US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
US4261989A
(en)
|
1979-02-19 |
1981-04-14 |
Kaken Chemical Co. Ltd. |
Geldanamycin derivatives and antitumor drug
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・2・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
US5720937A
(en)
|
1988-01-12 |
1998-02-24 |
Genentech, Inc. |
In vivo tumor detection assay
|
WO1989006692A1
(en)
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
US5120525A
(en)
|
1988-03-29 |
1992-06-09 |
Immunomedics, Inc. |
Radiolabeled antibody cytotoxic therapy of cancer
|
US20030232010A2
(en)
|
1988-03-29 |
2003-12-18 |
Immunomedics, Inc. |
Improved cytotoxic therapy
|
CA1329119C
(en)
|
1988-03-29 |
1994-05-03 |
Milton David Goldenberg |
Cytotoxic therapy
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
AU666852B2
(en)
|
1991-05-01 |
1996-02-29 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
A method for treating infectious respiratory diseases
|
ATE255131T1
(de)
|
1991-06-14 |
2003-12-15 |
Genentech Inc |
Humanisierter heregulin antikörper
|
EP0530537B1
(en)
|
1991-08-12 |
1997-01-08 |
Takeda Chemical Industries, Ltd. |
Condensed pyrimidine derivatives, their production and use as antitumor agents
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
AU4116793A
(en)
|
1992-04-24 |
1993-11-29 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
US7326535B2
(en)
|
1993-09-15 |
2008-02-05 |
Ortho Diagnostic Systems Inc. |
Immunoreactive peptides from Epstein-Barr virus
|
US7060283B1
(en)
|
1992-09-15 |
2006-06-13 |
Ortho Diagnostic Systems, Inc. |
Immunoreactive peptides from Epstein-Barr virus
|
ATE428724T1
(de)
|
1992-09-15 |
2009-05-15 |
Ortho Diagnostic Systems Inc |
Immunreaktive peptide des epstein-barrvirus
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
WO1994029351A2
(en)
|
1993-06-16 |
1994-12-22 |
Celltech Limited |
Antibodies
|
JPH10501532A
(ja)
|
1994-06-09 |
1998-02-10 |
スミスクライン・ビーチャム・コーポレイション |
エンドセリン受容体拮抗物質
|
US6132764A
(en)
|
1994-08-05 |
2000-10-17 |
Targesome, Inc. |
Targeted polymerized liposome diagnostic and treatment agents
|
US5686578A
(en)
|
1994-08-05 |
1997-11-11 |
Immunomedics, Inc. |
Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
PT885002E
(pt)
|
1996-03-04 |
2011-07-14 |
Massachusetts Inst Technology |
Materiais e métodos para aumento da internalização celular
|
WO1997039774A1
(en)
|
1996-04-23 |
1997-10-30 |
Novopharm Biotech, Inc. |
Human monoclonal antibody specific for melanoma-associated antigen and methods of use
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
JP3884484B2
(ja)
|
1997-01-16 |
2007-02-21 |
マサチューセッツ インスティチュート オブ テクノロジー |
吸入用粒子の調製
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
US6355257B1
(en)
|
1997-05-08 |
2002-03-12 |
Corixa Corporation |
Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
|
US7063967B2
(en)
|
1997-05-08 |
2006-06-20 |
Corixa Corporation |
Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
|
US6303347B1
(en)
|
1997-05-08 |
2001-10-16 |
Corixa Corporation |
Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
|
US6764840B2
(en)
|
1997-05-08 |
2004-07-20 |
Corixa Corporation |
Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
|
US7541020B2
(en)
|
1997-05-08 |
2009-06-02 |
Corixa Corporation |
Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors
|
US6113918A
(en)
|
1997-05-08 |
2000-09-05 |
Ribi Immunochem Research, Inc. |
Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
