SI20848A - Farmacevtska formulacija, ki vsebuje atorvastatin kalcij - Google Patents
Farmacevtska formulacija, ki vsebuje atorvastatin kalcij Download PDFInfo
- Publication number
- SI20848A SI20848A SI200100069A SI200100069A SI20848A SI 20848 A SI20848 A SI 20848A SI 200100069 A SI200100069 A SI 200100069A SI 200100069 A SI200100069 A SI 200100069A SI 20848 A SI20848 A SI 20848A
- Authority
- SI
- Slovenia
- Prior art keywords
- atorvastatin
- pharmaceutical formulation
- atorvastatin calcium
- amorphous
- calcium
- Prior art date
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- OJRHUICOVVSGSY-RXMQYKEDSA-N (2s)-2-chloro-3-methylbutan-1-ol Chemical compound CC(C)[C@H](Cl)CO OJRHUICOVVSGSY-RXMQYKEDSA-N 0.000 title claims description 26
- 229960001770 atorvastatin calcium Drugs 0.000 title claims description 26
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 22
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- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyrrole Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200100069A SI20848A (sl) | 2001-03-14 | 2001-03-14 | Farmacevtska formulacija, ki vsebuje atorvastatin kalcij |
| IL15753402A IL157534A0 (en) | 2001-03-14 | 2002-02-13 | Atorvastatin calcium in a pharmaceutical form composition thereof, and pharmaceutical formulation comprising atorvastatin calcium |
| PL396343A PL217835B1 (pl) | 2001-03-14 | 2002-03-13 | Preparat farmaceutyczny zawierający sól wapniową atorwastatyny, sposób wytwarzania tego preparatu i jego zastosowanie do leczenia hipercholesterolemii i hiperlipidemii |
| PCT/IB2002/000736 WO2002072073A2 (en) | 2001-03-14 | 2002-03-13 | Pharmaceutical formulation comprising atorvastatin calcium |
| EP10183122.0A EP2263655B1 (en) | 2001-03-14 | 2002-03-13 | Pharmaceutical formulation comprising atorvastatin calcium |
| EP02702654A EP1499297B1 (en) | 2001-03-14 | 2002-03-13 | Pharmaceutical formulation comprising atorvastatin calcium |
| PL371919A PL211803B1 (pl) | 2001-03-14 | 2002-03-13 | Preparat farmaceutyczny zawierający sól wapniową atorwastatyny, sposób wytwarzania tego preparatu i jego zastosowanie do leczenia hipercholesterolemii i hiperlipidemii |
| RU2003130378/15A RU2293555C2 (ru) | 2001-03-14 | 2002-03-13 | Аторвастатин кальций в фармацевтической форме, его композиция и фармацевтическая рецептура, содержащая аторвастатин кальций |
| CN028064739A CN1630510B (zh) | 2001-03-14 | 2002-03-13 | 药物形式的阿托伐他汀钙、其组合物和包含阿托伐他汀钙的药物制剂 |
| CZ2003-2469A CZ306128B6 (cs) | 2001-03-14 | 2002-03-13 | Kalcium-atorvastatin ve farmaceutické formě, prostředky obsahující tuto sloučeninu a farmaceutické přípravky obsahující kalcium-atorvastatin |
| CA002440331A CA2440331C (en) | 2001-03-14 | 2002-03-13 | Atorvastatin calcium in a pharmaceutical form, composition thereof, and pharmaceutical formulation comprising atorvastatin calcium |
| HRP20030726AA HRP20030726B1 (hr) | 2001-03-14 | 2002-03-13 | Atorvastatin kalcij u farmaceutskom obliku, njegova kompozicija i farmaceutska formulacija koja obuhvaä†a atorvastatin kalcij |
| MXPA03008340A MXPA03008340A (es) | 2001-03-14 | 2002-03-13 | Calcio de atorvastatina en una forma farmaceutica, su composicion, y formulacion farmaceutica que comprende calcio de atorvastatina. |
| JP2002571032A JP4295988B2 (ja) | 2001-03-14 | 2002-03-13 | 医薬形態のアトルバスタチンカルシウム、その構成物、及びアトルバスタチンカルシウムを含む医薬製剤 |
| AT02702654T ATE500818T1 (de) | 2001-03-14 | 2002-03-13 | Kalziumatorvastatin enthaltende arzneiformulierung |
| DE60239425T DE60239425D1 (de) | 2001-03-14 | 2002-03-13 | Kalziumatorvastatin enthaltende arzneiformulierung |
| ES02702654T ES2361609T3 (es) | 2001-03-14 | 2002-03-13 | Formulación farmaceútica que comprende atorvastanina cálcica. |
