CA2001401A1
(en)
*
|
1988-10-25 |
1990-04-25 |
Claude Piantadosi |
Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
|
CA2164717C
(en)
*
|
1993-06-10 |
2009-10-20 |
Louis S. Kucera |
Method of combatting hepatitis b virus infection
|
JPH09506333A
(ja)
*
|
1993-09-17 |
1997-06-24 |
ギリアード サイエンシーズ,インコーポレイテッド |
治療化合物の投薬方法
|
US5798340A
(en)
|
1993-09-17 |
1998-08-25 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
US5656745A
(en)
*
|
1993-09-17 |
1997-08-12 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
US7135584B2
(en)
|
1995-08-07 |
2006-11-14 |
Wake Forest University |
Lipid analogs for treating viral infections
|
WO1996006620A2
(en)
|
1994-08-29 |
1996-03-07 |
Wake Forest University |
Lipid analogs for treating viral infections
|
CA2224710A1
(en)
*
|
1995-06-15 |
1997-01-03 |
Naoko Inoue |
Phosphonate nucleotide derivatives
|
KR970015804A
(ko)
*
|
1995-09-28 |
1997-04-28 |
이웅열 |
저수축 나일론 6 필라멘트사 및 그의 제조방법
|
DE19540798A1
(de)
*
|
1995-11-02 |
1997-05-07 |
Hoechst Ag |
Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel
|
TW369536B
(en)
*
|
1996-01-18 |
1999-09-11 |
Mitsubishi Chem Corp |
Phosphonate nucleotide compounds
|
US5922695A
(en)
*
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
CN1085673C
(zh)
|
1996-08-13 |
2002-05-29 |
三菱化学株式会社 |
膦酸酯-核苷酸化合物
|
AU6452098A
(en)
|
1997-03-07 |
1998-09-22 |
Metabasis Therapeutics, Inc. |
Novel purine inhibitors of fructose-1,6-bisphosphatase
|
SG106657A1
(en)
*
|
1997-07-25 |
2004-10-29 |
Gilead Sciences Inc |
Nycleotide analog composition and sythesis method
|
TR200000224T2
(tr)
*
|
1997-07-25 |
2000-07-21 |
Gilead Sciences, Inc. |
Nükleotid analog kompozisyonlar.
|
US5935946A
(en)
*
|
1997-07-25 |
1999-08-10 |
Gilead Sciences, Inc. |
Nucleotide analog composition and synthesis method
|
ZA986614B
(en)
|
1997-07-25 |
1999-01-27 |
Gilead Sciences |
Nucleotide analog composition
|
EP1256585B1
(de)
*
|
1997-07-25 |
2004-09-29 |
Gilead Sciences, Inc. |
Verfahren zur Herstellung von 9-(2-(diethylphosphonomethoxy)ethyl)-adenin
|
CA2343027A1
(en)
|
1998-09-09 |
2000-03-16 |
Metabasis Therapeutics, Inc. |
Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
|
US7026469B2
(en)
|
2000-10-19 |
2006-04-11 |
Wake Forest University School Of Medicine |
Compositions and methods of double-targeting virus infections and cancer cells
|
EP1233770B1
(de)
|
1999-12-03 |
2008-02-13 |
The Regents of The University of California at San Diego |
Phosphonatverbindungen
|
EP1914237B1
(de)
|
1999-12-03 |
2014-06-18 |
The Regents of The University of California |
Antivirale Phosphonatesterverbindungen
|
US6965033B2
(en)
*
|
1999-12-22 |
2005-11-15 |
Metabasis Therapeutics, Inc. |
Bisamidate phosphonate prodrugs
|
US6767900B2
(en)
|
2000-02-29 |
2004-07-27 |
Mitsubishi Pharma Corporation |
Phosphonate nucleotide compound
|
RU2002126616A
(ru)
|
2000-03-08 |
2004-03-20 |
Метабэйсис Терапьютикс, Инк. (Us) |
Новые арильные ингибиторы фруктозо-1, 6-бисфосфатазы
|
US7563774B2
(en)
*
|
2000-06-29 |
2009-07-21 |
Metabasis Therapeutics, Inc. |
Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
|
US7309696B2
(en)
|
2000-10-19 |
2007-12-18 |
Wake Forest University |
Compositions and methods for targeting cancer cells
|
MY141789A
(en)
*
|
2001-01-19 |
2010-06-30 |
Lg Chem Investment Ltd |
Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
|
US20030114467A1
(en)
*
|
2001-06-21 |
2003-06-19 |
Shakespeare William C. |
Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof
|
WO2003028737A1
(en)
*
|
2001-08-30 |
2003-04-10 |
Mitsubishi Pharma Corporation |
Anti-viral agents and in-vitro method for the identification of candidates able to inhibit binding of polymerase to epsilon
|
EP1423976A1
(de)
|
2001-08-31 |
2004-06-02 |
Thomson Licensing S.A. |
Folgezähler für einen audiovisuellen datenstrom
|
WO2003050129A1
(en)
*
|
2001-12-07 |
2003-06-19 |
Eli Lilly And Company |
Use of phosphonate nucleotide analogue for treating hepatitis b virus infections
|
US20040121316A1
(en)
|
2002-04-26 |
2004-06-24 |
Gilead Sciences, Inc. |
Method and compositions for identifying anti-HIV therapeutic compounds
|
CA2485702C
(en)
|
2002-05-13 |
2011-07-19 |
Metabasis Therapeutics, Inc. |
Novel phosphonic acid based prodrugs of pmea and its analogues
|
JP4332496B2
(ja)
*
|
2002-05-13 |
2009-09-16 |
メタバシス・セラピューティクス・インコーポレイテッド |
Pmeaおよびpmpa環生成合成
|
CN1684970A
(zh)
*
|
2002-09-26 |
2005-10-19 |
株式会社Lg生命科学 |
(1-膦酰甲氧基-2-烷基环丙基) 甲基核苷衍生物的(+)-反式-异构体、用于制备其立体异构体的方法、及其抗病毒剂的用途
|
KR101115210B1
(ko)
*
|
2002-10-31 |
2012-04-12 |
메타베이시스 테라퓨틱스, 인크. |
신규 시타라빈 모노포스페이트 전구약물
|
DK1583542T3
(da)
|
2003-01-14 |
2008-09-22 |
Gilead Sciences Inc |
Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
EA200501676A1
(ru)
|
2003-04-25 |
2006-04-28 |
Джилид Сайэнс, Инк. |
Фосфонатсодержащие ингибиторы киназы (варианты), способ их получения, фармацевтическая композиция, лекарственная форма на их основе и способ ингибирования киназы у млекопитающего (варианты)
|
US7432261B2
(en)
|
2003-04-25 |
2008-10-07 |
Gilead Sciences, Inc. |
Anti-inflammatory phosphonate compounds
|
SG182849A1
(en)
|
2003-04-25 |
2012-08-30 |
Gilead Sciences Inc |
Antiviral phosphonate analogs
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
WO2004096287A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
WO2004096285A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Anti-infective phosphonate conjugates
|
US20050080053A1
(en)
*
|
2003-08-29 |
2005-04-14 |
Biocryst Pharmaceuticals, Inc. |
Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
|
US7427624B2
(en)
|
2003-10-24 |
2008-09-23 |
Gilead Sciences, Inc. |
Purine nucleoside phosphorylase inhibitory phosphonate compounds
|
JP2007508843A
(ja)
|
2003-10-24 |
2007-04-12 |
ギリアード サイエンシーズ, インコーポレイテッド |
治療用化合物の同定のための方法および組成物
|
WO2005044308A1
(en)
|
2003-10-24 |
2005-05-19 |
Gilead Sciences, Inc. |
Phosphonate analogs of antimetabolites
|
GB0326168D0
(en)
*
|
2003-11-10 |
2003-12-17 |
Arrow Therapeutics Ltd |
Chemical compounds
|
RU2422450C2
(ru)
|
2003-11-19 |
2011-06-27 |
Метабазис Терапеутикс, Инк. |
Новые фосфорсодержащие тиромиметики
|
JP2007515495A
(ja)
|
2003-12-22 |
2007-06-14 |
ギリアード サイエンシーズ, インコーポレイテッド |
4’−置換カルボビル誘導体およびアバカビル誘導体ならびにhivおよびhcv抗ウイルス活性を有する関連化合物
|
US20060052346A1
(en)
*
|
2004-02-17 |
2006-03-09 |
Averett Devron R |
Nucleoside phosphonate derivatives useful in the treatment of HIV infections
|
AU2005254940A1
(en)
|
2004-06-08 |
2005-12-29 |
Metabasis Therapeutics, Inc. |
Lewis acid mediated synthesis of cyclic esters
|
PT2258376T
(pt)
|
2004-07-27 |
2019-05-31 |
Gilead Sciences Inc |
Análogos fosfonatados de compostos inibidores do vih
|
WO2006023515A2
(en)
*
|
2004-08-18 |
2006-03-02 |
Metabasis Therapeutics, Inc. |
Novel thiazole inhibitors of fructose 1,6-bisphosphatase
|
WO2006110655A2
(en)
|
2005-04-08 |
2006-10-19 |
Chimerix, Inc. |
Compounds, compositions and methods for the treatment of poxvirus infections
|
TWI471145B
(zh)
|
2005-06-13 |
2015-02-01 |
Bristol Myers Squibb & Gilead Sciences Llc |
單一式藥學劑量型
|
TWI375560B
(en)
|
2005-06-13 |
2012-11-01 |
Gilead Sciences Inc |
Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
|
WO2007014491A1
(fr)
*
|
2005-08-03 |
2007-02-08 |
Beijing Fu Kang Ren Bio-Pharm Tech.Co.Ltd. |
Phosphonates de nucléotides acycliques et leur utilisation dans des agents antiviraux
|
EP3006424A1
(de)
|
2005-11-11 |
2016-04-13 |
The Scripps Research Institute |
Histondeacetylaseinhibitoren als therapeutika für neurologische erkrankungen
|
US20090227491A1
(en)
|
2006-07-07 |
2009-09-10 |
Gilead Sciences, Inc. |
Antiviral phosphinate compounds
|
US7842672B2
(en)
|
2006-07-07 |
2010-11-30 |
Gilead Sciences, Inc. |
Phosphonate inhibitors of HCV
|
WO2008098244A1
(en)
|
2007-02-09 |
2008-08-14 |
Metabasis Therapeutics, Inc. |
Novel antagonists of the glucagon receptor
|
MX2009011068A
(es)
|
2007-04-13 |
2010-01-13 |
Southern Res Inst |
Agentes anti-angiogenicos y metodos de utilizacion.
