SE510808C2 - Förfarande för framställning av furo-(3,4-c)-pyridinderivat i icke-racematisk form genom hydrolys med ett esteras - Google Patents

Förfarande för framställning av furo-(3,4-c)-pyridinderivat i icke-racematisk form genom hydrolys med ett esteras

Info

Publication number
SE510808C2
SE510808C2 SE9101431A SE9101431A SE510808C2 SE 510808 C2 SE510808 C2 SE 510808C2 SE 9101431 A SE9101431 A SE 9101431A SE 9101431 A SE9101431 A SE 9101431A SE 510808 C2 SE510808 C2 SE 510808C2
Authority
SE
Sweden
Prior art keywords
compound
hydrogen
process according
methyl
furo
Prior art date
Application number
SE9101431A
Other languages
English (en)
Swedish (sv)
Other versions
SE9101431D0 (sv
SE9101431L (sv
Inventor
C Eck
P C Ahrens
R M Saltzstein
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of SE9101431D0 publication Critical patent/SE9101431D0/xx
Publication of SE9101431L publication Critical patent/SE9101431L/xx
Publication of SE510808C2 publication Critical patent/SE510808C2/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SE9101431A 1990-05-14 1991-05-13 Förfarande för framställning av furo-(3,4-c)-pyridinderivat i icke-racematisk form genom hydrolys med ett esteras SE510808C2 (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/523,238 US5130252A (en) 1990-05-14 1990-05-14 Resolution of furopyridine enantiomers and synthetic precursors thereof

Publications (3)

Publication Number Publication Date
SE9101431D0 SE9101431D0 (sv) 1991-05-13
SE9101431L SE9101431L (sv) 1991-11-15
SE510808C2 true SE510808C2 (sv) 1999-06-28

Family

ID=24084213

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9101431A SE510808C2 (sv) 1990-05-14 1991-05-13 Förfarande för framställning av furo-(3,4-c)-pyridinderivat i icke-racematisk form genom hydrolys med ett esteras

Country Status (32)

Country Link
US (1) US5130252A (nl)
JP (1) JPH05117277A (nl)
KR (1) KR910020015A (nl)
AR (1) AR247762A1 (nl)
AT (1) AT400445B (nl)
AU (1) AU642368B2 (nl)
BE (1) BE1007016A3 (nl)
CA (1) CA2042421C (nl)
CH (1) CH682488A5 (nl)
DE (1) DE4115681C2 (nl)
DK (1) DK88991A (nl)
DZ (1) DZ1499A1 (nl)
ES (1) ES2033574B1 (nl)
FI (1) FI97807C (nl)
FR (1) FR2661919B1 (nl)
GB (1) GB2244056B (nl)
GR (1) GR1001593B (nl)
HK (1) HK131993A (nl)
IE (1) IE65891B1 (nl)
IT (1) IT1248743B (nl)
LU (1) LU87935A1 (nl)
MA (1) MA22154A1 (nl)
MY (1) MY107567A (nl)
NL (1) NL194615C (nl)
NO (1) NO180308C (nl)
NZ (1) NZ238009A (nl)
OA (1) OA09352A (nl)
PT (1) PT97657B (nl)
SE (1) SE510808C2 (nl)
TN (1) TNSN91035A1 (nl)
TW (1) TW226998B (nl)
ZA (1) ZA913461B (nl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0221494D0 (en) * 2002-09-16 2002-10-23 Generics Uk Ltd Novel processes for the preparation of 1.3-dihydro-6-methylfuro (3,4-c) pyndin derivatives
US20110251396A1 (en) * 2003-07-17 2011-10-13 Gilead Sciences, Inc. Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
US20060089374A1 (en) * 2003-07-17 2006-04-27 Glenn Cornett Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
US20050043391A1 (en) * 2003-07-17 2005-02-24 Fong Benson M. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
GB2423927A (en) * 2003-08-29 2006-09-13 Cotherix Inc Combination Of Cicletanine And An Oral Antidiabetic And/Or Blood Lipid-Lowering Agent For Treating Diabetes And Metabolic Syndrome
US20060154959A1 (en) * 2005-01-13 2006-07-13 Navitas Pharma Combination therapies of cicletanine and carvedilol
CA2593793A1 (en) * 2005-01-05 2006-07-13 Medicure International Inc. Compounds and methods for regulating triglyceride levels
US20070141174A1 (en) * 2005-01-13 2007-06-21 Navitas Pharma, Inc. Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension
US20080096915A1 (en) * 2005-01-13 2008-04-24 Greenberg Traurig LLP Compositions for the treatment of metabolic disorders
US20070105817A1 (en) * 2005-11-09 2007-05-10 Jim Page Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension
JP2010514841A (ja) * 2007-01-03 2010-05-06 グレン ブイ． コルネット， 肺疾患および心疾患の処置におけるシクレタニンおよびｐｋｃ阻害剤
EP2498605B1 (en) * 2009-10-29 2014-08-27 Merck Sharp & Dohme Corp. Diuretics

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN156817B (nl) * 1981-02-10 1985-11-09 Scras
US4985365A (en) * 1981-11-28 1991-01-15 Sumitomo Chemical Company, Ltd. Process for producing optically active benzyl alcohol compound
EP0101076B1 (en) * 1982-08-13 1989-01-04 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for production of optically active oxazolidinone derivative
IN160104B (nl) * 1983-04-05 1987-06-27 Scras
JPS59216590A (ja) * 1983-05-24 1984-12-06 Ube Ind Ltd 光学活性フエニルプロパルギルアルコ−ル誘導体の製法
GB8327817D0 (en) * 1983-10-18 1983-11-16 Scras 4-halo-furo-(3 4-c)-pyridine derivatives
GB8330517D0 (en) * 1983-11-16 1983-12-21 Scras 6-vinyl-furo-(3,4-c)pyridine derivatives
GB8330658D0 (en) * 1983-11-17 1983-12-29 Scras 7-carboxymethoxy-furo-(3,4-c)-pyridine derivatives
GB8402740D0 (en) * 1984-02-02 1984-03-07 Scras Furo-(3 4-c)-pyridine derivatives
JPS60224494A (ja) * 1984-04-24 1985-11-08 Nissan Chem Ind Ltd α−メチルベンジルアルコ−ル類の光学分割法
GB8414559D0 (en) * 1984-06-07 1984-07-11 Scras Pyridine derivatives
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
JPS61289899A (ja) * 1985-06-18 1986-12-19 Kanegafuchi Chem Ind Co Ltd 光学活性２−ハロ−１−フエニルエタノ−ルおよびそのエステルの製造法
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
DE3737335A1 (de) * 1987-11-04 1989-05-18 Basf Ag Verfahren zur herstellung eines biokatalysators und dessen verwendung zur razematspaltung
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
DE3990349T1 (de) * 1988-04-06 1990-04-26 Scras Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
GB8907480D0 (en) * 1989-04-03 1989-05-17 Scaras Societe De Conseils De Separation of insomers of furo(3,4-c)pyridine derivatives
GB8917168D0 (en) * 1989-07-27 1989-09-13 Scras Asymmetric synthesis of furo(3,4-c)pyridine derivatives

