|
US8846935B2
(en)
|
2010-05-07 |
2014-09-30 |
Glaxosmithkline Llc |
Indazoles
|
|
CA2841142C
(en)
|
2010-06-23 |
2020-12-15 |
Ryan D. Morin |
Biomarkers for non-hodgkin lymphomas and uses thereof
|
|
US9175331B2
(en)
|
2010-09-10 |
2015-11-03 |
Epizyme, Inc. |
Inhibitors of human EZH2, and methods of use thereof
|
|
BR112013005806B1
(pt)
|
2010-09-10 |
2022-05-10 |
Epizyme, Inc |
Métodos para detectar se um indivíduo é um candidato para o tratamento com ou responsivo a um inibidor de ezh2 e usos terapêuticos do dito inibidor de ezh2
|
|
EP2646020B1
(en)
*
|
2010-12-01 |
2016-09-21 |
Glaxosmithkline LLC |
Indoles
|
|
WO2012118812A2
(en)
*
|
2011-02-28 |
2012-09-07 |
Epizyme, Inc. |
Substituted 6,5-fused bicyclic heteroaryl compounds
|
|
TW201733984A
(zh)
|
2011-04-13 |
2017-10-01 |
雅酶股份有限公司 |
經取代之苯化合物
|
|
JO3363B1
(ar)
|
2011-04-13 |
2019-03-13 |
Epizyme Inc |
مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
|
|
AU2013203641B2
(en)
*
|
2011-04-13 |
2014-08-21 |
Epizyme, Inc. |
Aryl-or heteroaryl-substituted benzene compounds
|
|
US9730925B2
(en)
|
2011-09-30 |
2017-08-15 |
Glaxomithkline Llc |
Methods of treating cancer
|
|
AU2012332297B2
(en)
*
|
2011-11-04 |
2016-01-07 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Method of treatment
|
|
US9206128B2
(en)
|
2011-11-18 |
2015-12-08 |
Constellation Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
WO2013075084A1
(en)
|
2011-11-18 |
2013-05-23 |
Constellation Pharmaceuticals |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
EP2794565B1
(en)
|
2011-12-21 |
2017-07-26 |
Novira Therapeutics Inc. |
Hepatitis b antiviral agents
|
|
US9085583B2
(en)
|
2012-02-10 |
2015-07-21 |
Constellation—Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
CA3177515A1
(en)
|
2012-03-12 |
2013-09-19 |
Epizyme, Inc. |
Inhibitors of human ezh2, and methods of use thereof
|
|
ES2872348T3
(es)
|
2012-03-19 |
2021-11-02 |
Imperial College Innovations Ltd |
Compuestos de quinazolina y su uso en terapia
|
|
ES2617379T3
(es)
*
|
2012-04-13 |
2017-06-16 |
Epizyme, Inc. |
Forma de sal de un inhibidor de histona metiltransferasa EZH2 humana
|
|
US9562041B2
(en)
|
2012-05-16 |
2017-02-07 |
Glaxosmithkline Llc |
Enhancer of zeste homolog 2 inhibitors
|
|
US20150167062A1
(en)
|
2012-06-14 |
2015-06-18 |
Whitehead Institute For Biomedical Research |
Genome-wide Method of Assessing Interactions Between Chemical Entities And Their Target Molecules
|
|
CA2881057C
(en)
|
2012-08-28 |
2020-10-27 |
Janssen Sciences Ireland Uc |
Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
|
|
JP6254169B2
(ja)
*
|
2012-09-28 |
2017-12-27 |
ファイザー・インク |
ベンズアミドおよびヘテロベンズアミド化合物
|
|
KR20190105669A
(ko)
|
2012-10-15 |
2019-09-17 |
에피자임, 인코포레이티드 |
암을 치료하는 방법
|
|
BR112015008480A2
(pt)
|
2012-10-15 |
2017-07-04 |
Epizyme Inc |
compostos de benzeno substituído
|
|
RU2015127822A
(ru)
|
2012-12-13 |
2017-01-16 |
ГЛЭКСОСМИТКЛАЙН ЭлЭлСи |
Ингибиторы энхансера гомолога 2 белка zeste
|
|
EP2934531A4
(en)
*
|
2012-12-19 |
2016-06-15 |
Glaxosmithkline Llc |
COMBINATION
|
|
UA111305C2
(uk)
|
2012-12-21 |
2016-04-11 |
Пфайзер Інк. |
Конденсовані лактами арилу та гетероарилу
|
|
CA2894222A1
(en)
|
2012-12-21 |
2014-06-26 |
Epizyme, Inc. |
1,4-pyridone bicyclic heteroaryl compounds
|
|
PL2953941T3
(pl)
*
|
2013-02-11 |
2017-11-30 |
Constellation Pharmaceuticals, Inc. |
Modulatory enzymów modyfikujących metyl, ich kompozycje i zastosowania
|
|
JP6466348B2
(ja)
|
2013-02-28 |
2019-02-06 |
ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー |
スルファモイル−アリールアミドおよびb型肝炎を処置するための医薬品としてのその使用
|
|
US8993771B2
(en)
|
2013-03-12 |
2015-03-31 |
Novira Therapeutics, Inc. |
Hepatitis B antiviral agents
|
|
EP2970181B1
(en)
|
2013-03-14 |
2017-06-07 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
US9394258B2
(en)
|
2013-03-14 |
2016-07-19 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
CA2903394C
(en)
|
2013-03-14 |
2021-08-31 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
US9133189B2
(en)
|
2013-03-14 |
2015-09-15 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
US9120757B2
(en)
|
2013-03-14 |
2015-09-01 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
WO2014153172A1
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
JP2016514164A
(ja)
|
2013-03-14 |
2016-05-19 |
エピザイム,インコーポレイティド |
アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用
|
|
US20160039767A1
(en)
|
2013-03-14 |
2016-02-11 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
EP3363434A1
(en)
|
2013-03-14 |
2018-08-22 |
Epizyme Inc |
Arginine methyltransferase inhibitors and uses thereof
|
|
EP2968565A2
(en)
|
2013-03-14 |
2016-01-20 |
Genentech, Inc. |
Methods of treating cancer and preventing cancer drug resistance
|
|
EP2970135B1
(en)
|
2013-03-14 |
2018-07-18 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
US9745305B2
(en)
|
2013-03-15 |
2017-08-29 |
Constellation Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
WO2014155301A1
(en)
*
|
2013-03-26 |
2014-10-02 |
Piramal Enterprises Limited |
Substituted bicyclic compounds as inhibitors of ezh2
|
|
HUE033542T2
(en)
|
2013-04-03 |
2017-12-28 |
Janssen Sciences Ireland Uc |
Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B
|
|
HK1214815A1
(zh)
*
|
2013-04-30 |
2016-08-05 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Zeste增强子同源物2的抑制剂
|
|
TW202126620A
(zh)
|
2013-05-17 |
2021-07-16 |
愛爾蘭商健生科學愛爾蘭無限公司 |
胺磺醯基吡咯醯胺衍生物及其作為用於治療b型肝炎藥物的用途
|
|
HUE040446T2
(hu)
|
2013-05-17 |
2019-03-28 |
Janssen Sciences Ireland Uc |
Szulfamoiltiofenamid-származékok és gyógyszerként történõ alkalmazásuk hepatitis B kezelésére
|
|
CA2914414A1
(en)
*
|
2013-06-06 |
2014-12-11 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Enhancer of zeste homolog 2 inhibitors
