[C@]2(C)OCCC2)C2=NNN=N2)=C1 QIPDFGZPWXTBJN-HSZRJFAPSA-N 0.000 claims 1
• QIPDFGZPWXTBJN-QHCPKHFHSA-N 4-(3-methoxyphenyl)-2-[(2s)-2-methyloxolan-2-yl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound COC1=CC=CC(C=2C(=C(N=C3CCCCCC3=2)[C@@]2(C)OCCC2)C2=NNN=N2)=C1 QIPDFGZPWXTBJN-QHCPKHFHSA-N 0.000 claims 1
• IQNVRRMFSRDRQV-QHCPKHFHSA-N 4-(4-fluoro-3-methoxyphenyl)-2-[(2R)-2-(methoxymethyl)oxolan-2-yl]-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound FC1=C(C=C(C=C1)C1=C(C(=NC=2CCCCC12)[C@@]1(OCCC1)COC)C=1N=NNN1)OC IQNVRRMFSRDRQV-QHCPKHFHSA-N 0.000 claims 1
• IQNVRRMFSRDRQV-HSZRJFAPSA-N 4-(4-fluoro-3-methoxyphenyl)-2-[(2S)-2-(methoxymethyl)oxolan-2-yl]-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound FC1=C(C=C(C=C1)C1=C(C(=NC=2CCCCC12)[C@]1(OCCC1)COC)C=1N=NNN1)OC IQNVRRMFSRDRQV-HSZRJFAPSA-N 0.000 claims 1
• MBRJDYWPYGWCHE-UHFFFAOYSA-N 4-(4-fluoro-3-methoxyphenyl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=C(OC)C(F)=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 MBRJDYWPYGWCHE-UHFFFAOYSA-N 0.000 claims 1
• IQNVRRMFSRDRQV-UHFFFAOYSA-N 4-(4-fluoro-3-methoxyphenyl)-2-[2-(methoxymethyl)oxolan-2-yl]-3-(2H-tetrazol-5-yl)-5,6,7,8-tetrahydroquinoline Chemical compound FC1=C(C=C(C=C1)C1=C(C(=NC=2CCCCC12)C1(OCCC1)COC)C=1N=NNN1)OC IQNVRRMFSRDRQV-UHFFFAOYSA-N 0.000 claims 1
• YGNHBACRONMXMU-UHFFFAOYSA-N 4-(4-fluorophenyl)-2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N=1C=2CCCCCC=2C(C=2C=CC(F)=CC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 YGNHBACRONMXMU-UHFFFAOYSA-N 0.000 claims 1
• MRWSWOQTGWABSN-UHFFFAOYSA-N 4-(4-fluorophenyl)-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-7,8-dihydro-5h-pyrano[4,3-b]pyridine Chemical compound C1=CC(F)=CC=C1C1=C(COCC2)C2=NC(N2CCCCC2)=C1C1=NNN=N1 MRWSWOQTGWABSN-UHFFFAOYSA-N 0.000 claims 1
• AMYLNHIDFFGZLC-UHFFFAOYSA-N 4-(5-chlorothiophen-2-yl)-2-(3,3-difluoroazetidin-1-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1C(F)(F)CN1C(C(=C1C=2SC(Cl)=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 AMYLNHIDFFGZLC-UHFFFAOYSA-N 0.000 claims 1
• QQDMOLDRGBWHQJ-UHFFFAOYSA-N 4-(5-chlorothiophen-2-yl)-2-(3,3-difluoropiperidin-1-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1C(F)(F)CCCN1C(C(=C1C=2SC(Cl)=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 QQDMOLDRGBWHQJ-UHFFFAOYSA-N 0.000 claims 1
• LTHQOKZSGYLFLF-UHFFFAOYSA-N 4-(5-chlorothiophen-2-yl)-2-(3,3-difluoropyrrolidin-1-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1C(F)(F)CCN1C(C(=C1C=2SC(Cl)=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 LTHQOKZSGYLFLF-UHFFFAOYSA-N 0.000 claims 1
• QFTHCHFNYQZIRA-UHFFFAOYSA-N 4-(5-chlorothiophen-2-yl)-2-(3-fluoropiperidin-1-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1C(F)CCCN1C(C(=C1C=2SC(Cl)=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 QFTHCHFNYQZIRA-UHFFFAOYSA-N 0.000 claims 1
• HMUGVVJBFHJUSR-UHFFFAOYSA-N 4-(5-chlorothiophen-2-yl)-2-(4,4-difluoropiperidin-1-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CC(F)(F)CCN1C(C(=C1C=2SC(Cl)=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 HMUGVVJBFHJUSR-UHFFFAOYSA-N 0.000 claims 1
• IVPJUDIYSBSOPG-UHFFFAOYSA-N 4-(5-chlorothiophen-2-yl)-2-(4-fluoropiperidin-1-yl)-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CC(F)CCN1C(C(=C1C=2SC(Cl)=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 IVPJUDIYSBSOPG-UHFFFAOYSA-N 0.000 claims 1
• MFNYIKFYHRLQFU-UHFFFAOYSA-N 4-(5-chlorothiophen-2-yl)-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound S1C(Cl)=CC=C1C1=C(CCCCC2)C2=NC(N2CCCCC2)=C1C1=NNN=N1 MFNYIKFYHRLQFU-UHFFFAOYSA-N 0.000 claims 1
• BTENNZIKZWUXIV-UHFFFAOYSA-N 4-(5-chlorothiophen-2-yl)-3-(2h-tetrazol-5-yl)-2-[4-(trifluoromethyl)piperidin-1-yl]-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CC(C(F)(F)F)CCN1C(C(=C1C=2SC(Cl)=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 BTENNZIKZWUXIV-UHFFFAOYSA-N 0.000 claims 1
• JVYSPRUPGGZRIT-UHFFFAOYSA-N 4-(5-methylfuran-2-yl)-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound O1C(C)=CC=C1C1=C(CCCCC2)C2=NC(N2CCCCC2)=C1C1=NNN=N1 JVYSPRUPGGZRIT-UHFFFAOYSA-N 0.000 claims 1
• TYSIIBIGJRCQCO-UHFFFAOYSA-N 4-[2-[1-(methoxymethyl)cyclopentyl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-2-methyl-1,3-oxazole Chemical compound N=1C=2CCCCCC=2C(C=2N=C(C)OC=2)=C(C2=NNN=N2)C=1C1(COC)CCCC1 TYSIIBIGJRCQCO-UHFFFAOYSA-N 0.000 claims 1
• SMCNTVICQHXGND-UHFFFAOYSA-N 4-[2-cyclohexyl-3-(2H-tetrazol-5-yl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinolin-4-yl]-3,5-dimethyl-1,2-oxazole Chemical compound C1(CCCCC1)C1=NC=2CCC(CC2C(=C1C=1N=NNN1)C=1C(=NOC1C)C)C(F)(F)F SMCNTVICQHXGND-UHFFFAOYSA-N 0.000 claims 1
• UWQXRZZLSVPOKB-UHFFFAOYSA-N 4-[2-cyclohexyl-6-methyl-3-(2h-tetrazol-5-yl)-5,6,7,8-tetrahydroquinolin-4-yl]-3,5-dimethyl-1,2-oxazole Chemical compound N1=NNN=C1C=1C(C2=C(ON=C2C)C)=C2CC(C)CCC2=NC=1C1CCCCC1 UWQXRZZLSVPOKB-UHFFFAOYSA-N 0.000 claims 1
• JDRDRUSGJUHXNY-UHFFFAOYSA-N 4-[2-cyclopentyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-n-methylpyridin-2-amine Chemical compound C1=NC(NC)=CC(C=2C(=C(C3CCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 JDRDRUSGJUHXNY-UHFFFAOYSA-N 0.000 claims 1
• JPGPZEUPIUXDAK-UHFFFAOYSA-N 4-[2-tert-butyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-1,3-oxazole Chemical compound N1=NNN=C1C=1C(C(C)(C)C)=NC=2CCCCCC=2C=1C1=COC=N1 JPGPZEUPIUXDAK-UHFFFAOYSA-N 0.000 claims 1
• KMCWSNIUUARCDR-UHFFFAOYSA-N 4-[2-tert-butyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-2-methyl-1,3-oxazole Chemical compound O1C(C)=NC(C=2C(=C(N=C3CCCCCC3=2)C(C)(C)C)C2=NNN=N2)=C1 KMCWSNIUUARCDR-UHFFFAOYSA-N 0.000 claims 1
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
• RBFZGBQGNUJXDZ-UHFFFAOYSA-N 4-methyl-5-[2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-1,3-thiazole Chemical compound N1=CSC(C=2C(=C(N3CCCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1C RBFZGBQGNUJXDZ-UHFFFAOYSA-N 0.000 claims 1
• JENSQXGUFVBDBE-LMOVPXPDSA-N 4-phenyl-2-[(2s)-pyrrolidin-2-yl]-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.C1CCN[C@@H]1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 JENSQXGUFVBDBE-LMOVPXPDSA-N 0.000 claims 1
• KMNMSAMGORIHGL-UHFFFAOYSA-N 4-phenyl-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound C1CCCCN1C(C(=C1C=2C=CC=CC=2)C2=NNN=N2)=NC2=C1CCCCC2 KMNMSAMGORIHGL-UHFFFAOYSA-N 0.000 claims 1
• WFDHAXQWFFFPMS-UHFFFAOYSA-N 4-phenyl-2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinoline Chemical compound N1=NNN=C1C=1C(C=2C=CC=CC=2)=C2CC(C(F)(F)F)CCC2=NC=1N1CCCCC1 WFDHAXQWFFFPMS-UHFFFAOYSA-N 0.000 claims 1
• NRQAJJFGXQWIDN-UHFFFAOYSA-N 4-phenyl-2-piperidin-1-yl-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=C(N2CCCCC2)N=C2CCCCCC2=C1C1=CC=CC=C1 NRQAJJFGXQWIDN-UHFFFAOYSA-N 0.000 claims 1
• ZIFUULKFPABUEY-UHFFFAOYSA-N 4-phenyl-2-piperidin-1-yl-6,7-dihydro-5h-cyclopenta[b]pyridine-3-carboxylic acid Chemical compound OC(=O)C1=C(N2CCCCC2)N=C2CCCC2=C1C1=CC=CC=C1 ZIFUULKFPABUEY-UHFFFAOYSA-N 0.000 claims 1
• DQCYOCBJOXCZAL-UHFFFAOYSA-N 4-phenyl-2-propan-2-yloxy-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridine Chemical compound N1=NNN=C1C=1C(OC(C)C)=NC=2CCCCCC=2C=1C1=CC=CC=C1 DQCYOCBJOXCZAL-UHFFFAOYSA-N 0.000 claims 1
• BSJQCKPPSOLHSC-UHFFFAOYSA-N 4-phenyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-2-amine Chemical compound N1=NNN=C1C=1C(N)=NC=2CCCCCC=2C=1C1=CC=CC=C1 BSJQCKPPSOLHSC-UHFFFAOYSA-N 0.000 claims 1
• NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 claims 1
• ZXJRSRBAAFQYLU-UHFFFAOYSA-N 5-(6-methyl-4-phenyl-2-piperidin-1-yl-5,6,7,8-tetrahydroquinolin-3-yl)-3h-1,3,4-oxadiazole-2-thione Chemical compound N=1NC(=S)OC=1C=1C(C=2C=CC=CC=2)=C2CC(C)CCC2=NC=1N1CCCCC1 ZXJRSRBAAFQYLU-UHFFFAOYSA-N 0.000 claims 1