|
EP2185570B1
(de)
|
2007-08-13 |
2014-03-19 |
Metabasis Therapeutics, Inc. |
Neuartige glucokinase-aktivatoren
|
CA2713105C
(en)
|
2008-01-25 |
2016-06-07 |
Chimerix, Inc. |
Methods of treating viral infections
|
TWI444384B
(zh)
*
|
2008-02-20 |
2014-07-11 |
Gilead Sciences Inc |
核苷酸類似物及其在治療惡性腫瘤上的用途
|
CN102089318B
(zh)
|
2008-07-08 |
2014-05-21 |
吉里德科学公司 |
Hiv抑制剂化合物的盐
|
CA2966273C
(en)
|
2008-08-13 |
2019-08-27 |
Metabasis Therapeutics, Inc. |
Glucagon antagonists
|
CA2748174A1
(en)
|
2008-12-30 |
2010-07-08 |
Arqule, Inc. |
Substituted 1h-pyrazolo[3,4-d]pyrimidine-6-amine compounds
|
WO2010114894A1
(en)
|
2009-03-31 |
2010-10-07 |
Arqule, Inc. |
Substituted heterocyclic compounds
|
US8614200B2
(en)
|
2009-07-21 |
2013-12-24 |
Chimerix, Inc. |
Compounds, compositions and methods for treating ocular conditions
|
ES2629165T3
(es)
|
2010-02-12 |
2017-08-07 |
Chimerix, Inc. |
Métodos de tratamiento de una infección vírica
|
US8940313B2
(en)
|
2010-04-23 |
2015-01-27 |
University Of Southern California |
Tyrosine-based prodrugs of antiviral agents
|
EP2563367A4
(de)
|
2010-04-26 |
2013-12-04 |
Chimerix Inc |
Verfahren zur behandlung von retroviren-infektionen und entsprechende dosierungspläne
|
CA2819548C
(en)
|
2010-12-10 |
2019-04-09 |
Sigmapharm Laboratories, Llc |
Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs
|
US9550803B2
(en)
|
2011-05-06 |
2017-01-24 |
University Of Southern California |
Method to improve antiviral activity of nucleotide analogue drugs
|
EP3578563B1
(de)
|
2011-12-22 |
2021-04-14 |
Geron Corporation |
Guanin-analoga als telomerasesubstrate und telomerlängenaffektoren
|
CN102786549B
(zh)
*
|
2012-08-13 |
2013-07-03 |
洛阳聚慧投资股份有限公司 |
一组具有抑制hiv-1病毒复制活性的替诺福韦双酯化合物、制备方法及其药物用途
|
SG10201800188SA
(en)
|
2013-03-15 |
2018-02-27 |
Univ California |
Acyclic nucleoside phosphonate diesters
|
CN106061984A
(zh)
|
2014-02-13 |
2016-10-26 |
配体药物公司 |
前药化合物及其用途
|
CN103819472A
(zh)
*
|
2014-03-18 |
2014-05-28 |
福建天泉药业股份有限公司 |
缬恩替卡韦酸式加成盐及其制备方法
|
US10076504B2
(en)
|
2014-06-12 |
2018-09-18 |
Ligand Pharmaceuticals, Inc. |
Glucagon antagonists
|
EP3164136A4
(de)
|
2014-07-02 |
2018-04-04 |
Ligand Pharmaceuticals, Inc. |
Prodrug-verbindungen und verwendungen davon
|
JP6708329B2
(ja)
|
2014-09-15 |
2020-06-10 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
ヌクレオチド類似体
|
WO2017048956A1
(en)
|
2015-09-15 |
2017-03-23 |
The Regents Of The University Of California |
Nucleotide analogs
|
ES2969496T3
(es)
|
2017-08-01 |
2024-05-20 |
Gilead Sciences Inc |
Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2- il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales
|
CA3087932A1
(en)
|
2018-01-09 |
2019-07-18 |
Ligand Pharmaceuticals, Inc. |
Acetal compounds and therapeutic uses thereof
|