SG11201507883SA - Wt1-antigen peptide conjugate vaccine - Google Patents

Wt1-antigen peptide conjugate vaccine

Info

Publication number
SG11201507883SA
SG11201507883SA SG11201507883SA SG11201507883SA SG11201507883SA SG 11201507883S A SG11201507883S A SG 11201507883SA SG 11201507883S A SG11201507883S A SG 11201507883SA SG 11201507883S A SG11201507883S A SG 11201507883SA SG 11201507883S A SG11201507883S A SG 11201507883SA
Authority
SG
Singapore
Prior art keywords
peptide conjugate
antigen peptide
conjugate vaccine
vaccine
antigen
Prior art date
Application number
SG11201507883SA
Other languages
English (en)
Inventor
Hitoshi Ban
Yukihiro Nishio
Masashi Goto
Toshio Nishihara
Yosuke Takanashi
Chiang Jia Li
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
Int Inst Cancer Immunology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd, Int Inst Cancer Immunology Inc filed Critical Sumitomo Dainippon Pharma Co Ltd
Publication of SG11201507883SA publication Critical patent/SG11201507883SA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001152Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153Wilms tumor 1 [WT1]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/64Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
SG11201507883SA 2013-03-29 2014-03-28 Wt1-antigen peptide conjugate vaccine SG11201507883SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013072173 2013-03-29
JP2013158383 2013-07-31
PCT/JP2014/059336 WO2014157692A1 (ja) 2013-03-29 2014-03-28 Wt1抗原ペプチドコンジュゲートワクチン

Publications (1)

Publication Number Publication Date
SG11201507883SA true SG11201507883SA (en) 2015-10-29

Family

ID=51624648

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201507883SA SG11201507883SA (en) 2013-03-29 2014-03-28 Wt1-antigen peptide conjugate vaccine

Country Status (20)

Country Link
US (4) US9181302B2 (ja)
EP (2) EP2982681B8 (ja)
JP (4) JP5885885B2 (ja)
KR (1) KR102121638B1 (ja)
CN (1) CN105308063B (ja)
AU (1) AU2014244860B2 (ja)
CA (1) CA2907782C (ja)
DK (1) DK2982681T3 (ja)
ES (1) ES2691091T3 (ja)
HK (1) HK1220471A1 (ja)
IL (1) IL241566B (ja)
MX (1) MX364459B (ja)
MY (1) MY171854A (ja)
NZ (1) NZ712148A (ja)
PH (1) PH12015502180B1 (ja)
RU (1) RU2668560C2 (ja)
SG (1) SG11201507883SA (ja)
TR (1) TR201816260T4 (ja)
TW (1) TWI666026B (ja)
WO (1) WO2014157692A1 (ja)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2900087C (en) 2005-10-17 2024-02-13 Sloan Kettering Institute For Cancer Research Wt1 hla class ii-binding peptides and compositions and methods comprising same
EP3117836A1 (en) 2006-04-10 2017-01-18 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and uses thereof
WO2013106834A2 (en) 2012-01-13 2013-07-18 Memorial Sloan Kettering Cancer Center Immunogenic wt-1 peptides and methods of use thereof
KR102208505B1 (ko) 2012-12-11 2021-01-27 앨버트 아인슈타인 컬리지 오브 메디신 고처리량 수용체:리간드 확인을 위한 방법
PT2945647T (pt) 2013-01-15 2020-11-26 Memorial Sloan Kettering Cancer Center Péptidos imunogénicos wt-1 e métodos de uso dos mesmos
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
JP6671956B2 (ja) * 2013-03-29 2020-03-25 大日本住友製薬株式会社 Erap1によるトリミング機能をきっかけとしたコンジュゲートワクチン
RU2668560C2 (ru) * 2013-03-29 2018-10-02 Сумитомо Дайниппон Фарма Ко., Лтд. Конъюгированная вакцина на основе пептида антигена wt1
DK3199175T3 (da) * 2014-09-27 2022-06-13 Sumitomo Pharma Co Ltd Farmaceutisk sammensætning til injektion
JP6515182B2 (ja) * 2015-05-20 2019-05-15 大日本住友製薬株式会社 Wt1抗原ペプチドおよび免疫調節剤の併用
MY189596A (en) * 2015-07-15 2022-02-18 Immatics Biotechnologies Gmbh A novel peptides for use in immunotherapy against epithelial ovarian cancer and other cancers
US11752238B2 (en) 2016-02-06 2023-09-12 President And Fellows Of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
EP3458095A4 (en) 2016-05-18 2019-11-27 Albert Einstein College of Medicine PD-L1 POLYPEPTIDE VARIANTS, T-LYMPHOCYTE MODULATOR MULTIMERIC POLYPEPTIDES AND METHODS OF USING SAME
CN109475628A (zh) 2016-05-18 2019-03-15 库尔生物制药有限公司 T细胞调节性多聚体多肽及其使用方法
US11555177B2 (en) 2016-07-13 2023-01-17 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
CN109415410B (zh) * 2016-09-21 2022-12-13 一般财团法人阪大微生物病研究会 靶向树突细胞的肽、利用了该肽的肽融合体、及利用了该肽融合体的疫苗
WO2018101309A1 (ja) 2016-11-30 2018-06-07 大日本住友製薬株式会社 Wt1ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ
EP3558339B1 (en) 2016-12-22 2024-01-24 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
EP3565829A4 (en) 2017-01-09 2021-01-27 Cue Biopharma, Inc. MULTIMER POLYPEPTIDES T-LYMPHOCYTE MODULATORS AND THEIR METHODS OF USE
IL309479A (en) 2017-03-15 2024-02-01 Cue Biopharma Inc Methods for modulating an immune response
WO2018181648A1 (ja) 2017-03-30 2018-10-04 大日本住友製薬株式会社 Wt1癌抗原ペプチドおよびこれを含むペプチドコンジュゲート体
US20200368338A1 (en) * 2017-12-27 2020-11-26 Sumitomo Dainippon Pharma Co., Ltd. Conjugate of wt1-derived peptides and composition comprising the same
EP3737689A4 (en) 2018-01-09 2021-12-01 Cue Biopharma, Inc. MULTIMERIC T CELL-MODULATING POLYPEPTIDES AND METHOD OF USING THEREOF
KR20210068060A (ko) 2018-09-28 2021-06-08 다이니뽄 스미토모 세이야쿠 가부시키가이샤 주사용 조성물
WO2020071551A1 (ja) 2018-10-05 2020-04-09 株式会社癌免疫研究所 良性腫瘍の予防または治療薬
TW202045528A (zh) 2019-02-28 2020-12-16 日商大日本住友製藥股份有限公司 選擇可期待用於治療或預防癌之醫藥組合物之效果之對象之方法
US20220211844A1 (en) 2019-04-05 2022-07-07 Sumitomo Dainippon Pharma Co., Ltd. Water soluble adjuvant and composition containing same
CN113905758A (zh) 2019-04-05 2022-01-07 大日本住友制药株式会社 水溶性佐剂和含有其的组合物
KR20220113428A (ko) 2019-12-10 2022-08-12 스미토모 파마 가부시키가이샤 펩티드 에멀션 제제의 조제 방법
JP2023521219A (ja) * 2020-04-14 2023-05-23 ウニヴェルシテ ド モントリオール 急性骨髄性白血病(aml)に対する新規の腫瘍特異的抗原及びそれらの使用
KR20230009426A (ko) * 2020-05-12 2023-01-17 스미토모 파마 가부시키가이샤 암을 처치하기 위한 의약 조성물
CA3169949A1 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
CN111647066B (zh) * 2020-07-01 2020-12-18 维肽瀛(上海)生物技术有限公司 Wt1多肽肿瘤抑制剂
JP2022156071A (ja) 2021-03-31 2022-10-14 株式会社小糸製作所 画像投影装置
WO2023017836A1 (ja) 2021-08-12 2023-02-16 株式会社癌免疫研究所 癌を処置または予防するための医薬組成物および方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410022B1 (en) * 1995-05-01 2002-06-25 Avant Immunotherapeutics, Inc. Modulation of cholesteryl ester transfer protein (CETP) activity
CA2242878C (en) 1996-01-24 2010-06-22 Cytel Corporation Induction of immune response against desired determinants
CN1178956C (zh) 1998-07-31 2004-12-08 杉山治夫 基于癌抑制基因wt1的产物的癌抗原
US20120301492A1 (en) 1998-09-30 2012-11-29 Corixa Corporation Compositions and methods for wt1 specific immunotherapy
CA2349442C (en) 1998-09-30 2012-12-04 Corixa Corporation Compositions and methods for wt1 specific immunotherapy
GB9823897D0 (en) 1998-11-02 1998-12-30 Imp College Innovations Ltd Immunotherapeutic methods and molecules
GB9826143D0 (en) 1998-11-27 1999-01-20 Ludwig Inst Cancer Res Tumour rejection antigens
JPWO2002047474A1 (ja) 2000-12-13 2004-04-15 住友製薬株式会社 Hla−a24発現トランスジェニック動物及びその利用
TWI318630B (en) 2001-03-22 2009-12-21 Int Inst Cancer Immunology Inc Wt1 modified peptide
AU2003242305A1 (en) 2002-06-12 2003-12-31 Chugai Seiyaku Kabushiki Kaisha Hla-a24-restricted cancer antigen peptide
US7378384B2 (en) 2002-09-20 2008-05-27 International Institute Of Cancer Immunology, Inc. WT1 substitution peptides
DE60329115D1 (de) 2002-09-27 2009-10-15 Dainippon Sumitomo Pharma Co Tumorantigenprotein und dessen verwendung
EP2572715A1 (en) 2002-12-30 2013-03-27 3M Innovative Properties Company Immunostimulatory Combinations
WO2004063217A1 (ja) * 2003-01-15 2004-07-29 Chugai Seiyaku Kabushiki Kaisha 二量体化ペプチド
EP1613308A4 (en) 2003-03-27 2008-02-20 Lankenau Inst Medical Res CANCER TREATMENT METHODS
US20040197312A1 (en) 2003-04-02 2004-10-07 Marina Moskalenko Cytokine-expressing cellular vaccine combinations
JPWO2004113530A1 (ja) 2003-06-18 2006-08-03 三菱化学株式会社 ラベル化蛋白質合成用ポリヌクレオチド
RU2375076C2 (ru) 2003-07-10 2009-12-10 Цитос Биотехнологи Аг Укомплектованные вирусоподобные частицы
JP2007507543A (ja) 2003-10-06 2007-03-29 セダーズ−シナイ メディカル センター 樹状細胞治療によって誘導されるt細胞アネルギーを予防するためのcox−2インヒビターの使用
ES2378264T3 (es) 2003-11-05 2012-04-10 International Institute Of Cancer Immunology, Inc. Péptido antigénico de unión a HLA-DR derivado de WT1
CN101111258B (zh) 2005-01-19 2011-07-06 大日本住友制药株式会社 稀释用乳化组合物及癌疫苗组合物
JP4719876B2 (ja) * 2005-04-04 2011-07-06 国立大学法人愛媛大学 Hlaクラスii拘束性wt1抗原ペプチド
CA2900087C (en) 2005-10-17 2024-02-13 Sloan Kettering Institute For Cancer Research Wt1 hla class ii-binding peptides and compositions and methods comprising same
CN101336249A (zh) 2005-11-30 2008-12-31 株式会社癌免疫研究所 新型肽化合物
EP3117836A1 (en) 2006-04-10 2017-01-18 Sloan Kettering Institute For Cancer Research Immunogenic wt-1 peptides and uses thereof
JP5427027B2 (ja) 2006-05-03 2014-02-26 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・コロラド,ア・ボディー・コーポレイト Cd40アゴニスト抗体/i型インターフェロン相乗性アジュバントの結合体、それを含む複合体、および細胞性免疫を強化する治療としてのその使用
CA2652599C (en) 2006-05-03 2019-09-24 Ross Kedl Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity
GB0620894D0 (en) 2006-10-20 2006-11-29 Univ Southampton Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
US8653038B2 (en) 2006-12-28 2014-02-18 International Institute Of Cancer Immunology, Inc. HLA-A* 1101-restricted WT1 peptide and pharmaceutical composition comprising the same
KR101183705B1 (ko) * 2007-02-07 2012-09-17 사이단호진한다이비세이부쯔뵤우겐큐우카이 암의 치료제
JP5463013B2 (ja) 2007-06-19 2014-04-09 国立大学法人 岡山大学 軟骨マーカー
WO2009036246A2 (en) 2007-09-14 2009-03-19 Immunotope, Inc. Immunogens that induce cytotoxic t-lymphocytes and their use in prevention, treatment, and diagnosis of cancer
US20100255020A1 (en) * 2007-11-20 2010-10-07 Nec Corporation Method for inducing cytotoxic t-cells, cytotoxic t-cell inducers, and pharmaceutical compositions and vaccines employing them
TWI504407B (zh) * 2007-12-05 2015-10-21 Int Inst Cancer Immunology Inc 癌疫苗組合物
EP2337795A2 (en) 2008-10-01 2011-06-29 Dako Denmark A/S Mhc multimers in cancer vaccines and immune monitoring
JP5520961B2 (ja) 2008-11-28 2014-06-11 エモリー ユニバーシティ 感染症および腫瘍を処置するための方法
BRPI1012560A2 (pt) 2009-04-01 2016-07-26 Genentech Inc anticorpos anti-fcrh5 e imunoconjugados e métodos de uso
AR076349A1 (es) 2009-04-23 2011-06-01 Int Inst Cancer Immunology Inc Peptido auxiliar del antigeno del cancer
KR101208587B1 (ko) 2009-06-24 2012-12-06 여오영 하이드록시클로로퀸을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물
US20130011424A1 (en) 2010-03-09 2013-01-10 Timur ARTEMEV Polyepitope constructs and methods for their preparation and use
US20120213771A1 (en) 2010-04-13 2012-08-23 Celldex Therapeutics Inc. Antibodies that bind human cd27 and uses thereof
KR101958753B1 (ko) 2010-04-13 2019-03-15 셀덱스 쎄라퓨틱스, 인크. 인간 cd27에 결합하는 항체 및 이의 용도
JPWO2012026309A1 (ja) * 2010-08-23 2013-10-28 公立大学法人横浜市立大学 抗pad4抗体医薬の創成
SG189287A1 (en) 2010-10-05 2013-05-31 Int Inst Cancer Immunology Inc Method for activating helper t cell
EP2757373A4 (en) 2011-09-14 2015-07-01 Int Inst Cancer Immunology Inc METHOD FOR MEASURING ANTI-WT1 ANTIBODIES
JP5704034B2 (ja) 2011-09-26 2015-04-22 コベルコ建機株式会社 建設機械の燃料供給装置及び同装置の組立方法
CN103157108B (zh) 2011-12-13 2016-01-20 宁云山 免疫调节剂组合物及其药物组合物和应用
JP2015501839A (ja) 2011-12-15 2015-01-19 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago 受容体に対する親和性が増大した変異型light分子を使用する癌療法のための方法および組成物
JP5883668B2 (ja) 2012-02-02 2016-03-15 Hoya株式会社 分光データ採取システム、及び電子内視鏡システム
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
WO2014007266A1 (ja) 2012-07-02 2014-01-09 大日本住友製薬株式会社 癌抗原ペプチド経皮剤
CN103830211A (zh) 2012-11-27 2014-06-04 上海曼克尔瑞生物医药技术有限公司 一种β-catenin蛋白抑制剂-姜黄素在肝癌治疗方面的应用
US10206985B2 (en) 2013-02-05 2019-02-19 Nitto Denko Corporation WT1 peptide cancer vaccine composition for mucosal administration
HUE050787T2 (hu) 2013-02-26 2021-01-28 Memorial Sloan Kettering Cancer Center Immunterápiás készítmények és eljárások
JP6671956B2 (ja) * 2013-03-29 2020-03-25 大日本住友製薬株式会社 Erap1によるトリミング機能をきっかけとしたコンジュゲートワクチン
RU2668560C2 (ru) * 2013-03-29 2018-10-02 Сумитомо Дайниппон Фарма Ко., Лтд. Конъюгированная вакцина на основе пептида антигена wt1
EP3030322A2 (en) 2013-08-05 2016-06-15 Cambridge Enterprise Limited Inhibition of cxcr4 signaling in cancer immunotherapy
JP6329834B2 (ja) * 2014-07-22 2018-05-23 株式会社アマダホールディングス レーザ切断加工方法及び装置
JP6515182B2 (ja) 2015-05-20 2019-05-15 大日本住友製薬株式会社 Wt1抗原ペプチドおよび免疫調節剤の併用
WO2018101309A1 (ja) 2016-11-30 2018-06-07 大日本住友製薬株式会社 Wt1ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ
WO2018181648A1 (ja) 2017-03-30 2018-10-04 大日本住友製薬株式会社 Wt1癌抗原ペプチドおよびこれを含むペプチドコンジュゲート体

Also Published As

Publication number Publication date
CN105308063B (zh) 2019-11-08
AU2014244860B2 (en) 2018-07-26
JP5885885B2 (ja) 2016-03-16
JP6847089B2 (ja) 2021-03-24
NZ712148A (en) 2019-11-29
EP2982681A4 (en) 2016-10-19
JP2016155813A (ja) 2016-09-01
JP6495839B2 (ja) 2019-04-03
TWI666026B (zh) 2019-07-21
TW201505650A (zh) 2015-02-16
BR112015024583A2 (pt) 2017-10-31
CA2907782A1 (en) 2014-10-02
EP3461493A1 (en) 2019-04-03
JP2021059580A (ja) 2021-04-15
CN105308063A (zh) 2016-02-03
CA2907782C (en) 2021-01-05
JP2019069970A (ja) 2019-05-09
KR102121638B1 (ko) 2020-06-10
US20190030149A1 (en) 2019-01-31
US20160114019A1 (en) 2016-04-28
ES2691091T3 (es) 2018-11-23
PH12015502180A1 (en) 2016-01-25
RU2668560C2 (ru) 2018-10-02
US11759509B2 (en) 2023-09-19
DK2982681T3 (en) 2018-12-10
IL241566B (en) 2020-03-31
US9248173B2 (en) 2016-02-02
KR20150135454A (ko) 2015-12-02
BR112015024583A8 (pt) 2023-05-09
US9181302B2 (en) 2015-11-10
EP2982681B8 (en) 2018-11-07
US20150238587A1 (en) 2015-08-27
AU2014244860A1 (en) 2015-10-08
JP7248247B2 (ja) 2023-03-29
PH12015502180B1 (en) 2016-01-25
MX364459B (es) 2019-04-26
RU2015146614A (ru) 2017-05-04
HK1220471A1 (zh) 2017-05-05
JPWO2014157692A1 (ja) 2017-02-16
EP2982681B1 (en) 2018-08-22
MX2015013813A (es) 2016-03-01
TR201816260T4 (tr) 2018-11-21
MY171854A (en) 2019-11-05
EP2982681A1 (en) 2016-02-10
WO2014157692A1 (ja) 2014-10-02
US20150080321A1 (en) 2015-03-19

Similar Documents

Publication Publication Date Title
IL276210B1 (en) Mers-cov vaccine
HK1220471A1 (zh) 抗原肽綴合物疫苗
IL245744A0 (en) Therapeutic peptides
HK1219983A1 (zh) 治療性肽
HK1214829A1 (zh) 治療肽
GB201301085D0 (en) Glycoconjugate Vaccine
HRP20180452T1 (hr) Peptidi
ZA201602834B (en) Salmonella conjugate vaccines
GB201314411D0 (en) Peptide conjugates
HK1217206A1 (zh) 疫苗
HK1211596A1 (en) Peptide
HK1211595A1 (en) Peptide
GB201315130D0 (en) Peptides
GB201320646D0 (en) Vaccine
GB201320421D0 (en) Conjugated vaccine
GB201315556D0 (en) Vaccine
GB201316660D0 (en) Peptides
GB201300381D0 (en) Peptides