ES2164087T3 - Ester de hidrolasa tipo norbornane. - Google Patents

Ester de hidrolasa tipo norbornane.

Info

Publication number
ES2164087T3
ES2164087T3 ES94302834T ES94302834T ES2164087T3 ES 2164087 T3 ES2164087 T3 ES 2164087T3 ES 94302834 T ES94302834 T ES 94302834T ES 94302834 T ES94302834 T ES 94302834T ES 2164087 T3 ES2164087 T3 ES 2164087T3
Authority
ES
Spain
Prior art keywords
norbornane type
type hydrolase
norbornane
type ester
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94302834T
Other languages
English (en)
Inventor
Bunji Kageyama
Masanori Nakae
Shigeo Yagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2164087T3 publication Critical patent/ES2164087T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/823—Acetobacter

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE PROPORCIONA UN ESTER HIDROLASA DEL TIPO NORBORNANO QUE SE HIDROLIZA ENANTIO-SELECTIVAMENTE A UN (L (MAS MENOS) ) LA QUE R ES ACILO, Y A Y B SON HIDROGENOS RESPECTIVAMENTE, O DONDE A Y B ESTAN AUSENTES, RESULTANDO EN UN ENLACE DOBLE CARBONO LA FORMULA I. EL ESTER HIDROLASA DEL TIPO NORBORNANO TIENE UN PH OPTIMO DE APROXIMADAMENTE 8 Y INDICE DE PH ESTABLE DE APROXIMADAMENTE 6 A 8.
ES94302834T 1993-04-22 1994-04-21 Ester de hidrolasa tipo norbornane. Expired - Lifetime ES2164087T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP09628693A JP3431204B2 (ja) 1993-04-22 1993-04-22 ノルボルナン型エステル・ヒドロラーゼ

Publications (1)

Publication Number Publication Date
ES2164087T3 true ES2164087T3 (es) 2002-02-16

Family

ID=14160856

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94302834T Expired - Lifetime ES2164087T3 (es) 1993-04-22 1994-04-21 Ester de hidrolasa tipo norbornane.

Country Status (13)

Country Link
US (2) US5484725A (es)
EP (1) EP0623678B1 (es)
JP (1) JP3431204B2 (es)
KR (1) KR100306008B1 (es)
AT (1) ATE206461T1 (es)
AU (1) AU679487B2 (es)
CA (1) CA2121180C (es)
DE (1) DE69428478T2 (es)
DK (1) DK0623678T3 (es)
ES (1) ES2164087T3 (es)
NZ (1) NZ260310A (es)
PT (1) PT623678E (es)
SI (1) SI0623678T1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001506621A (ja) * 1996-12-13 2001-05-22 メデバ・ユアラプ・リミテッド エナンチオマー濃縮されたトレオ−メチルフェニデートの調製法
US20020137171A1 (en) * 2000-12-01 2002-09-26 Diversa Corporation Hydrolase enzymes and their use in kinetic resolution

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2560532C2 (es) * 1974-11-26 1988-11-10 Takeda Chemical Industries, Ltd., Osaka, Jp
US5274300A (en) * 1988-10-26 1993-12-28 Sepracor, Inc. Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion
JPH02273196A (ja) * 1989-03-08 1990-11-07 Wisconsin Alumni Res Found ラセミ化合物の生体触媒分割のエナンチオ選択性の改良法
JP2844224B2 (ja) * 1989-10-09 1999-01-06 チッソ株式会社 光学活性モノエステル化合物およびその製造法
DK0557519T3 (da) * 1989-10-18 1997-06-23 Shionogi & Co Fremgangsmåde til fremstilling af sulfonamidderivater af norbornan
RU2104306C1 (ru) * 1989-11-13 1998-02-10 Пфайзер Инк. Способ получения оптически активного (2s)- или (2r)-эндо-бицикло[2.2.1]гептан-2-ола, способ получения 5-(3-[(2r)-экзо-бицикло[2.2.1]гепт-2-илокси]-4-метоксифенил)-3,4,5,6-тетрагидропиримидин-2(1н)-она, оптически активный 5-(3-[экзо-бицикло[2.2.1]гепт-2-илокси]4-метоксифенил)-3,4,5,6-тетрагидропиримидин-2(1н)-он, оптически активные промежуточные соединения и способ их получения
US5270206A (en) * 1989-11-13 1993-12-14 Pfizer Inc. Enzymatic resolution of endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents
AT398310B (de) * 1991-08-30 1994-11-25 Chemie Linz Gmbh Immobilisierte lipase, verfahren zu ihrer herstellung sowie verfahren zur erhöhung der enantioselektivität einer candida lipase bei der veresterung chiraler alkohole
NZ246087A (en) * 1991-12-06 1995-04-27 Shionogi Seiyaku Kk Production of optically active norborneol from a racemic ester mixture using a microoganism or treated cells thereof

Also Published As

Publication number Publication date
AU679487B2 (en) 1997-07-03
PT623678E (pt) 2002-02-28
DE69428478T2 (de) 2002-05-29
AU5948594A (en) 1994-10-27
EP0623678A3 (en) 1995-06-28
US5484725A (en) 1996-01-16
EP0623678A2 (en) 1994-11-09
JP3431204B2 (ja) 2003-07-28
DK0623678T3 (da) 2001-12-10
ATE206461T1 (de) 2001-10-15
US5686285A (en) 1997-11-11
DE69428478D1 (de) 2001-11-08
CA2121180A1 (en) 1994-10-23
KR100306008B1 (ko) 2001-11-30
SI0623678T1 (en) 2001-12-31
EP0623678B1 (en) 2001-10-04
CA2121180C (en) 1999-02-09
JPH06303972A (ja) 1994-11-01
NZ260310A (en) 1995-03-28

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