|
ES2534804T3
(es)
|
2010-05-07 |
2015-04-28 |
Glaxosmithkline Llc |
Indazoles
|
|
US20130102477A1
(en)
|
2010-06-23 |
2013-04-25 |
Ryan D. Morin |
Biomarkers for non-hodgkin lymphomas and uses thereof
|
|
US9175331B2
(en)
|
2010-09-10 |
2015-11-03 |
Epizyme, Inc. |
Inhibitors of human EZH2, and methods of use thereof
|
|
JP6389036B2
(ja)
*
|
2010-09-10 |
2018-09-12 |
エピザイム インコーポレイテッド |
ヒトｅｚｈ２の阻害剤、およびその使用方法
|
|
EP2646020B1
(en)
*
|
2010-12-01 |
2016-09-21 |
Glaxosmithkline LLC |
Indoles
|
|
EP3323820B1
(en)
*
|
2011-02-28 |
2023-05-10 |
Epizyme, Inc. |
Substituted 6,5-fused bicyclic heteroaryl compounds
|
|
TW201733984A
(zh)
|
2011-04-13 |
2017-10-01 |
雅酶股份有限公司 |
經取代之苯化合物
|
|
JO3438B1
(ar)
*
|
2011-04-13 |
2019-10-20 |
Epizyme Inc |
مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
|
|
AU2013203641B2
(en)
*
|
2011-04-13 |
2014-08-21 |
Epizyme, Inc. |
Aryl-or heteroaryl-substituted benzene compounds
|
|
CN103987842A
(zh)
*
|
2011-09-30 |
2014-08-13 |
葛兰素史密斯克莱有限责任公司 |
治疗癌症的方法
|
|
EP2773754B1
(en)
*
|
2011-11-04 |
2016-08-03 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Compounds for use in the treatment of T-cell mediated diseases
|
|
US9206128B2
(en)
|
2011-11-18 |
2015-12-08 |
Constellation Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
EP2780013A4
(en)
*
|
2011-11-18 |
2015-07-01 |
Constellation Pharmaceuticals Inc |
MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
|
|
JP5977837B2
(ja)
|
2011-12-21 |
2016-08-24 |
ノヴィラ・セラピューティクス・インコーポレイテッド |
Ｂ型肝炎抗ウイルス剤
|
|
EP2812001B1
(en)
*
|
2012-02-10 |
2017-06-14 |
Constellation Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
CA2867282C
(en)
|
2012-03-12 |
2024-04-02 |
Epizyme, Inc. |
Inhibitors of human ezh2, and methods of use thereof
|
|
US9932317B2
(en)
|
2012-03-19 |
2018-04-03 |
Imperial Innovations Limited |
Quinazoline compounds and their use in therapy
|
|
PL3184523T3
(pl)
*
|
2012-04-13 |
2019-12-31 |
Epizyme Inc |
Bromowodorek N-((4,6-dimetylo-2-okso-1,2-dihydropirydyn-3-ylo)metylo)-5- (etylo(tetrahydro-2H-piran-4-ylo)amino)-4-metylo-4'-(morfolinometylo)-[1,1'- bifenylo]-3-karboksyamidu do zastosowania w leczeniu zaburzenia proliferacji komórkowej układu hematologicznego
|
|
WO2013173441A2
(en)
|
2012-05-16 |
2013-11-21 |
Glaxosmithkline Llc |
Enhancer of zeste homolog 2 inhibitors
|
|
CA2876304C
(en)
|
2012-06-14 |
2021-07-20 |
Whitehead Institute For Biomedical Research |
Genome-wide method of assessing interactions between chemical entities and their target molecules
|
|
MX373711B
(es)
|
2012-08-28 |
2020-05-08 |
Janssen Sciences Ireland Uc |
Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b.