| SK1136-2003A SK287925B6 (sk) | 2001-03-14 | 2002-03-13 | Pharmaceutical formulation comprising atorvastatin calcium, method for the preparation and use |
| MEP-2008-845A ME00517B (me) | 2001-03-14 | 2002-03-13 | Atorvastati kalcijum u farmaceutskom obliku, njegovoj smješi i farmaceutskoj formulaciji, koja sadrži atorvastatin kalcijum |
| ES10183122T ES2417881T3 (es) | 2001-03-14 | 2002-03-13 | Formulación farmacéutica que comprende atorvastatina cálcica |
| BR0207880-5A BR0207880A (pt) | 2001-03-14 | 2002-03-13 | Formulação farmacêutica, processo para preparação da mesma e uso de formulação sólida |
| YU69603A RS51746B (sr) | 2001-03-14 | 2002-03-13 | Atorvastatin kalcijum u farmaceutskom obliku, njegovoj smeši i farmaceutskoj formulaciji, koja sadrži atorvastatin kalcijum |
| HU0303434A HU230213B1 (hu) | 2001-03-14 | 2002-03-13 | Atorvasztatin-kalciumot tartalmazó gyógyszerkészítmény |
| SI200230945T SI1499297T1 (sl) | 2001-03-14 | 2002-03-13 | Farmacevtska oblika, ki vsebuje atorvastatin kalcij |
| RS20110313A RS55021B1 (sr) | 2001-03-14 | 2002-03-13 | Atorvastatin kalcijum u farmaceutskom obliku, njegovoj smeši i farmaceutskoj formulaciji, koja sadrži atorvastatin kalcijum |
| KR1020037011535A KR100905730B1 (ko) | 2001-03-14 | 2002-03-13 | 약제학적 형태의 아토르바스타틴 칼슘, 이의 조성물 및아토르바스타틴 칼슘을 함유하는 약제학적 제형 |
| UA2003098317A UA78201C2 (en) | 2001-03-14 | 2002-03-13 | Pharmaceutical formulation containing amorphous micronized atorvastatin calcium and method for preparation thereof |
| US10/471,906 US7030151B2 (en) | 2001-03-14 | 2002-03-13 | Atorvastatin calcium in a pharmaceutical form composition thereof and pharmaceutical formulation comprising atorvastatin calcium |
| IL157534A IL157534A (en) | 2001-03-14 | 2003-08-21 | Atorvastatin calcium in a pharmaceutical form, composition thereof and pharmaceutical formulation comprising atorvastatin calcium |
| ZA200306575A ZA200306575B (en) | 2001-03-14 | 2003-08-22 | Atorvastatin calcium in a pharmaceutical form, composition thereof, and pharmaceutical formulation comprising atorvastatin calcium. |
| BG108175A BG66339B1 (bg) | 2001-03-14 | 2003-09-12 | Фармацевтична форма съдържаща калциев аторвастатин |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200100069A SI20848A (sl) | 2001-03-14 | 2001-03-14 | Farmacevtska formulacija, ki vsebuje atorvastatin kalcij |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI20848A true SI20848A (sl) | 2002-10-31 |
Family
ID=20432850
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200100069A SI20848A (sl) | 2001-03-14 | 2001-03-14 | Farmacevtska formulacija, ki vsebuje atorvastatin kalcij |
| SI200230945T SI1499297T1 (sl) | 2001-03-14 | 2002-03-13 | Farmacevtska oblika, ki vsebuje atorvastatin kalcij |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200230945T SI1499297T1 (sl) | 2001-03-14 | 2002-03-13 | Farmacevtska oblika, ki vsebuje atorvastatin kalcij |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7030151B2 (cs) |
| EP (2) | EP2263655B1 (cs) |
| JP (1) | JP4295988B2 (cs) |
| KR (1) | KR100905730B1 (cs) |
| CN (1) | CN1630510B (cs) |
| AT (1) | ATE500818T1 (cs) |
| BG (1) | BG66339B1 (cs) |
| BR (1) | BR0207880A (cs) |
| CA (1) | CA2440331C (cs) |
| CZ (1) | CZ306128B6 (cs) |
| DE (1) | DE60239425D1 (cs) |
| ES (2) | ES2417881T3 (cs) |
| HR (1) | HRP20030726B1 (cs) |
| HU (1) | HU230213B1 (cs) |
| IL (2) | IL157534A0 (cs) |
| ME (1) | ME00517B (cs) |
| MX (1) | MXPA03008340A (cs) |
| PL (2) | PL217835B1 (cs) |
| RS (2) | RS51746B (cs) |
| RU (1) | RU2293555C2 (cs) |
| SI (2) | SI20848A (cs) |
| SK (1) | SK287925B6 (cs) |
| UA (1) | UA78201C2 (cs) |
| WO (1) | WO2002072073A2 (cs) |
| ZA (1) | ZA200306575B (cs) |