• VMDZGTTYEVPCAX-UHFFFAOYSA-N 5-[2-cyclobutyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-1-methylpyridin-2-one Chemical compound C1=CC(=O)N(C)C=C1C1=C(CCCCC2)C2=NC(C2CCC2)=C1C1=NNN=N1 VMDZGTTYEVPCAX-UHFFFAOYSA-N 0.000 claims 1
• WXPFONNKJXFJPF-UHFFFAOYSA-N 5-[2-cyclohexyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-1-ethylpyridin-2-one Chemical compound C1=CC(=O)N(CC)C=C1C1=C(CCCCC2)C2=NC(C2CCCCC2)=C1C1=NNN=N1 WXPFONNKJXFJPF-UHFFFAOYSA-N 0.000 claims 1
• AXCUECNHOFDDMC-UHFFFAOYSA-N 5-[2-cyclohexyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-1-methylpyridin-2-one Chemical compound C1=CC(=O)N(C)C=C1C1=C(CCCCC2)C2=NC(C2CCCCC2)=C1C1=NNN=N1 AXCUECNHOFDDMC-UHFFFAOYSA-N 0.000 claims 1
• PFTAFXBSAHQKLI-UHFFFAOYSA-N 5-[2-cyclohexyl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-1h-pyridin-2-one Chemical compound N1C(=O)C=CC(C=2C(=C(C3CCCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=C1 PFTAFXBSAHQKLI-UHFFFAOYSA-N 0.000 claims 1
• DNLZHZFJXWMXHS-UHFFFAOYSA-N 5-methyl-3-[2-piperidin-1-yl-3-(2h-tetrazol-5-yl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-4-yl]-1,2-oxazole Chemical compound O1C(C)=CC(C=2C(=C(N3CCCCC3)N=C3CCCCCC3=2)C2=NNN=N2)=N1 DNLZHZFJXWMXHS-UHFFFAOYSA-N 0.000 claims 1
• FLBDPZRPSJYBSC-UHFFFAOYSA-N 6,6-difluoro-2-(2-methyloxolan-2-yl)-4-(2-methylpyrazol-3-yl)-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound FC1(CC=2C(=C(C(=NC2CC1)C1(OCCC1)C)C=1N=NNN1)C1=CC=NN1C)F FLBDPZRPSJYBSC-UHFFFAOYSA-N 0.000 claims 1
• JWDKYYJGOGIUSK-UHFFFAOYSA-N 6,6-difluoro-2-(2-methyloxolan-2-yl)-4-phenyl-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound CC1(CCCO1)c1nc2CCC(F)(F)Cc2c(-c2ccccc2)c1-c1nn[nH]n1 JWDKYYJGOGIUSK-UHFFFAOYSA-N 0.000 claims 1
• ZMYQHMVWKRLPRD-UHFFFAOYSA-N 6,6-difluoro-2-(4-methyloxan-4-yl)-4-phenyl-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound CC1(CCOCC1)c1nc2CCC(F)(F)Cc2c(-c2ccccc2)c1-c1nn[nH]n1 ZMYQHMVWKRLPRD-UHFFFAOYSA-N 0.000 claims 1
• JWDKYYJGOGIUSK-HXUWFJFHSA-N 6,6-difluoro-2-[(2R)-2-methyloxolan-2-yl]-4-phenyl-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound C[C@@]1(CCCO1)c1nc2CCC(F)(F)Cc2c(-c2ccccc2)c1-c1nn[nH]n1 JWDKYYJGOGIUSK-HXUWFJFHSA-N 0.000 claims 1
• JWDKYYJGOGIUSK-FQEVSTJZSA-N 6,6-difluoro-2-[(2S)-2-methyloxolan-2-yl]-4-phenyl-3-(2H-tetrazol-5-yl)-7,8-dihydro-5H-quinoline Chemical compound C[C@]1(CCCO1)c1nc2CCC(F)(F)Cc2c(-c2ccccc2)c1-c1nn[nH]n1 JWDKYYJGOGIUSK-FQEVSTJZSA-N 0.000 claims 1
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• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1