|
|
EP2900653A1
(en)
*
|
2012-09-28 |
2015-08-05 |
Pfizer Inc. |
Benzamide and heterobenzamide compounds
|
|
BR112015008447A2
(pt)
|
2012-10-15 |
2017-07-04 |
Epizyme Inc |
métodos para tratar câncer
|
|
SG10201705989YA
(en)
|
2012-10-15 |
2017-08-30 |
Epizyme Inc |
Substituted benzene compounds
|
|
KR20150095779A
(ko)
*
|
2012-12-13 |
2015-08-21 |
글락소스미스클라인 엘엘씨 |
제스트 인핸서 상동체 2 억제제
|
|
US20150313906A1
(en)
*
|
2012-12-19 |
2015-11-05 |
Glaxosmithkline Llc |
Combination
|
|
WO2014100665A1
(en)
*
|
2012-12-21 |
2014-06-26 |
Epizyme, Inc. |
1,4-pyridone bicyclic heteroaryl compounds
|
|
UA111305C2
(uk)
|
2012-12-21 |
2016-04-11 |
Пфайзер Інк. |
Конденсовані лактами арилу та гетероарилу
|
|
RS56207B1
(sr)
*
|
2013-02-11 |
2017-11-30 |
Constellation Pharmaceuticals Inc |
Modulatori enzima koji modifikuju metil, njihove kompozicije i upotreba
|
|
DK2961732T3
(en)
|
2013-02-28 |
2017-07-10 |
Janssen Sciences Ireland Uc |
SULFAMOYLARYLAMIDS AND USE THEREOF AS MEDICINES TO TREAT HEPATITIS B
|
|
US8993771B2
(en)
|
2013-03-12 |
2015-03-31 |
Novira Therapeutics, Inc. |
Hepatitis B antiviral agents
|
|
US9394258B2
(en)
|
2013-03-14 |
2016-07-19 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
US20160031839A1
(en)
|
2013-03-14 |
2016-02-04 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
EP2970136A1
(en)
|
2013-03-14 |
2016-01-20 |
Epizyme, Inc. |
Arginine methyl transferase inhibtors and uses thereof
|
|
WO2014144659A1
(en)
|
2013-03-14 |
2014-09-18 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
EP2970133B1
(en)
|
2013-03-14 |
2018-10-24 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
SG11201506972PA
(en)
|
2013-03-14 |
2015-10-29 |
Epizyme Inc |
Arginine methyltransferase inhibitors and uses thereof
|
|
HK1220916A1
(zh)
|
2013-03-14 |
2017-05-19 |
基因泰克公司 |
治疗癌症和预防癌症药物抗性的方法
|
|
WO2014153208A1
(en)
|
2013-03-14 |
2014-09-25 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
US9120757B2
(en)
|
2013-03-14 |
2015-09-01 |
Epizyme, Inc. |
Arginine methyltransferase inhibitors and uses thereof
|
|
AU2014260433A1
(en)
|
2013-03-14 |
2015-09-10 |
Epizyme, Inc. |
Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
|
|
EP2970134B1
(en)
|
2013-03-14 |
2018-02-28 |
Epizyme, Inc. |
Pyrazole derivatives as prmt1 inhibitors and uses thereof
|
|
EP2970305B1
(en)
|
2013-03-15 |
2017-02-22 |
Constellation Pharmaceuticals, Inc. |
Modulators of methyl modifying enzymes, compositions and uses thereof
|
|
WO2014155301A1
(en)
*
|
2013-03-26 |
2014-10-02 |
Piramal Enterprises Limited |
Substituted bicyclic compounds as inhibitors of ezh2
|
|
CN105102451B
(zh)
|
2013-04-03 |
2018-09-18 |
爱尔兰詹森科学公司 |
N-苯基-氨甲酰衍生物及其作为药物用于治疗乙型肝炎的用途
|
|
CA2910873A1
(en)
*
|
2013-04-30 |
2014-11-06 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Enhancer of zeste homolog 2 inhibitors
|
|
JO3603B1
(ar)
|
2013-05-17 |
2020-07-05 |
Janssen Sciences Ireland Uc |
مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
|
|
DK2997019T3
(en)
|
2013-05-17 |
2018-12-03 |
Janssen Sciences Ireland Uc |
SULFAMOYLTHIOPHENAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B
|
|
RU2015155595A
(ru)
*
|
2013-06-06 |
2017-07-14 |
Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед |
Ингибиторы энхансера zeste гомолога 2 область техники, к которой относится изобретение
|
|
JP2016523955A
(ja)
*
|
2013-07-10 |
2016-08-12 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｎｏ．２ Ｌｉｍｉｔｅｄ |
Ｚｅｓｔｅホモログ２エンハンサー阻害剤
|
|
KR102244937B1
(ko)
|
2013-07-25 |
2021-04-27 |
얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 |
글리옥사미드 치환된 피롤아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도
|
|
EP3033334A1
(en)
*
|
2013-08-15 |
2016-06-22 |
Constellation Pharmaceuticals, Inc. |
Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof
|
|
EP4324525A3
(en)
|
2013-10-16 |
2024-07-17 |
Epizyme, Inc. |
Hydrochloride salt form for ezh2 inhibition
|
|
DK3060547T3
(en)
|
2013-10-23 |
2018-01-15 |
Janssen Sciences Ireland Uc |
CARBOXAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATMENT OF HEPATITS B
|
|
WO2015077194A1
(en)
*
|
2013-11-22 |
2015-05-28 |
Bristol-Myers Squibb Company |
Inhibitors of lysine methyl transferase
|
|
US9169212B2
(en)
|
2014-01-16 |
2015-10-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
US10392349B2
(en)
|
2014-01-16 |
2019-08-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
EP3102225B1
(en)
|
2014-02-05 |
2020-03-25 |
Novira Therapeutics Inc. |
Combination therapy for treatment of hbv infections
|
|
US11078193B2
(en)
|
2014-02-06 |
2021-08-03 |
Janssen Sciences Ireland Uc |
Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
|
|
WO2015120372A2
(en)
*
|
2014-02-10 |
2015-08-13 |
University Of Rochester |
Compositions and methods to inhibit ezh2 for the treatment of cardiovascular diseases
|
|
WO2015128837A1
(en)
|
2014-02-26 |
2015-09-03 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Methods of treating cancer patients responding to ezh2 inhibitor gsk126
|
|
US20170105997A1
(en)
*
|
2014-03-21 |
2017-04-20 |
Northwestern University |
Methods of treating cancer
|
|
CN105037360B
(zh)
*
|
2014-04-28 |
2016-08-17 |
四川大学 |
吡啶酮衍生物及其制备方法和用途
|
|
CN105017221B
(zh)
*
|
2014-04-30 |
2019-05-28 |
中国医学科学院药物研究所 |
苯并咪唑衍生物及其制法和药物组合物与用途
|
|
EP3157915B1
(en)
|
2014-06-17 |
2019-02-27 |
Pfizer Inc |
Substituted dihydroisoquinolinone compounds
|
|
WO2015200650A1
(en)
*
|
2014-06-25 |
2015-12-30 |
Epizyme, Inc. |
Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
|
|
KR20170068603A
(ko)
*
|
2014-10-28 |
2017-06-19 |
글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 |
제스트 인핸서 상동체 2 억제제
|
|
CN107105651A
(zh)
|
2014-11-06 |
2017-08-29 |
达纳-法伯癌症研究所股份有限公司 |
Ezh2抑制剂及其用途
|
|
TW201636344A
(zh)
|
2014-12-05 |
2016-10-16 |
美國禮來大藥廠 |
Ｅｚｈ２抑制劑
|
|
WO2016102493A1
(en)
*
|
2014-12-22 |
2016-06-30 |
Bayer Pharma Aktiengesellschaft |
Imidazopyridine ezh2 inhibitors
|
|
US20180271857A1
(en)
|
2014-12-23 |
2018-09-27 |
University Of Copenhagen |
Treatment of cancer by inhibiting ezh2 activity
|
|
UA120945C2
(uk)
*
|
2014-12-23 |
2020-03-10 |
Новартіс Аг |
Сполуки триазолопіримідину та їх застосування
|
|
US9884831B2
(en)
|
2015-03-19 |
2018-02-06 |
Novira Therapeutics, Inc. |
Azocane and azonane derivatives and methods of treating hepatitis B infections
|
|
WO2016164463A1
(en)
|
2015-04-07 |
2016-10-13 |
The General Hospital Corporation |
Methods for reactivating genes on the inactive x chromosome
|
|
CA2988816A1
(en)
*
|
2015-06-10 |
2016-12-15 |
Epizyme, Inc. |
Ezh2 inhibitors for treating lymphoma
|
|
US10875876B2
(en)
|
2015-07-02 |
2020-12-29 |
Janssen Sciences Ireland Uc |
Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
|
|
US10493076B2
(en)
|
2015-08-24 |
2019-12-03 |
Epizyme, Inc. |
Method for treating cancer
|
|
TW201718598A
(zh)
|
2015-08-27 |
2017-06-01 |
美國禮來大藥廠 |
Ｅｚｈ２抑制劑
|
|
WO2017040190A1
(en)
|
2015-08-28 |
2017-03-09 |
Constellation Pharmaceuticals, Inc. |
Crystalline forms of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide
|
|
TW201718496A
(zh)
|
2015-09-29 |
2017-06-01 |
諾維拉治療公司 |
B型肝炎抗病毒劑之晶型
|
|
EP4309738A3
(en)
|
2015-10-06 |
2024-07-17 |
Epizyme, Inc. |
Method of treating medulloblastoma with an ezh2 inhibitor
|
|
EP3674709A1
(en)
|
2015-11-05 |
2020-07-01 |
Epizyme Inc |
Flow cytometry for monitoring histone h3 methylation status
|
|
HRP20192209T1
(hr)
*
|
2015-11-19 |
2020-07-24 |
Jiangsu Hengrui Medicine Co., Ltd. |
Derivati benzofurana, postupci njihove pripreme i njihova uporaba u medicini
|
|
US11951108B2
(en)
|
2016-01-29 |
2024-04-09 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
KR102852334B1
(ko)
|
2016-02-10 |
2025-09-01 |
웨이크 포리스트 유니버시티 헬스 사이언시즈 |
간 섬유화의 모델 시스템 및 그의 제조 및 사용 방법
|
|
AU2017233898B2
(en)
|
2016-03-15 |
2022-12-15 |
Oryzon Genomics, S.A. |
Combinations of LSD1 inhibitors for use in the treatment of solid tumors
|
|
CN109640980A
(zh)
|
2016-04-15 |
2019-04-16 |
诺维拉治疗公司 |
包含壳体装配抑制剂的组合和方法
|
|
CA3018270A1
(en)
|
2016-04-22 |
2017-10-26 |
Dana-Farber Cancer Institute, Inc. |
Ezh2 inhibitors and uses thereof
|
|
CN105777718B
(zh)
*
|
2016-04-27 |
2019-03-19 |
上海应用技术学院 |
潜在ezh2小分子抑制剂及其合成方法
|
|
WO2017192290A1
(en)
|
2016-05-04 |
2017-11-09 |
The Wistar Institute Of Anatomy And Biology |
Methods of treating cancers overexpressing carm1 with ezh2 inhibitors and platinum-based antineoplastic drugs
|
|
MA45406A
(fr)
|
2016-06-17 |
2019-04-24 |
Epizyme Inc |
Inhibiteurs d'ezh2 pour traiter le cancer
|
|
US10689378B2
(en)
*
|
2016-06-20 |
2020-06-23 |
Novartis Ag |
Triazolopyridine compounds and uses thereof
|
|
CN107573336B
(zh)
*
|
2016-07-05 |
2021-01-19 |
四川大学 |
苯并杂环-甲酰胺-吡啶酮衍生物及其制备方法和用途
|
|
CN107573327B
(zh)
*
|
2016-07-05 |
2020-03-31 |
四川大学 |
吲唑-甲酰胺-吡啶酮衍生物及其制备方法和用途
|
|
EP3529242A1
(en)
|
2016-10-19 |
2019-08-28 |
Constellation Pharmaceuticals, Inc. |
Synthesis of inhibitors of ezh2
|
|
CN108699002B
(zh)
*
|
2016-11-11 |
2021-11-09 |
上海海雁医药科技有限公司 |
1,5,7-三取代的异喹啉衍生物、其制法与医药上的用途
|
|
WO2018086590A1
(zh)
*
|
2016-11-11 |
2018-05-17 |
上海海雁医药科技有限公司 |
砜基取代的苯并杂环衍生物、其制法与医药上的用途
|
|
AU2017367768A1
(en)
|
2016-12-02 |
2019-07-18 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
CA3050221C
(en)
|
2017-01-19 |
2021-09-28 |
Daiichi Sankyo Company, Limited |
Pharmaceutical composition used for treatment of htlv-1-associated myelopathy
|
|
US10266542B2
(en)
|
2017-03-15 |
2019-04-23 |
Mirati Therapeutics, Inc. |
EZH2 inhibitors
|
|
WO2018183885A1
(en)
|
2017-03-31 |
2018-10-04 |
Epizyme, Inc. |
Combination therapy for treating cancer
|
|
WO2018231973A1
(en)
|
2017-06-13 |
2018-12-20 |
Epizyme, Inc. |
Inhibitors of ezh2 and methods of use thereof
|
|
TWI698238B
(zh)
|
2017-11-14 |
2020-07-11 |
美商輝瑞股份有限公司 |
Ｅｚｈ２抑制劑組合治療
|
|
FI4043466T3
(fi)
|
2018-01-31 |
2024-10-30 |
Mirati Therapeutics Inc |
Prc2:n estäjiä
|
|
CN110229151B
(zh)
*
|
2018-03-06 |
2021-09-10 |
上海海和药物研究开发股份有限公司 |
吲嗪类化合物、其制备方法及用途
|
|
JP2021515769A
(ja)
|
2018-03-14 |
2021-06-24 |
ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー |
カプシド集合調節剤の投薬レジメン
|
|
CA3104209A1
(en)
|
2018-07-09 |
2020-01-16 |
Fondation Asile Des Aveugles |
Inhibition of prc2 subunits to treat eye disorders
|
|
JP7411256B2
(ja)
|
2018-07-27 |
2024-01-11 |
エボポイント、バイオサイエンシズ、カンパニー、リミテッド |
多置換ベンゼン環化合物、製造方法及びその用途
|
|
MA55020A
(fr)
|
2019-02-22 |
2021-12-29 |
Janssen Sciences Ireland Unlimited Co |
Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b
|
|
CN113773304B
(zh)
*
|
2019-02-25 |
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|
|
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(ja)
|
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|
|
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(es)
|
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|
|
WO2020247475A1
(en)
|
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|
|
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(ja)
|
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|
|
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(en)
|
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Water processing apparatus
|
|
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(zh)
*
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
*
|
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|
|
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(zh)
*
|
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|
|
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(zh)
*
|
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|