SG165414A1 - Glp-1 ( glucagon-like peptide-1 ) fusion polypeptides with increased peptidase resistance - Google Patents
Glp-1 ( glucagon-like peptide-1 ) fusion polypeptides with increased peptidase resistanceInfo
- Publication number
- SG165414A1 SG165414A1 SG201006921-9A SG2010069219A SG165414A1 SG 165414 A1 SG165414 A1 SG 165414A1 SG 2010069219 A SG2010069219 A SG 2010069219A SG 165414 A1 SG165414 A1 SG 165414A1
- Authority
- SG
- Singapore
- Prior art keywords
- glp
- peptide
- component
- sequence
- glucagon
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 title abstract 5
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title abstract 5
- 230000004927 fusion Effects 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
- 101800000224 Glucagon-like peptide 1 Proteins 0.000 title 1
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 235000019833 protease Nutrition 0.000 title 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 1
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 1
- 102400000326 Glucagon-like peptide 2 Human genes 0.000 abstract 1
- 101800000221 Glucagon-like peptide 2 Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 208000034615 apoptosis-related disease Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05020718A EP1767545B1 (de) | 2005-09-22 | 2005-09-22 | Fusionspolypeptide vom glp-1 (glucagon-like peptide-1) mit erhöhten peptidaseresistenz |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG165414A1 true SG165414A1 (en) | 2010-10-28 |
Family
ID=35700191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG201006921-9A SG165414A1 (en) | 2005-09-22 | 2006-09-22 | Glp-1 ( glucagon-like peptide-1 ) fusion polypeptides with increased peptidase resistance |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8431533B2 (de) |
| EP (5) | EP1767545B1 (de) |
| JP (2) | JP5222729B2 (de) |
| KR (1) | KR20080064840A (de) |
| CN (1) | CN101273058A (de) |
| AT (1) | ATE448247T1 (de) |
| AU (1) | AU2006299134B2 (de) |
| BR (1) | BRPI0616107A2 (de) |
| CA (1) | CA2619053A1 (de) |
| CY (1) | CY1109778T1 (de) |
| DE (1) | DE602005017628D1 (de) |
| DK (1) | DK1767545T3 (de) |
| EA (1) | EA013796B1 (de) |
| ES (3) | ES2397289T3 (de) |
| HR (1) | HRP20100062T1 (de) |
| IL (1) | IL188904A0 (de) |
| PL (1) | PL1767545T3 (de) |
| PT (1) | PT1767545E (de) |
| RS (1) | RS51319B (de) |
| SG (1) | SG165414A1 (de) |
| SI (1) | SI1767545T1 (de) |
| WO (1) | WO2007039140A1 (de) |
| ZA (1) | ZA200803488B (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1767545T3 (da) | 2005-09-22 | 2010-03-15 | Biocompatibles Uk Ltd | GLP-1 (Glucagon-lignende peptid-1)-fusionspolypeptider med forøget peptidaseresistens |
| JP2009513627A (ja) * | 2005-10-27 | 2009-04-02 | ペプトロン カンパニー リミテッド | 生理活性物質−血液蛋白質複合体及びこれを利用する生理活性物質の安定化方法 |
| US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
| US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
| ATE444741T1 (de) * | 2006-05-10 | 2009-10-15 | Biocompatibles Uk Ltd | Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendung |
| EP1972349A1 (de) * | 2007-03-21 | 2008-09-24 | Biocompatibles UK Limited | Mit Polymer(en) konjugierte GLP-1-Fusionspeptide, ihre Herstellung und Verwendung |
| EP1975176A1 (de) * | 2007-03-27 | 2008-10-01 | Biocompatibles UK Limited | Neue GLP-1-Fusionspeptide, ihre Herstellung und Verwendung |
| EP4074327A1 (de) | 2008-06-27 | 2022-10-19 | Duke University | Therapeutika mit elastinähnlichen peptiden |
| EP2163243A1 (de) * | 2008-09-12 | 2010-03-17 | Biocompatibles UK Limited | Behandlung akuter Herzinfarkte mithilfe eingekapselter Zellen, welche GLP-1-Peptide oder deren Analoga kodieren und absondern |
| CN101993485B (zh) * | 2009-08-20 | 2013-04-17 | 重庆富进生物医药有限公司 | 促胰岛素分泌肽类似物同源二聚体及其用途 |
| MX339559B (es) * | 2010-02-11 | 2016-05-31 | Hoffmann La Roche | Conjugados de igf-i poli(etilenglicol). |
| US20130225508A1 (en) * | 2010-10-01 | 2013-08-29 | Osamu Masaki | Peptide capable of binding to immunoglobulin |
| CN102766204B (zh) * | 2011-05-05 | 2014-10-15 | 天津药物研究院 | 胰高血糖素样肽-1突变体多肽及其制备方法和其应用 |
| CN102363633B (zh) * | 2011-11-16 | 2013-11-20 | 天津拓飞生物科技有限公司 | 胰高血糖素样肽-1突变体多肽及其制备方法、药物组合物和其应用 |
| BR112015011478B1 (pt) | 2012-11-20 | 2022-10-25 | Mederis Diabetes, Llc | Produtos de peptídeo, seus usos e composição farmacêutica |
| CN104371019B (zh) | 2013-08-13 | 2019-09-10 | 鸿运华宁（杭州）生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
| CN104707131A (zh) * | 2013-12-13 | 2015-06-17 | 上海建华精细生物制品有限公司 | 一种药物组合物及其制备方法和用途 |
| EP4397374A2 (de) | 2014-05-28 | 2024-07-10 | Mederis Diabetes, LLC | Verbesserte peptidarzneimittel für insulinresistenz |
| JP6731953B2 (ja) | 2015-02-11 | 2020-07-29 | ジーエムエーエックス バイオファーム エルエルシー． | Ｇｌｐ−１ｒ抗体融合タンパク質の安定な医薬溶液製剤 |
| ES2968038T3 (es) | 2015-12-23 | 2024-05-06 | Univ Johns Hopkins | Agonista GLP-1R de acción prolongada como terapia de afecciones neurológicas y neurodegenerativas |
| CN107818433B (zh) * | 2016-09-14 | 2022-07-05 | 菜鸟智能物流控股有限公司 | 取件方法、物流信息处理方法及装置、系统 |
| WO2018104558A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Acylated glp-1/glp-2 dual agonists |
| WO2018104559A1 (en) * | 2016-12-09 | 2018-06-14 | Zealand Pharma A/S | Glp-1/glp-2 dual agonists |
| BR112019010624A2 (pt) | 2016-12-09 | 2019-10-22 | Zealand Pharma As | agonistas duplos de glp-1/glp-2 acilados e composição |
| CN108341880B (zh) * | 2017-01-23 | 2023-07-04 | 天津药物研究院有限公司 | 含有胰高血糖素样肽-1和胰高血糖素的片段类似物的嵌合多肽及其用途 |
| KR101827245B1 (ko) * | 2017-12-26 | 2018-02-08 | (주)제이유타이드 | 알라린을 주성분으로 하는 요독증 치료제 |
| CN111818971A (zh) | 2018-01-03 | 2020-10-23 | 梅德瑞斯糖尿病有限责任公司 | 用于治疗nash和其他紊乱的改进的肽药物 |
| KR101903564B1 (ko) * | 2018-01-31 | 2018-11-13 | 한국지질자원연구원 | 제지공정에서 발생되는 부산물의 재활용 방법 |
| SI4122954T1 (sl) | 2018-04-05 | 2024-07-31 | Sun Pharmaceutical Industries Limited | Novi analogi GLP-1 |
| US20220153853A1 (en) | 2018-12-21 | 2022-05-19 | Jiangsu Hengrui Medicine Co., Ltd. | Bispecific protein |
| KR102349717B1 (ko) * | 2020-03-12 | 2022-01-11 | 주식회사 에스엘메타젠 | 신규 대사증후군 및 그와 관련된 질환 치료용 약학 조성물 |
| KR102349718B1 (ko) * | 2020-03-12 | 2022-01-11 | 주식회사 에스엘메타젠 | 신규 이중 특이성 단백질 및 그의 용도 |
| WO2022015039A1 (ko) * | 2020-07-14 | 2022-01-20 | (주)지아이이노베이션 | 글루카곤-유사 펩타이드-1 및 글루카곤-유사 펩타이드-2를 포함하는 융합 단백질 및 이의 용도 |
| MX2023006189A (es) * | 2020-11-27 | 2023-07-04 | D&D Pharmatech Inc | Formulacion oral de conjugado de material biologicamente activo que tiene acoplada un resto de biotina, un resto de acido graso o una combinacion de estos. |
| IL303229A (en) * | 2020-11-27 | 2023-07-01 | D& D Pharmatech Inc | A biologically active substance conjugate is linked to a biotin unit, a fatty acid unit or a combination thereof |
| CN112661862B (zh) * | 2020-12-25 | 2023-03-31 | 深圳大学 | 一种融合蛋白及其制备方法和应用 |
| CN113846124A (zh) * | 2021-09-26 | 2021-12-28 | 康霖生物科技（杭州）有限公司 | 一种用于糖代谢相关疾病基因治疗的核酸构建体 |
| CN114874314B (zh) * | 2021-12-28 | 2022-11-11 | 北京惠之衡生物科技有限公司 | 一种高表达glp-1类似物的重组工程菌及其构建方法 |
| WO2024144431A1 (ru) * | 2022-12-29 | 2024-07-04 | Авва Фармасьютикалс Лтд | Новый штамм-продуцент escherichia coli, продуцирующий гибридный белок cbd-hs-es-glp1, и способ получения полипептида glp-1 |
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