|
GB2339430A
(en)
|
1997-05-21 |
2000-01-26 |
Biovation Ltd |
Method for the production of non-immunogenic proteins
|
DK0985039T3
(da)
|
1997-06-12 |
2008-06-09 |
Novartis Int Pharm Ltd |
Kunstige antistof-polypeptider
|
US6248564B1
(en)
|
1997-08-29 |
2001-06-19 |
Harvard University |
Mutant MHC class I molecules
|
US6238667B1
(en)
|
1997-09-19 |
2001-05-29 |
Heinz Kohler |
Method of affinity cross-linking biologically active immunogenic peptides to antibodies
|
US7569674B2
(en)
|
1998-05-04 |
2009-08-04 |
Innexus Biotechnology International Limited |
Autophilic antibodies
|
US20040185039A1
(en)
|
2002-08-30 |
2004-09-23 |
Heinz Kohler |
Therapeutic applications of noncovalent dimerizing antibodies
|
US20030103984A1
(en)
|
1998-05-04 |
2003-06-05 |
Heinz Kohler |
Fusion proteins of biologically active peptides and antibodies
|
US20050033033A1
(en)
|
1998-05-04 |
2005-02-10 |
Heinz Kohler |
Trans-membrane-antibody induced inhibition of apoptosis
|
US20090075339A1
(en)
|
1997-09-19 |
2009-03-19 |
Innexus Biotechnology International Limited |
Autophilic antibodies
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
DE69942021D1
(de)
|
1998-04-20 |
2010-04-01 |
Glycart Biotechnology Ag |
Glykosylierungs-engineering von antikörpern zur verbesserung der antikörperabhängigen zellvermittelten zytotoxizität
|
US6573245B1
(en)
|
1998-04-28 |
2003-06-03 |
Galenica Pharmaceuticals, Inc. |
Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof
|
US20090208418A1
(en)
|
2005-04-29 |
2009-08-20 |
Innexus Biotechnology Internaltional Ltd. |
Superantibody synthesis and use in detection, prevention and treatment of disease
|
US7387772B1
(en)
|
1999-06-22 |
2008-06-17 |
Immunimedics, Inc. |
Chimeric, human and humanized anti-CSAP monoclonal antibodies
|
DE69907456T2
(de)
|
1998-06-24 |
2004-03-25 |
Advanced Inhalation Research, Inc., Cambridge |
Grosse poröse partikel ausgestossen von einem inhalator
|
WO2000030680A1
(en)
|
1998-11-23 |
2000-06-02 |
Idec Pharmaceuticals Corporation |
Tumor antigen-specific antibody-gp39 chimeric protein constructs
|
KR100609800B1
(ko)
|
1998-12-16 |
2006-08-09 |
워너-램버트 캄파니 엘엘씨 |
Mek 저해제를 사용한 관절염 치료 방법
|
PL220113B1
(pl)
|
1999-01-15 |
2015-08-31 |
Genentech Inc |
Wariant macierzystego polipeptydu zawierającego region Fc, polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania receptora Fc gamma (FcγR), polipeptyd zawierający wariant regionu Fc o zmienionym powinowactwie wiązania noworodkowego receptora Fc (FcRn), kompozycja, wyizolowany kwas nukleinowy, wektor, komórka gospodarza, sposób otrzymywania wariantu polipeptydu, zastosowanie wariantu polipeptydu i sposób otrzymywania wariantu regionu Fc
|
US6897044B1
(en)
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
EP2270150B2
(en)
|
1999-04-09 |
2019-08-07 |
Kyowa Hakko Kirin Co., Ltd. |
Method for controlling the activity of immunologically functional molecule
|
AU4591600A
(en)
|
1999-05-05 |
2000-11-21 |
Aventis Pharma Limited |
Substituted bicyclic compounds
|
JP2003516718A
(ja)
|
1999-07-29 |
2003-05-20 |
メダレックス インク |
HER2/neuに対するヒトモノクローナル抗体
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
US6916925B1
(en)
|
1999-11-05 |
2005-07-12 |
3M Innovative Properties Co. |
Dye labeled imidazoquinoline compounds
|
US6376669B1
(en)
|
1999-11-05 |
2002-04-23 |
3M Innovative Properties Company |
Dye labeled imidazoquinoline compounds
|
US7306801B2
(en)
|
2000-05-15 |
