DE69610627D1 - Neuartige peptidderivate - Google Patents
Neuartige peptidderivateInfo
- Publication number
- DE69610627D1 DE69610627D1 DE69610627T DE69610627T DE69610627D1 DE 69610627 D1 DE69610627 D1 DE 69610627D1 DE 69610627 T DE69610627 T DE 69610627T DE 69610627 T DE69610627 T DE 69610627T DE 69610627 D1 DE69610627 D1 DE 69610627D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- peptide derivatives
- new peptide
- chem
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11909095 | 1995-04-21 | ||
JP11909195 | 1995-04-21 | ||
PCT/JP1996/000949 WO1996033212A1 (fr) | 1995-04-21 | 1996-04-08 | Nouveaux derives peptidiques |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69610627D1 true DE69610627D1 (de) | 2000-11-16 |
DE69610627T2 DE69610627T2 (de) | 2001-02-15 |
Family
ID=26456890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69610627T Expired - Fee Related DE69610627T2 (de) | 1995-04-21 | 1996-04-08 | Neuartige peptidderivate |
Country Status (13)
Country | Link |
---|---|
US (1) | US5840699A (de) |
EP (1) | EP0831100B1 (de) |
KR (1) | KR100408909B1 (de) |
CN (1) | CN1113066C (de) |
AT (1) | ATE196913T1 (de) |
AU (1) | AU704973B2 (de) |
CA (1) | CA2218606A1 (de) |
DE (1) | DE69610627T2 (de) |
DK (1) | DK0831100T3 (de) |
ES (1) | ES2150664T3 (de) |
GR (1) | GR3034924T3 (de) |
PT (1) | PT831100E (de) |
WO (1) | WO1996033212A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE282630T1 (de) * | 1993-10-01 | 2004-12-15 | Teikoku Hormone Mfg Co Ltd | Dolastatin-derivate |
EP2266607A3 (de) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunokonjugate für Krebsbehandlung |
US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
US6884869B2 (en) * | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
EP1545613B9 (de) | 2002-07-31 | 2012-01-25 | Seattle Genetics, Inc. | Auristatin-konjugate und ihre verwendung zur behandlung von krebs, einer autoimmunkranheit oder einer infektionskrankheit |
SG195524A1 (en) | 2003-11-06 | 2013-12-30 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
JP2008519863A (ja) * | 2004-11-12 | 2008-06-12 | シアトル ジェネティクス インコーポレイティッド | N末端にアミノ安息香酸単位を有するオーリスタチン |
US8871720B2 (en) * | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
WO2007008603A1 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus |
US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
TWI439286B (zh) | 2007-07-16 | 2014-06-01 | Genentech Inc | 抗-cd79b抗體及免疫共軛物及使用方法 |
ES2528922T3 (es) | 2007-07-16 | 2015-02-13 | Genentech, Inc. | Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso |
MY157403A (en) | 2008-01-31 | 2016-06-15 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
NO2842575T3 (de) | 2008-03-18 | 2018-02-24 | ||
SG11201401452PA (en) | 2011-11-17 | 2014-06-27 | Pfizer | Cytotoxic peptides and antibody drug conjugates thereof |
EP3539563A1 (de) | 2012-07-19 | 2019-09-18 | Redwood Bioscience, Inc. | Für cd22 spezifischer antikörper und verfahren zur verwendung davon |
EP2917240A1 (de) | 2012-11-07 | 2015-09-16 | Pfizer Inc. | Antikörper gegen notch-3 und antikörper-wirkstoff-konjugate |
KR20150083121A (ko) | 2012-11-12 | 2015-07-16 | 레드우드 바이오사이언스 인코포레이티드 | 화합물, 및 컨쥬게이트의 제조방법 |
CN105849086B (zh) | 2012-11-24 | 2018-07-31 | 杭州多禧生物科技有限公司 | 亲水性链接体及其在药物分子和细胞结合分子共轭反应上的应用 |
WO2015081282A1 (en) | 2013-11-27 | 2015-06-04 | Redwood Bioscience, Inc. | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate |
EP3753578A1 (de) | 2013-12-17 | 2020-12-23 | Novartis AG | Zytotoxische peptide und konjugate davon |
DK3122757T3 (da) | 2014-02-28 | 2023-10-09 | Hangzhou Dac Biotech Co Ltd | Ladede linkere og anvendelse deraf til konjugering |
CN106573956A (zh) | 2014-06-13 | 2017-04-19 | 诺华股份有限公司 | 澳瑞他汀衍生物及其缀合物 |
PL3262071T3 (pl) | 2014-09-23 | 2020-08-10 | F. Hoffmann-La Roche Ag | Sposób stosowania immunokoniugatów anty-CD79b |
EP3319936A4 (de) | 2015-07-12 | 2019-02-06 | Suzhou M-conj Biotech Co., Ltd. | Brückenlinker zur konjugation von zellbindenden molekülen |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
WO2017083637A1 (en) | 2015-11-12 | 2017-05-18 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery |
CN109071634A (zh) | 2016-04-26 | 2018-12-21 | R.P.谢勒技术有限责任公司 | 抗体偶联物及其制备和使用方法 |
EP4019007A1 (de) | 2016-06-01 | 2022-06-29 | Servier IP UK Limited | Formulierungen von polyalkylen-oxid-asparaginase und verfahren zur herstellung und verwendung davon |
WO2018086139A1 (en) | 2016-11-14 | 2018-05-17 | Hangzhou Dac Biotech Co., Ltd | Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers |
WO2019051269A1 (en) | 2017-09-08 | 2019-03-14 | The Board Of Trustees Of The Leland Stanford Junior University | ENPP1 INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER |
US20230174537A1 (en) | 2020-06-18 | 2023-06-08 | The Board Of Trustees Of The Leland Stanford Junior University | Isoform-Specific Aldehyde Dehydrogenase Inhibitors |
KR20240051956A (ko) | 2021-09-03 | 2024-04-22 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816444A (en) * | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
US4978744A (en) * | 1989-01-27 | 1990-12-18 | Arizona Board Of Regents | Synthesis of dolastatin 10 |
DE69230824T2 (de) * | 1991-08-09 | 2000-07-27 | Teikoku Hormone Mfg Co Ltd | Neue tetrapeptidderivate |
US5635483A (en) * | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
ATE282630T1 (de) * | 1993-10-01 | 2004-12-15 | Teikoku Hormone Mfg Co Ltd | Dolastatin-derivate |
US5741892A (en) * | 1996-07-30 | 1998-04-21 | Basf Aktiengesellschaft | Pentapeptides as antitumor agents |
-
1996
- 1996-04-08 AT AT96908363T patent/ATE196913T1/de not_active IP Right Cessation
- 1996-04-08 PT PT96908363T patent/PT831100E/pt unknown
- 1996-04-08 KR KR1019970706606A patent/KR100408909B1/ko not_active IP Right Cessation
- 1996-04-08 AU AU51627/96A patent/AU704973B2/en not_active Ceased
- 1996-04-08 ES ES96908363T patent/ES2150664T3/es not_active Expired - Lifetime
- 1996-04-08 WO PCT/JP1996/000949 patent/WO1996033212A1/ja active IP Right Grant
- 1996-04-08 US US08/945,211 patent/US5840699A/en not_active Expired - Fee Related
- 1996-04-08 EP EP96908363A patent/EP0831100B1/de not_active Expired - Lifetime
- 1996-04-08 DK DK96908363T patent/DK0831100T3/da active
- 1996-04-08 DE DE69610627T patent/DE69610627T2/de not_active Expired - Fee Related
- 1996-04-08 CA CA002218606A patent/CA2218606A1/en not_active Abandoned
- 1996-04-08 CN CN96193417A patent/CN1113066C/zh not_active Expired - Fee Related
-
2000
- 2000-11-28 GR GR20000402631T patent/GR3034924T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE196913T1 (de) | 2000-10-15 |
EP0831100B1 (de) | 2000-10-11 |
AU704973B2 (en) | 1999-05-13 |
AU5162796A (en) | 1996-11-07 |
KR19980703203A (ko) | 1998-10-15 |
KR100408909B1 (ko) | 2004-04-29 |
DE69610627T2 (de) | 2001-02-15 |
ES2150664T3 (es) | 2000-12-01 |
CN1182434A (zh) | 1998-05-20 |
DK0831100T3 (da) | 2001-01-02 |
CA2218606A1 (en) | 1996-10-24 |
EP0831100A1 (de) | 1998-03-25 |
CN1113066C (zh) | 2003-07-02 |
EP0831100A4 (de) | 1998-07-29 |
US5840699A (en) | 1998-11-24 |
WO1996033212A1 (fr) | 1996-10-24 |
PT831100E (pt) | 2001-01-31 |
GR3034924T3 (en) | 2001-02-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |