JP2016519096A5 - - Google Patents

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Publication number
JP2016519096A5
JP2016519096A5 JP2016505527A JP2016505527A JP2016519096A5 JP 2016519096 A5 JP2016519096 A5 JP 2016519096A5 JP 2016505527 A JP2016505527 A JP 2016505527A JP 2016505527 A JP2016505527 A JP 2016505527A JP 2016519096 A5 JP2016519096 A5 JP 2016519096A5
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JP
Japan
Prior art keywords
carbonyl
carboxamide
tetrahydroisoquinoline
chloro
fluorophenyl
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JP2016505527A
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English (en)
Japanese (ja)
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JP2016519096A (ja
JP6479763B2 (ja
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Priority claimed from PCT/US2014/031651 external-priority patent/WO2014160668A1/en
Publication of JP2016519096A publication Critical patent/JP2016519096A/ja
Publication of JP2016519096A5 publication Critical patent/JP2016519096A5/ja
Application granted granted Critical
Publication of JP6479763B2 publication Critical patent/JP6479763B2/ja
Expired - Fee Related legal-status Critical Current
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JP2016505527A 2013-03-25 2014-03-25 第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン Expired - Fee Related JP6479763B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361804883P 2013-03-25 2013-03-25
US61/804,883 2013-03-25
US201361840736P 2013-06-28 2013-06-28
US61/840,736 2013-06-28
US201361894607P 2013-10-23 2013-10-23
US61/894,607 2013-10-23
PCT/US2014/031651 WO2014160668A1 (en) 2013-03-25 2014-03-25 Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors

Publications (3)

Publication Number Publication Date
JP2016519096A JP2016519096A (ja) 2016-06-30
JP2016519096A5 true JP2016519096A5 (enExample) 2017-04-13
JP6479763B2 JP6479763B2 (ja) 2019-03-06

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JP2016505527A Expired - Fee Related JP6479763B2 (ja) 2013-03-25 2014-03-25 第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン

Country Status (6)

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US (1) US9738655B2 (enExample)
EP (1) EP2978751B1 (enExample)
JP (1) JP6479763B2 (enExample)
CN (1) CN105228996B (enExample)
ES (1) ES2712699T3 (enExample)
WO (1) WO2014160668A1 (enExample)

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WO2019218899A1 (zh) * 2018-05-17 2019-11-21 四川科伦博泰生物医药股份有限公司 含聚乙二醇醚的四氢异喹啉酰胺化合物及其药物用途
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CN113004286B (zh) * 2019-12-20 2022-08-12 成都康弘药业集团股份有限公司 作为血浆激肽释放酶抑制剂的三环类化合物及其用途
WO2021136390A1 (zh) * 2019-12-31 2021-07-08 上海京新生物医药有限公司 凝血因子XIa抑制剂
CN116917293B (zh) * 2020-11-19 2026-01-27 默沙东有限责任公司 血浆激肽释放酶抑制剂
KR20230121867A (ko) * 2020-12-18 2023-08-21 유씨비 바이오파마 에스알엘 무정형 고체 분산체
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