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| AU2001253287B2 (en) | 2000-04-10 | 2005-04-28 | Teva Pharmaceutical Industries Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
| USRE44578E1 (en) | 2000-04-10 | 2013-11-05 | Teva Pharmaceutical Industries, Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
| IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| CZ20032019A3 (cs) | 2000-12-27 | 2003-10-15 | Ciba Specialty Chemicals Holding Inc. | Krystalické formy Atorvastatinu |
| WO2003004470A1 (en) | 2001-06-29 | 2003-01-16 | Warner-Lambert Company Llc | Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) |
| KR20040101229A (ko) * | 2002-02-14 | 2004-12-02 | 랜박시 래보러터리스 리미티드 | 알칼리 금속 첨가에 의해 안정화된 아토르바스타틴 배합물 |
| US20070053976A1 (en) * | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
| AU2003298514A1 (en) * | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| CA2385529A1 (en) * | 2002-05-21 | 2003-11-21 | Bernard Charles Sherman | Stable dosage forms comprising atorvastatin calcium |
| SI21302A (sl) * | 2002-10-11 | 2004-04-30 | LEK farmacevtska dru�ba d.d. | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
| SI21402A (sl) * | 2003-02-12 | 2004-08-31 | LEK farmacevtska dru�ba d.d. | Obloženi delci in farmacevtske oblike |
| US7790197B2 (en) | 2003-06-09 | 2010-09-07 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
| CA2465565A1 (en) * | 2003-06-12 | 2004-12-12 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
| CA2465693A1 (en) | 2003-06-12 | 2004-12-12 | Warner-Lambert Company Llc | Pharmaceutical compositions of atorvastatin |
| US20050271717A1 (en) * | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
| TR200301614A2 (tr) * | 2003-09-26 | 2005-10-21 | Bi̇ofarma İlaç Sanayi̇ Ve Ti̇caret A.Ş. | Atorvastatin kalsiyum tablet formülasyonunun hazırlanması için yeni yöntem |
| BRPI0510713A (pt) | 2004-05-05 | 2007-11-20 | Pfizer Prod Inc | formas de sal de ácido [r-(r*,r*)]-2-(4-fluorofenil)-beta, delta-diidróxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)ca rbonil]-1h-pirrol-1- heptanóico |
| BRPI0513422A (pt) * | 2004-07-20 | 2008-05-06 | Warner Lambert Co | formas de sais cálcio do ácido (r-(r*))-2-(4- fluorfenil)-(beta), (sigma)-diidróxi-5-(1-metiletil) -3-fenil-4-((fenilamino) carbonil)-1h-pirrol-1-heptanóico (2:1) |
| NZ554541A (en) * | 2004-10-28 | 2011-01-28 | Warner Lambert Co | Process for forming amorphous atorvastatin |
| CA2588216A1 (en) | 2004-11-22 | 2006-05-26 | Dexcel Pharma Technologies Ltd. | Stable atorvastatin formulations |
| US20090088465A1 (en) * | 2004-12-02 | 2009-04-02 | Stephen Craig Dyar | Pharmaceutical Compositions of Amorphous Atorvastatin and Process for Preparing Same |
| ES2263370B1 (es) * | 2005-02-16 | 2007-12-01 | Ercros Industrial, S.A. | Atorvastatina calcica amorfa estabilizada y procedimiento para su obtencion. |
| WO2006123358A2 (en) * | 2005-02-22 | 2006-11-23 | Sun Pharmaceutical Industries Limited | Stabilized atorvastatin-containing formulation |
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| PT1957452E (pt) | 2005-11-21 | 2010-05-25 | Warner Lambert Co | Novas formas de ácido [r-(r*,r*)]-2-(4-fluorofenil)-b,b--di-hidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)-carbonil]-1h-pirrole-1-heptanóico magnésico |
| WO2007058664A1 (en) * | 2005-11-21 | 2007-05-24 | Teva Pharmaceutical Industries Ltd. | Atorvastatin formulation |
| EP1810667A1 (en) * | 2006-01-20 | 2007-07-25 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising amorphous atorvastatin |
| US7772273B2 (en) | 2006-02-10 | 2010-08-10 | Lifecycle Pharma A/S | Stabilized atorvastatin |
| US20080038332A1 (en) * | 2006-08-10 | 2008-02-14 | Cai Gu Huang | Stable pharmaceutical formulation comprising atorvastatin calcium |
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