|
|
CA2917463A1
(en)
|
2013-07-10 |
2015-01-15 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Enhancer of zeste homolog 2 inhibitors
|
|
WO2015011281A1
(en)
|
2013-07-25 |
2015-01-29 |
Janssen R&D Ireland |
Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
|
|
US9969716B2
(en)
|
2013-08-15 |
2018-05-15 |
Constellation Pharmaceuticals, Inc. |
Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof
|
|
PE20161273A1
(es)
|
2013-10-16 |
2016-12-18 |
Epizyme Inc |
Forma salina de hidrocloruro para la inhibicion de ezh2
|
|
MX368158B
(es)
|
2013-10-23 |
2019-09-20 |
Janssen Sciences Ireland Uc |
Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
|
|
WO2015077194A1
(en)
*
|
2013-11-22 |
2015-05-28 |
Bristol-Myers Squibb Company |
Inhibitors of lysine methyl transferase
|
|
US9169212B2
(en)
|
2014-01-16 |
2015-10-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
US10392349B2
(en)
|
2014-01-16 |
2019-08-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
JP6553059B2
(ja)
|
2014-02-05 |
2019-07-31 |
ノヴィラ・セラピューティクス・インコーポレイテッド |
Hbv感染の治療のための併用療法
|
|
PL3102572T3
(pl)
|
2014-02-06 |
2019-04-30 |
Janssen Sciences Ireland Uc |
Pochodne sulfamoilopirolamidu i ich zastosowanie jako leki do leczenia wirusowego zapalenia wątroby typu B
|
|
WO2015120372A2
(en)
*
|
2014-02-10 |
2015-08-13 |
University Of Rochester |
Compositions and methods to inhibit ezh2 for the treatment of cardiovascular diseases
|
|
US20160361309A1
(en)
|
2014-02-26 |
2016-12-15 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Methods of treating cancer patients responding to ezh2 inhibitor gsk126
|
|
WO2015143424A2
(en)
*
|
2014-03-21 |
2015-09-24 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Methods of treating cancer
|
|
CN105037360B
(zh)
*
|
2014-04-28 |
2016-08-17 |
四川大学 |
吡啶酮衍生物及其制备方法和用途
|
|
CN105017221B
(zh)
*
|
2014-04-30 |
2019-05-28 |
中国医学科学院药物研究所 |
苯并咪唑衍生物及其制法和药物组合物与用途
|
|
AP2016009605A0
(en)
|
2014-06-17 |
2016-12-31 |
Pfizer |
Substituted dihydroisoquinolinone compounds
|
|
EP3160940A4
(en)
*
|
2014-06-25 |
2018-05-02 |
Epizyme, Inc. |
Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
|
|
MA40848A
(fr)
*
|
2014-10-28 |
2021-05-05 |
Glaxosmithkline Ip No 2 Ltd |
Inhibiteurs d'ezh2 (enhancer of zeste homolog 2)
|
|
CA2964629A1
(en)
*
|
2014-11-06 |
2016-05-12 |
Dana-Farber Cancer Institute, Inc. |
Ezh2 inhibitors and uses thereof
|
|
TW201636344A
(zh)
|
2014-12-05 |
2016-10-16 |
美國禮來大藥廠 |
Ezh2抑制劑
|
|
WO2016102493A1
(en)
*
|
2014-12-22 |
2016-06-30 |
Bayer Pharma Aktiengesellschaft |
Imidazopyridine ezh2 inhibitors
|
|
WO2016101956A2
(en)
|
2014-12-23 |
2016-06-30 |
University Of Copenhagen |
Treatment of cancer by inhibiting ezh2 activity
|
|
MX375970B
(es)
*
|
2014-12-23 |
2025-03-06 |
Novartis Ag |
Compuestos de triazolopirimidina y usos de los mismos.
