AR241533A1 - Nuevos derivados de 5-bromonicotinato de 1,6-dimetil-10 alfa-metoxi-4,5,7,8,9,10-hexahidro-1h,6h-indolo(4,3-g,h)quinolin-8 beta-metilo. - Google Patents
Nuevos derivados de 5-bromonicotinato de 1,6-dimetil-10 alfa-metoxi-4,5,7,8,9,10-hexahidro-1h,6h-indolo(4,3-g,h)quinolin-8 beta-metilo.Info
- Publication number
- AR241533A1 AR241533A1 AR86304332A AR30433286A AR241533A1 AR 241533 A1 AR241533 A1 AR 241533A1 AR 86304332 A AR86304332 A AR 86304332A AR 30433286 A AR30433286 A AR 30433286A AR 241533 A1 AR241533 A1 AR 241533A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- salt
- addition
- steritized
- methyllumylisergol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PREPARACION DE DERIVADOS DE 5-BROMONICOTINATO DE 1,6-DIMETIL 10 ALFA-METOXI 4,5,7,8,9,10-HEXAHIDRO-1H,6H-INDOLO (4,3-G,H)QUINOLIN-8 BETA-METILO (HALOGENADOS EN POSICION 2 DE FORMULA (I), DONDE XES CLORO, BROMO O YODO, Y DE SUS SALES DE ADICION DE ACIDO. SE ESTERIFICA UN 2-HALO-1- METILLUMILISERGOL DE FORMULA (II), DONDE X ES LO DEFINIDO ANTES, O UNA SAL DE ADICION DE ACIDO DE LA MISMA CON UN ESTER REACTIVO, OBTENIDO HACIENDO REACCIONAR HIDROXISUCCINIMIDA N CON ACIDO 5-BROMONICOTINICO, Y, SI SE DESEA, EN TRANSFORMAR EL DERIVADO DE LA 2-HALONICERGOLINA, ASI OBTENIDO, DE FORMULA (I), EN UNA SAL DE ADICION DE ACIDO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU852447A HU193782B (en) | 1985-06-21 | 1985-06-21 | Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AR241533A1 true AR241533A1 (es) | 1992-08-31 |
Family
ID=10959403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR86304332A AR241533A1 (es) | 1985-06-21 | 1986-06-19 | Nuevos derivados de 5-bromonicotinato de 1,6-dimetil-10 alfa-metoxi-4,5,7,8,9,10-hexahidro-1h,6h-indolo(4,3-g,h)quinolin-8 beta-metilo. |
Country Status (30)
Country | Link |
---|---|
US (1) | US4753949A (es) |
JP (1) | JPS62485A (es) |
CN (1) | CN1015365B (es) |
AR (1) | AR241533A1 (es) |
AT (1) | AT390614B (es) |
AU (1) | AU594686B2 (es) |
BE (1) | BE904957A (es) |
CH (1) | CH671018A5 (es) |
CS (1) | CS255875B1 (es) |
DD (1) | DD246111A5 (es) |
DE (1) | DE3620647A1 (es) |
DK (1) | DK292086A (es) |
ES (1) | ES8800953A1 (es) |
FI (1) | FI84605C (es) |
FR (1) | FR2583756B1 (es) |
GB (1) | GB2176788B (es) |
HU (1) | HU193782B (es) |
IL (1) | IL79179A0 (es) |
IN (1) | IN163116B (es) |
IT (1) | IT1204865B (es) |
LU (1) | LU86485A1 (es) |
NL (1) | NL8601612A (es) |
NO (1) | NO164099C (es) |
PH (1) | PH24732A (es) |
PL (1) | PL147390B1 (es) |
PT (1) | PT82808B (es) |
SE (1) | SE463716B (es) |
SU (1) | SU1445557A3 (es) |
YU (1) | YU107986A (es) |
ZA (1) | ZA864633B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU193781B (en) * | 1985-06-21 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing 10alpha-methoxy-6-methylergoline derivatives and acid additional salts thereof |
HU196394B (en) * | 1986-06-27 | 1988-11-28 | Richter Gedeon Vegyeszet | Process for preparing 2-halogenated ergoline derivatives |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3228943A (en) * | 1962-06-11 | 1966-01-11 | Lumilysergol derivatives | |