Also Published As

Publication number Publication date
NO180308B (no) 1996-12-16
FR2661919A1 (fr) 1991-11-15
TNSN91035A1 (fr) 1992-10-25
GR910100180A (en) 1992-07-30
US5130252A (en) 1992-07-14
IE911628A1 (en) 1991-11-20
GB2244056B (en) 1993-08-11
TW226998B (nl) 1994-07-21
MY107567A (en) 1996-04-30
GB2244056A (en) 1991-11-20
ATA98291A (de) 1995-05-15
DZ1499A1 (fr) 2004-09-13
JPH05117277A (ja) 1993-05-14
ES2033574B1 (es) 1994-02-01
AU642368B2 (en) 1993-10-14
DE4115681A1 (de) 1991-11-21
IT1248743B (it) 1995-01-26
NL194615C (nl) 2002-09-03
DE4115681C2 (de) 2003-10-30
KR910020015A (ko) 1991-12-19
SE9101431D0 (sv) 1991-05-13
DK88991A (da) 1991-11-15
HK131993A (en) 1993-12-10
FI912315A (fi) 1991-11-15
OA09352A (fr) 1992-09-15
LU87935A1 (fr) 1992-03-03
ITMI911255A0 (it) 1991-05-08
FI912315A0 (fi) 1991-05-13
MA22154A1 (fr) 1991-12-31
IE65891B1 (en) 1995-11-29
NL9100749A (nl) 1991-12-02
ZA913461B (en) 1992-02-26
NL194615B (nl) 2002-05-01
CA2042421A1 (en) 1991-11-15
BE1007016A3 (fr) 1995-02-21
PT97657B (pt) 1998-09-30
NO911852L (no) 1991-11-15
AU7620091A (en) 1991-11-14
ITMI911255A1 (it) 1992-11-08
CH682488A5 (fr) 1993-09-30
GB9109810D0 (en) 1991-06-26
DK88991D0 (da) 1991-05-13
PT97657A (pt) 1992-02-28
FI97807B (fi) 1996-11-15
CA2042421C (en) 2000-08-22
NZ238009A (en) 1992-11-25
NO911852D0 (no) 1991-05-13
AR247762A1 (es) 1995-03-31
AT400445B (de) 1995-12-27
SE9101431L (sv) 1991-11-15
NO180308C (no) 1997-03-26
GR1001593B (el) 1993-03-31
FR2661919B1 (fr) 1994-12-30
ES2033574A1 (es) 1993-03-16
FI97807C (fi) 1997-02-25

Similar Documents

Publication Publication Date Title
FI104488B (fi) Monoklavulanaattisuola polyamiinien kanssa
SE510808C2 (sv) Förfarande för framställning av furo-(3,4-c)-pyridinderivat i icke-racematisk form genom hydrolys med ett esteras
SE435286B (sv) Klavulansyra for anvendning som kemisk mellanprodukt vid framstellning av klavulansyraderivat
JP2873143B2 (ja) 新規なアルキレンジアンモニウム ジクラブラネート誘導体、その製造方法並びにその使用
GB2264944A (en) 2-amino-2,4,4-trimethylpentane salt of clavulanic acid
KR19990007892A (ko) 클라블란산염의 제조방법
JP2003522769A (ja) ヌクレオシド類似体の立体選択的合成
HU225765B1 (en) Process for preparing intermediates for the synthesis of antifungal agents
AU670088B2 (en) Enzymatic process to separate racemic mixtures of delta valerolactones
US3838008A (en) Stereoselective preparation of l-dopa and l-m-tyrosine and novel compounds
JP2002538780A (ja) ヌクレオシド類似体の立体選択的合成
HU202289B (en) Process for racemate-splitting 7-alpha-acyloxy-6-beta-(hydroxy-methyl)-2-oxabicyclo(3.3.0)octan-3-one derivatives with stereospecific enzymatic acylate-hydrolysis
ES2228274B1 (es) Sintesis quimioenzimatica de (+)-citalopram y (-)-citalopram.
HU201975B (en) Process for stereospecific oxoreduction of bicyclooctanedione-carboxylic acid esters with microorganisms
EP0159695B1 (en) Cyclopentenone compound and process for production thereof
DE3638758A1 (de) Racematspaltung von 3-acyloxy-bicyclo(3.3.0)octan-7-on-2- carbonsaeureestern durch stereospezifische enzymatische oder mikrobiologische acylat-hydrolyse
JP2000072760A (ja) 新規シストチアゾール類縁体
HU198098B (en) New process for producing penem derivatives
JP3173850B2 (ja) 光学活性イノシトール誘導体の製造法
JP3410452B2 (ja) 光学活性イノシトールトリフォスフェートの製造法
JPH01156993A (ja) マクロライド化合物の製法
JPH0253497A (ja) 光学活性なマンデル酸の製法
JPS59120095A (ja) 抗生物質オキシラペンチンおよびその製造法
KR850007602A (ko) 트리아졸로피리미딘 유도체의 제조방법
JPH07107994A (ja) 光学活性なα−トコフェロール化合物の製造法

Legal Events

Date Code Title Description
NUG Patent has lapsed