|
|
EP3271019A1
(en)
|
2015-03-19 |
2018-01-24 |
Novira Therapeutics Inc. |
Azocane and azonane derivatives and methods of treating hepatitis b infections
|
|
US10961532B2
(en)
|
2015-04-07 |
2021-03-30 |
The General Hospital Corporation |
Methods for reactivating genes on the inactive X chromosome
|
|
EA201890009A1
(ru)
*
|
2015-06-10 |
2018-07-31 |
Эпизайм, Инк. |
Ингибиторы ezh2 для лечения лимфомы
|
|
US10875876B2
(en)
|
2015-07-02 |
2020-12-29 |
Janssen Sciences Ireland Uc |
Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
|
|
WO2017035234A1
(en)
|
2015-08-24 |
2017-03-02 |
Epizyme, Inc. |
Method for treating cancer
|
|
TW201718598A
(zh)
|
2015-08-27 |
2017-06-01 |
美國禮來大藥廠 |
Ezh2抑制劑
|
|
WO2017040190A1
(en)
|
2015-08-28 |
2017-03-09 |
Constellation Pharmaceuticals, Inc. |
Crystalline forms of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide
|
|
AR106192A1
(es)
|
2015-09-29 |
2017-12-20 |
Novira Therapeutics Inc |
Formas cristalinas de un agente antiviral contra la hepatitis b
|
|
WO2017062495A2
(en)
|
2015-10-06 |
2017-04-13 |
Epizyme, Inc. |
Method of treating medulloblastoma with an ezh2 inhibitor
|
|
EP3371601A1
(en)
|
2015-11-05 |
2018-09-12 |
Epizyme Inc |
Flow cytometry for monitoring histone h3 methylation status
|
|
SI3378859T1
(sl)
*
|
2015-11-19 |
2020-03-31 |
Jiangsu Hengrui Medicine Co., Ltd., |
Derivat benzofurana, postopek za njegovo pripravo in njegova uporaba v medicini
|
|
US11951108B2
(en)
|
2016-01-29 |
2024-04-09 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
EP3414319B1
(en)
|
2016-02-10 |
2024-07-24 |
Wake Forest University Health Sciences |
Model system of liver fibrosis and method of making and using the same
|
|
CN120661674A
(zh)
|
2016-03-15 |
2025-09-19 |
奥莱松基因组股份有限公司 |
用于治疗实体瘤的lsd1抑制剂的组合
|
|
WO2017181141A2
(en)
|
2016-04-15 |
2017-10-19 |
Novira Therapeutics, Inc. |
Combinations and methods comprising a capsid assembly inhibitor
|
|
WO2017184999A1
(en)
|
2016-04-22 |
2017-10-26 |
Dana-Farber Cancer Institute, Inc. |
Ezh2 inhibitors and uses thereof
|
|
CN105777718B
(zh)
*
|
2016-04-27 |
2019-03-19 |
上海应用技术学院 |
潜在ezh2小分子抑制剂及其合成方法
|
|
US10987353B2
(en)
|
2016-05-04 |
2021-04-27 |
The Wistar Institute Of Anatomy And Biology |
Methods of treating cancers overexpressing CARM1 with EZH2 inhibitors and platinum-based antineoplastic drugs
|
|
US11147819B2
(en)
|
2016-06-17 |
2021-10-19 |
Epizyme, Inc. |
EZH2 inhibitors for treating cancer
|
|
US10689378B2
(en)
*
|
2016-06-20 |
2020-06-23 |
Novartis Ag |
Triazolopyridine compounds and uses thereof
|
|
CN107573327B
(zh)
*
|
2016-07-05 |
2020-03-31 |
四川大学 |
吲唑-甲酰胺-吡啶酮衍生物及其制备方法和用途
|
|
CN107573336B
(zh)
*
|
2016-07-05 |
2021-01-19 |
四川大学 |
苯并杂环-甲酰胺-吡啶酮衍生物及其制备方法和用途
|
|
WO2018075598A1
(en)
|
2016-10-19 |
2018-04-26 |
Constellation Pharmaceuticals, Inc. |
Synthesis of inhibitors of ezh2
|
|
US20200262813A1
(en)
*
|
2016-11-11 |
2020-08-20 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. |
1,5,7-trisubstituted isoquinoline derivatives, preparation thereof, and use thereof in medicines
|
|
US10793549B2
(en)
|
2016-11-11 |
2020-10-06 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. |
Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof
|
|
WO2018102687A2
(en)
|
2016-12-02 |
2018-06-07 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
BR112019014924A2
(pt)
|
2017-01-19 |
2020-03-31 |
St. Marianna University School Of Medicine |
Composição farmacêutica usada para o tratamento de mielopatia associada ao htlv-1
|
|
US10266542B2
(en)
|
2017-03-15 |
2019-04-23 |
Mirati Therapeutics, Inc. |
EZH2 inhibitors
|
|
WO2018183885A1
(en)
|
2017-03-31 |
2018-10-04 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
US20230201212A1
(en)
|
2017-06-13 |
2023-06-29 |
Epizyme, Inc. |
Inhibitors of ezh2 and methods of use thereof
|
|
US11529344B2
(en)
|
2017-11-14 |
2022-12-20 |
Pfizer Inc. |
EZH2 inhibitor combination therapies
|
|
DK3746446T3
(da)
|
2018-01-31 |
2022-06-27 |
Mirati Therapeutics Inc |
PRC2-inhibitorer
|
|
CN110229151B
(zh)
*
|
2018-03-06 |
2021-09-10 |
上海海和药物研究开发股份有限公司 |
吲嗪类化合物、其制备方法及用途
|
|
SG11202007097QA
(en)
|
2018-03-14 |
2020-08-28 |
Janssen Sciences Ireland Unlimited Co |
Capsid assembly modulator dosing regimen
|
|
MX2020010999A
(es)
|
2018-04-18 |
2021-01-20 |
Constellation Pharmaceuticals Inc |
Moduladores de enzimas modificadoras de metilo, composiciones y usos de estos.
|
|
WO2020011607A1
(en)
|
2018-07-09 |
2020-01-16 |
Fondation Asile Des Aveugles |
Inhibition of prc2 subunits to treat eye disorders
|
|
JP7411256B2
(ja)
|
2018-07-27 |
2024-01-11 |
エボポイント、バイオサイエンシズ、カンパニー、リミテッド |
多置換ベンゼン環化合物、製造方法及びその用途
|
|
AU2020223865A1
(en)
|
2019-02-22 |
2021-07-15 |
Janssen Sciences Ireland Unlimited Company |
Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
|
|
CN113773304B
(zh)
*
|
2019-02-25 |
2023-03-10 |
江苏豪森药业集团有限公司 |
抗耐药抗肿瘤egfr抑制剂的制备方法
|
|
US12421228B2
(en)
|
2019-04-22 |
2025-09-23 |
Mirati Therapeutics, Inc. |
Naphthyridine derivatives as PRC2 inhibitors
|
|
BR112021021454A2
(pt)
|
2019-05-06 |
2021-12-21 |
Janssen Sciences Ireland Unlimited Co |
Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv
|
|
CN114269748A
(zh)
|
2019-06-05 |
2022-04-01 |
米拉蒂医疗股份有限公司 |
作为用于治疗癌症的PRC2抑制剂的咪唑并[1,2-c]嘧啶衍生物
|
|
PE20220562A1
(es)
|
2019-07-24 |
2022-04-13 |
Constellation Pharmaceuticals Inc |
Formas cristalinas de 7-cloro-2-(4-(3-metoxiazetidin-1-il)ciclohexil)-2,4-dimetil-n-((6-metil-4-(metiltio)-2-oxo-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioxol-5-carboxamida
|
|
KR20220066892A
(ko)
|
2019-08-22 |
2022-05-24 |
주노 쎄러퓨티크스 인코퍼레이티드 |
T 세포 요법 및 제스트 동족체 2의 인핸서 (ezh2) 억제제의 병용 요법 및 관련 방법
|
|
US12006232B2
(en)
|
2020-06-09 |
2024-06-11 |
Rapid Water Technology LLC |
Water processing apparatus
|
|
WO2022133046A2
(en)
*
|
2020-12-16 |
2022-06-23 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
|
CN113307765A
(zh)
*
|
2021-05-24 |
2021-08-27 |
上海泰坦科技股份有限公司 |
吡啶甲胺类化合物及其制备方法
|
|
EP4392034A1
(en)
|
2021-08-25 |
2024-07-03 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Use of ezh2 inhibitors for the treatment of aortic valve stenosis
|
|
US20250049802A1
(en)
|
2021-12-14 |
2025-02-13 |
Pfizer Inc. |
Combination therapies and uses for treating cancer
|
|
CA3249707A1
(en)
|
2022-04-27 |
2023-11-02 |
Daiichi Sankyo Company, Limited |
COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH AN EZH1 AND/OR EZH2 INHIBITOR
|
|
CN117088810A
(zh)
*
|
2023-06-27 |
2023-11-21 |
海南医学院 |
3-氰基吡啶酮化合物的串联合成方法
|
|
CN117362277B
(zh)
*
|
2023-10-13 |
2025-02-11 |
沈阳药科大学 |
含咪唑啉酮结构的苯甲酰胺类化合物及其制备方法和应用
|
|
CN118745144B
(zh)
*
|
2024-06-21 |
2026-07-14 |
辽宁大学 |
新型ezh2抑制剂化合物及其制备方法和应用
|