2007-12-11 |
Health Research, Inc. |
Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein
|
DE10024069A1
(de)
|
2000-05-17 |
2001-12-13 |
Gluesenkamp Karl Heinz |
Konjugat auf der Basis einer heterobifunktionalen Brückenverbindung, die mit einem Immunmodulator und einer zellerkennenden Einheit substituiert ist
|
AU2001275072A1
(en)
|
2000-05-31 |
2001-12-11 |
The Scripps Research Institute |
Molecular marker for mitosis
|
PL203387B1
(pl)
|
2000-07-19 |
2009-09-30 |
Warner Lambert Co |
Utlenione estry kwasu 4-jodofenyloaminobenzhydroksamowego
|
US20060142202A1
(en)
|
2000-12-08 |
2006-06-29 |
3M Innovative Properties Company |
Compositions and methods for targeted delivery of immune response modifiers
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
US20050271663A1
(en)
|
2001-06-28 |
2005-12-08 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
WO2003035835A2
(en)
|
2001-10-25 |
2003-05-01 |
Genentech, Inc. |
Glycoprotein compositions
|
TW200303759A
(en)
|
2001-11-27 |
2003-09-16 |
Schering Corp |
Methods for treating cancer
|
ATE395413T1
(de)
|
2001-12-03 |
2008-05-15 |
Amgen Fremont Inc |
Antikörperkategorisierung auf der grundlage von bindungseigenschaften
|
JP4547911B2
(ja)
|
2002-02-01 |
2010-09-22 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
リン含有化合物およびその用途
|
PL221491B1
(pl)
|
2002-03-08 |
2016-04-29 |
Eisai R&D Man Co |
Związki makrocykliczne, środek farmaceutyczny zawierający te związki oraz zastosowanie tych związków
|
CA2484049A1
(en)
|
2002-03-19 |
2003-10-02 |
Powdermed Limited |
Imidazoquinoline adjuvants for vaccines
|
US20030190308A1
(en)
|
2002-03-19 |
2003-10-09 |
Braun Ralph P. |
Adjuvant
|
AU2003216852B2
(en)
|
2002-03-19 |
2008-09-11 |
Glaxo Group Limited |
Imidazoquinolineamines as adjuvants in HIV DNA vaccination
|
US20030185835A1
(en)
|
2002-03-19 |
2003-10-02 |
Braun Ralph P. |
Adjuvant for vaccines
|
ES2543710T3
(es)
|
2002-04-04 |
2015-08-21 |
Zoetis Belgium S.A. |
Oligorribonucleótidos inmunoestimulantes que contienen G y U
|
US20040248151A1
(en)
|
2002-04-05 |
2004-12-09 |
Ventana Medical Systems, Inc. |
Method for predicting the response to HER2-directed therapy
|
CA2481515C
(en)
|
2002-04-10 |
2013-10-01 |
Genentech, Inc. |
Anti-her2 antibody variants
|
TWI275390B
(en)
|
2002-04-30 |
2007-03-11 |
Wyeth Corp |
Process for the preparation of 7-substituted-3- quinolinecarbonitriles
|
US20090068178A1
(en)
|
2002-05-08 |
2009-03-12 |
Genentech, Inc. |
Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin
|
KR100485155B1
(ko)
|
2002-05-22 |
2005-04-22 |
주식회사 삼양제넥스 |
효소저항전분을 포함하는 면역활성 증강용 조성물
|
GB0215823D0
(en)
|
2002-07-09 |
2002-08-14 |
Astrazeneca Ab |
Quinazoline derivatives
|
ATE415413T1
(de)
|
2002-07-15 |
2008-12-15 |
Univ Princeton |
Iap-bindende verbindungen
|
US8968730B2
(en)
|
2002-08-14 |
2015-03-03 |
Macrogenics Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
US7427629B2
(en)
|
2002-08-15 |
2008-09-23 |
3M Innovative Properties Company |
Immunostimulatory compositions and methods of stimulating an immune response
|
AU2003286692A1
(en)
|
2002-10-25 |
2004-05-13 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Modulation of dendritic cell function and other cellular responses mediated by defensin compositions
|
EP1576014B1
(en)
|
2002-12-23 |
2011-06-29 |
Wyeth LLC |
Antibodies against pd-1 and uses thereof
|
CA2512729C
(en)
|
2003-01-09 |
2014-09-16 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant fc regions and methods of using same
