SE463716B - 2-halonicergolinderivat, foerfarande foer framstaellning av detta och en farmaceutisk beredning - Google Patents

2-halonicergolinderivat, foerfarande foer framstaellning av detta och en farmaceutisk beredning

Info

Publication number
SE463716B
SE463716B SE8602737A SE8602737A SE463716B SE 463716 B SE463716 B SE 463716B SE 8602737 A SE8602737 A SE 8602737A SE 8602737 A SE8602737 A SE 8602737A SE 463716 B SE463716 B SE 463716B
Authority
SE
Sweden
Prior art keywords
formula
acid addition
halonicergoline
acid
mmol
Prior art date
Application number
SE8602737A
Other languages
English (en)
Swedish (sv)
Other versions
SE8602737L (sv
SE8602737D0 (sv
Inventor
G Megyeri
T Keve
B Stefko
E Bogsch
J Galambos
A Kassai
F Trischler
E Palosi
D Groo
E Karpati
Z Szombathelyi
L Szporny
B Kiss
I Laszlovszky
E Lapis
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8602737D0 publication Critical patent/SE8602737D0/xx
Publication of SE8602737L publication Critical patent/SE8602737L/xx
Publication of SE463716B publication Critical patent/SE463716B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE8602737A 1985-06-21 1986-06-19 2-halonicergolinderivat, foerfarande foer framstaellning av detta och en farmaceutisk beredning SE463716B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU852447A HU193782B (en) 1985-06-21 1985-06-21 Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof

Publications (3)

Publication Number Publication Date
SE8602737D0 SE8602737D0 (sv) 1986-06-19
SE8602737L SE8602737L (sv) 1986-12-22
SE463716B true SE463716B (sv) 1991-01-14

Family

ID=10959403

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8602737A SE463716B (sv) 1985-06-21 1986-06-19 2-halonicergolinderivat, foerfarande foer framstaellning av detta och en farmaceutisk beredning

Country Status (30)

Country Link
US (1) US4753949A (ja)
JP (1) JPS62485A (ja)
CN (1) CN1015365B (ja)
AR (1) AR241533A1 (ja)
AT (1) AT390614B (ja)
AU (1) AU594686B2 (ja)
BE (1) BE904957A (ja)
CH (1) CH671018A5 (ja)
CS (1) CS255875B1 (ja)
DD (1) DD246111A5 (ja)
DE (1) DE3620647A1 (ja)
DK (1) DK292086A (ja)
ES (1) ES8800953A1 (ja)
FI (1) FI84605C (ja)
FR (1) FR2583756B1 (ja)
GB (1) GB2176788B (ja)
HU (1) HU193782B (ja)
IL (1) IL79179A0 (ja)
IN (1) IN163116B (ja)
IT (1) IT1204865B (ja)
LU (1) LU86485A1 (ja)
NL (1) NL8601612A (ja)
NO (1) NO164099C (ja)
PH (1) PH24732A (ja)
PL (1) PL147390B1 (ja)
PT (1) PT82808B (ja)
SE (1) SE463716B (ja)
SU (1) SU1445557A3 (ja)
YU (1) YU107986A (ja)
ZA (1) ZA864633B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193781B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof
HU196394B (en) * 1986-06-27 1988-11-28 Richter Gedeon Vegyeszet Process for preparing 2-halogenated ergoline derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228943A (en) * 1962-06-11 1966-01-11 Lumilysergol derivatives
US3879554A (en) * 1970-03-20 1975-04-22 Farmaceutici Italia Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
US4199579A (en) * 1975-03-14 1980-04-22 Siphar S. A. Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof
GB1513322A (en) * 1976-01-09 1978-06-07 Farmaceutici Italia Heterocyclic ergoline derivatives
YU39278B (en) * 1976-12-22 1984-10-31 Lek Tovarna Farmacevtskih Process for preparing 5-bromo nicotinic acid esters
IT1094965B (it) * 1978-04-05 1985-08-10 Corvi Mora E Procedimento di preparazione di derivati del lisergolo
DE91652T1 (de) * 1982-04-13 1984-03-29 Farmitalia Carlo Erba S.p.A., 20159 Milano Ergolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
CH649998A5 (de) * 1982-08-09 1985-06-28 Sandoz Ag Ergolinderivate, ein verfahren zu ihrer herstellung und heilmittel, enthaltend diese ergolinderivate als wirkstoff.
GB8612366D0 (en) * 1986-05-21 1986-06-25 Erba Farmitalia Ergoline esters
GB8615471D0 (en) * 1986-06-25 1986-07-30 Erba Farmitalia T-butyl ergoline derivatives

Also Published As

Publication number Publication date
FR2583756A1 (fr) 1986-12-26
US4753949A (en) 1988-06-28
AR241533A1 (es) 1992-08-31
CN86104086A (zh) 1986-12-17
SE8602737L (sv) 1986-12-22
PH24732A (en) 1990-10-01
NO862493L (no) 1986-12-22
FI862635A0 (fi) 1986-06-19
IT1204865B (it) 1989-03-10
IT8620873A0 (it) 1986-06-20
SE8602737D0 (sv) 1986-06-19
IN163116B (ja) 1988-08-13
LU86485A1 (de) 1986-12-02
JPS62485A (ja) 1987-01-06
ES8800953A1 (es) 1987-12-16
HUT41024A (en) 1987-03-30
GB2176788A (en) 1987-01-07
PL147390B1 (en) 1989-05-31
DD246111A5 (de) 1987-05-27
ES556359A0 (es) 1987-12-16
ATA168486A (de) 1989-11-15
FR2583756B1 (fr) 1990-01-12
NL8601612A (nl) 1987-01-16
CN1015365B (zh) 1992-02-05
CH671018A5 (ja) 1989-07-31
FI862635A (fi) 1986-12-22
IL79179A0 (en) 1986-09-30
ZA864633B (en) 1987-02-25
AT390614B (de) 1990-06-11
DK292086D0 (da) 1986-06-20
DK292086A (da) 1986-12-22
NO862493D0 (no) 1986-06-20
JPH0529227B2 (ja) 1993-04-28
DE3620647A1 (de) 1987-01-02
GB8615120D0 (en) 1986-07-23
YU107986A (en) 1988-04-30
HU193782B (en) 1987-11-30
GB2176788B (en) 1989-07-26
FI84605B (fi) 1991-09-13
NO164099C (no) 1990-08-29
NO164099B (no) 1990-05-21
BE904957A (fr) 1986-12-19
PT82808A (en) 1986-07-01
SU1445557A3 (ru) 1988-12-15
PT82808B (pt) 1988-04-21
FI84605C (fi) 1991-12-27
AU594686B2 (en) 1990-03-15
CS255875B1 (en) 1988-03-15
AU5891686A (en) 1986-12-24

Similar Documents

Publication Publication Date Title
DE3750596T2 (de) 1,2,3,3a,8,8a-Hexahydro-1,3a,8-Trimethylpyrrolo[2,3-b]indole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
CA2104883A1 (fr) Derives d'acide thienyl ou pyrrolyl carboxyliques, leur preparation et medicaments les contenant
RU2125571C1 (ru) СОЛЬ 7-([1α,5α,6α]-6-АМИНО-3-АЗАБИЦИКЛО [3.1.0] ГЕКС-3-ИЛ)-6-ФТОР-1-(2,4-ДИФТОРФЕНИЛ)-1,4- ДИГИДРО-4-ОКСО-1,8-НАФТИРИДИН-3-КАРБОНОВОЙ И МЕТАНСУЛЬФОНОВОЙ КИСЛОТ И СПОСОБ ЕЕ ПОЛУЧЕНИЯ
EP0579681B1 (en) Crystalline tiagabine hydrochloride monohydrate, its preparation and use
KR20010014316A (ko) 8-클로로-6,11-디하이드로-11-(4-피페리딜리덴)-5Ｈ-벤조[5,6]사이클로헵타[1,2-ｂ]피리딘의 동질이상체
CZ200471A3 (cs) Způsob purifikace N-[3-(3-kyanopyrazol[1,5-a]pyrimidin-7-yl)fenyl]-N-ethylacetamidu (zaleplon) a krystalické formy zaleplonu připravitelné tímto způsobem
CS270249B2 (en) Method of purine's new derivatives production
FR2536398A1 (fr) Nouveaux composes heterocycliques
RU2228931C2 (ru) Кристаллические формы 3-(2,4-дихлорбензил)-2-метил-n-(пентилсульфонил)-3h- бензимидазол-5-карбоксамида
SE463716B (sv) 2-halonicergolinderivat, foerfarande foer framstaellning av detta och en farmaceutisk beredning
KR100659927B1 (ko) 다형태를갖는독사조신메실레이트의새로운형태(제iii형)
CA1337348C (fr) Produits optiquement actifs de derives de 20,21-dinoreburnamenine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US4299836A (en) Novel ergol-8-ene and ergolin compounds and process for preparing same
NO854574L (no) Fremgangsmaate for fremstilling av en ny krystallinsk form av et benzotiazin-dioksyd-salt.
JPH0560478B2 (ja)
US4138489A (en) Vasodilating octahydro-1,12-methano-oxymethano[2,3-a]-indoloquinolizines
US7521472B2 (en) Crystal of two-ring heterocyclic sulfonamide compound
US4904654A (en) 7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
EP0003286B1 (de) Ergopeptidalkaloid-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
CA2184598C (en) Novel crystal forms of 1-[5-methanesulfonamidoindolyl-2-carbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine
KR880001280B1 (ko) 2-할로니세르골린 유도체와 그 산부가염의 제조방법
JPS5810387B2 (ja) ４，５，６，７テトラヒドロイミダゾ〔４，５−ｃ〕ピリジン誘導体及びその製法
JPH0525170A (ja) ピリドン誘導体、その製造法及びそれを含有する抗潰瘍剤
NO152750B (no) Fremgangsmaate for fremstilling av nitrogen brohode-kondenserte pyrimidinforbindelser
JP3001975B2 (ja) 結晶性チアガビン塩酸塩−水和物、その製造方法および用途

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8602737-2

Effective date: 19940110

Format of ref document f/p: F