US3879554A (en) * | 1970-03-20 | 1975-04-22 | Farmaceutici Italia | Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders |
US4199579A (en) * | 1975-03-14 | 1980-04-22 | Siphar S. A. | Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof |
GB1513322A (en) * | 1976-01-09 | 1978-06-07 | Farmaceutici Italia | Heterocyclic ergoline derivatives |
YU39278B (en) * | 1976-12-22 | 1984-10-31 | Lek Tovarna Farmacevtskih | Process for preparing 5-bromo nicotinic acid esters |
IT1094965B (it) * | 1978-04-05 | 1985-08-10 | Corvi Mora E | Procedimento di preparazione di derivati del lisergolo |
ATE18223T1 (de) * | 1982-04-13 | 1986-03-15 | Erba Farmitalia | Ergolinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
CH649998A5 (de) * | 1982-08-09 | 1985-06-28 | Sandoz Ag | Ergolinderivate, ein verfahren zu ihrer herstellung und heilmittel, enthaltend diese ergolinderivate als wirkstoff. |
GB8612366D0 (en) * | 1986-05-21 | 1986-06-25 | Erba Farmitalia | Ergoline esters |
GB8615471D0 (en) * | 1986-06-25 | 1986-07-30 | Erba Farmitalia | T-butyl ergoline derivatives |
-
1985
- 1985-06-21 HU HU852447A patent/HU193782B/hu not_active IP Right Cessation
-
1986
- 1986-06-10 IN IN430/CAL/86A patent/IN163116B/en unknown
- 1986-06-19 AR AR86304332A patent/AR241533A1/es active
- 1986-06-19 SE SE8602737A patent/SE463716B/sv not_active IP Right Cessation
- 1986-06-19 FI FI862635A patent/FI84605C/fi not_active IP Right Cessation
- 1986-06-19 BE BE0/216806A patent/BE904957A/fr not_active IP Right Cessation
- 1986-06-19 CH CH2487/86A patent/CH671018A5/de not_active IP Right Cessation
- 1986-06-20 NL NL8601612A patent/NL8601612A/nl not_active Application Discontinuation
- 1986-06-20 PL PL1986260192A patent/PL147390B1/pl unknown
- 1986-06-20 DK DK292086A patent/DK292086A/da not_active Application Discontinuation
- 1986-06-20 AU AU58916/86A patent/AU594686B2/en not_active Ceased
- 1986-06-20 FR FR868608933A patent/FR2583756B1/fr not_active Expired - Fee Related
- 1986-06-20 PH PH33913A patent/PH24732A/en unknown
- 1986-06-20 CS CS864584A patent/CS255875B1/cs unknown
- 1986-06-20 JP JP61143162A patent/JPS62485A/ja active Granted
- 1986-06-20 ZA ZA864633A patent/ZA864633B/xx unknown
- 1986-06-20 IT IT20873/86A patent/IT1204865B/it active
- 1986-06-20 AT AT0168486A patent/AT390614B/de not_active IP Right Cessation
- 1986-06-20 ES ES556359A patent/ES8800953A1/es not_active Expired
- 1986-06-20 IL IL79179A patent/IL79179A0/xx not_active IP Right Cessation
- 1986-06-20 DD DD86291510A patent/DD246111A5/de not_active IP Right Cessation
- 1986-06-20 YU YU01079/86A patent/YU107986A/xx unknown
- 1986-06-20 DE DE19863620647 patent/DE3620647A1/de not_active Withdrawn
- 1986-06-20 NO NO862493A patent/NO164099C/no unknown
- 1986-06-20 GB GB8615120A patent/GB2176788B/en not_active Expired
- 1986-06-20 LU LU86485A patent/LU86485A1/de unknown
- 1986-06-20 PT PT82808A patent/PT82808B/pt not_active IP Right Cessation
- 1986-06-20 SU SU864027691A patent/SU1445557A3/ru active
- 1986-06-21 CN CN86104086A patent/CN1015365B/zh not_active Expired
- 1986-06-23 US US06/877,294 patent/US4753949A/en not_active Expired - Fee Related
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