SI1001955T1 - 1,2,4-triazolo 4,3-b)pyrido 3,2-d)pyridazine derivatives and pharmaceutical compositions containing them - Google Patents

1,2,4-triazolo 4,3-b)pyrido 3,2-d)pyridazine derivatives and pharmaceutical compositions containing them

Info

Publication number
SI1001955T1
SI1001955T1 SI9830042T SI9830042T SI1001955T1 SI 1001955 T1 SI1001955 T1 SI 1001955T1 SI 9830042 T SI9830042 T SI 9830042T SI 9830042 T SI9830042 T SI 9830042T SI 1001955 T1 SI1001955 T1 SI 1001955T1
Authority
SI
Slovenia
Prior art keywords
triazolo
pyrido
pharmaceutical compositions
compositions containing
pyridazine derivatives
Prior art date
Application number
SI9830042T
Other languages
English (en)
Slovenian (sl)
Inventor
Ferrer Jordi Gracia
Crespo M Isabel Crespo
Noverola Armando Vega
Garcia Andres Fernandez
Original Assignee
Almirall-Prodesfarma, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall-Prodesfarma, S.A. filed Critical Almirall-Prodesfarma, S.A.
Publication of SI1001955T1 publication Critical patent/SI1001955T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI9830042T 1997-07-29 1998-07-13 1,2,4-triazolo 4,3-b)pyrido 3,2-d)pyridazine derivatives and pharmaceutical compositions containing them SI1001955T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
EP98940218A EP1001955B1 (fr) 1997-07-29 1998-07-13 Derives de 1,2,4-triazolo 4,3-b]pyrido 3,2-d]pyridazine et compositions pharmaceutiques a base de ces derives
PCT/EP1998/004340 WO1999006404A1 (fr) 1997-07-29 1998-07-13 Derives de 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine et compositions pharmaceutiques a base de ces derives

Publications (1)

Publication Number Publication Date
SI1001955T1 true SI1001955T1 (en) 2002-02-28

Family

ID=8300216

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9830042T SI1001955T1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo 4,3-b)pyrido 3,2-d)pyridazine derivatives and pharmaceutical compositions containing them

Country Status (36)

Country Link
US (2) US6407108B1 (fr)
EP (1) EP1001955B1 (fr)
JP (1) JP4320118B2 (fr)
KR (1) KR20010022353A (fr)
CN (1) CN1135231C (fr)
AR (1) AR015927A1 (fr)
AT (1) ATE207069T1 (fr)
AU (1) AU737709B2 (fr)
BG (1) BG64448B1 (fr)
BR (1) BR9810829B1 (fr)
CA (1) CA2298935A1 (fr)
CO (1) CO4970780A1 (fr)
CZ (1) CZ290208B6 (fr)
DE (1) DE69802100T2 (fr)
DK (1) DK1001955T3 (fr)
EE (1) EE04313B1 (fr)
EG (1) EG24041A (fr)
ES (2) ES2137113B1 (fr)
HK (1) HK1024914A1 (fr)
HU (1) HUP0004708A3 (fr)
ID (1) ID24506A (fr)
IL (1) IL134081A (fr)
MY (1) MY118796A (fr)
NO (1) NO315118B1 (fr)
NZ (1) NZ502356A (fr)
PE (1) PE111099A1 (fr)
PL (1) PL191031B1 (fr)
PT (1) PT1001955E (fr)
RU (1) RU2202552C2 (fr)
SI (1) SI1001955T1 (fr)
SK (1) SK284046B6 (fr)
TR (1) TR200000243T2 (fr)
TW (1) TW542837B (fr)
UA (1) UA60339C2 (fr)
WO (1) WO1999006404A1 (fr)
ZA (1) ZA986248B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
CA2715683A1 (fr) 1999-08-21 2001-03-01 Nycomed Gmbh Combinaison synergiste
WO2002080974A1 (fr) * 2001-04-04 2002-10-17 Sankyo Company, Limited Utilisation medicale d'inhibiteur de production de cytokine
PL210463B1 (pl) * 2001-09-19 2012-01-31 Nycomed Gmbh Zastosowanie kombinacji roflumilastu z diklofenakiem w leczeniu zapalnych chorób stawów
FR2832711B1 (fr) * 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
ES2372600T3 (es) * 2002-11-06 2012-01-24 Aska Pharmaceutical Co., Ltd. Derivado de pirazolonaftiridina.
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
RU2246496C1 (ru) * 2003-09-12 2005-02-20 Тец Виктор Вениаминович Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
NZ563423A (en) * 2005-06-10 2010-05-28 Merck Sharp & Dohme Inhibitors of AKT activity
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline
KR20080046728A (ko) 2005-09-15 2008-05-27 아스카 세이야쿠 가부시키가이샤 복소환 화합물, 그의 제조 방법 및 용도
CA2625153A1 (fr) 2005-10-21 2007-04-26 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (fr) 2006-05-09 2011-10-19 Braincells, Inc. Neurogénèse par modulation de l'angiotensine
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
TW200817410A (en) 2006-08-07 2008-04-16 Incyte Corp Triazolotriazines as kinase inhibitors
WO2008030651A1 (fr) 2006-09-08 2008-03-13 Braincells, Inc. Combinaisons contenant un dérivé de 4-acylaminopyridine
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
ME02372B (me) 2006-11-22 2016-06-20 Incyte Holdings Corp Imidazotriazini i imidazopiramidini kao inhibitori kinaze
US20110112079A1 (en) * 2008-01-09 2011-05-12 Thomas Craig J Phosphodiesterase inhibitors
TWI472529B (zh) 2008-05-21 2015-02-11 Incyte Corp ２－氟－Ｎ－甲基－４－〔７－（喹啉－６－基－甲基）－咪唑并〔１，２－ｂ〕〔１，２，４〕三－２－基〕苯甲醯胺之鹽類及其相關製備方法
EP2196465A1 (fr) 2008-12-15 2010-06-16 Almirall, S.A. Dérivés de (3-oxo)pyridazin-4-ylurée comme inhibiteurs de PDE4
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (fr) 2009-02-27 2010-09-08 Almirall, S.A. Nouveaux dérivés de tétrahydropyrazolo [3,4-c]isoquinoléine-5-amine
CN102791715B (zh) 2009-12-31 2016-04-27 卡洛斯三世国家癌症研究中心基金会 用作激酶抑制剂的三环化合物
EP2531509B1 (fr) 2010-02-03 2016-10-05 Incyte Holdings Corporation Imidazo[1,2-b][1,2,4]triazines en tant qu'inhibiteurs de c met
EP2380890A1 (fr) 2010-04-23 2011-10-26 Almirall, S.A. Nouveaux dérivés de 7,8-dihydro-1,6-naphthyridin-5(6h)-one comme PDE4 inhibiteurs
EP2394998A1 (fr) 2010-05-31 2011-12-14 Almirall, S.A. Dérivés de 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl en tant qu'inhibiteurs de la PDE4
WO2012098387A1 (fr) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) Dérivés de triazolo[4,3-b]pyridazines au cycle 6,7 fusionné utilisés en tant qu'inhibiteurs de pim
WO2013004984A1 (fr) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Composés tricycliques pour l'utilisation en tant qu'inhibiteurs de kinase
WO2013005057A1 (fr) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Nouveaux composés
WO2013005041A1 (fr) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Composés hétérocycliques tricycliques en tant qu'inhibiteurs de kinases
WO2013106547A1 (fr) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3122670A1 (de) 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
JP3120857B2 (ja) * 1990-02-19 2000-12-25 中外製薬株式会社 新規な縮合複素環化合物とこれを用いた抗喘息剤
ES2105920B1 (es) * 1991-10-09 1998-07-01 Syntex Inc Procedimiento para preparar compuestos de benzo-y piridopiridazinona y piridazinationa.
GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds

Also Published As

Publication number Publication date
CZ290208B6 (cs) 2002-06-12
WO1999006404A1 (fr) 1999-02-11
CA2298935A1 (fr) 1999-02-11
PL191031B1 (pl) 2006-03-31
UA60339C2 (uk) 2003-10-15
NO315118B1 (no) 2003-07-14
SK284046B6 (sk) 2004-08-03
US6407108B1 (en) 2002-06-18
CN1135231C (zh) 2004-01-21
TW542837B (en) 2003-07-21
EE200000052A (et) 2000-10-16
CO4970780A1 (es) 2000-11-07
BG104112A (en) 2001-01-31
HUP0004708A2 (hu) 2001-07-30
BR9810829A (pt) 2000-07-25
NZ502356A (en) 2001-03-30
RU2202552C2 (ru) 2003-04-20
ES2137113A1 (es) 1999-12-01
DE69802100T2 (de) 2002-03-14
US20020183326A1 (en) 2002-12-05
CN1266434A (zh) 2000-09-13
SK862000A3 (en) 2000-07-11
JP2001512121A (ja) 2001-08-21
MY118796A (en) 2005-01-31
EP1001955B1 (fr) 2001-10-17
BR9810829B1 (pt) 2009-08-11
TR200000243T2 (tr) 2000-07-21
ZA986248B (en) 1999-02-05
EP1001955A1 (fr) 2000-05-24
ES2137113B1 (es) 2000-09-16
PE111099A1 (es) 1999-11-18
IL134081A0 (en) 2001-04-30
HUP0004708A3 (en) 2002-11-28
PL338214A1 (en) 2000-10-09
BG64448B1 (en) 2005-02-28
ES2162466T3 (es) 2001-12-16
CZ2000333A3 (cs) 2000-05-17
AR015927A1 (es) 2001-05-30
ATE207069T1 (de) 2001-11-15
KR20010022353A (ko) 2001-03-15
AU737709B2 (en) 2001-08-30
DK1001955T3 (da) 2001-11-19
HK1024914A1 (en) 2000-10-27
NO20000394D0 (no) 2000-01-26
NO20000394L (no) 2000-03-27
EG24041A (en) 2008-04-03
ID24506A (id) 2000-07-20
AU8861298A (en) 1999-02-22
JP4320118B2 (ja) 2009-08-26
EE04313B1 (et) 2004-06-15
IL134081A (en) 2004-02-08
PT1001955E (pt) 2002-02-28
DE69802100D1 (de) 2001-11-22

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