WO2006017688A3 - Combination therapy using transferrin fusion proteins comprising glp-1 - Google Patents

Combination therapy using transferrin fusion proteins comprising glp-1 Download PDF

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Publication number
WO2006017688A3
WO2006017688A3 PCT/US2005/027800 US2005027800W WO2006017688A3 WO 2006017688 A3 WO2006017688 A3 WO 2006017688A3 US 2005027800 W US2005027800 W US 2005027800W WO 2006017688 A3 WO2006017688 A3 WO 2006017688A3
Authority
WO
WIPO (PCT)
Prior art keywords
transferrin fusion
combination therapy
glp
fusion proteins
inhibitors
Prior art date
Application number
PCT/US2005/027800
Other languages
French (fr)
Other versions
WO2006017688A2 (en
Inventor
Homayoun Sadeghi
Christopher Prior
David J Balance
Original Assignee
Biorexis Pharmaceutical Corp
Homayoun Sadeghi
Christopher Prior
David J Balance
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BRPI0514115-0A priority Critical patent/BRPI0514115A/en
Priority to EA200700391A priority patent/EA200700391A1/en
Priority to MX2007001424A priority patent/MX2007001424A/en
Priority to EP05782173A priority patent/EP1814599A4/en
Priority to JP2007525008A priority patent/JP2008509153A/en
Priority to AU2005271403A priority patent/AU2005271403A1/en
Priority to AP2007003920A priority patent/AP2007003920A0/en
Priority to CA002575756A priority patent/CA2575756A1/en
Application filed by Biorexis Pharmaceutical Corp, Homayoun Sadeghi, Christopher Prior, David J Balance filed Critical Biorexis Pharmaceutical Corp
Publication of WO2006017688A2 publication Critical patent/WO2006017688A2/en
Publication of WO2006017688A3 publication Critical patent/WO2006017688A3/en
Priority to IL181108A priority patent/IL181108A0/en
Priority to TNP2007000039A priority patent/TNSN07039A1/en
Priority to NO20071018A priority patent/NO20071018L/en
Priority to GB0703685A priority patent/GB2431583A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)

Abstract

The present invention provides combination therapy comprising transferrin fusion protein and DPP-IV inhibitors and/or neutral endopeptidase (NEP) inhibitors. The transferrin fusion protein comprises therapeutic polypeptides or peptides useful in the treatment of diseases such as diabetes.
PCT/US2005/027800 2004-08-03 2005-08-03 Combination therapy using transferrin fusion proteins comprising glp-1 WO2006017688A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AP2007003920A AP2007003920A0 (en) 2004-08-03 2005-08-03 Combination therapy using transferrin fusion proteins comprising glp-1
MX2007001424A MX2007001424A (en) 2004-08-03 2005-08-03 Combination therapy using transferrin fusion proteins comprising glp-1.
EP05782173A EP1814599A4 (en) 2004-08-03 2005-08-03 Combination therapy using transferrin fusion proteins comprising glp-1
JP2007525008A JP2008509153A (en) 2004-08-03 2005-08-03 Combination therapy using transferrin fusion protein containing GLP-1
AU2005271403A AU2005271403A1 (en) 2004-08-03 2005-08-03 Combination therapy using transferrin fusion proteins comprising GLP-1
BRPI0514115-0A BRPI0514115A (en) 2004-08-03 2005-08-03 combination therapy employing transferrin fusion proteins comprising glp-1
CA002575756A CA2575756A1 (en) 2004-08-03 2005-08-03 Combination therapy using transferrin fusion proteins comprising glp-1
EA200700391A EA200700391A1 (en) 2004-08-03 2005-08-03 COMBINED TREATMENT WITH THE APPLICATION OF TRANSFERRIN SLIP PROTEINS CONTAINING GLP-1
IL181108A IL181108A0 (en) 2004-08-03 2007-02-01 Combination therapy using transferrin fusion proteins comprising glp-1
TNP2007000039A TNSN07039A1 (en) 2004-08-03 2007-02-02 ASSOCIATION THERAPY USING TRANSFERRIN FUSION PROTEINS COMPRISING GLP-1
NO20071018A NO20071018L (en) 2004-08-03 2007-02-22 Combination treatment using fusion proteins comprising GLP-1
GB0703685A GB2431583A (en) 2004-08-03 2007-02-26 Combination therapy using transferrin fusion proteins comprising GLP-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59803104P 2004-08-03 2004-08-03
US60/598,031 2004-08-03

Publications (2)

Publication Number Publication Date
WO2006017688A2 WO2006017688A2 (en) 2006-02-16
WO2006017688A3 true WO2006017688A3 (en) 2006-08-03

Family

ID=35839920

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/027800 WO2006017688A2 (en) 2004-08-03 2005-08-03 Combination therapy using transferrin fusion proteins comprising glp-1

Country Status (19)

Country Link
EP (1) EP1814599A4 (en)
JP (1) JP2008509153A (en)
KR (1) KR20070085224A (en)
CN (1) CN101035568A (en)
AP (1) AP2007003920A0 (en)
AU (1) AU2005271403A1 (en)
BR (1) BRPI0514115A (en)
CA (1) CA2575756A1 (en)
CR (1) CR8954A (en)
EA (1) EA200700391A1 (en)
GB (1) GB2431583A (en)
IL (1) IL181108A0 (en)
MA (1) MA28843B1 (en)
MX (1) MX2007001424A (en)
NO (1) NO20071018L (en)
RU (1) RU2007107808A (en)
TN (1) TNSN07039A1 (en)
WO (1) WO2006017688A2 (en)
ZA (1) ZA200701484B (en)

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US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
EP1494732B1 (en) 2002-03-20 2008-01-30 MannKind Corporation Inhalation apparatus
KR101273120B1 (en) 2004-08-20 2013-06-13 맨카인드 코포레이션 Catalysis of diketopiperazine synthesis
KR20130066695A (en) 2004-08-23 2013-06-20 맨카인드 코포레이션 Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery
EP1858546A4 (en) * 2005-03-04 2009-03-04 Biorexis Pharmaceutical Corp Modified transferrin fusion proteins
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CN101432025B (en) * 2006-03-21 2012-04-04 安米林药品公司 Peptide-peptidase inhibitor conjugates and methods of using same
WO2008012629A2 (en) * 2006-07-24 2008-01-31 Biorexis Pharmaceutical Corporation Exendin fusion proteins
WO2008033395A2 (en) * 2006-09-14 2008-03-20 Biorexis Pharmaceutical Corporation Melanocortin and transferrin fusion proteins
US8598314B2 (en) 2007-09-27 2013-12-03 Amylin Pharmaceuticals, Llc Peptide-peptidase-inhibitor conjugates and methods of making and using same
CN109568740B (en) 2008-06-13 2022-05-27 曼金德公司 Dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
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PL2405963T3 (en) 2009-03-11 2014-04-30 Mannkind Corp Apparatus, system and method for measuring resistance of an inhaler
KR101875969B1 (en) 2009-06-12 2018-07-06 맨카인드 코포레이션 Diketopiperazine microparticles with defined specific surface areas
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WO2013162050A1 (en) * 2012-04-23 2013-10-31 株式会社Ｎｒｌファーマ Lactoferrin fusion protein and method for producing same
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UA116217C2 (en) 2012-10-09 2018-02-26 Санофі Exendin-4 derivatives as dual glp1/glucagon agonists
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US20030138404A1 (en) * 1995-07-14 2003-07-24 Meiogen Biotechnology Corporation Interferon antagonists useful for the treatment of interferon related diseases
US5925351A (en) * 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US20020156036A1 (en) * 2000-09-06 2002-10-24 Nicolau Yves Claude Methods and compositions for diseases associated with amyloidosis
US20030221201A1 (en) * 2001-08-30 2003-11-27 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents

Also Published As

Publication number Publication date
CN101035568A (en) 2007-09-12
WO2006017688A2 (en) 2006-02-16
AP2007003920A0 (en) 2007-02-28
RU2007107808A (en) 2008-09-10
EA200700391A1 (en) 2007-10-26
EP1814599A4 (en) 2008-12-17
JP2008509153A (en) 2008-03-27
KR20070085224A (en) 2007-08-27
EP1814599A2 (en) 2007-08-08
NO20071018L (en) 2007-04-11
MX2007001424A (en) 2008-03-13
GB0703685D0 (en) 2007-04-04
AU2005271403A1 (en) 2006-02-16
BRPI0514115A (en) 2008-05-27
ZA200701484B (en) 2008-07-30
GB2431583A (en) 2007-05-02
MA28843B1 (en) 2007-09-03
CR8954A (en) 2007-10-02
TNSN07039A1 (en) 2008-06-02
CA2575756A1 (en) 2006-02-16
IL181108A0 (en) 2007-07-04

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