|
ZA200506202B
(en)
|
2003-01-31 |
2006-10-25 |
Celldex Therapeutics Inc |
Antibody vaccine conjugates and uses therefor
|
US9259459B2
(en)
|
2003-01-31 |
2016-02-16 |
Celldex Therapeutics Inc. |
Antibody vaccine conjugates and uses therefor
|
EP1592302A4
(en)
|
2003-02-13 |
2007-04-25 |
3M Innovative Properties Co |
METHODS AND COMPOSITIONS ASSOCIATED WITH IMMUNE RESPONSE MODIFIER COMPOUNDS AND TOLL-LIKE RECEPTOR 8
|
KR20060006775A
(ko)
|
2003-03-05 |
2006-01-19 |
이넥스 바이오테크놀로지 인크. |
세포자살을 억제하는 유도된 막 횡단 항체
|
US20040265351A1
(en)
|
2003-04-10 |
2004-12-30 |
Miller Richard L. |
Methods and compositions for enhancing immune response
|
AU2004244962A1
(en)
|
2003-04-10 |
2004-12-16 |
3M Innovative Properties Company |
Delivery of immune response modifier compounds using metal-containing particulate support materials
|
JP2007514644A
(ja)
|
2003-04-10 |
2007-06-07 |
スリーエム イノベイティブ プロパティズ カンパニー |
免疫反応を向上させる方法および組成物
|
US7731967B2
(en)
|
2003-04-30 |
2010-06-08 |
Novartis Vaccines And Diagnostics, Inc. |
Compositions for inducing immune responses
|
KR100712081B1
(ko)
|
2003-06-27 |
2007-05-02 |
티디케이가부시기가이샤 |
R-t-b계 영구자석
|
PL1653959T3
(pl)
|
2003-08-14 |
2015-10-30 |
3M Innovative Properties Co |
Modyfikatory odpowiedzi immunologicznej modyfikowane lipidami
|
EP1660122A4
(en)
|
2003-08-25 |
2007-10-24 |
3M Innovative Properties Co |
IMMUNOSTIMULATORY COMBINATIONS AND TREATMENTS
|
JP2007503268A
(ja)
|
2003-08-25 |
2007-02-22 |
スリーエム イノベイティブ プロパティズ カンパニー |
免疫応答修飾化合物の送達
|
US7399865B2
(en)
|
2003-09-15 |
2008-07-15 |
Wyeth |
Protein tyrosine kinase enzyme inhibitors
|
US7687628B2
(en)
|
2003-10-01 |
2010-03-30 |
Taro Pharmaceuticals U.S.A., Inc. |
Method of preparing 4-amino-1H-imidazo(4,5-c)quinolines and acid addition salts thereof
|
US20050239733A1
(en)
|
2003-10-31 |
2005-10-27 |
Coley Pharmaceutical Gmbh |
Sequence requirements for inhibitory oligonucleotides
|
US20050175630A1
(en)
|
2003-12-23 |
2005-08-11 |
Eyal Raz |
Immunogenic compositions and methods of use thereof
|
CN1950106A
(zh)
|
2003-12-24 |
2007-04-18 |
莱顿大学医学中心 |
用作肿瘤特异性疫苗的合成蛋白质
|
BRPI0506883A
(pt)
|
2004-01-16 |
2007-05-29 |
Univ Michigan |
miméticos de smac conformacionalmente comprimidos e seus usos
|
CA2553871A1
(en)
|
2004-01-16 |
2005-08-04 |
The Regents Of The University Of Michigan |
Smac peptidomimetics and the uses thereof
|
US20060002941A1
(en)
|
2004-01-23 |
2006-01-05 |
Vievax Corp. |
Compositions comprising immune response altering agents and methods of use
|
US7968557B2
(en)
|
2004-02-14 |
2011-06-28 |
Novartis Ag |
Substituted pyrrolo[2,3-2]pyrimidines as protein kinase inhibitors
|
AU2005228950B2
(en)
|
2004-03-23 |
2012-02-02 |
Genentech, Inc. |
Azabicyclo-octane inhibitors of IAP
|
AR048927A1
(es)
|
2004-04-07 |
2006-06-14 |
Novartis Ag |
Compuestos heterociclicos como inhibidores de proteinas de apoptosis (iap); composiciones farmaceuticas que los contienen y su uso en el tratamiento de una enfermedad proliferativa
|
EP1735010A4
(en)
|
2004-04-09 |
2008-08-27 |
3M Innovative Properties Co |
METHODS, COMPOSITIONS AND PREPARATIONS FOR ADMINISTRATION OF IMMUNE RESPONSE MODIFIERS (MRI)
|
WO2005107760A1
(en)
|
2004-04-30 |
2005-11-17 |
Irm Llc |
Compounds and compositions as inducers of keratinocyte differentiation
|
MEP8409A
(en)
|
2004-06-02 |
2011-12-20 |
|
Fused heterocyclic compound
|
AU2005326144A1
(en)
|
2004-06-08 |
2006-08-03 |
Coley Pharmaceutical Gmbh |
Abasic oligonucleotide as carrier platform for antigen and immunostimulatory agonist and antagonist
|
CA2570321C
(en)
|
2004-07-02 |
2013-10-08 |
Genentech, Inc. |
Inhibitors of iap
|
US7674787B2
(en)
|
2004-07-09 |
2010-03-09 |
The Regents Of The University Of Michigan |
Conformationally constrained Smac mimetics and the uses thereof
|
WO2006017295A2
(en)
|
2004-07-12 |
2006-02-16 |
Idun Pharmaceuticals, Inc. |
Tetrapeptide analogs
|
CA2574040C
(en)
|
2004-07-15 |
2014-05-06 |
Tetralogic Pharmaceuticals Corporation |
Iap binding compounds
|
EP1776105A2
(en)
|
2004-07-18 |
2007-04-25 |
Coley Pharmaceutical Group, Ltd |
Methods and compositions for inducing innate immune responses
|
ES2521140T3
(es)
|
2004-07-22 |
2014-11-12 |
Genentech, Inc. |
Composición de anticuerpos de HER2
|
US20060045885A1
(en)
|
2004-08-27 |
2006-03-02 |
Kedl Ross M |
Method of eliciting an immune response against HIV
|
BRPI0516284A
(pt)
|
2004-09-23 |
2008-09-02 |
Genentech Inc |
anticorpo construìdo com cisteìna, método de selecionar anticorpos, compostos conjugados de droga-anticorpo, composição farmacêutica, método para matar ou inibir a proliferação de células de tumor, métodos de inibir a proliferação celular e o crescimento de células de tumor, artigo manufaturado e método para produzir um composto
|
AU2005289685B2
(en)
|
2004-09-24 |
2009-07-16 |
Amgen Inc. |
Modified Fc molecules
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
WO2006052900A2
(en)
|
2004-11-09 |
2006-05-18 |
University Of Southern California |
Targeted innate immunity
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
EA019420B1
(ru)
|
2004-12-20 |
2014-03-31 |
Дженентех, Инк. |
Пирролидиновые ингибиторы иап (ингибиторов апоптоза)
|
US20080188483A1
(en)
|
2005-03-15 |
2008-08-07 |
Irm Llc |
Compounds and Compositions as Protein Kinase Inhibitors
|
KR101205064B1
(ko)
|
2005-04-26 |
2012-11-27 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
암 면역요법을 위한 조성물과 방법
|
KR101339628B1
(ko)
|
2005-05-09 |
2013-12-09 |
메다렉스, 인코포레이티드 |
예정 사멸 인자 1(pd-1)에 대한 인간 모노클로날 항체, 및 항-pd-1 항체를 단독 사용하거나 기타 면역 요법제와 병용한 암 치료 방법
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
KR101888321B1
(ko)
|
2005-07-01 |
2018-08-13 |
이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. |
예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
|
PT1912636E
(pt)
|
2005-07-21 |
2014-07-24 |
Ardea Biosciences Inc |
Inibidores de n-(arilamino)-sulfonamida de mek
|
WO2008020827A2
(en)
|
2005-08-01 |
2008-02-21 |
Biogen Idec Ma Inc. |
Altered polypeptides, immunoconjugates thereof, and methods related thereto
|
WO2007021841A2
(en)
|
2005-08-10 |
2007-02-22 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant fc regions and methods of using same
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
US7786089B2
(en)
|
2005-12-20 |
2010-08-31 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory activity of immune modulatory oligonucleotides (IMO™) containing different lengths of palindromic segments
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
EP3085373A1
(en)
|
2006-02-22 |
2016-10-26 |
3M Innovative Properties Company |
Immune response modifier conjugates
|
US20080031887A1
(en)
|
2006-06-30 |
2008-02-07 |
Joseph Lustgarten |
Conjugates for inducing targeted immune responses and methods of making and using same
|
US20090074711A1
(en)
|
2006-09-07 |
2009-03-19 |
University Of Southhampton |
Human therapies using chimeric agonistic anti-human cd40 antibody
|
ES2636089T3
(es)
|
2006-10-27 |
2017-10-05 |
Genentech, Inc. |
Anticuerpos e inmunoconjugados y usos para los mismos
|
WO2008140603A2
(en)
|
2006-12-08 |
2008-11-20 |
Macrogenics, Inc. |
METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
|
JP5368428B2
(ja)
|
2007-04-30 |
2013-12-18 |
ジェネンテック, インコーポレイテッド |
Iapのインヒビター
|
PL2170959T3
(pl)
|
2007-06-18 |
2014-03-31 |
Merck Sharp & Dohme |
Przeciwciała przeciwko ludzkiemu receptorowi programowanej śmierci PD-1
|
WO2009002939A2
(en)
|
2007-06-23 |
2008-12-31 |
Innexus Biotechnology International Limited |
Autophilic antibodies
|
TWI471134B
(zh)
|
2007-09-12 |
2015-02-01 |
Genentech Inc |
肌醇磷脂3-激酶抑制劑化合物及化療劑之組合及使用方法
|
WO2009052249A1
(en)
|
2007-10-19 |
2009-04-23 |
Genentech, Inc. |
Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
|
WO2009055730A1
(en)
|
2007-10-25 |
2009-04-30 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
US20110053865A1
(en)
|
2007-11-27 |
2011-03-03 |
Ablynx N.V. |
Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
|
CA2713137C
(en)
|
2008-01-25 |
2017-10-24 |
Hadasit Medical Research Services And Development Ltd. |
Targeting of innate immune response to tumor site
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至her2結構域ii之抗體及其酸性變異體的組合物
|
BRPI0908433A2
(pt)
|
2008-02-06 |
2019-09-24 |
Novartis Ag |
pirrolo[2,3-d]piridinas e empregos destas como inibidores tirosina cinase
|
CN101970499B
(zh)
|
2008-02-11 |
2014-12-31 |
治疗科技公司 |
用于肿瘤治疗的单克隆抗体
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
CN107325182A
(zh)
|
2008-04-02 |
2017-11-07 |
宏观基因有限公司 |
HER2/neu‑特异性抗体和其使用方法
|
ES2620285T3
(es)
*
|
2008-05-02 |
2017-06-28 |
Novartis Ag |
Moléculas de unión con base en fibronectina mejorada y usos de las mismas
|
US8168784B2
(en)
|
2008-06-20 |
2012-05-01 |
Abbott Laboratories |
Processes to make apoptosis promoters
|
CA2735006A1
(en)
|
2008-08-25 |
2010-03-11 |
Amplimmune, Inc. |
Pd-1 antagonists and methods of use thereof
|
PL2350129T3
(pl)
|
2008-08-25 |
2015-12-31 |
Amplimmune Inc |
Kompozycje antagonistów PD-1 i sposoby stosowania
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
KR20210060670A
(ko)
|
2008-12-09 |
2021-05-26 |
제넨테크, 인크. |
항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도
|
AR074760A1
(es)
|
2008-12-18 |
2011-02-09 |
Metabolex Inc |
Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
|
WO2010089411A2
(en)
|
2009-02-09 |
2010-08-12 |
Universite De La Mediterranee |
Pd-1 antibodies and pd-l1 antibodies and uses thereof
|
BRPI1015234A2
(pt)
|
2009-06-22 |
2018-02-20 |
Medimmune Llc |
regiões fc projetadas para conjugação sítio específica.
|
JP2012532838A
(ja)
|
2009-07-09 |
2012-12-20 |
エフ−シュタール・ビオテヒノロギシェ・フォルシュングス−ウント・エントヴィックルングスゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
安定化された免疫グロブリン定常ドメイン
|
ES2672121T3
(es)
|
2009-10-07 |
2018-06-12 |
Macrogenics, Inc. |
Polipéptidos que contienen región Fc que presentan una función efectora mejorada debido a alteraciones del grado de fucosilación, y métodos para su uso
|
GB0920127D0
(en)
|
2009-11-17 |
2009-12-30 |
Ucb Pharma Sa |
Antibodies
|
GB0920324D0
(en)
|
2009-11-19 |
2010-01-06 |
Ucb Pharma Sa |
Antibodies
|
US20130017199A1
(en)
|
2009-11-24 |
2013-01-17 |
AMPLIMMUNE ,Inc. a corporation |
Simultaneous inhibition of pd-l1/pd-l2
|
PL2330131T3
(pl)
|
2009-12-07 |
2015-05-29 |
Fundacio Privada Inst Catalana De Recerca I Estudis Avancants |
