DE69018375D1 - Pro-drugs von 6-Mercaptopurin und 6-Thioguanin. - Google Patents

Pro-drugs von 6-Mercaptopurin und 6-Thioguanin.

Info

Publication number
DE69018375D1
DE69018375D1 DE69018375T DE69018375T DE69018375D1 DE 69018375 D1 DE69018375 D1 DE 69018375D1 DE 69018375 T DE69018375 T DE 69018375T DE 69018375 T DE69018375 T DE 69018375T DE 69018375 D1 DE69018375 D1 DE 69018375D1
Authority
DE
Germany
Prior art keywords
thioguanine
mercaptopurine
prodrugs
pro
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69018375T
Other languages
English (en)
Other versions
DE69018375T2 (de
Inventor
Adnan Elfarra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE69018375D1 publication Critical patent/DE69018375D1/de
Publication of DE69018375T2 publication Critical patent/DE69018375T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE69018375T 1989-11-03 1990-11-01 Pro-drugs von 6-Mercaptopurin und 6-Thioguanin. Expired - Fee Related DE69018375T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43209889A 1989-11-03 1989-11-03
US07/542,664 US5120740A (en) 1989-11-03 1990-06-25 Prodrugs of 6-mercaptopurine and 6-thioguanine

Publications (2)

Publication Number Publication Date
DE69018375D1 true DE69018375D1 (de) 1995-05-11
DE69018375T2 DE69018375T2 (de) 1996-01-04

Family

ID=27029358

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69018375T Expired - Fee Related DE69018375T2 (de) 1989-11-03 1990-11-01 Pro-drugs von 6-Mercaptopurin und 6-Thioguanin.

Country Status (5)

Country Link
US (1) US5120740A (de)
EP (1) EP0426467B1 (de)
JP (1) JPH03240789A (de)
AT (1) ATE120747T1 (de)
DE (1) DE69018375T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5502037A (en) * 1993-07-09 1996-03-26 Neuromed Technologies, Inc. Pro-cytotoxic drug conjugates for anticancer therapy
US6491905B1 (en) * 1993-09-14 2002-12-10 The Uab Research Foundation Recombinant bacterial cells for delivery of PNP to tumor cells
DE19953414A1 (de) * 1999-11-06 2001-05-10 Merck Patent Gmbh Imidazopyridinderivate als Phospodiesterase VII-Hemmer
US20040023994A1 (en) * 2002-06-04 2004-02-05 Elfarra Adnan A. Glutathione-activated anti-tumor prodrugs of 6-mercaptopurine and 6-thioguanine
WO2005030135A2 (en) * 2003-09-26 2005-04-07 Nitromed, Inc. Nitrosated glutamic acid compounds, compositions and methods of use
EP1746975A2 (de) * 2004-04-01 2007-01-31 Teva Pharmaceutical Industries Limited Formulierungen für die verzögerte freisetzung von 6-mercaptopurin
US8188067B2 (en) 2004-04-01 2012-05-29 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
WO2009128955A1 (en) * 2008-04-18 2009-10-22 Teva Pharmaceutical Industries Ltd. Treatment of inflammatory bowel disease with 6-mercaptopurine
WO2017066619A1 (en) 2015-10-16 2017-04-20 Teva Pharmaceutical Industries Ltd. Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2875203A (en) * 1958-03-03 1959-02-24 Shive William Alkylthiopurines
US2952539A (en) * 1958-10-23 1960-09-13 Gen Aniline & Film Corp Photographic emulsions and developers stabilized with purine compounds
US3238207A (en) * 1960-03-01 1966-03-01 Burroughs Wellcome Co 6-oxyorganopurines and method of preparing them
US3149111A (en) * 1961-09-29 1964-09-15 Burroughs Wellcome Co Dinitrophenylmercaptopurines
US3232938A (en) * 1962-08-02 1966-02-01 Burroughs Wellcome Co 6-alkylmercaptopurines
US3232937A (en) * 1962-08-02 1966-02-01 Burroughs Wellcome Co 6-benzylmercaptopurines
CH501652A (de) * 1966-07-01 1971-01-15 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von N-( -(6-Purinylthio)-valeryl)-aminosäureestern
US4169948A (en) * 1977-05-20 1979-10-02 The Dow Chemical Company Pyrazolopyrimidines
US4139705A (en) * 1977-05-20 1979-02-13 The Dow Chemical Company Pyrazolopyrimidines
GR75219B (de) * 1980-04-21 1984-07-13 Merck & Co Inc
IL78643A0 (en) * 1985-05-02 1986-08-31 Wellcome Found Purine derivatives,their preparation and pharmaceutical compositions containing them
JPS62240663A (ja) * 1986-04-11 1987-10-21 Mitsubishi Chem Ind Ltd 複素環チオアラニン誘導体
DE3730542A1 (de) * 1987-09-11 1989-04-06 Hoechst Ag Arzneimittel mit einem gehalt an bestimmten 6-mercaptopurin-derivaten, verwendung dieser 6-mercaptopurin-derivate, verfahren zur herstellung der arzneimittel sowie einige neue 6-mercaptopurin-derivate und verfahren zu deren herstellung
DE3823345A1 (de) * 1988-07-09 1990-01-25 Hoechst Ag 6-merkaptopurin-derivate, ihre herstellung und ihre verwendung zur bekaempfung von retrovirusinfektionen

Also Published As

Publication number Publication date
DE69018375T2 (de) 1996-01-04
EP0426467A1 (de) 1991-05-08
EP0426467B1 (de) 1995-04-05
US5120740A (en) 1992-06-09
JPH03240789A (ja) 1991-10-28
ATE120747T1 (de) 1995-04-15

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee