CY1110570T1 - Χρηση της ουριδινης σε συνδυασμο με χολινη για τη θεραπεια διαταραχων της μνημης - Google Patents

Χρηση της ουριδινης σε συνδυασμο με χολινη για τη θεραπεια διαταραχων της μνημης

Info

Publication number
CY1110570T1
CY1110570T1 CY20091101264T CY091101264T CY1110570T1 CY 1110570 T1 CY1110570 T1 CY 1110570T1 CY 20091101264 T CY20091101264 T CY 20091101264T CY 091101264 T CY091101264 T CY 091101264T CY 1110570 T1 CY1110570 T1 CY 1110570T1
Authority
CY
Cyprus
Prior art keywords
choline
uridine
treatment
combination
memory disorders
Prior art date
Application number
CY20091101264T
Other languages
English (en)
Inventor
Carol Watkins
Richard J Wurtman
Original Assignee
Massachusetts Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute Of Technology filed Critical Massachusetts Institute Of Technology
Publication of CY1110570T1 publication Critical patent/CY1110570T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Θεραπεία ασθενειών μνήμης με χρήση εξωγενούς ουριδίνης ή μιας πηγής ουριδίνης ως πρόδρομος ενδογενούς κυτιδίνης, ειδικά στο ανθρώπινο μυαλό, όπου η εξωγενής ουριδίνη ή πηγή ουριδίνης συνδυάζεται με ενώσεις που εξυπηρετούν ως πηγή χολίνης σε συνθέσεις φωσφολιπίδων.
CY20091101264T 1998-07-31 2009-12-01 Χρηση της ουριδινης σε συνδυασμο με χολινη για τη θεραπεια διαταραχων της μνημης CY1110570T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9500298P 1998-07-31 1998-07-31
EP07116909A EP1870103B1 (en) 1998-07-31 1999-07-30 Use of uridine in combination with choline for the treatment of memory disorders

Publications (1)

Publication Number Publication Date
CY1110570T1 true CY1110570T1 (el) 2015-04-29

Family

ID=22248474

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101264T CY1110570T1 (el) 1998-07-31 2009-12-01 Χρηση της ουριδινης σε συνδυασμο με χολινη για τη θεραπεια διαταραχων της μνημης

Country Status (11)

Country Link
US (1) US6989376B2 (el)
EP (5) EP1140104B1 (el)
JP (1) JP2003517437A (el)
AT (2) ATE374029T1 (el)
CA (1) CA2339008C (el)
CY (1) CY1110570T1 (el)
DE (2) DE69941586D1 (el)
DK (5) DK2329829T3 (el)
ES (5) ES2294850T3 (el)
PT (5) PT2145627E (el)
WO (1) WO2000006174A1 (el)

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Also Published As

Publication number Publication date
CA2339008C (en) 2009-12-15
ES2478044T3 (es) 2014-07-18
EP2145627B1 (en) 2014-04-16
DK2145627T3 (da) 2014-07-21
EP1870103A3 (en) 2008-08-06
PT2322187E (pt) 2014-07-24
ES2477568T3 (es) 2014-07-17
EP2329829A2 (en) 2011-06-08
DK2322187T3 (da) 2014-07-21
EP2322187B1 (en) 2014-05-14
EP1140104A1 (en) 2001-10-10
EP1870103B1 (en) 2009-10-21
US6989376B2 (en) 2006-01-24
ES2476940T3 (es) 2014-07-15
ATE374029T1 (de) 2007-10-15
EP1140104A4 (en) 2004-12-22
EP2322187A2 (en) 2011-05-18
ES2294850T3 (es) 2008-04-01
WO2000006174A1 (en) 2000-02-10
EP1140104B1 (en) 2007-09-26
EP2329829A3 (en) 2011-07-20
EP1870103A2 (en) 2007-12-26
PT2145627E (pt) 2014-07-24
EP2329829B1 (en) 2014-04-16
DE69937198D1 (de) 2007-11-08
DE69937198T2 (de) 2008-07-03
PT1140104E (pt) 2007-12-26
PT1870103E (pt) 2010-02-23
US20020028787A1 (en) 2002-03-07
PT2329829E (pt) 2014-07-24
ES2332669T3 (es) 2010-02-10
JP2003517437A (ja) 2003-05-27
CA2339008A1 (en) 2000-02-10
ATE446097T1 (de) 2009-11-15
EP2145627A1 (en) 2010-01-20
DK2329829T3 (da) 2014-07-21
DE69941586D1 (de) 2009-12-03
EP2322187A3 (en) 2011-07-20
DK1870103T3 (da) 2010-01-11
DK1140104T3 (da) 2008-01-21

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