ATE196913T1 - Neuartige peptidderivate - Google Patents
Neuartige peptidderivateInfo
- Publication number
- ATE196913T1 ATE196913T1 AT96908363T AT96908363T ATE196913T1 AT E196913 T1 ATE196913 T1 AT E196913T1 AT 96908363 T AT96908363 T AT 96908363T AT 96908363 T AT96908363 T AT 96908363T AT E196913 T1 ATE196913 T1 AT E196913T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- peptide derivatives
- novel peptide
- chem
- salts
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- -1 1-dimethylamino-2-methylpropyl group Chemical group 0.000 abstract 5
- 239000002246 antineoplastic agent Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OFDNQWIFNXBECV-UHFFFAOYSA-N Dolastatin 10 Natural products CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)CC)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-UHFFFAOYSA-N 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical compound CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 abstract 1
- 108010045524 dolastatin 10 Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11909195 | 1995-04-21 | ||
| JP11909095 | 1995-04-21 | ||
| PCT/JP1996/000949 WO1996033212A1 (fr) | 1995-04-21 | 1996-04-08 | Nouveaux derives peptidiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE196913T1 true ATE196913T1 (de) | 2000-10-15 |
Family
ID=26456890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96908363T ATE196913T1 (de) | 1995-04-21 | 1996-04-08 | Neuartige peptidderivate |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5840699A (de) |
| EP (1) | EP0831100B1 (de) |
| KR (1) | KR100408909B1 (de) |
| CN (1) | CN1113066C (de) |
| AT (1) | ATE196913T1 (de) |
| AU (1) | AU704973B2 (de) |
| CA (1) | CA2218606A1 (de) |
| DE (1) | DE69610627T2 (de) |
| DK (1) | DK0831100T3 (de) |
| ES (1) | ES2150664T3 (de) |
| GR (1) | GR3034924T3 (de) |
| PT (1) | PT831100E (de) |
| WO (1) | WO1996033212A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69434136T2 (de) * | 1993-10-01 | 2005-12-01 | Teikoku Hormone Mfg. Co., Ltd. | Dolastatin-derivate |
| JP4776843B2 (ja) | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
| US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6884869B2 (en) * | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| EP2478912B1 (de) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Konjugate von Auristatin mit gegen HER2- oder CD22-gerichtete Antikörper und deren therapeutische Verwendung |
| EP3505191A1 (de) * | 2004-11-12 | 2019-07-03 | Seattle Genetics, Inc. | Auristatine mit einer aminobenzoesäureeinheit am n-ende |
| AU2006269422B2 (en) | 2005-07-07 | 2012-12-06 | Seagen Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the C-terminus |
| US8871720B2 (en) | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
| US7750116B1 (en) * | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| CN101802013B (zh) | 2007-07-16 | 2014-07-02 | 健泰科生物技术公司 | 人源化抗cd79b抗体和免疫偶联物及使用方法 |
| PL2176296T3 (pl) | 2007-07-16 | 2012-07-31 | Genentech Inc | Przeciwciała anty-CD79B i immunokoniugaty i sposoby stosowania |
| PT2247620T (pt) | 2008-01-31 | 2016-08-23 | Genentech Inc | Anticorpos e imunoconjugados anti-cd79b e métodos de utilização |
| PL2265283T3 (pl) * | 2008-03-18 | 2015-03-31 | Seattle Genetics Inc | Koniugaty aurystatyny lek łącznik |
| PL3327027T3 (pl) | 2011-11-17 | 2021-06-28 | Pfizer Inc. | Cytotoksyczne peptydy i ich koniugaty przeciwciało lek |
| KR102165464B1 (ko) | 2012-07-19 | 2020-10-14 | 레드우드 바이오사이언스 인코포레이티드 | Cd22에 대해 특이적인 항체 및 이들의 사용 방법 |
| JP2016505513A (ja) | 2012-11-07 | 2016-02-25 | ファイザー・インク | 抗ｎｏｔｃｈ３抗体および抗体−薬物コンジュゲート |
| WO2014074218A1 (en) | 2012-11-12 | 2014-05-15 | Redwood Bioscience, Inc. | Compounds and methods for producing a conjugate |
| WO2014080251A1 (en) | 2012-11-24 | 2014-05-30 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
| EP3074010B1 (de) | 2013-11-27 | 2025-05-14 | Redwood Bioscience, Inc. | Hydrazinylpyrrolverbindungen und verfahren zur herstellung eines konjugats |
| PT3082877T (pt) | 2013-12-17 | 2019-12-03 | Novartis Ag | Péptidos citotóxicos e seus conjugados |
| WO2015127685A1 (en) | 2014-02-28 | 2015-09-03 | Hangzhou Dac Biotech Co., Ltd | Charged linkers and their uses for conjugation |
| JP6681346B2 (ja) | 2014-06-13 | 2020-04-15 | ノバルティス アーゲー | オーリスタチン誘導体およびその抱合体 |
| HRP20200924T8 (hr) | 2014-09-23 | 2023-07-21 | F. Hoffmann - La Roche Ag | Postupak primjene imunokonjugata anti-cd79b |
| CN112125929A (zh) | 2015-06-15 | 2020-12-25 | 杭州多禧生物科技有限公司 | 用于偶联的亲水链接体 |
| WO2015151081A2 (en) | 2015-07-12 | 2015-10-08 | Suzhou M-Conj Biotech Co., Ltd | Bridge linkers for conjugation of a cell-binding molecule |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| WO2017083637A1 (en) | 2015-11-12 | 2017-05-18 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery |
| CA3019398A1 (en) | 2016-04-26 | 2017-11-02 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
| NZ788906A (en) | 2016-06-01 | 2025-07-25 | Servier Ip Uk Ltd | Formulations of polyalkylene oxide-asparaginase and methods of making and using the same |
| US12364767B2 (en) | 2016-11-14 | 2025-07-22 | Hangzhou Dac Biotech Co., Ltd. | Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers |
| US11629122B2 (en) | 2017-05-24 | 2023-04-18 | The Board Of Regents Of The University Of Texas System | Linkers for antibody drug conjugates |
| HUE066413T2 (hu) | 2017-09-08 | 2024-08-28 | Univ Leland Stanford Junior | ENPP1 inhibitorok és alkalmazásuk rák kezelésére |
| EP4167995A4 (de) | 2020-06-18 | 2024-09-11 | The Board of Trustees of the Leland Stanford Junior University | Isoformspezifische aldehyddehydrogenaseinhibitoren |
| MX2023005979A (es) | 2020-11-20 | 2023-08-11 | Scherer Technologies Llc R P | Enlazadores de escisión doble de glicósido para conjugados de anticuerpo y fármaco. |
| AU2022338463A1 (en) | 2021-09-03 | 2024-03-21 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
| JP2024541058A (ja) | 2021-11-03 | 2024-11-06 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | 抗体の特異的共役 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816444A (en) * | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US4978744A (en) * | 1989-01-27 | 1990-12-18 | Arizona Board Of Regents | Synthesis of dolastatin 10 |
| KR0185440B1 (ko) * | 1991-08-09 | 1999-04-01 | 야마구찌 다까시 | 신규의 테트라 펩티트 유도체 |
| US5635483A (en) * | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| DE69434136T2 (de) * | 1993-10-01 | 2005-12-01 | Teikoku Hormone Mfg. Co., Ltd. | Dolastatin-derivate |
| US5741892A (en) * | 1996-07-30 | 1998-04-21 | Basf Aktiengesellschaft | Pentapeptides as antitumor agents |
-
1996
- 1996-04-08 EP EP96908363A patent/EP0831100B1/de not_active Expired - Lifetime
- 1996-04-08 US US08/945,211 patent/US5840699A/en not_active Expired - Fee Related
- 1996-04-08 ES ES96908363T patent/ES2150664T3/es not_active Expired - Lifetime
- 1996-04-08 AU AU51627/96A patent/AU704973B2/en not_active Ceased
- 1996-04-08 CN CN96193417A patent/CN1113066C/zh not_active Expired - Fee Related
- 1996-04-08 PT PT96908363T patent/PT831100E/pt unknown
- 1996-04-08 AT AT96908363T patent/ATE196913T1/de not_active IP Right Cessation
- 1996-04-08 DK DK96908363T patent/DK0831100T3/da active
- 1996-04-08 KR KR1019970706606A patent/KR100408909B1/ko not_active Expired - Fee Related
- 1996-04-08 WO PCT/JP1996/000949 patent/WO1996033212A1/ja active IP Right Grant
- 1996-04-08 DE DE69610627T patent/DE69610627T2/de not_active Expired - Fee Related
- 1996-04-08 CA CA002218606A patent/CA2218606A1/en not_active Abandoned
-
2000
- 2000-11-28 GR GR20000402631T patent/GR3034924T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2218606A1 (en) | 1996-10-24 |
| EP0831100A4 (de) | 1998-07-29 |
| GR3034924T3 (en) | 2001-02-28 |
| ES2150664T3 (es) | 2000-12-01 |
| US5840699A (en) | 1998-11-24 |
| DE69610627D1 (de) | 2000-11-16 |
| WO1996033212A1 (fr) | 1996-10-24 |
| KR100408909B1 (ko) | 2004-04-29 |
| PT831100E (pt) | 2001-01-31 |
| KR19980703203A (ko) | 1998-10-15 |
| DK0831100T3 (da) | 2001-01-02 |
| DE69610627T2 (de) | 2001-02-15 |
| CN1182434A (zh) | 1998-05-20 |
| AU5162796A (en) | 1996-11-07 |
| EP0831100A1 (de) | 1998-03-25 |
| CN1113066C (zh) | 2003-07-02 |
| AU704973B2 (en) | 1999-05-13 |
| EP0831100B1 (de) | 2000-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |