KR850007602A - 트리아졸로피리미딘 유도체의 제조방법 - Google Patents

트리아졸로피리미딘 유도체의 제조방법 Download PDF

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KR850007602A
KR850007602A KR1019850002768A KR850002768A KR850007602A KR 850007602 A KR850007602 A KR 850007602A KR 1019850002768 A KR1019850002768 A KR 1019850002768A KR 850002768 A KR850002768 A KR 850002768A KR 850007602 A KR850007602 A KR 850007602A
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group
carbon atoms
thiadiazolo
salt
triazolo
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KR1019850002768A
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KR920002133B1 (ko
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수미로 이소다 (외 3)
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미아다께 가즈오
다이이찌 세이야꾸 가부시끼 가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

트리아졸로피리미딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 다음 일반식(Ⅱ) 화합물 또는 이의 염을 산중의 아질산염 또는 아질산에스테르로 디아조화시킴을 특징으로 하여 다음 일반식(Ⅰ) 화합물 및 생리학적으로 허용되는 이의 염을 제조하는 방법.
    상기 식에서, A는 CH 또는 N이고; R은 탄소수 1 내지 6의 알킬그룹, 탄소수 1 내지 10의 알킬렌그룹, 탄소수 3 내지 10의 사이클로알킬그룹, 탄소수 1 내지 6의 알콕시스룹, 탄소수 1 내지 8의 알킬렌디 옥시그룹 및 할로겐원자 중에서 선택된 하나 이상의 치환체로 치환될 수 있는 아릴그룹 또는 헤테로사이클릭 그룹이고; X는 단일결합을 나타내거나, 산소원자 또는 황원자에 의해 치환체 R 또는 축합된 환에 결합될 수 있고, 탄소수 1 내지 6의 알킬그룹, 아릴그룹 및 헤테로사이클릭 그룹중에서 선택된 하나 이상의 치환체로 치환될 수 있는, 탄소수 1 내지 10의 알킬렌그룹 또는 탄소수 2 내지 10의 알케닐렌그룹이다.
  2. 제1항에 있어서, X가 알킬렌그룹이고, R이 알킬그룹, 알콕시그룹 및 할로겐원자중에서 선택된 하나이상의 치환체로 치환될 수 있는 페닐그룹인 화합물 또는 이의 염을 제조하는 방법.
  3. 제1항에 있어서, X가 에틸렌그룹이고, R이 페닐그룹, 알킬페닐그룹 또는 할로페닐 그룹인 화합물 또는 이의 염을 제조하는 방법.
  4. 제1항에 있어서, 6-(2-페닐에틸)-[1,3,4] 티아디아졸로[3,2-a][1,2,3]트리아졸로[4,5-d]피리미딘-9(1H)-온 또는 이의 염을 제조하는 방법.
  5. 제1항에 있어서, 6-[2-(3-클로로페닐)에틸]-[1,3,4]티아디아졸로[3,2-a][1,2,3]트리아볼로[4,5-d]피리미딘-9(1H)-온 또는 이의 염을 제조하는 방법.
  6. 제1항에 있어서, 6-[2-(3,4-디클로로페닐)에틸]-[1,3,4] 티아디아졸로[3,2-a][1,2,3]트리아졸로[4,5-d]피리미딘-9(1-H)-온 또는 이의 염을 제조하는 방법.
  7. 제1항에 있어서, 6-[2-(2-클로로페닐)에틸)-[1,3,4]티아디아졸로[3,2-a]
    [1,2,3]트리아졸로[4,5-d]피리미딘-9(1-H)-온 또는 이의 염을 제조하는 방법.
  8. 제1항에 있어서, 6-[2-(2-메틸페닐)에틸]-[1,3,4]티아디아졸로[3,2-a]
    [1,2,3]트리아졸로[4,5-d]피리미딘-9(1H)-온 또는 이의 염을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850002768A 1984-04-25 1985-04-24 트리아졸로 피리미딘 유도체의 제조방법 KR920002133B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP83232/84 1984-04-25
JP59083232A JPS60226887A (ja) 1984-04-25 1984-04-25 トリアゾロピリミジン誘導体

Publications (2)

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KR850007602A true KR850007602A (ko) 1985-12-07
KR920002133B1 KR920002133B1 (ko) 1992-03-12

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US (1) US4652646A (ko)
EP (1) EP0159707B1 (ko)
JP (1) JPS60226887A (ko)
KR (1) KR920002133B1 (ko)
AT (1) ATE49765T1 (ko)
AU (1) AU580050B2 (ko)
CA (1) CA1250836A (ko)
DE (1) DE3575562D1 (ko)
DK (1) DK181985A (ko)
ES (1) ES8603500A1 (ko)
FI (1) FI81585C (ko)
GR (1) GR850995B (ko)
IL (1) IL75012A (ko)
MX (1) MX8232A (ko)
NO (1) NO170584C (ko)
PH (1) PH21387A (ko)
PT (1) PT80346B (ko)
YU (1) YU44048B (ko)
ZA (1) ZA853113B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85207A (en) * 1987-02-06 1992-06-21 Daiichi Seiyaku Co 6-substituted thiazolo-(and 1,3,4-thiadiazolo-)(3,2-a)-(1,2,3)triazolo(4,5-d)pyrimidin-9(1h)-ones and their preparation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1338235A (en) * 1970-12-15 1973-11-21 May & Baker Ltd Azapurinones
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones
US4366156A (en) * 1979-03-05 1982-12-28 Mead Johnson & Company Antiallergic methods using diazaheterocyclopurines

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ES542583A0 (es) 1985-12-16
DK181985A (da) 1985-10-26
YU44048B (en) 1990-02-28
ATE49765T1 (de) 1990-02-15
NO170584C (no) 1992-11-04
YU69385A (en) 1987-10-31
ES8603500A1 (es) 1985-12-16
IL75012A (en) 1988-12-30
MX8232A (es) 1993-12-01
PH21387A (en) 1987-10-15
FI81585B (fi) 1990-07-31
FI851617A0 (fi) 1985-04-24
DE3575562D1 (de) 1990-03-01
FI851617L (fi) 1985-10-26
GR850995B (ko) 1985-11-25
PT80346B (pt) 1987-06-17
ZA853113B (en) 1985-12-24
EP0159707A2 (en) 1985-10-30
AU4164085A (en) 1985-10-31
FI81585C (fi) 1990-11-12
NO851654L (no) 1985-10-28
AU580050B2 (en) 1988-12-22
EP0159707A3 (en) 1986-10-22
NO170584B (no) 1992-07-27
KR920002133B1 (ko) 1992-03-12
PT80346A (en) 1985-05-01
JPS60226887A (ja) 1985-11-12
DK181985D0 (da) 1985-04-23
EP0159707B1 (en) 1990-01-24
US4652646A (en) 1987-03-24
CA1250836A (en) 1989-03-07
JPH0421676B2 (ko) 1992-04-13
IL75012A0 (en) 1985-08-30

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