GR3034924T3 - Novel peptide derivatives - Google Patents

Novel peptide derivatives

Info

Publication number
GR3034924T3
GR3034924T3 GR20000402631T GR20000402631T GR3034924T3 GR 3034924 T3 GR3034924 T3 GR 3034924T3 GR 20000402631 T GR20000402631 T GR 20000402631T GR 20000402631 T GR20000402631 T GR 20000402631T GR 3034924 T3 GR3034924 T3 GR 3034924T3
Authority
GR
Greece
Prior art keywords
group
peptide derivatives
novel peptide
chem
salts
Prior art date
Application number
GR20000402631T
Other languages
English (en)
Inventor
Kyoichi Sakakibara
Masaaki Gondo
Koichi Miyazaki
Takeshi Ito
Akihiro Sugimura
Motohiro Kobayashi
Original Assignee
Teikoku Hormone Mfg Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Mfg Co Ltd filed Critical Teikoku Hormone Mfg Co Ltd
Publication of GR3034924T3 publication Critical patent/GR3034924T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
GR20000402631T 1995-04-21 2000-11-28 Novel peptide derivatives GR3034924T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11909095 1995-04-21
JP11909195 1995-04-21
PCT/JP1996/000949 WO1996033212A1 (fr) 1995-04-21 1996-04-08 Nouveaux derives peptidiques

Publications (1)

Publication Number Publication Date
GR3034924T3 true GR3034924T3 (en) 2001-02-28

Family

ID=26456890

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000402631T GR3034924T3 (en) 1995-04-21 2000-11-28 Novel peptide derivatives

Country Status (13)

Country Link
US (1) US5840699A (el)
EP (1) EP0831100B1 (el)
KR (1) KR100408909B1 (el)
CN (1) CN1113066C (el)
AT (1) ATE196913T1 (el)
AU (1) AU704973B2 (el)
CA (1) CA2218606A1 (el)
DE (1) DE69610627T2 (el)
DK (1) DK0831100T3 (el)
ES (1) ES2150664T3 (el)
GR (1) GR3034924T3 (el)
PT (1) PT831100E (el)
WO (1) WO1996033212A1 (el)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69434136T2 (de) * 1993-10-01 2005-12-01 Teikoku Hormone Mfg. Co., Ltd. Dolastatin-derivate
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
HUE027549T2 (hu) 2002-07-31 2016-10-28 Seattle Genetics Inc Hatóanyagot tartalmazó konjugátumok és alkalmazásuk rák, autoimmun betegség vagy fertõzéses betegség kezelésére
KR101192496B1 (ko) 2003-11-06 2012-10-18 시애틀 지네틱스, 인크. 리간드에 접합될 수 있는 모노메틸발린 화합물
CA2586909A1 (en) * 2004-11-12 2006-12-14 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the n terminus
WO2007008848A2 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
CA2614436C (en) 2005-07-07 2016-05-17 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
US7750116B1 (en) * 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
CN101802013B (zh) 2007-07-16 2014-07-02 健泰科生物技术公司 人源化抗cd79b抗体和免疫偶联物及使用方法
PE20090943A1 (es) 2007-07-16 2009-08-05 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados
EP2657253B1 (en) 2008-01-31 2017-07-19 Genentech, Inc. Anti-CD79b antibodies and immunoconjugates and methods of use
ES2647927T3 (es) 2008-03-18 2017-12-27 Seattle Genetics, Inc. Conjugados enlazadores del fármaco auriestatina
SI2780039T1 (en) 2011-11-17 2018-06-29 Pfizer Inc. Cytotoxic peptides and their conjugates between the antibody and the drug
EP3539563A1 (en) 2012-07-19 2019-09-18 Redwood Bioscience, Inc. Antibody specific for cd22 and methods of use thereof
AU2013343045A1 (en) 2012-11-07 2015-05-21 Pfizer Inc. Anti-Notch3 antibodies and antibody-drug conjugates
EP2916835A4 (en) 2012-11-12 2016-07-27 Redwood Bioscience Inc COMPOUNDS AND METHOD FOR PRODUCING A CONJUGATE
US10131682B2 (en) 2012-11-24 2018-11-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
CA2927806C (en) 2013-11-27 2023-01-10 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
PL3082877T3 (pl) 2013-12-17 2020-02-28 Novartis Ag Cytotoksyczne peptydy i ich koniugaty
CN106414465B (zh) 2014-02-28 2021-11-16 杭州多禧生物科技有限公司 带电荷链接体及其在共轭反应上的应用
EP3154997B9 (en) 2014-06-13 2021-04-14 Novartis AG Auristatin derivatives and conjugates thereof
HUE049175T2 (hu) 2014-09-23 2020-09-28 Hoffmann La Roche Eljárás anti-CD79b immunkonjugátumok alkalmazására
CN113350518A (zh) 2015-07-12 2021-09-07 杭州多禧生物科技有限公司 与细胞结合分子的共轭偶联的桥连接体
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
US10654875B2 (en) 2015-11-12 2020-05-19 The Board Of Trustees Of The Leland Stanford Junior University Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery
US11208632B2 (en) 2016-04-26 2021-12-28 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
KR20230162139A (ko) 2016-06-01 2023-11-28 세르비에 아이피 유케이 리미티드 폴리알킬렌 옥시드-아스파라기나제의 제형, 및 그의 제조 및 사용 방법
NZ752394A (en) 2016-11-14 2021-07-30 Hangzhou Dac Biotech Co Ltd Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
IL302338A (en) 2017-09-08 2023-06-01 Univ Leland Stanford Junior ENPP1 inhibitors and their use for cancer treatment
EP4167995A1 (en) 2020-06-18 2023-04-26 The Board of Trustees of the Leland Stanford Junior University Isoform-specific aldehyde dehydrogenase inhibitors
WO2023033129A1 (ja) 2021-09-03 2023-03-09 東レ株式会社 癌の治療及び／又は予防用医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
ATE215962T1 (de) * 1991-08-09 2002-04-15 Teikoku Hormone Mfg Co Ltd Tetrapeptide derivat
US5635483A (en) * 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
DE69434136T2 (de) * 1993-10-01 2005-12-01 Teikoku Hormone Mfg. Co., Ltd. Dolastatin-derivate
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents

Also Published As

Publication number Publication date
CN1182434A (zh) 1998-05-20
DK0831100T3 (da) 2001-01-02
EP0831100A4 (en) 1998-07-29
EP0831100A1 (en) 1998-03-25
KR100408909B1 (ko) 2004-04-29
CA2218606A1 (en) 1996-10-24
AU704973B2 (en) 1999-05-13
CN1113066C (zh) 2003-07-02
ATE196913T1 (de) 2000-10-15
WO1996033212A1 (fr) 1996-10-24
AU5162796A (en) 1996-11-07
ES2150664T3 (es) 2000-12-01
US5840699A (en) 1998-11-24
KR19980703203A (ko) 1998-10-15
DE69610627T2 (de) 2001-02-15
EP0831100B1 (en) 2000-10-11
DE69610627D1 (de) 2000-11-16
PT831100E (pt) 2001-01-31

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