AR247762A1 - Un metodo para la preparacion de derivados de furo /3, 4-c/piridina en forma no-racemica - Google Patents

Un metodo para la preparacion de derivados de furo /3, 4-c/piridina en forma no-racemica

Info

Publication number
AR247762A1
AR247762A1 AR91319663A AR31966391A AR247762A1 AR 247762 A1 AR247762 A1 AR 247762A1 AR 91319663 A AR91319663 A AR 91319663A AR 31966391 A AR31966391 A AR 31966391A AR 247762 A1 AR247762 A1 AR 247762A1
Authority
AR
Argentina
Prior art keywords
yes
compound
preparation
racemic
pyridine derivatives
Prior art date
Application number
AR91319663A
Other languages
English (en)
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of AR247762A1 publication Critical patent/AR247762A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO PARA PREPARAR, EN UN FORMA NO RACEMICA, DERIVADOS DE FURO ¡3, 4-C¿ PIRIDINA DE FORMULA I Y SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO, DONDE -R3 Y R'3, SON HIDROGENO; ALQUILO; HETEROCICLICO DE 5 MIEMBROS; O FENILO SUSTITUIDO POR HALOGENO; Y -R6 ES ALQUILO; RESOLVIENDO UNA MEZCLA RACEMICA DEL COMPUESTO DE FORMULA (4), DONDE A1 Y A2 ESTAN UNIDOS ENTRE SI Y A1-A2 SI -C(CH3)2-O- Y A3 ES R7, O A1 ES R7 Y A2 Y A3 ESTAN UNIDOS ENTRE SI Y A2- A3 ES UNA LIGADURA; Y R7 ES ACILO, SOMETIENDO EL COMPUESTO A LA ACCION DE UNA ESTERASA CAPAZ DE HIDROLIZAR LA FORMA ENANTIOMERICA (+) O (-) DE DICHO COMPUESTO, Y LUEGO SEPARAR LOS COMPUESTOS NO HIDROLIZADOS Y LOS HIDROLIZADOS.
AR91319663A 1990-05-14 1991-05-10 Un metodo para la preparacion de derivados de furo /3, 4-c/piridina en forma no-racemica AR247762A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/523,238 US5130252A (en) 1990-05-14 1990-05-14 Resolution of furopyridine enantiomers and synthetic precursors thereof

Publications (1)

Publication Number Publication Date
AR247762A1 true AR247762A1 (es) 1995-03-31

Family

ID=24084213

Family Applications (1)

Application Number Title Priority Date Filing Date
AR91319663A AR247762A1 (es) 1990-05-14 1991-05-10 Un metodo para la preparacion de derivados de furo /3, 4-c/piridina en forma no-racemica

Country Status (32)

Country Link
US (1) US5130252A (es)
JP (1) JPH05117277A (es)
KR (1) KR910020015A (es)
AR (1) AR247762A1 (es)
AT (1) AT400445B (es)
AU (1) AU642368B2 (es)
BE (1) BE1007016A3 (es)
CA (1) CA2042421C (es)
CH (1) CH682488A5 (es)
DE (1) DE4115681C2 (es)
DK (1) DK88991A (es)
DZ (1) DZ1499A1 (es)
ES (1) ES2033574B1 (es)
FI (1) FI97807C (es)
FR (1) FR2661919B1 (es)
GB (1) GB2244056B (es)
GR (1) GR1001593B (es)
HK (1) HK131993A (es)
IE (1) IE65891B1 (es)
IT (1) IT1248743B (es)
LU (1) LU87935A1 (es)
MA (1) MA22154A1 (es)
MY (1) MY107567A (es)
NL (1) NL194615C (es)
NO (1) NO180308C (es)
NZ (1) NZ238009A (es)
OA (1) OA09352A (es)
PT (1) PT97657B (es)
SE (1) SE510808C2 (es)
TN (1) TNSN91035A1 (es)
TW (1) TW226998B (es)
ZA (1) ZA913461B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0221494D0 (en) * 2002-09-16 2002-10-23 Generics Uk Ltd Novel processes for the preparation of 1.3-dihydro-6-methylfuro (3,4-c) pyndin derivatives
US20110251396A1 (en) * 2003-07-17 2011-10-13 Gilead Sciences, Inc. Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
US20060089374A1 (en) * 2003-07-17 2006-04-27 Glenn Cornett Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
WO2005009446A1 (en) * 2003-07-17 2005-02-03 Cotherix, Inc. Combination therapies for treatment of hypertension and complications in patients with diabetes or metabolic syndrome
GB2423927A (en) * 2003-08-29 2006-09-13 Cotherix Inc Combination Of Cicletanine And An Oral Antidiabetic And/Or Blood Lipid-Lowering Agent For Treating Diabetes And Metabolic Syndrome
US20060154959A1 (en) * 2005-01-13 2006-07-13 Navitas Pharma Combination therapies of cicletanine and carvedilol
US7375112B2 (en) * 2005-01-05 2008-05-20 Medicure International Inc. Compounds and methods for regulating triglyceride levels
US20070141174A1 (en) * 2005-01-13 2007-06-21 Navitas Pharma, Inc. Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension
US20080096915A1 (en) * 2005-01-13 2008-04-24 Greenberg Traurig LLP Compositions for the treatment of metabolic disorders
US20070105817A1 (en) * 2005-11-09 2007-05-10 Jim Page Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension
CA2674367A1 (en) * 2007-01-03 2008-07-17 Glenn V. Cornett Cicletanine and pkc inhibitors in the treatment of pulmonary and cardiac disorders
EP2498605B1 (en) * 2009-10-29 2014-08-27 Merck Sharp & Dohme Corp. Diuretics

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN156817B (es) * 1981-02-10 1985-11-09 Scras
US4985365A (en) * 1981-11-28 1991-01-15 Sumitomo Chemical Company, Ltd. Process for producing optically active benzyl alcohol compound
DE3378834D1 (en) * 1982-08-13 1989-02-09 Kanegafuchi Chemical Ind Process for production of optically active oxazolidinone derivative
IN160104B (es) * 1983-04-05 1987-06-27 Scras
JPS59216590A (ja) * 1983-05-24 1984-12-06 Ube Ind Ltd 光学活性フエニルプロパルギルアルコ−ル誘導体の製法
GB8327817D0 (en) * 1983-10-18 1983-11-16 Scras 4-halo-furo-(3 4-c)-pyridine derivatives
GB8330517D0 (en) * 1983-11-16 1983-12-21 Scras 6-vinyl-furo-(3,4-c)pyridine derivatives
GB8330658D0 (en) * 1983-11-17 1983-12-29 Scras 7-carboxymethoxy-furo-(3,4-c)-pyridine derivatives
GB8402740D0 (en) * 1984-02-02 1984-03-07 Scras Furo-(3 4-c)-pyridine derivatives
JPS60224494A (ja) * 1984-04-24 1985-11-08 Nissan Chem Ind Ltd α−メチルベンジルアルコ−ル類の光学分割法
GB8414559D0 (en) * 1984-06-07 1984-07-11 Scras Pyridine derivatives
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
JPS61289899A (ja) * 1985-06-18 1986-12-19 Kanegafuchi Chem Ind Co Ltd 光学活性２−ハロ−１−フエニルエタノ−ルおよびそのエステルの製造法
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
DE3737335A1 (de) * 1987-11-04 1989-05-18 Basf Ag Verfahren zur herstellung eines biokatalysators und dessen verwendung zur razematspaltung
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
DE3990349T1 (de) * 1988-04-06 1990-04-26 Scras Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
GB8907480D0 (en) * 1989-04-03 1989-05-17 Scaras Societe De Conseils De Separation of insomers of furo(3,4-c)pyridine derivatives
GB8917168D0 (en) * 1989-07-27 1989-09-13 Scras Asymmetric synthesis of furo(3,4-c)pyridine derivatives

Also Published As

Publication number Publication date
ITMI911255A1 (it) 1992-11-08
SE510808C2 (sv) 1999-06-28
ES2033574A1 (es) 1993-03-16
GB9109810D0 (en) 1991-06-26
MY107567A (en) 1996-04-30
FI97807C (fi) 1997-02-25
FR2661919B1 (fr) 1994-12-30
ITMI911255A0 (it) 1991-05-08
NO180308B (no) 1996-12-16
FI912315A0 (fi) 1991-05-13
GB2244056A (en) 1991-11-20
KR910020015A (ko) 1991-12-19
JPH05117277A (ja) 1993-05-14
US5130252A (en) 1992-07-14
NZ238009A (en) 1992-11-25
ES2033574B1 (es) 1994-02-01
CA2042421A1 (en) 1991-11-15
ZA913461B (en) 1992-02-26
NL9100749A (nl) 1991-12-02
DK88991D0 (da) 1991-05-13
FI912315A (fi) 1991-11-15
MA22154A1 (fr) 1991-12-31
ATA98291A (de) 1995-05-15
PT97657A (pt) 1992-02-28
DZ1499A1 (fr) 2004-09-13
LU87935A1 (fr) 1992-03-03
FR2661919A1 (fr) 1991-11-15
DE4115681A1 (de) 1991-11-21
GR1001593B (el) 1993-03-31
BE1007016A3 (fr) 1995-02-21
CH682488A5 (fr) 1993-09-30
TW226998B (es) 1994-07-21
DE4115681C2 (de) 2003-10-30
SE9101431L (sv) 1991-11-15
AU7620091A (en) 1991-11-14
AU642368B2 (en) 1993-10-14
GR910100180A (en) 1992-07-30
PT97657B (pt) 1998-09-30
IE65891B1 (en) 1995-11-29
NO180308C (no) 1997-03-26
DK88991A (da) 1991-11-15
HK131993A (en) 1993-12-10
SE9101431D0 (sv) 1991-05-13
IE911628A1 (en) 1991-11-20
NL194615C (nl) 2002-09-03
GB2244056B (en) 1993-08-11
IT1248743B (it) 1995-01-26
NL194615B (nl) 2002-05-01
OA09352A (fr) 1992-09-15
TNSN91035A1 (fr) 1992-10-25
NO911852L (no) 1991-11-15
CA2042421C (en) 2000-08-22
FI97807B (fi) 1996-11-15
AT400445B (de) 1995-12-27
NO911852D0 (no) 1991-05-13

Similar Documents

Publication Publication Date Title
AR247762A1 (es) Un metodo para la preparacion de derivados de furo /3, 4-c/piridina en forma no-racemica
DE69100079D1 (de) Naphthalin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
PE31691A1 (es) Procedimiento para la preparacion de nuevos compuestos fungicidas
AR241161A2 (es) "procedimiento para la preparacion de derivados n-aminoalquilen sustituidos de la glutarimida"
PE20030131A1 (es) Derivados de 6-fenildihidropirrolpirimidindiona
AU3158093A (en) Novel phosphono-succinic acid derivatives, process for producing them and medicaments containing these compounds
KR960701878A (ko) 수용성 캄프토테신 유도체, 이의 제조 방법 및 항종양제로서의 이의 용도(Water-soluble camptothecin derivatives, process for their preparation and their use as antitumor agents)
BG94282A (bg) 2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
KR910700253A (ko) N_6-치환-9-메틸아데닌: 신규한 부류의 아데노신 수용체 길항질
KR850002269A (ko) 피리도인돌 유도체의 제조방법
KR920006360A (ko) 스쿠알렌 합성효소 억제제
DE3684225D1 (de) Verfahren zur herstellung von 3-imidazolylmethyltetrahydrocarbazolonen.
DE3684235D1 (de) Verfahren zur herstellung von 3-imidazolylmethyltetrahydrocarbazolonen.
ATE27956T1 (de) Cephalosporinverbindungen und verfahren zu ihrer herstellung.
DE3376421D1 (en) Analgesia-effecting 5-hydroxytryptophan derivatives
ES8506652A1 (es) Un metodo de preparar dihidrobenzopirrolbenzodiazepinas
PT87716A (pt) Process for preparing cycloalkylamides of (8-beta)-1-alkyl-6-(substituted) ergolines
ATE31921T1 (de) Amidine, verfahren zu ihrer herstellung und deren anwendung in der therapie.
DK136987D0 (da) Selektive alfa-adrenerge receptorantagonister, fremgangsmaade til fremstilling heraf samt farmaceutiske midler indeholdende disse
ES2143630T3 (es) Derivados azabicicloalquilos de imidazo(1,5-a)indol-3-ona utilizados como antagonistas de 5ht3.
ATE188700T1 (de) Indol-2,3-dione-3-oximderivate, ihre herstellung und verwendung
PE86698A1 (es) Derivados de indolina
CA2273894A1 (en) Novel n-benzenesulphonyl-l-proline derivatives, method for preparing and therapeutic use
KR890013015A (ko) 복소환 화합물 및 항궤양제
ES514634A0 (es) "un procedimiento para la preparacion de 2-(1,4-benzodioxan-2-il-metil)-imidazolina".