Przeciwciała przeciwko CTF-611, skróconemu wariantowi HER2
|
WO2011084496A1
(en)
|
2009-12-16 |
2011-07-14 |
Abbott Biotherapeutics Corp. |
Anti-her2 antibodies and their uses
|
CN102167742B
(zh)
|
2010-02-25 |
2014-05-14 |
上海百迈博制药有限公司 |
一种全人源抗her2单克隆抗体、其制备方法及用途
|
US8609095B2
(en)
|
2010-03-04 |
2013-12-17 |
Symphogen A/S |
Anti-HER2 antibodies and compositions
|
WO2011130580A1
(en)
|
2010-04-15 |
2011-10-20 |
Alper Biotech, Llc |
Monoclonal antibodies against her2 antigens, and uses therefor
|
US20130137709A1
(en)
|
2010-05-05 |
2013-05-30 |
Nathanael S. Gray |
Compounds that modulate EGFR activity and methods for treating or preventing conditions therewith
|
JP2013166700A
(ja)
*
|
2010-06-02 |
2013-08-29 |
Dainippon Sumitomo Pharma Co Ltd |
新規4,5−縮環ピリミジン誘導体
|
KR101839163B1
(ko)
|
2010-06-08 |
2018-03-15 |
제넨테크, 인크. |
시스테인 조작된 항체 및 접합체
|
MY162132A
(en)
|
2010-06-23 |
2017-05-31 |
Hanmi Science Co Ltd |
Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity
|
TWI506035B
(zh)
|
2010-08-13 |
2015-11-01 |
Baylor Res Inst |
以直接針對抗原呈現細胞之抗體的標靶佐劑為主之新穎疫苗佐劑
|
US20120328605A1
(en)
|
2010-10-27 |
2012-12-27 |
Daniel Larocque |
Compositions and uses
|
US20120231023A1
(en)
*
|
2011-03-08 |
2012-09-13 |
Baylor Research Institute |
Novel Vaccine Adjuvants Based on Targeting Adjuvants to Antibodies Directly to Antigen-Presenting Cells
|
GB201113570D0
(en)
|
2011-08-05 |
2011-09-21 |
Glaxosmithkline Biolog Sa |
Vaccine
|
EP2570125A1
(en)
|
2011-09-16 |
2013-03-20 |
Almirall, S.A. |
Ep1 receptor ligands
|
ES2721882T3
(es)
|
2011-12-23 |
2019-08-06 |
Pfizer |
Regiones constantes de anticuerpo modificadas por ingeniería genética para conjugación específica de sitio y procedimientos y usos de las mismas
|
WO2013179174A1
(en)
|
2012-05-29 |
2013-12-05 |
Koninklijke Philips N.V. |
Lighting arrangement
|
BR112014030098A2
(pt)
|
2012-06-04 |
2017-07-25 |
Irm Llc |
métodos de rotulagem específica de sítio e moléculas produzidas pelos mesmos
|
UA114108C2
(uk)
|
2012-07-10 |
2017-04-25 |
Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем |
Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання
|
CN112587671A
(zh)
|
2012-07-18 |
2021-04-02 |
博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
CA2884478C
(en)
|
2012-10-10 |
2021-02-16 |
Janssen Sciences Ireland Uc |
Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
|
EP2925368B1
(en)
*
|
2012-11-30 |
2019-03-27 |
Novartis AG |
Methods for making conjugates from disulfide-containing proteins
|
WO2014124258A2
(en)
|
2013-02-08 |
2014-08-14 |
Irm Llc |
Specific sites for modifying antibodies to make immunoconjugates
|
PT2953976T
(pt)
|
2013-02-08 |
2021-06-23 |
Novartis Ag |
Sítios específicos de modificação de anticorpos para preparar imunoconjugados
|
WO2014165277A2
(en)
|
2013-03-12 |
2014-10-09 |
Amgen Inc. |
POTENT AND SELECTIVE INHIBITORS OF Nav1.7
|
MX366978B
(es)
*
|
2013-03-15 |
2019-08-01 |
Novartis Ag |
Conjugados de anticuerpo - farmaco.
|
CN105451773A
(zh)
|
2013-03-15 |
2016-03-30 |
诺华股份有限公司 |
细胞增殖抑制剂及其缀合物
|
KR20160009039A
(ko)
|
2013-05-18 |
2016-01-25 |
아두로 바이오테크, 인코포레이티드 |
“인터페론 유전자의 자극기”-의존성 신호전달을 활성화하기 위한 조성물 및 방법
|
MY176142A
(en)
|
2013-06-27 |
2020-07-24 |
Janssen Sciences Ireland Uc |
Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
|
US10172948B2
(en)
|
2013-11-26 |
2019-01-08 |
Novartis Ag |
Methods for oxime conjugation to ketone-modified polypeptides
|
EP3092255A4
(en)
|
2014-01-10 |
2017-09-20 |
Birdie Biopharmaceuticals Inc. |
Compounds and compositions for treating egfr expressing tumors
|
EP3096787A4
(en)
*
|
2014-01-22 |
2018-02-07 |
The Board of Trustees of the Leland Stanford Junior University |
Methods and compositions for antibody and antibody-loaded dendritic cell mediated therapy
|
JP2017509337A
(ja)
*
|
2014-03-12 |
2017-04-06 |
ノバルティス アーゲー |
イムノコンジュゲートを作製する抗体を修飾するための特定部位
|
CN107001354B
(zh)
|
2014-04-11 |
2021-06-22 |
台北医学大学 |
组蛋白去乙酰酶抑制剂
|
WO2015168269A1
(en)
|
2014-05-01 |
2015-11-05 |
Novartis Ag |
Compounds and compositions as toll-like receptor 7 agonists
|
CA2945504A1
(en)
*
|
2014-05-01 |
2015-11-05 |
Novartis Ag |
Compounds and compositions as toll-like receptor 7 agonists
|
WO2015189791A1
(en)
|
2014-06-13 |
2015-12-17 |
Novartis Ag |
Auristatin derivatives and conjugates thereof
|
JP6760919B2
(ja)
|
2014-07-09 |
2020-09-23 |
バーディー バイオファーマシューティカルズ インコーポレイテッド |
腫瘍を治療するための抗pd−l1組み合わせ
|
CN112546230A
(zh)
|
2014-07-09 |
2021-03-26 |
博笛生物科技有限公司 |
用于治疗癌症的联合治疗组合物和联合治疗方法
|
EP3714898A1
(en)
|
2014-07-17 |
2020-09-30 |
Brian J. Czerniecki |
Dendritic cell vaccines in combination with therapy for blocking her2 and her3
|
WO2016011422A2
(en)
|
2014-07-17 |
2016-01-21 |
Czerniecki Brian J |
Manufacturing of multi-dose injection ready dendritic cell vaccines and combination therapy for blocking her2 and her3
|
US10786578B2
(en)
|
2014-08-05 |
2020-09-29 |
Novartis Ag |
CKIT antibody drug conjugates
|
CN106794246B
(zh)
|
2014-08-08 |
2021-10-15 |
OncoQuest制药有限公司 |
肿瘤抗原特异性抗体和tlr3刺激以增强检查点干扰癌症疗法的性能
|
CN110938076B
(zh)
|
2014-08-15 |
2021-08-10 |
正大天晴药业集团股份有限公司 |
作为tlr7激动剂的吡咯并嘧啶化合物
|
CN112587672A
(zh)
|
2014-09-01 |
2021-04-02 |
博笛生物科技有限公司 |
用于治疗肿瘤的抗-pd-l1结合物
|
MA41538A
(fr)
|
2014-10-17 |
2017-12-26 |
Baylor College Medicine |
Cellules immunitaires bipartites et tripartites de signalisation
|
US9938323B2
(en)
|
2014-11-06 |
2018-04-10 |
Novartis Ag |
Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase
|
CN104650228B
(zh)
|
2014-11-26 |
2017-11-28 |
嘉和生物药业有限公司 |
一种全人源her2抗体、其编码基因及应用
|
PL3230298T3
(pl)
|
2014-12-08 |
2021-06-14 |
F.Hoffmann-La Roche Ag |
3-podstawione związki 5-amino-6h-tiazolo[4,5-d]pirymidyno-2,7-dionowe do leczenia i profilaktyki zakażenia wirusowego
|
CA2968141C
(en)
|
2015-01-16 |
2020-08-04 |
Hsing-Mao CHU |
Molecular constructs with targeting and effector elements
|
CA2986486C
(en)
|
2015-05-20 |
2023-03-07 |
Immunwork Inc. |
Molecular constructs with targeting and effector elements and their applications
|
US10975112B2
(en)
|
2015-06-16 |
2021-04-13 |
Hangzhou Dac Biotech Co., Ltd. |
Linkers for conjugation of cell-binding molecules
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
WO2015155753A2
(en)
|
2015-08-10 |
2015-10-15 |
Suzhou M-Conj Biotech Co., Ltd |
Novel linkers and their uses in specific conjugation of drugs to a biological molecule
|
TWI780988B
(zh)
|
2015-08-24 |
2022-10-11 |
英商葛蘭素史密斯克藍智慧財產權有限公司 |
生藥組成物
|
JO3555B1
(ar)
|
2015-10-29 |
2020-07-05 |
Merck Sharp & Dohme |
جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري
|
AU2016349080B2
(en)
|
2015-11-05 |
2019-03-14 |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
7-(thiazol-5-yl) pyrrolopyrimidine compound as TLR7 agonist
|
SG11201806594QA
(en)
|
2016-02-04 |
2018-09-27 |
Suzhou M Conj Biotech Co Ltd |
Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof
|
CN107043379A
(zh)
|
2016-02-05 |
2017-08-15 |
正大天晴药业集团股份有限公司 |
一种tlr7激动剂的晶型a、其制备方法和医药用途
|