MX2020007866A - Composiciones y dispositivos para el suministro sistemico de uridina. - Google Patents

Composiciones y dispositivos para el suministro sistemico de uridina.

Info

Publication number
MX2020007866A
MX2020007866A MX2020007866A MX2020007866A MX2020007866A MX 2020007866 A MX2020007866 A MX 2020007866A MX 2020007866 A MX2020007866 A MX 2020007866A MX 2020007866 A MX2020007866 A MX 2020007866A MX 2020007866 A MX2020007866 A MX 2020007866A
Authority
MX
Mexico
Prior art keywords
uridine
compositions
devices
systemic delivery
solution
Prior art date
Application number
MX2020007866A
Other languages
English (en)
Inventor
Borstel Reid W Von
Garcia Rolando Alejandro Garcia
Original Assignee
Wellstat Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp
Publication of MX2020007866A publication Critical patent/MX2020007866A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Saccharide Compounds (AREA)

Abstract

Una solución de uridina en solución salina, y que contiene también opcionalmente beta-hidroxibutirato, se puede administrar por la ruta subcutánea. Se describe un depósito capaz de retener una solución de uridina en solución salina, el depósito está vinculado fluídicamente a una o más agujas de infusión, y una bomba configurada para mover la solución del depósito a través de una o más de las agujas de infusión dentro de un sujeto.
MX2020007866A 2018-02-01 2019-02-01 Composiciones y dispositivos para el suministro sistemico de uridina. MX2020007866A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862624911P 2018-02-01 2018-02-01
US201862715848P 2018-08-08 2018-08-08
PCT/US2019/016246 WO2019152776A1 (en) 2018-02-01 2019-02-01 Compositions and devices for systemic delivery of uridine

Publications (1)

Publication Number Publication Date
MX2020007866A true MX2020007866A (es) 2020-12-03

Family

ID=67479521

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020007866A MX2020007866A (es) 2018-02-01 2019-02-01 Composiciones y dispositivos para el suministro sistemico de uridina.

Country Status (13)

Country Link
US (1) US20210187001A1 (es)
EP (1) EP3746050A4 (es)
JP (2) JP2021512061A (es)
KR (1) KR20200116096A (es)
CN (1) CN111601589B (es)
AU (1) AU2019215105A1 (es)
BR (1) BR112020013342A2 (es)
CA (2) CA3217123A1 (es)
IL (1) IL276236A (es)
MX (1) MX2020007866A (es)
RU (1) RU2020128453A (es)
WO (1) WO2019152776A1 (es)
ZA (1) ZA202003700B (es)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60136515A (ja) * 1983-12-23 1985-07-20 Yasuo Komoda 睡眠促進剤
US5654266A (en) * 1992-02-10 1997-08-05 Chen; Chung-Ho Composition for tissues to sustain viability and biological functions in surgery and storage
EP0768883A4 (en) * 1994-07-01 2004-09-15 Wellstat Therapeutics Corp PYRIMIDINE NUCLEOTIDE PRECURSORS FOR THE TREATMENT OF SYSTEMIC INFLAMMATION AND INFLAMMATORY HEPATITIS
US5776498A (en) * 1995-11-06 1998-07-07 Nutrition 21 Magnesium taurate as an adjuvant to rapid thrombolytic therapy
JP4598203B2 (ja) * 1995-12-01 2010-12-15 ビーティージー・インターナショナル・リミテッド 脳機能改善剤
US5858005A (en) * 1997-08-27 1999-01-12 Science Incorporated Subcutaneous infusion set with dynamic needle
DK2322187T3 (da) * 1998-07-31 2014-07-21 Massachusetts Inst Technology Anvendelse af uridin i kombination med cholin til behandling af hukommelses-lidelser
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
CN1434709A (zh) * 2000-04-06 2003-08-06 小野药品工业株式会社 基于狭窄性血管病变的疾病治疗剂
CN102600199A (zh) * 2004-09-15 2012-07-25 麻省理工学院 含有尿苷的组合物及使用其的方法
JP5999712B2 (ja) * 2011-03-03 2016-09-28 国立大学法人 宮崎大学 高体温治療剤
WO2014027882A1 (en) * 2012-08-13 2014-02-20 N.V. Nutricia Product and method for supporting uridine homeostasis
CA2902603C (en) * 2013-03-19 2021-03-02 University Of South Florida Compositions and methods for producing elevated and sustained ketosis
US10568854B2 (en) * 2014-05-30 2020-02-25 The Johns Hopkins University Compositions and methods for treating kabuki syndrome and related disorders
US20170209476A1 (en) * 2014-08-19 2017-07-27 Wellstat Therapeutics Corporation Treatment of Glycosylation Deficiency Diseases
US10123985B2 (en) * 2015-06-08 2018-11-13 Whitehead Institute For Biomedical Research Therapeutic strategies for treating mitochondrial disorders
US10376482B2 (en) * 2016-04-03 2019-08-13 Franco Cavaleri Butyrate and beta-hydroxybutyrate compositions

Also Published As

Publication number Publication date
WO2019152776A8 (en) 2020-07-30
JP2021512061A (ja) 2021-05-13
EP3746050A1 (en) 2020-12-09
WO2019152776A1 (en) 2019-08-08
US20210187001A1 (en) 2021-06-24
JP2024023386A (ja) 2024-02-21
ZA202003700B (en) 2021-08-25
CN111601589B (zh) 2024-05-24
IL276236A (en) 2020-09-30
CA3088213A1 (en) 2019-08-08
CN111601589A (zh) 2020-08-28
AU2019215105A1 (en) 2020-08-13
CA3217123A1 (en) 2019-08-08
BR112020013342A2 (pt) 2020-12-01
RU2020128453A (ru) 2022-03-01
KR20200116096A (ko) 2020-10-08
EP3746050A4 (en) 2022-02-09

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